CN1276216A - Process for preparing non-decoction Chinese medicine - Google Patents
Process for preparing non-decoction Chinese medicine Download PDFInfo
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- CN1276216A CN1276216A CN 00107662 CN00107662A CN1276216A CN 1276216 A CN1276216 A CN 1276216A CN 00107662 CN00107662 CN 00107662 CN 00107662 A CN00107662 A CN 00107662A CN 1276216 A CN1276216 A CN 1276216A
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Abstract
A process for preparing the non-decoction Chinese medicine using the animal and plant materials or inorganic materials as raw materials includes pretrating raw materials, extracting in hot water twice, merging the extract, filtering, vacuum concentrating to obtain extract with 1.2-1.35 of specific weight, drying dregs, pulverizing, mixing it with said extract and spray drying. Its advantages are convenient application, quickly taking its effect and high uniformity.
Description
The present invention relates to animal, vegetable material, inorganic material a kind of material wherein is the method for mixture effective ingredient in the extraction Chinese crude drug of raw material.
It is with a long history that the Chinese herbal medicine of China is used, clinical thousands of years have been applied to, the deep Gu doctor culture and the intension of philosophic thinking are arranged, through the clinical extensive use of successive dynasties medical expert, accumulated the dialectical theory of abundant clinical experience and philosophy, have huge effect, also enrich so far, become the rarity of the Chinese nation in development.
Traditional Chinese medicine patent medicine is ball, loose, cream, pellet, but the form of decoction takes, and is more effective, with strong points, instant effect.But fried very trouble, more because decocting method (be decocted first, the back down, decoct a drug wrapped molten etc.) complexity, the person's of boiling medicine proficiency level's difference is easy to cause the loss of effective components of Chinese medicinal and the uncertainty of effective dose, brings to subtract effect, even invalid drawback; Because taking dose is improper, may cause diseases such as gastrointestinal upset, more is not easy to journey and uses.Decoction mostly is two and fries in shallow oil, and divides secondary to take, because weather sweltering heat in summer, temperature height, the medicinal liquid of taking for the second time are easy to rotten and are unsuitable for taking, and the saying that causes be unsuitable for the hot summer days to take decoction influences treatment of diseases.
Introduction along with the new drug dosage form, formed the form of Chinese drug of oral granule electuary, but the oral granule solubility property that has is poor, adjuvant is too much, and adjuvant mostly is saccharides such as sucrose, lactose, causes invalid components too much, makes the content of effective in the medicine uncertain, affect the treatment, and diabetics is difficult for taking.
Tradition Chinese medicine decoction pieces medicine is faced with challenge in changeable situation market and in the kownledge economy formation, also be faced with the raising of Chinese medicine scientific and technological content and the reform of form of Chinese drug simultaneously, and " innovating pseudo-classic " is the cultural a kind of approach of the ancient doctor of continuity.Utilize " dialectical " of the traditional Chinese medical science and doctor trained in Western medicine " debating disease " the exploitation Chinese medicine that combines, and application modern science and technology analysis means, in conjunction with contemporary pharmacy and relevant document " Chinese medicine modern study, Clinical Chinese Materia Medica, pharmacology of Chinese materia medica, the science of Chinese drug processing, the science of identification of Chinese materia medica, pharmacy of Chinese materia medica " authentication of science is carried out in the function of the many target spots of single medicinal material multicomponent, and then quantification content standard, formation modern Chinese medicine theory, this is to reinvent the ancient certainty of curing culture and meeting World Economics to challenge.General just qualitative now for the check of Chinese medicine, and adopt medical material than mensuration more.This method is just fixing on quality of medicinal material specification and preparation technology, and rule of operation is carried out standard.The electuary granule for preparing like this can only have a fuzzy notion to mixture content of effective in the Chinese medicine, and not have accurate data.
Chinese patent literature CN1238944A (application number 98102252.9) proposes a kind of method that the natural plants dip is processed into the powdery medicine.This method is water heating extraction from natural plant crude drugs, generates extracting solution, with the extracting solution concentrating under reduced pressure, and fecula shape medicine after vacuum freeze-drying or spray drying again.The powdered drug steady quality of Sheng Chenging has kept the effective ingredient in the natural plant crude drugs effectively in this way, and long shelf-life is easy to use.But said method only is used for the preparation of body lotion powdery medicine, still is not used in animal drug, the mineral medicinal material, and its medicinal residues do not utilize yet.
A kind of preparation method of Chinese medicine of exempting to fry in shallow oil of the present invention, root with natural medicinal plant, stem, skin, leaf, flower, fruit, seed, the medicinal part of natural medicinal animal, the natural minerals medical material wherein a kind of medical material or needed several the Chinese crude drug of pressing pharmaceutical formulation after pretreatment as raw medicinal material, the 4-10 water doubly that in raw medicinal material, adds the raw medicinal material amount, under normal pressure under 60-100 ℃ temperature heating extraction 1-8 hour, take out extracting solution for the first time, obtain extracting solution and medicinal residues for the first time for the first time, in first time medicinal residues, add the water that the 2-8 of raw medicinal material amount doubly measures, under normal pressure under 60-100 ℃ temperature heating extraction 0.5-6 hour, take out extracting solution for the second time, obtain extracting solution and medicinal residues for the second time for the second time, merge first, secondary raffinate, filter, to passing through filtering extracting solution at pressure 0.02-0.09Mpa, carry out concentrating under reduced pressure under the condition of 30-90 ℃ of temperature, be condensed into the fluid extract of proportion 1.20-1.35, for the second time after the medicinal residues drying, be ground into the medicinal residues fine powder as compound, the fluid extract of medicinal residues fine powder and above-mentioned proportion 1.20-1.35 is mixed, form mixture, with water vapour gas or nitrogen is atomization gas, carry out spray drying, generate the medicated powder granule.
Said pretreatment to Chinese crude drug is exactly to select up-to-standard Chinese crude drug, just analyze content of effective as the Chinese crude drug of raw material with the assay method of country mark product, see whether it meets desired standard, water flushing medical material, color until water is limpid, again medical material is dried or drenches and do.In order to put forward extraction ratio of effective constituents, can be cut into sheet, bulk or be ground into graininess, this is that those skilled in the art all know.Certainly the Chinese crude drug that yet has can not cut into slices yet, piece or be ground into granule.The medical material that has also needs to soak before heating extraction, soak the suitable time, so that when heating extraction, help the stripping of effective ingredient, the length of soak time is decided on the character of medical material, what have will soak 10～60 minutes, that have even soaked 12～24 hours, the water that will soak that has is as the part of the amount of water first time, and this also will decide on the character of medical material.Used water has wherein a kind of of tap water, distilled water, deionized water.
