CN1456329B - Chinese medicine extracting method - Google Patents
Chinese medicine extracting method Download PDFInfo
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- CN1456329B CN1456329B CN 03121114 CN03121114A CN1456329B CN 1456329 B CN1456329 B CN 1456329B CN 03121114 CN03121114 CN 03121114 CN 03121114 A CN03121114 A CN 03121114A CN 1456329 B CN1456329 B CN 1456329B
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Abstract
A process for extracting active components from Chinese-medicinal material features that the Chinese-medicinal material is extracted at low temp (5-85 deg.C), several times (5-25 min per time). Its advantages are high extracting efficiency and simple method.
Description
Technical field
The present invention relates to a kind of method of extracting Chinese medicine.
Background technology
Modern medicine has been made significant contribution for human health care and existence procreation, but also is faced with more and more insoluble problems.Chemicals is powerless to multiple disease, but also has toxic and side effects and drug-fast problem, so people turn to traditional medicine to sight again.Chinese medicine and pharmacy also more and more causes people's attention as one of the world's four great tradition medical systems.
Chinese medicine and pharmacy is different with pharmacy of western medicine, and pharmacy of western medicine generally comprises the unification compound, and Chinese medicine and pharmacy is to carry out dialectical executing to control, and has globality and complexity.Chinese medicine preparation by certain compatibility and consumption, is processed different dosage form through certain method often by several kinds of Chinese medicinal materials, and its chemical constituent comprises the comprehensive function of number of chemical compositions such as inorganic matter, micromolecule organic compound and biomacromolecule and reaches therapeutic effect.Sequence of operations processes such as Chinese medicine production comprises extraction, concentrates, separation, drying, pelletize; Wherein leaching process is the primary and very important process of Chinese medicine preparation; Because leaching process is not a simple leaching process; Physics, chemical change can take place closing when frying in shallow oil in Chinese medicine compound, impel the proposition of effective ingredient.The extraction of Chinese medicine at present mainly contains following several method:
(1) normal-pressure boiler extraction Chinese medicine exists some obviously not enough: the one, and Chang Daliang uses inflammable organic solvent; The 2nd, numerous and diverse, the length that expends time in of processing step was extracted purification separation and purification 2-3 days at least from Chinese medicine, nearly at most 1 week; The 3rd, no matter be the decocting in water or the heating and refluxing extraction of organic solvent all owing to the heating of long period, and be prone to cause the degraded of thermal sensitivity composition and the loss of volatile ingredient; The 4th, the organic solvent that remains in the effective ingredient is difficult to be able to remove more completely through evaporation or drying.Its total result is quality and the stability that influences Chinese patent medicine; The 5th, extraction efficiency is low, and effective component extracting is the highest just to reach 30%.
(2) marmite is boiled medicine or now more advanced computer control automatic bagging boiling machine, because of technology is unreasonable, causes the aromatics loss of effective components; Animal class and mineral medicine effective ingredient then difficulty are all fried; Especially the efficient composition in the Chinese medicine is sticky on medicinal residues, can not be fried, can not be utilized.
(3) Chinese medicine of the broken traditional Chinese medicine technology production of cell grade micropowder is clinical with directly acting on after the Chinese medicine pulverizing, owing to do not extract through overcuring, the medicine macromole can not be absorbed by the body, and high-efficiency activated composition can not be utilized by the people.
(4) other method, as: also all there are some shortcomings in supercritical extraction technique, resin absorption innovation technology.
The object of the invention is to provide that a kind of method is simple, extraction ratio is high, cost is low, and can extract the method for the extraction Chinese medicine of more effective ingredient.Compared with former method, the Chinese medicine that the present invention extracts can reach efficient, quick-acting, makes low, the instant effect of patient's cost.
A kind of method of extracting Chinese medicine of summary of the invention, step such as comprise pulverizing, extraction, filtration, concentrate is characterized in that the temperature in the leaching process is 5 ℃～85 ℃, each time is about 5～25 minutes, and repeats 3～35 times.