For the first time, for the second time during heating extraction, the time of the water yield that is added and the heating extraction of wanting, look the character of different medicinal raw materials and difference.If with root, stem, the skin of medicinal green natural plant is raw material, for the first time during heating extraction, the water yield that is added be the raw medicinal material amount 6-8 doubly, under 60-100 ℃ temperature heating extraction 1-3 hour for well; For the second time during heating extraction, the water yield that is added be the raw medicinal material amount 5-7 doubly, under 60-100 ℃ temperature heating extraction 0.5-2 hour.If leaf, flower class with medicinal green natural plant are raw material, for the first time during heating extraction, the water yield that is added is 6-8 a times of raw medicinal material amount, under 60-100 ℃ temperature, heating extraction 1-3 hour, for the second time during heating extraction, the water yield that is added be the raw medicinal material amount 3-7 doubly, under 60-100 ℃ temperature heating extraction 0.5-2 hour.If with fruit, the seed of medicinal green natural plant is raw material, for the first time during heating extraction, the water yield that is added be the raw medicinal material amount 6-8 doubly, under 60-100 ℃ temperature, heating extraction 1-3 hour; For the second time during heating extraction, the water yield that is added be the raw medicinal material amount 4-7 doubly, under 60-100 ℃ temperature heating extraction 0.5-2 hour.If with the medicinal part of medicinal green natural medicinal animal is raw material, for the first time during heating extraction, the water yield that is added be the raw medicinal material amount 6-8 doubly, under 60-100 ℃ temperature heating extraction 1-3 hour; The water yield that is added when extracting for the second time be the raw medicinal material amount 5-7 doubly, under 60-100 ℃ temperature heating extraction 0.5-2 hour.If with the natural minerals medical material is raw material, for the first time during heating extraction, the water yield that is added is 4-7 a times of raw medicinal material amount, under 60-100 ℃ temperature heating extraction 3-8 hour, the water yield that is added when extracting for the second time be the raw medicinal material amount 3-6 doubly, under 60-100 ℃ temperature heating extraction 2-6 hour.Can be undertaken the 3rd, the 4th time by above-mentioned method if necessary ... heating extraction.When above-mentioned all first, second time heating extraction, monitor automatically wherein effective ingredient etc. is carried out microcomputer at the ad-hoc location of every section operation, carry out quantitative assay for best, can grasp the situation of extraction at any time.Merge first and second time extracting solution, after filtering, can also carry out quantitative assay effective ingredient wherein with the microcomputer automatic monitoring method its filtrate.
The green natural medicinal plants root that is adopted; stem; skin is a raw medicinal material, and its raw medicinal material is: the Radix Astragali; Rhizoma Dioscoreae; Radix Isatidis; Radix Angelicae Sinensis; Rhizoma Cibotii; the Rhizoma Atractylodis Macrocephalae; Radix Glycyrrhizae; Radix Morindae Officinalis; Rhizoma Curculiginis; Radix Dipsaci; Rhizoma Drynariae; Herba Cynomorii; Radix Rehmanniae Preparata; Radix Polygoni Multiflori; Radix Paeoniae Alba Radix Asparagi; Bulbus Lilii; Radix Ephedrae; Ramulus Cinnamomi; Herba Schizonepetae; Radix Saposhnikoviae; Rhizoma Et Radix Notopterygii; the Radix Angelicae Dahuricae; Radix Gentianae Macrophyllae; Rhizoma Ligustici; Ramulus et Folium Tamaricis; Radix Puerariae; Radix Bupleuri; Rhizoma Cimicifugae; Radix Kansui; the Radix Euphorbiae Pekinensis; Radix Phytolaccae; Radix Angelicae Pubescentis; Radix Clematidis; Rhizoma Atractylodis; Herba Eupatorii; Radix Et Caulis Acanthopanacis Senticosi; Rhizoma Polygonati; Radix Trichosanthis; Radix Adenophorae (Radix Glehniae); Herb Gynostemmae Pentaphylli; Rhizoma Osmundae; Radix Cirsii Japonici; Herba Cirsii; Radix Sanguisorbae; Radix Boehmeriae; Semen Trigonellae; Fructus Mori; Radix Oryzae Glutinosae; Cortex Ailanthi; Pericarpium Granati; Herba Ephedrae; purple medicine; Herba Moslae; very light blue; Herba Coriandri; Herba Menthae; the Herba Equiseti Hiemalis; Radix Stephaniae Tetrandrae; charred Petiolus Trachycarpi; Radix Gentianae Macrophyllae; Folium et Ramulus Clerodendri Trichotomi; Caulis Trachelospermi; Radix Cynanchi Paniculati; Ramulus Mori; Herba Taxilli; Cortex Acanthopancis; Cortex erythrinae; Herba Aristolochiae Mollissimae; rattan through the country; Rhizoma Homalomenae; Lignum Pini Nodi; Cortex Magnoliae Officinalis; Herba Pogostemonis; the Cortex Eucommiae; Lignum Aquilariae Resinatum; Radix Aristolochiae; Bulbus Allii Macrostemonis; Lignum Santali Albi; Calyx Kaki; Radix Et Rhizoma Nardostachyos; Fructus Akebiae; Herba Salviae Chinensis; Massa Medicata Fermentata; Fructus Hordei Germinatus; Fructus Setariae Germinatus; Cortex Meliae; Fructus Ulmus preparatium; Rhizoma Imperatae; Herba Agrimoniae; the Pseudobulbus Bletillae (Rhizoma Bletillae); charred Petiolus Trachycarpi; Radix Notoginseng; Radix Rubiae; Radix Rumicis Japonici; Nodus Nelumbinis Rhizomatis; Rhizoma Chuanxiong; Rhizoma Corydalis; Radix Curcumae; Rhizoma Curcumae Longae; Rhizoma Curcumae; rhizoma sparganic; Radix Salviae Miltiorrhizae; Rhizoma Polygoni Cuspidati; Caulis Spatholobi; Radix Achyranthis Bidentatae; Lignum Dalbergiae Odoriferae; the Herba Lycopi; Herba Artemisiae Anomalae; Lignum Sappan; the Rhizoma Pinelliae; Rhizoma Arisaematis; Fructus Gleditsia; Radix Platycodonis; Rhizoma Cynanchi Stauntonii; Radix Peucedani; Bulbus Fritillariae Uninbracteatae; Concretio silicea Bambusae seu schizostachyi; Caulis Bambusae In Taenia; Succus Bambusae; the Radix Stemonae; Cortex Mori; the Japan Herba Ardisiae Japonicae; Radix Polygalae; Cortex Albiziae; Ramulus Uncariae Cum Uncis; Rhizoma Gastrodiae; Fructus Tribuli; Rhizoma Acori Graminei; Radix Ginseng; Radix Panacis Quinquefolii; Radix Codonopsis; Radix Pseudostellariae; Cortex Fraxini; Radix Sophorae Flavescentis; Rhizoma Smilacis Glabrae; Radix et Caulis Opuntiae Dillenii; Herba Centipedae; Radix Asteris; the plain rice tree; continuous ; Petiolus Trachycarpi; Radix Stephaniae Epigaeae; Herba Erodii; Rhizoma Cimicifugae; the Rhizoma Anemarrhenae; Rhizoma Phragmitis; Radix Trichosanthis; Herba Commelinae; Flos Eriocauli; Radix Scutellariae; Rhizoma Coptidis; Cortex Phellodendri; Radix Gentianae; Radix Rehmanniae; Radix Scrophulariae; Cortex Moutan; Radix Paeoniae Rubra; Radix Arnebiae (Radix Lithospermi); dandelion; Herba Violae; Indigo Naturalis; Rhizoma Paridis; BANLIANLIAN; heavy basin grass; Herba Houttuyniae; Rhizoma Belamcandae; Radix Sophorae Tonkinensis; Lasiosphaera Seu Calvatia; the Radix Pulsatillae; Caulis Sargentodoxae; Herba Patriniae; Hedyotidis Diffusae; Radix Ampelopsis; Cortex Dictamni; Radix Rhapontici; Pseudobulbus cremastrae seu pleiones; Ilex purpurea Hassk.[I.chinensis Sims; Fagopyrum cymosum Meisn.; Herba Euphorbiae Humifusae; the Bai Maofu hay; Herba Artemisiae Annuae; the silver Radix Bupleuri; Rhizoma Picrorhizae; Herba Equiseti Arvinsis; Poria; Polyporus; Rhizoma Alismatis; Caulis Akebiae; Medulla Tetrapanacis; Herba Lysimachiae; Folium Pyrrosiae; ; Herba Artemisiae Scopariae; Herba Euphorbiae Helioscopiae; holds; Medulla Junci; Radix Aconiti Lateralis Preparata; Rhizoma Zingiberis; Cortex Cinnamomi; Herba Asari Fructus Piperis Longi; Rhizoma Alpiniae Officinarum; the Radix Aucklandiae; Rhizoma Cyperi; the Radix Linderae; Cortex Hibisci; Bulbus Allii; buttercup; Radix Alangii; Rhizoma et Radix Dysosmae Veitchii; Herba Pileae Scriptae; Herba Senecionis Scandentis; Radix Et Rhizoma Tylophorae Ovatae; Rhizoma Bolbostematis; Herba Fici Simplicissimae; Pseudobulbus Cremastrae seu Pleiones; the Acronychi apedunculata (L.) Miq. skin; a thousand pieces of gold grass; garden lettuce; Radix Dipsaci; Wei Mao; Radix Veratri mengtzeani; Radix Tylophorae Yunnanensis; Radix Rubiae Yunnanensis; Herba Portulacae; Herba Verbenae; Radix Trichosanthis Cucumeroidis; Moschus; the wood sesame; kapok; Caulis Kadsurae Longipedunculatae; Radix Rumicis Crispi; Caulis Bambusae Germinatus; Radix Actinidiae Erianthae; Cortex Moutan; Herba Pteridis Multifidae; Radix Fissistigmatis Glaucescentis; Radix Cissi hexangularis; Radix et Rhizoma Dispori Cantoniensis; Herba Solani Nigri; Rhizoma et Radix Doellingeriae (Herba Doellingeriae); Herba Hyperici Japonici; Radix Et Rhizoma Rhei; Rabdosia rubescens; to knot; Herba Violae; Herba Elephantopi scaberis; Herba Euphorbiae Humifusae; Fructus Colocasiae Esculentae; Herba Damnacanthi; the west Radix Sophorae Tonkinensis; centipede; bamboo sprout; Caulis et Folium Crotalariae Assamicae; the leukemia grass; Arisaema balansae Engl. grass; Herba Trifolii Pratentis; the reed root; Radix Panacis Quinquefolii; the JINCHONG rabbit ear; Herba Sedi Linearis; Spina Gleditsiae; Herba Paederiae; Cor Gigeriae Galli is attached in vain; the old bud of thorn; Fructus Solani Dulcamarae; Radix Sophorae Alopecuroidis; Herba Scorzonerae Divaricatae; Herba Saxifragae; Radix Anemones Rivularis; pick up the ears; Rhizoma Smilacis Bockii; the spun gold Rhizoma Coptidis; the Herba Clematidis Huchouensis grass; gold thread hangs Hibisci Mutabilis; Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis); Lignum Cudraniae tricuspidatae; Herba Caraganae intermediae; red willow; Ramulus Juglandis; Bulbus Iphigeniae Indicae; Caulis et Folium Brassicae junceae; Rhizoma Typhonium Gigantei (Rhizoma Typhonii); Folium Mayteni hookeri; Pericarpium Lagenariae sicerariae; cacumen et folium sabinae vulgaris; Bulbus Fritillariae Thunbergii; Caulis Marsdeniae Tenacissimae; MANSHANXIANG; Herba Hedyotidis Chrysotrichae; Dioscorea bulbifera L.; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani); Radix ampelopsis brevipedunculatae; the Radix solani coagulantis tree root; the macaque Radix pyri; Herba cassiae occidentalis; the Quercus acutissima parasitism; light Rhizoma Zingiberis; Radix Osbeckiae Crinitae; fertile Rhizoma Polygonati Odorati; purple Bai Song; Hericium erinaceus (Bull. Ex Fr.) Pers.; yellow everywhere; the Fructus Sophorae; Auricularia Sophorae; Pleurotus citrinopileatus Sing (Pleurotus ulmarius (Bull. Ex Fr.) Quel.); Rhizoma Curcumae; Semen livistonae chinensis; Fructus Zanthoxyli; Herba veronicastri villosuli; Pericarpium Citri tangerinae; pericarpium arecae; the Calyx seu fructus physalis young pilose antler; Caulis Hederae Sinensis; Radix Oryzae Glutinosae; DILAOSHU; Radix Fici Hirtae; Herba Crotalariae sessiliflorae; Rhizoma Ardisiae Gigantifoliae; Radix Rauvolfiae; Guangxi zedoary; Rhizoma Dysosmae Versipellis; Caulis Impatientis; wide muscle Teng; Cortex Cinnamomi Burmannii; Cortex Periplocae; Cortex Ilicis Rotundae; Petiolus Trachycarpi; Semen Caesalpiniae; Semen Oroxyli; Herba Rabdosiae Nervosae; Herba Chelidonii; the Flos Carthami Sinomenium acutum; kidney tea; Herba Sedi; certain kind of berries leaf committee mound tea; Herba Sedi Aizoon; Herba Potentillae Discoloris; Radix Aconiti; Rhizoma Pinelliae Preparatum; Rhizoma Panacis Japonici; the moxibustion Radix Hedysari; Herba Swertiae Mileensis; Herba Potentillae Chinensis; Bergeninum; Herba Solidaginis; Herba Cichorii; Fructus Liquidambaris; Mount Huang is red; Radix Peucedani japonici; Rhizoma Arisaematis ringentis Ze head; ZUONACAO; rhododendron molle (bl.) g.don; Herba Ranunculi Scelerati (Radix Anemones rupicolae); vomiting nut; Radix campsis; Fructus rosae multiflorae; Chinese juniper is regged; Caulis Clematidis apiifoliae; goose embraces; rice-paper plant; Herba seu Radix Metaplexis hemsleyanae; purple Pueraria lobota; trachelospermum