The method of said extracted Chinese medicine, carry out according to following steps:
(1) single or prescription Chinese medicine powder are broken to 60～120 order fine powders, and place the container of boiling medicine;
(2) according to Chinese medicine: water=1: the weight ratio of (0.5～2.0) adds entry;
(3) under 5 ℃～85 ℃, fried in shallow oil 5～25 minutes;
(4) filtration obtains extracting solution and medicinal residues;
(5) step (4) gained medicinal residues are put back in the container repeating step (2), (3), (4) 3～38 times;
(6) step (4) and step (5) gained extracting solution are merged, concentrate then, promptly get the Chinese medicine that is extracted.
Temperature can be 20 ℃～85 ℃ during extraction described in the said method.
Temperature can be 30 ℃～70 ℃ during extraction described in the said method.
Temperature can be 50 ℃～60 ℃ during extraction described in the said method.
Each extraction time described in the said method can be 5～20 minutes.
Each extraction time described in the said method can be 5～10 minutes.
Can then 50%～100% of gained medicinal residues be joined in the extracting solution after concentrating extracting remaining medicinal residues drying and crushing to the 120 order～300 order fine powders in back in the said method, mixing, drying is reprocessed into different dosage form and uses.The medicinal residues that add play expanded effect, and it is met water and expands rapidly, can quicken the dissolution velocity of medicine in stomach, and effective ingredient is absorbed by the body faster.
Products therefrom can be processed into said dosage form on any pharmaceutics in the said method.
Dosage form described in the said method can be (1) concentrated granular, (2) powder, (3) electuary, (4) tablet, (5) powder, (6) capsule different dosage form.
Advantage of the present invention and beneficial effect: 1. method is simple, does not need complex apparatus, also need not add organic solvent; 2. improved output, extracted through ripening repeatedly, made that the stripping of effective site has increased in the Chinese medicine, its extraction ratio improves greatly; 3. improved curative effect of medication, clinical observation draws, and is keeping taking the medicine that the present invention produces under the identical condition of curative effect, and dosage can reduce (1/2～2/3), and the dosage minimizing just means that cost reduces, and drug effect improves, and the use value of medicine improves.Show: first three is fried in shallow oil, the medicinal liquid bitter in the mouth of extraction, suffering, salty, sour, impurity is arranged is medicinal epidermis composition, accounts for 15%; Three fry in shallow oil after, the medicinal liquid free from admixture of proposition, pungent taste are little, and drug effect is higher than first three and fries in shallow oil, concentration also is higher than first three fries in shallow oil, and is efficient medicinal ingredient, accounts for 35%～75%, drug effect obviously improves, and has reduced patient's taking dose.
Following table is that normal-pressure boiler, cell grade micropowder are broken, marmite is boiled medicine several method extracted amount and the comprehensive synopsis of curative effect for oral administration:
Specific embodiment embodiment 1: treatment children's chronic infantile convulsion, dyspepsia, rubella, prescription is made up of following component: Radix Astragali Preparata 10g, Radix Puerariae 8g, Herba Schizonepetae 6g, windproof 5g, Radix Polygalae 8g, Fructus Foeniculi 6g, Fructus Crataegi (parched to brown) 10g, Massa Medicata Fermentata (parched to brown) 10g, Rhizoma Gastrodiae 8g, Periostracum Cicadae 6g, Endothelium Corneum Gigeriae Galli 10g, Bulbus Lilii 8g, Radix Et Caulis Acanthopanacis Senticosi 10g, Radix Bupleuri 6g.
(1) above-mentioned Chinese medicine is taken by weighing mixing by writing proportioning after, be ground into 100 order fine powders, and insert in the container of boiling medicine;
(2) add entry 200g, under 80 ℃, fried in shallow oil 5 minutes, filter then and obtain extracting solution and medicinal residues;
(3) medicinal residues are put back in the container repeating step (2) 35 times;
(4) extracting solution with step (2) and step (3) gained merges, and concentrates then;
(5) the medicinal residues crushed after being dried is become 200 order fine powders;
(6) the 30g fine powder that (5) is obtained adds (4) gained medicinal liquid, and mixing, dry post-treatment become Chinese patent medicine fine powder 80.4g altogether.