jasminoide; Fructus Fici Pumilae; contain water wine; hundred rib Tengs; economize rattan; HERBA SENECIONIS SCANDENTIS; Radix rumicis acetosae; wild rice; spatterdock; Herba braseniaeel.; get over Wang Yusun; Herba Sedi Linearis; Phymatopsis griffithiana (Hook.) J. Sm.; Herba hylotelephii erythrosticti; Drymoglossum subcordatum; the japanese bugle herb grass; Radix Astragali; the Fructus Pruni ginseng; Radix Loti Corniculati; the Rhizoma Paridis tetraphyllae; all manage grass; Herba Asari Forbesii; yellow moccasin flower; Radix Cynanchi Paniculati; Radix Seu Herba Luisiae Morsei; ward off the Serpentis thunder; Herba droserae burmannii; Caulis et Folium Ligustici Wallichii; Rhizoma Kaempferiae; dried tuber; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae); line spices; Herba Lysimachiae foenum-graeci; Herba Rostellulariae; the Herba Elatostematis Involucrati; Herba Stachydis Japonicae; Herba Dendranthematis indici; luxuriant; Chinese mugwort in thousand; Herba Artemisiae Sieversianae; Herba Incarvilleae sinensis; Radix seu Herba Pedicularis; faint in the shaded place; Herba Artemisiae Japonicae; nine timothys; motherwort; Herba leonuri pseudoma cranthi; the common vetch rank; Qu Jiecao; cockscomb; bitter cottonrose hibiscus; Herba Cardui Crispi; litchi is real; Radix Carpesii; uncommon celestial; cover the marshland full of water weeds; dragon must; Diarrhena manshurica Maxim.; beat HUGEN; Althaea rosea (L.) Cavan.; certain herbaceous plants with big flowers; Calyx seu fructus physalis; Herba Solani Lyrati; Herba pyrolae japonicae; Herba Patriniae; Flos Farfarae; rice-koji; the Radix Zanthoxyli Fructus Kochiae; Radix Agrimoniae; Herba potentillae kleinianae; Salvia japonica Thunb.; Alternanthera sessilis (L.) DC.; Rhizoma seu Herba Elatostematis stewardii; the blue shallow lake; Indigo Naturalis; knotweed; Herb Polygoni Chinensis; the Herba caryopteridis nepetaefoliae; Radix Berberidis; Patrinia villosa; Rui's grass; Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae); Rhizoma Saururi (Herba Saururi); old granary rice; cold tool; the yellow steaming; tiller rice; Folium et Ramulus Cephalotaxi; Herba Allii Japonici; Herba Alii fistulosi; Bulbus Allii Ascalonici; Chinese onion; calabash; five hot dishes; mustard; Radix Brassicae rapae; same Artemisia; Herba Seselis Seseloidis; horse is begged; Fructus anethi; peppery rice dish; the Persian grass; shepherd's purse; Herba stellariae mediae; eritrichium pedumculare; Herba Medicaginis; Semen Amaranthi tricoloris; Herba Sonchi Oleracei; Caulis et Folium Lactucae Sativae; Caulis et Folium Lactucae sativae; two chaste tree skins; pittosporum tobira; Chinese bush cherry; Radix Achyranthis Bidentatae; Semen Glycine Germinatum; the Semen sojae atricolor tiller looses; Semen Maydis; cubeb; Semen zanthoxyli; the yarn face side; emblic leafflower fruit; veneer; acron; Chinese torreya is real; A Lebo; Pericarpium Zanthoxyli; climing green pepper; Fructus Zanthoxyli Ailanthoidis; the melon reed; Cinnamomum japonica; sesame; Auricularia Sophorae; matter antiperspirant; Zhan's sugar is fragrant; Resina Ferulae; Resina Populi Diversifoliae; bark of a cork tree wood; Tan Huan; Ramulus et Folium Cotini Coggygiae; the Chinese catalpa Firmiana platanifolia (Linn. f.) Marsili; pittosporum tobira; Fructus Gymnocladi Chinensis; mother-in-law sieve gets; willow glue; lignum sappan; Scobis Diospyroris Ebeni; the slave three-bristle cudrania; wood is red; white sour jujube; Fructus Elaeagni; Vaccinium bracteatum Thunb.; Fructus deutziae scabrae; Photiniaserrulata; the goldenrain tree chaste tree; Hibiscus rosa-sinensis; Ixora stricta; Ramulus Sambuci Williamsii; Radix Rumicis; account for this; Folium Pleioblasti; Huaihe River wood; ancient coffin plate; Boehmeria; Herba Abutili; Folium Isatidis; little green grass or young crops; unknown essence; uncommon celestial; indocalamus; Chinese alpine rush; Medulla Junci; Diarrhena manshurica Maxim.; Herba Turczaninowiae Fastigiatae; Radix seu Cortex Heteropanacis; Luo Kui; Fructus Corni; Herba Gnaphalii Affinis; Radix Codonopsis lanceolatae; Calendula arvensis L.; Herba Senecionis Scandentis; the woman is blue or green; Herba Bidentis Tripartitae; Radix Stephaniae Japonicae; Herba Sambuci Chiensis; Radix Asparagi Officinalis; Herba Polygoni hydropiperis; red grass; Herba Polygoni Barbati; silkworm net grass; Herba Arthraxonis Hispidi; Radix et Rhizoma Thalictri; the DIWUGONG grass; JIANCAO; Herba seu Radix Metaplexis hemsleyanae; Herba Polygoni cymosi; crow is held back poison; the rule grass; carambola; wood connects; the GANTENG Caulis et Folium piperis; hundred rib rattans; economize rattan; Herba Otteliae Alismoidis; Bai Chang; duckweed; Radix Pesudostellariae; the wild duck certain herbaceous plants with big flowers; from the grass of separating; the precipice palm fibre; the japanese bugle herb grass; ascend li; HENGYI; Herba Bidentis Bipinnatae; private general; amsonia elliptica; Coriolous Dersicolor (Fr.) Quel fungus; Semen Ricini; Radix Dichroae; the art Li Lu tiger palm; the ghost head; Impatientis; Fructus Fici Pumilae; Flos Wikstroemiae Dolichanthae; Herba Buddlejae Lindleyanae; Folium illicii Lanceolati; Caulis Et Folium Skimmiae; Herba Ranunculi Scelerati (Radix Anemones rupicolae); Herba Aconiti Ochranthi; Herba Gelsemii Elegantis; Herba Duchesneae Indicae; Bulbus Lycoridis Radiatae; Huang Huan; Rhizoma Smilacis Chinensis; reddish brown chief; volt Ovum Gallus domesticus root; the room trip; yesterday is what grass of leaf; Stenoloma chusana; the soil Iuba Equi; the hair cypress; Fossilia Spiriferis; Flos Mori; Lycopodium clavatum; Herba Selaginellae Doederleinii; Caulis Mahoniae; Herba Salviae Chinensis; Radix Physochlainae; Rhizoma Anemones Raddeanae; emblic; Caulis Lonicerae; Herba Swertiae Mileensis; Herba Inulae; the gold fruit lookes at; Radix Echinopsis; Rhizoma Panacis Majoris; Herba Clinopodii.
The leaf of the green natural medicinal plants that is adopted; flower is raw medicinal material, and its raw medicinal material is: Folium Mori; Herba Epimedii; Folium Eriobotryae; the LVDOU clothing; Herba Apocyni veneti; Herba Lophatheri; Folium Isatidis; Folium Hibisci Mutabilis; the mountain peach leaf; tail any of several broadleaf plants leaf; Folium Ilicis Purpureae; the Liao Dynasty's leaf; Isatis indigotica Fort. leaf Foliumet Ramulus Evodiae leaf; Flos Sauropi changiani leaf; Cacumen Platycladi; Folium Perillae; Folium Nelumbinis; Folium Polygoni Tinctorii; Folium Mahoniae; Folium Artemisiae Argyi; the Liao Dynasty's leaf; Cacumen Platycladi (Cacumen Biotae); Folium Pleioblasti; unmrellaleaf; Folium Rhododendri Daurici; Folium eucalypti globueli (Eucalyptus globulus Labill.); Folium Clerodendri Trichotomi; Folium Sennae; Folium Ilicis Cornutae; Flos Sophorae; Flos Carthami; Flos Inulae; Flos Farfarae; Flos Daturae; Flos Chrysanthemi; Flos Buddlejae; Flos Lonicerae; the Radix campsis flower; Flos Hibisci; Flos Buddlejae; Flos lupuli (Flos Humuli Lupuli); Flos Carthami; Herba Dendranthematis indici; Stigma Croci; Flos Hydrangeae Macrophyllae; Flos Rosae Chinensis; Flos Mori; Flos Rhododendri Mollis; Flos puerariae lobatae; Folium Perillae.
The fruit of the green natural medicinal plants that is adopted, seed is a raw medicinal material, and its raw medicinal material is: Seem Lablab Album, Fructus Jujubae, Fructus Psoraleae, Semen Juglandis, Semen Cuscutae, Semen Astragali Complanati, Semen Allii Tuberosi, Arillus Longan, Fructus Ligustri Lucidi, Semen Sesami Nigrum, Fructus Schisandrae Chinensis, Fructus Mume, Galla Chinensis, Fructus Tritici Levis, Radix Oryzae Glutinosae, the Fructus Chebulae, Semen Myristicae, Pericarpium Papaveris, Semen Nelumbinis, Semen Euryales, Fructus Rosae Laevigatae, Fructus Rubi, Fructus Xanthii, very light blue, Fructus Arctii, Semen Sojae Preparatum, Flos Chrysanthemi, Fructus Viticis, Fructus Cannabis, Semen Pruni, Flos Genkwa, Fructus Crotonis, Semen Pharbitidis, Semen Euphorbiae, Fructus Chaenomelis, Fructus Amomi, Fructus Amomi Rotundus, Semen Alpiniae Katsumadai, Fructus Lycii, Fructus Crataegi, Semen Canavaliae, Calyx Kaki, Semen Raphani, Fructus Quisqualis, Semen Arecae, Semen Cucurbitae, Semen Torreyae, Folium Callicarpae Formosanae, Semen Persicae, Rhizoma Typhonii, Semen Sinapis Albae, Fructus Trichosanthis, Semen Sterculiae Lychnophorae, Semen Armeniacae Amarum, Fructus Perillae, Semen Ginkgo, Semen Ziziphi Spinosae, Semen Platycladi, Concha Haliotidis, Semen Cassiae, tasteless preserved soybean, Fructus Gardeniae, Semen Celosiae, Fructus Forsythiae, Semen phaseoli radiati, Semen Phaseoli, Semen Abutili, Flos Caryophylli, Fructus Foeniculi, Fructus Piperis, Pericarpium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Fructus Citri Sarcodactylis, Fructus Citri, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Fructus Ilicis Purpureae, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Herba tetragoniae, Hericium erinaceus (Bull. Ex Fr.) Pers., Fructus Nandinae Domesticae, Silybum marianum Gaertn, vine, Fructus Terminaliae Billericae, the west Fructus Broussonetiae, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Semen Nigellae, Fructus Rubi corchorifolii Immaturus, continuous son, Aconitum carmichaeli Debx., Radix Aconiti, Fructus Akebiae, nine fairy maidens, epigeal srephaia root, Fructus Momordicae, Calyx seu fructus physalis, Fructus Adinae, Semen vignae sinensis, Semen Lablab Album, Fructus rhois chinensis, Fructus anacardii, Semen pini koraiensis, kernel, Fructus Elaeagni, strongly fragrant Lee, banana, Rhizoma Dioscoreae Bulbiferae, epigeal srephaia root, Radix Stephaniae Cepharanthae, Fructus Fici, cover basin, Herba Duchesneae Indicae, Stigma Maydis, Semen Allii Tuberosi, Receptaculum Nelumbinis, Spica Prunellae, Flos Magnoliae, fructus amomi, Herba tetragoniae, Radix Calotropis giganteae, Fructus Nandinae Domesticae.
The medicinal part of the green natural medicinal animal that is adopted is a raw medicinal material, and its raw medicinal material is: Cornu Cervi Pantotrichum, Gecko, Testis et Pentis Canis, Carapax et Plastrum Testudinis, Carapax Trionycis, Ootheca Mantidis, Os Sepiae, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Agkistrodon, Bombyx mori L., Aspongopus, Endothelium Corneum Gigeriae Galli, Squama Manis, female ground beetle, Hirudo, Tabanus, Concha Ostreae, Cornu Saigae Tataricae, Carapax Eretmochelydis, Concha Erosariae seu Cypraeae halogen, Scorpio, Scolopendra, Bombyx Batryticatus, Moschus, Calculus Bovis, Fel Ursi, Nidus Vespae, Venenum Bufonis, Mylabris, thousand-legger, Placenta Hominis, water rat muscle, Air Bladder pseudosciaenae seu Acipenser, Blatta seu periplaneta, Agkistrodon halys, Eupolyphaga Seu Steleophaga, Cutis Bufonis, Crinis Carbonisatus, Oletum Trogopterori.
The mineral drug that is adopted is a raw medicinal material, and its raw medicinal material is: Actinolitum, Limonitum, Ophicalcitum, Pumex, Concha Meretricis seu Cyclinae, Lapis Micae Aureus, Cinnabaris, Magnetitum, Os Draconis, succinum, Concha Haliotidis, Haematitum, Spora Lygodii, Gekko Swinhonis, Melanteritum.