A nascent boy baby of 40 days, dyspepsia 1 month, stool resembles fish roe, tarnish, and separated in one day 5,6 times.Take said extracted gained Chinese patent medicine fine powder, each 0.1g, every day 2 times, warm water delivery service.Take two days later, stool resembles the egg yolk that stirs, and glossy, number of times also keeps 1 day 2 times, acts normally, and this nascent boy baby's dyspepsia is cured.
Embodiment 2: treatment rheumatism, wind and cold, skelalgia, and prescription is made up of following component:
Windproof 15g, Poria cum Radix Pini 15g, Radix Aucklandiae 15g, Cortex Cinnamomi 5g, Bulbus Lilii 10g 、 Herba Siegesbeckiae 20g, Cortex Albiziae 10g, drynaria baronii 10g, Radix Polygoni Multiflori 20g, Radix Achyranthis Bidentatae 15g, Radix Dipsaci 15g, Rhizoma Homalomenae 12g, Herba Lycopodii 15g, Caulis Polygoni Multiflori 50g, Ramulus Mori 30g, Massa Medicata Fermentata 15g, Radix Angelicae Pubescentis 30g, Fructus Chaenomelis 30g, Cortex Acanthopancis 10g, Cortex Eucommiae 10g, Herba Taxilli 10g, Rhizoma Dioscoreae Nipponicae 50g, Herba Asari 5g, Folium Photiniae (Folium Photiniae serrulatae) 10g, Caulis Spatholobi 15g
(1) above-mentioned Chinese medicine is taken by weighing mixing by writing proportioning after, be ground into 100 order fine powders, and insert in the container of boiling medicine;
(2) add entry 800g, heated 10 minutes down, filter then and obtain extracting solution and medicinal residues at 70 ℃;
(3) medicinal residues are put back in the container repetitive process (2) 35 times;
(4) extracting solution with step (2) and step (3) gained merges, and concentrates then;
(5) the medicinal residues crushed after being dried is become 200 order fine powders;
(6) the whole fine powders that step (5) obtained add (4) gained medicinal liquid, mixing, and dry post-treatment becomes the Chinese patent medicine granule, altogether 430g.
Liu Dengshan, the man, 45 years old, looked after one's family people from village of battalion Qingyuan County, Baoding, Hebei province.Skelalgia is repeatedly treated two months inefficacies, the pain almost can not walk.Change clothes said extracted gained Chinese patent medicine granule, each 3 grams, every day 3 times, warm water delivery service was taken medicine 15 days, lower limb not bitterly, this disease is cured.
Embodiment 3: nasal obstruction, headache, heating, throat pain that the treatment flu causes, prescription is made up of following component: Radix Platycodonis 50g, Folium Perillae 20g, Periostracum Cicadae 5g, Radix Sophorae Tonkinensis 20g, Rhizoma Belamcandae 8g 、 Herba Siegesbeckiae 15g, Flos Magnoliae 10g, Folium Isatidis 15g, Radix Polygoni Multiflori 12g, Rhizoma Acori Graminei 10g, Flos Buddlejae 20g, Cortex Albiziae 10g, Radix Trichosanthis 15g
(1) above-mentioned Chinese medicine is taken by weighing mixing by writing proportioning after, be ground into 120 order fine powders, and insert in the container of boiling medicine;
(2) add entry 420 grams, heated 5 minutes down, filter then and obtain extracting solution and medicinal residues at 80 ℃;
(3) medicinal residues are put back in the container repetitive process (2) 10 times;
(4) step (2) and step (3) gained extracting solution are merged, yet concentrate;
(5) the medicinal residues crushed after being dried is become 200 order fine powders;
(6) 90% of (5) gained fine powder is added (4) gained medicinal liquid, mixing, drying is processed the Chinese patent medicine microgranule, altogether 185g.