Merge extracted twice liquid, filter, if repeatedly carry out heating extraction, then merge multiple extraction liquid, filtration at pressure 0.02-0.09MPa, is carried out concentrating under reduced pressure to the filtering extracting solution of process under the condition of 30-90 ℃ temperature.Concentrating under reduced pressure is to carry out in airtight container, takes out air and steam on the liquid level, makes the solution boiling point lowering of extracting solution, evaporates.Because the boiling point lowering of solution, prevent or reduced the decomposition of effective ingredient in the Chinese medicine of thermal sensitivity, increased the speed of evaporation, evaporation is carried out smoothly, until extracting solution being condensed into the fluid extract that proportion is 1.20-1.35.In the process of concentrating under reduced pressure, the monitoring of available microcomputer automatic control is measured its content of effective at any time for well.
For the second time medicinal residues carry out drying, with 55-115 ℃ to the second time medicinal residues carry out drying and be advisable, pulverize again.Extract if carry out heating for multiple times, the medicinal residues of last heating extraction carry out drying and crushing, and exsiccant temperature can also be 55-115 ℃.Exsiccant medicinal residues are ground into the medicinal residues fine powder, and the granularity that makes the medicinal residues fine powder was 100 orders～800 orders, and the medicinal residues fine powder is thin more good more.Fluid extract with medicinal residues fine powder and proportion 1.20-1.35 mixes the formation mixture again.Again so that the medicinal residues fine powder of the 10-40% of medicinal residues total amount and the fluid extract of proportion 1.20-1.35 are mixed to good, more so that the medicinal residues fine powder of the 15-25% of medicinal residues gross weight and the fluid extract of proportion 1.20-1.35 are mixed to better.When medicinal residues fine powder and fluid extract mix, the speed of its stirring and the quality of product are irrelevant, as long as with medicinal residues fine powder and fluid extract mix medicinal residues fine powder and fluid extract can be mixed after, water steam gas or nitrogen are atomization gas, carry out spray drying.During spray drying, the pressure of atomization gas is 0.1-1.0Mpa, and spray-dired temperature is 60-400 ℃, is advisable with 200-400 ℃ again.When spraying, so that medicinal residues fine powder and fluid extract mixture are sprayed in the hot-air to well by the centrifugal spray head.Temperature as the hot-air of drying medium is 60-400 ℃, is advisable with 200-400 ℃ again.Said mixture sprays in the hot-air and forms in the hot-air that vaporific drop falls within certain flow rate, carries out the transient heat exchange, makes it rapid drying, and forms the medicated powder granular product, average medicated powder particle diameter 100-2000 μ m.Because be instantaneous drying, be applicable to heat-sensitive substance, made it to keep original effective ingredient, and epigranular, the color and luster unanimity, granule is bonded crisp, is easy to moisture and soaks into disintegrate, form suspension with water, be beneficial to human body after entering in the human body to absorb rapidly, heighten the effect of a treatment.In the process of carrying out spray-drying process, can monitor detection with microcomputer, more can guarantee the quality of product.Exempting from of producing fried in shallow oil tcm product carry out packing, and can mark wherein content of effective by certain requirement.
The assay method of all available country mark product is measured in whole process of the present invention.With means such as ultraviolet spectrometry spectrum, gas chromatogram, atomic absorption spectrum, thin layer chromatography, high performance liquid chromatography, capillary electrophoresis in process of production extracting solution, fluid extract carried out the detection of effective ingredient, at last the effective ingredient in the product is detected.
Preparation method of the present invention is applicable to the extraction preparation of single medicinal material, also is applicable to preparation and the preparation of Chinese medicine health care product and the preparation of traditional Chinese patent medicine novel form thereof of multidigit medicine prescription.
The advantage of exempting to fry in shallow oil preparation method of Chinese medicine of the present invention just is:
1. the present invention collects biological preparation and biochemical preparation and studies and form the modern times and exempt to fry in shallow oil preparation method of Chinese medicine, the combination of two kinds of methods, the mensuration monitoring analysis of the biological activity that mixture is extracted and the qualitative, quantitative of effective ingredient, the decoct type is exempted from formation, efficient quick-acting only doses reduce by 3～10 times than traditional decoction pieces consumption, slow down the misery of the difficulty of taking medicine.
2. exempt to fry in shallow oil tcm product with what the inventive method was prepared, be convenient to take, liquid such as water dash and form suspension, can take, it is fast both to have kept decoction to absorb, produce effects is rapid, performance drug effect in the short time, and the decoction effect that its drug effect is fried in shallow oil than Chinese medicine has improved 15-30 doubly, overcome decoction again and taken preceding interim decoction, be convenient to take during the journey, applicable to taking in the various environment, general decoction is placed the long period in temperature more than 25 ℃, perishable, volatile loss of effective components so be unsuitable for taking decoction medicine the hot summer days in summer, has overcome this shortcoming and fry in shallow oil Chinese medicine with exempting from of making of preparation method of the present invention.And fry in shallow oil the concentrated property that Chinese medicine has height with exempting from of preparing of preparation method of the present invention, available water, all kinds of fruit juice, liquid milk product are washed into suspension and take, and are convenient to children taking.
3. the product composition unanimity of producing with preparation method of the present invention, be easy to transportation, preserve, steady quality, good, its product of producing is not under-32～-47 ℃ temperature or 27～47 ℃ high warm purgative thing invariance, go mouldy, and fried Chinese medicine decoction is just perishable more than 25 ℃ temperature.
4. form fine drug powder in the fluid extract by in technology of the present invention, the medicinal residues fine powder being added to, increased the Plant fiber in the medicine, take the medicine that contains a large amount of Plant fiber, the health that is of value to human body, strengthen the curative effect of medicine, increased coarse-fibred intake, cleared up intravital free radical.
Below exempt to fry in shallow oil preparation method of Chinese medicine and be further described of the present invention with embodiment; to help preparation method of the present invention and advantage thereof are done further to understand; protection scope of the present invention is not subjected to the qualification of these embodiment, and protection scope of the present invention is decided by claims.
Embodiment 1
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. the dry root with natural green plant Radix Ginseng is 100 kilograms of raw materials, and the content of the Radix Ginseng total saponins in this Radix Ginseng is 20.5 milligrams/gram after measured.Constantly wash Radix Ginseng with tap water, till the color of water is limpid, drenches and do.The water (generally adding the 20-50 premium on currency soaks) that adds 35 liters in 100 kilograms Radix Ginseng soaked after 60 minutes, took out Radix Ginseng, for through pretreated Radix Ginseng as raw medicinal material.
2. the water that adds 7 times of amounts of raw medicinal material amount in raw medicinal material, under 100 ℃ temperature, heating extraction 2 hours is taken out under normal pressure, obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 6 times of amounts of raw medicinal material amount in the medicinal residues first time (through the Radix Ginseng of the heating extraction first time), under 100 ℃ temperature, heating extraction 1.5 hours is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time at normal pressure.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.06MPa, carries out concentrating under reduced pressure under the condition of 60 ℃ of temperature, is condensed into proportion and is 1.28 fluid extract.
With secondary medicinal residues after drying under 85 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 400 orders, 25% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.28 are mixed, form mixture.
6. be atomization gas with water vapour gas, the mixture of medicinal residues fine powder and fluid extract is carried out spray drying.The pressure of atomization gas is 0.4MPa, and baking temperature is 300 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 300 ℃, generate the medicated powder granule of 150 μ m of average particulate diameter, the Radix Ginseng that contains 201 milligrams of Radix Ginseng total saponinss/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, can take after mixing it with water with boiled water, can exempt to fry in shallow oil Chinese medicine with other and cooperate and take.
Embodiment 2
Its operational approach and equipment are substantially the same manner as Example 1, and only different is, add the water of 8 times of amounts of raw medicinal material amount for the first time during heating extraction, and heating extraction is 1 hour under the temperature of 80 ℃ of normal pressures; For the second time during heating extraction, add the water of 7 times of amounts of raw medicinal material amount, under normal pressure under 80 ℃ the temperature, heating extraction 2 hours.At pressure 0.09MPa, carry out concentrating under reduced pressure under the condition that temperature is 90 ℃, be condensed into the fluid extract of proportion 1.35, in 100 ℃ of dry medicinal residues, medicinal residues were ground into 800 purpose medicinal residues fine powders, 10% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.35 are mixed, with nitrogen is that atomization gas carries out atomization drying, the pressure of atomization gas is 0.9MPa, and baking temperature is 400 ℃, generates the medicated powder granule of average particulate diameter 100 μ m.
Embodiment 3
Its operational approach and equipment are substantially the same manner as Example 1, only different is, add the water of 6 times of amounts of raw medicinal material amount during heating extraction in the first time, heating extraction is 3 hours under the temperature of 60 ℃ of normal pressures, for the second time during heating extraction, add the water of 5 times of amounts of raw medicinal material amount, heating extraction is 0.5 hour under the temperature of 60 ℃ of normal pressures.At pressure 0.02MPa, carry out concentrating under reduced pressure under the condition that temperature is 45 ℃, be concentrated into the fluid extract of proportion 1.20, dry medicinal residues under 55 ℃ temperature were ground into 100 purpose medicinal residues fine powders with medicinal residues.40% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.20 are mixed, carry out atomization drying with water vapour as atomization gas, the pressure of atomization gas is 0.25MPa, and baking temperature is 200 ℃, generates the medicated powder granule of average particulate diameter 1000 μ m.
Embodiment 4
Its operational approach and equipment are substantially the same manner as Example 1, only different is when carrying out concentrating under reduced pressure, to be condensed into the fluid extract of proportion 1.20, with the second time medicinal residues gross weight 70% medicinal residues fine powder and the fluid extract of above-mentioned proportion 1.20 mix, the pressure of atomization gas is 1MPa.
Embodiment 5
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. the base of leaf with natural green plant Herba Epimedii is 100 kilograms of raw materials, and the content of icariine is 9.1 milligrams/gram in the Herba Epimedii base of leaf after measured, constantly washes the base of leaf of Herba Epimedii with tap water, till the color of water is limpid, drenches and does.In the base of leaf of 100 kilograms Herba Epimedii, add 30 premium on currency, soaked 30 minutes, take out its stem and leaf, for the base of leaf that passes through pretreated Herba Epimedii as raw medicinal material.
2. the water that adds 6 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 90 ℃ of normal pressures, heating extraction 2.5 hours is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 5 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under 100 ℃ temperature, heating extraction 1.5 hours is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time at normal pressure.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.06MPa, carries out concentrating under reduced pressure under the condition of 80 ℃ of temperature, is condensed into proportion and is 1.30 fluid extract.
With secondary medicinal residues after drying under 65 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 300 orders, 15% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.30 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the mixture of medicinal residues fine powder and fluid extract is carried out spray drying, the pressure of atomization gas is 0.6MPa, and baking temperature is 120 ℃ (or 70 ℃).Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 120 ℃ (or 70 ℃), generate the medicated powder granule of average particulate diameter 400 μ m, the Herba Epimedii that contains 229 milligrams of icariines/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, available water is taken after mixing it with water, and also can exempt to fry in shallow oil Chinese medicine with other and cooperate and take.
Embodiment 6
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. the fruit Fructus Crataegi with the natural green plant is 100 kilograms of raw materials, and the content of Crataegolic acid is 11.3 milligrams/gram in the Fructus Crataegi after measured, constantly washes Fructus Crataegi with tap water, till the color of water is limpid, drenches and does.In 100 kilograms of Fructus Crataegis, add 75 premium on currency, soaked 60 minutes, take out Fructus Crataegi, for passing through pretreated Fructus Crataegi as raw medicinal material.
2. the water that adds 8 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 100 ℃ of normal pressures, heating extraction 1 hour is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 6 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under 100 ℃ temperature, heating extraction 1 hour is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time at normal pressure.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.06MPa, carries out concentrating under reduced pressure under the condition of 80 ℃ of temperature, is condensed into proportion and is 1.25 fluid extract.
With secondary medicinal residues after drying under 70 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 200 orders, 27% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.25 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the mixture of medicinal residues fine powder and fluid extract is carried out spray drying, the pressure of atomization gas is 0.6MPa, and baking temperature is 250 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 250 ℃, generate the medicated powder granule of average particulate diameter 500 μ m, the Fructus Crataegi that contains 113 milligrams of Crataegolic acids/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, can take after mixing it with hot water, can exempt to fry in shallow oil Chinese medicine with other and cooperate and take.
Embodiment 7
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. be 100 kilograms of raw materials with the natural minerals alunite, the content of aluminium potassium sulfate is 8.3 milligrams/gram in the alunite after measured, constantly washes alunite with tap water, till the color of water is limpid, drenches and does.In 100 kilograms of alunites, add 20 premium on currency, soaked 10 minutes, take out alunite, for passing through pretreated alunite as raw medicinal material.
2. the water that adds 7 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 80 ℃ of normal pressures, heating extraction 8 hours is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 3 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under the temperature of 80 ℃ of normal pressures, heating extraction 5 hours is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.06MPa, carries out concentrating under reduced pressure under the condition of 80 ℃ of temperature, is condensed into proportion and is 1.23 fluid extract.
With secondary medicinal residues after drying under 75 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 200 orders, 20% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.23 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the pressure of atomization gas is 0.7MPa, and baking temperature is 240 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 240 ℃, generate the medicated powder granule of average particulate diameter 800 μ m, sulfur acid aluminum potassium is that the alunite of 176.3 milligrams/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, can take after mixing it with hot water, can exempt to fry in shallow oil Chinese medicine with other and cooperate and take.
Embodiment 8
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. be 100 kilograms of raw materials with the natural green plant Cortex Eucommiae, the content of gutta-percha is 10.3 milligrams/gram in the Cortex Eucommiae after measured, constantly washes Cortex Eucommiae medical material with tap water, till the color of water is limpid, drenches and does.In 100 kilograms of Cortexs Eucommiae, add 150 premium on currency, soak after 60 minutes, take out the Cortex Eucommiae, for passing through the pretreated Cortex Eucommiae as raw medicinal material.