Liu Chengyan, the man, 50 years old, looked after one's family people from village of battalion Qingyuan County, Baoding, Hebei province.Cold has caused symptoms such as nasal obstruction, heating, headache, throat pain.Take said extracted gained Chinese patent medicine granule, each 3 grams, every day 3 times, warm water delivery service was taken 5 days, this healing of catching cold.
Embodiment 4: Liu Dongfang, and the woman, 28 years old, looked after one's family people from village of battalion Qingyuan County, Baoding, Hebei province.III type pulmonary tuberculosis, the course of disease 3 months.Baoding province prison retirement doctor doctor Wang Wenquan opens Chinese medicine, extracts with the present invention, carries out according to following steps:
(1) Chinese medicine that doctor Wang Wenquan opens is broken into 100 order fine powders, weight is 430g, and inserts in the container of boiling medicine;
(2) add entry 860g, heated 5 minutes down, filter then and obtain extracting solution and medicinal residues at 70 ℃;
(3) medicinal residues are put back in the container repetitive process (2) 25 times;
(4) extracting solution with step (2) and step (3) gained merges, and concentrates then;
(5) the medicinal residues crushed after being dried is become 200 order fine powders;
(6) 90% of the fine powder that step (5) is obtained adds (4) gained medicinal liquid, mixing, and dry post-treatment becomes the Chinese patent medicine granule, altogether 375g.
Baoding three X of hospital ray examination reports
Liu Dongfang, chest, X line finding: bilateral thorax symmetry, the rib marshalling, the intercostal space is wide; Visible mottled, the lamellar shade of right upper lung, density unevenness, obscure boundary, surplus lung field is clear; The texture rule, the bilateral diaphram is smooth, and the diaphragm angle is sharp keen, and the podiod size belongs to normal range.Diagnostic impression: III type tuberculosis on the right lung.
Doctor: Wang Peiyi signature
May 17 calendar year 2001
Take said extracted gained Chinese patent medicine granule, each 3 grams, every day 3 times, warm water delivery service, after taking medicine 40 days:
Baoding three X of hospital ray examination reports
Liu Dongfang, chest, X line finding: visible on the right lung have patch shape shade, and density is medium, and surplus lung field is no abnormality seen still.With contrast on May 17 calendar year 2001, there is not obviously change, controlled the focus development.
The slope signature forever of doctor Wang Pei hundred million height
June 27 calendar year 2001
Continue medication, instructions of taking is the same, after 280 days:
Baoding three X of hospital ray examination reports
Liu Dongfang, chest, X line finding: former is tuberculosis treatment back check on the right lung, and modern film making shows: both sides thorax symmetry, vertical diaphragm is placed in the middle, and two lung fields are clear, the texture rule, the bilateral diaphram is smooth, and the diaphragm angle is sharp keen, and the podiod size belongs to normal range.With contrast on June 27 calendar year 2001, foci disappearance on the right lung, this disease is cured.
Doubly hundred million Liu Zheng signature of doctor king
On March 17th, 2002
Embodiment 5: Zhao Wenhui, man, 64 years old, relay factory, Baoding retired employees.Hyperosteogeny, the course of disease 30 years, Baoding province prison retirement doctor doctor Wang Wenquan opens Chinese medicine, extracts with the present invention, carries out according to following steps:
(1) doctor Wang opens the heavy 460g of Chinese medicine potion, is ground into 100 order fine powders, and inserts in the container;
(2) add water 920g, under 70 ℃, fried in shallow oil 5 minutes, filter then and obtain extracting solution and medicinal residues;
(3) medicinal residues are put back in the container repetitive process (2) 35 times;
(4) step (2) and step (3) gained extracting solution are merged, concentrate then;
(5) the medicinal residues crushed after being dried is become 200 order fine powders;
(6) step (5) gained fine powder is all added step (4) gained medicinal liquid, mixing is processed the Chinese patent medicine granule after the drying, altogether 446g.