2. the water that adds 6 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 100 ℃ of normal pressures, heating extraction 1 hour is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 7 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under the temperature of 100 ℃ of normal pressures, heating extraction 1 hour is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.03MPa, carries out concentrating under reduced pressure under the condition of 40 ℃ of temperature, is condensed into proportion and is 1.21 fluid extract.
With secondary medicinal residues after drying under 60 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 100 orders, 10% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.21 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the pressure of atomization gas is 0.5MPa, and baking temperature is 200 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 250 ℃, generate the medicated powder granule of average particulate diameter 900 μ m, the Cortex Eucommiae that contains 237.6 milligrams of gutta-percha/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, can take after mixing it with hot water, also can exempt to fry in shallow oil Chinese medicine and cooperate and take with other.
Embodiment 9
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. the dry body with natural green boneblack Formica fusca is 100 kilograms of raw materials, with tap water flushing Formica fusca medical material, till the color of water is limpid, drenches and does.In 100 kilograms of Formica fuscas, add 130 premium on currency, soaked 60 minutes, take out Formica fusca, for passing through pretreated Formica fusca as raw medicinal material.
2. the water that adds 7 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 100 ℃ of normal pressures, heating extraction 1 hour is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 6 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under 100 ℃ temperature, heating extraction 1 hour is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time at normal pressure.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.05MPa, carries out concentrating under reduced pressure under the condition of 80 ℃ of temperature, is condensed into proportion and is 1.21 fluid extract.
With secondary medicinal residues after drying under 70 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 300 orders, 30% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.21 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the pressure of atomization gas is 0.6Mpa, and dry temperature is 200 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 200 ℃, generate the medicated powder granule of average particulate diameter 300 μ m, the Formica fusca that contains 213.7 milligrams in protein/gram exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, and guide the mode of taking, can take after mixing it with hot water, can exempt to fry in shallow oil Chinese medicine with other and cooperate and take.
Embodiment 10
Present embodiment exempts to fry in shallow oil preparation method of Chinese medicine:
1. the dried floral with natural green plant Flos Carthami is 100 kilograms of raw materials, and the total content of the carthamin in the Flos Carthami, Flos Carthami quinone glycoside, neocarthamin is 23.7 a milligrams/gram after measured.Constantly wash flos carthami with tap water, limpid until the color of water is last, drench to do, and adds 35 premium on currency in 100 kilograms of Flos Carthamis, soaks 60 minutes, takes out Flos Carthami, for the pretreated Flos Carthami of process as raw medicinal material.
2. the water that adds 6 times of amounts of raw medicinal material amount in raw medicinal material, under the temperature of 100 ℃ of normal pressures, heating extraction 1 hour is taken out, and obtains extracting solution and medicinal residues for the first time for the first time.
3. the water that adds 5.5 times of amounts of raw medicinal material amount to the first time in the medicinal residues, under 100 ℃ temperature, heating extraction 1 hour is taken out extracting solution for the second time, obtains extracting solution and medicinal residues for the second time for the second time at normal pressure.
4. the extracting solution that merges first and second time filters, and to through filtering extracting solution, at pressure 0.04MPa, carries out concentrating under reduced pressure under the condition of 55 ℃ of temperature, is condensed into proportion and is 1.29 fluid extract.
With secondary medicinal residues after drying under 78 ℃ the temperature, be ground into the medicinal residues fine powder, make the medicinal residues fine powder cross 200 orders, 25% the medicinal residues fine powder of medicinal residues gross weight and the fluid extract of above-mentioned proportion 1.29 are mixed, form mixture.
6. be atomization gas with the nitrogen gas, the pressure of atomization gas is 0.55MPa, and baking temperature is 240 ℃.Specifically the mixture with medicinal residues fine powder and fluid extract sprays in the hot-air by fog-spray nozzle, the temperature of hot-air is 240 ℃, generate the medicated powder granule of average particulate diameter 800 μ m, the Flos Carthami that contains carthamin, Flos Carthami quinone glycoside, 267.5 milligrams/gram of neocarthamin exempts to fry in shallow oil Chinese medicine, by certain requirement packing, mark taking dose one time, take after mixing it with hot water, also can exempt to fry in shallow oil Chinese medicine and cooperate and take with other.
Claims (9)
1. exempt to fry in shallow oil preparation method of Chinese medicine for one kind, it is characterized in that,
1) with root, stem, skin, leaf, fruit, the seed of natural medicinal plant, wherein a kind of of the medicinal part of natural medicinal animal, natural minerals medical material or press needed several the Chinese crude drug of pharmaceutical formulation after pretreatment as raw medicinal material,
2) in raw medicinal material, add the 4-10 water doubly of raw medicinal material amount, under normal pressure under 60-100 ℃ temperature heating extraction 1-8 hour, take out extracting solution for the first time, obtain extracting solution and medicinal residues for the first time for the first time,
3) in first time medicinal residues, add the water that the 2-8 of raw medicinal material amount doubly measures, under normal pressure under 60-100 ℃ temperature heating extraction 0.5-6 hour, take out extracting solution for the second time, obtain extracting solution and medicinal residues for the second time for the second time,
4) merge first and second time extracting solution, filter, the filtering extracting solution of process at pressure 0.02-0.09MPa, is carried out concentrating under reduced pressure under the condition of 30-90 ℃ of temperature, be condensed into the fluid extract of proportion 1.20-1.35,
5) for the second time after the medicinal residues drying, be ground into the medicinal residues fine powder, the fluid extract of medicinal residues fine powder and above-mentioned proportion 1.20-1.35 is mixed as compound, the formation mixture,
6) be atomization gas with water vapour gas or nitrogen, carry out spray drying, generate the medicated powder granule.
2. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 a kind of, it is characterized in that, the baking temperature of medicinal residues is 55-115 ℃ for the second time.
3. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 a kind of, it is characterized in that exsiccant medicinal residues are ground into the medicinal residues fine powder, and the granularity that makes the medicinal residues fine powder was 100 orders～800 orders.
4. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 or 2 or 3 a kind of, it is characterized in that, the medicinal residues fine powder of the 10-40% of medicinal residues total amount and the fluid extract of proportion 1.20-1.35 are mixed, form mixture.
5. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 4 a kind of, it is characterized in that, the medicinal residues fine powder of the 15-25% of medicinal residues total amount and the fluid extract of proportion 1.20-1.35 are mixed, form mixture.
6. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 a kind of, it is characterized in that during spray drying, the pressure of atomization gas is 0.1-1.0MPa.
7. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 a kind of, it is characterized in that spray-dired temperature is 60-400 ℃.
8. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 7 a kind of, it is characterized in that spray-dired temperature is 200-400 ℃.
9. exempt to fry in shallow oil preparation method of Chinese medicine according to claim 1 a kind of, it is characterized in that the medicated powder particle diameter is 100-2000 μ m.
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| CN 00107662 CN1276216A (en) | 2000-05-25 | 2000-05-25 | Process for preparing non-decoction Chinese medicine |
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