Zhao Wenhui takes said extracted gained Chinese patent medicine granule, each 3 grams, and every day 3 times, warm water delivery service, after taking medicine 10 days, the neurasthenia cures, and continues medication 20 days, and cervical vertebra is cured.
Claims (7)
1. a method of extracting Chinese medicine is carried out according to following steps,
(1) single or prescription Chinese medicine powder are broken into 60～120 order fine powders, insert in the container of boiling medicine;
(2) according to Chinese medicine: water=1: the weight ratio of (0.5～2.0) adds water in container;
(3) under 5 ℃～85 ℃, fried in shallow oil 5～25 minutes;
(4) filter extracting solution and medicinal residues excessively;
(5) step (4) gained medicinal residues are put back in the container repeating step (2), (3), (4) 3～38 times;
(6) step (4) and step (5) gained extracting solution are merged, concentrate then;
(7) 1. characteristic is emphasis in three extractions after frying in shallow oil, and first three is fried in shallow oil, and the medicinal liquid bitter in the mouth of extraction, suffering, salty, acid have impurity, for medicinal epidermis composition, account for 15%; Three to fry in shallow oil medicinal liquid free from admixture, pungent taste that the back proposes little, and drug effect is higher than first three and fries in shallow oil, and concentration also is higher than first three fries in shallow oil, and for efficient medicinal ingredient, accounts for 35～75%; 2. characteristic is extracting the remaining medicinal residues in back dry, is ground into 120-300 order fine powder, then 50～100% of gained medicinal residues is joined in the extracting solution after concentrating; Mixing, drying is processed the Chinese patent medicine finished product then, and the medicinal residues of adding play expanded effect; Effective ingredient is absorbed by the body faster; 3. characteristic is survival dose, and oral consumption is 0.1～3g, every day 1～3 time.
2. method according to claim 1 is characterized in that described temperature is 20 ℃～85 ℃.
3. method according to claim 2 is characterized in that described temperature is 30 ℃～70 ℃.
4. method according to claim 3 is characterized in that described temperature is 50 ℃～60 ℃.
5. method according to claim 1 is characterized in that the described time is 5～20 minutes.
6. method according to claim 5 is characterized in that the described time is 5～10 minutes.
7. according to claim 1,2,3,4,5 or 6 described methods, it is characterized in that products therefrom can be processed into said dosage form on any pharmaceutics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03121114 CN1456329B (en) | 2002-09-09 | 2003-03-27 | Chinese medicine extracting method |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02129393 CN1426826A (en) | 2002-09-09 | 2002-09-09 | Extraction, separation technology of fesible new Chinese medicine |
| CN02129393.7 | 2002-09-09 | ||
| CN 03121114 CN1456329B (en) | 2002-09-09 | 2003-03-27 | Chinese medicine extracting method |
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| CN1456329A CN1456329A (en) | 2003-11-19 |
| CN1456329B true CN1456329B (en) | 2012-09-05 |
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| CN 03121114 Expired - Fee Related CN1456329B (en) | 2002-09-09 | 2003-03-27 | Chinese medicine extracting method |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276216A (en) * | 2000-05-25 | 2000-12-13 | 赵国林 | Process for preparing non-decoction Chinese medicine |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276216A (en) * | 2000-05-25 | 2000-12-13 | 赵国林 | Process for preparing non-decoction Chinese medicine |
Non-Patent Citations (2)
| Title |
|---|
| 作者姓名:范碧亭主编.中药药剂学 卷号: 版本号:1997.出版者名称:上海科学技术出版社,1997,99页第4行至100页第5行. * |
| 作者姓名:范碧亭主编.中药药剂学卷号： 版本号：1997.出版者名称:上海科学技术出版社,1997,99页第4行至100页第5行. |
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