CN101198347A - 使用可溶性ctla4突变型分子治疗与移植物移植有关的免疫病症的方法 - Google Patents

使用可溶性ctla4突变型分子治疗与移植物移植有关的免疫病症的方法 Download PDF

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Publication number
CN101198347A
CN101198347A CNA2006800198976A CN200680019897A CN101198347A CN 101198347 A CN101198347 A CN 101198347A CN A2006800198976 A CNA2006800198976 A CN A2006800198976A CN 200680019897 A CN200680019897 A CN 200680019897A CN 101198347 A CN101198347 A CN 101198347A
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ctla4
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ctla4 mutant
csa
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Chinese (zh)
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D·哈格尔蒂
J·鲁斯纳克
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Bristol Myers Squibb Co
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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CNA2006800198976A 2005-04-06 2006-04-05 使用可溶性ctla4突变型分子治疗与移植物移植有关的免疫病症的方法 Pending CN101198347A (zh)

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US66877405P 2005-04-06 2005-04-06
US60/668,774 2005-04-06

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CN101198347A true CN101198347A (zh) 2008-06-11

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US (2) US7482327B2 (enExample)
EP (1) EP1868635B1 (enExample)
JP (1) JP2008535841A (enExample)
KR (1) KR101235484B1 (enExample)
CN (1) CN101198347A (enExample)
AR (1) AR055052A1 (enExample)
AU (1) AU2006231622B2 (enExample)
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EA (1) EA013122B1 (enExample)
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ME (1) ME02930B (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104673822A (zh) * 2013-11-27 2015-06-03 深圳先进技术研究院 一种重组载体及其制备方法和应用
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CN111801347A (zh) * 2017-10-10 2020-10-20 高山免疫科学股份有限公司 Ctla-4变体免疫调节蛋白和其用途
CN115089718A (zh) * 2021-11-30 2022-09-23 杭州瑞普晨创科技有限公司 用于异种移植的免疫抑制剂组合和免疫抑制方法

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US7094874B2 (en) * 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
WO2006108035A1 (en) * 2005-04-06 2006-10-12 Bristol-Myers Squibb Company Methods for treating immune disorders associated with graft transplantation with soluble ctla4 mutant molecules
US9309316B2 (en) 2005-12-20 2016-04-12 Bristol-Myers Squibb Company Stable subcutaneous protein formulations and uses thereof
US7528111B2 (en) * 2006-05-12 2009-05-05 Bristol-Myers Squibb Company Method of vaccinating subjects receiving immune modulating therapy
WO2008014035A2 (en) * 2006-07-25 2008-01-31 The Regents Of The University Of California Modulation of nkg2d and method for treating or preventing solid organ allograft rejection
EP2612867A1 (en) 2007-11-01 2013-07-10 Perseid Therapeutics LLC Immunosuppressive polypeptides and nucleic acids
US20110159023A1 (en) * 2008-08-25 2011-06-30 Solomon Langermann Pd-1 antagonists and methods for treating infectious disease
EP2365823B1 (en) * 2008-10-30 2016-11-30 Yeda Research And Development Company Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
US20100297123A1 (en) * 2009-05-15 2010-11-25 Garrison Fathman C Combination therapy to inhibit t cell effector function
US8329867B2 (en) * 2010-02-19 2012-12-11 Xencor, Inc. CTLA4-Ig immunoadhesins
TW201134481A (en) 2010-03-12 2011-10-16 Abbott Biotherapeutics Corp CTLA4 proteins and their uses
SG188471A1 (en) 2010-09-08 2013-04-30 Yeda Res & Dev An immunosuppressive drug combination for a stable and long term engraftment
PT2613801T (pt) 2010-09-08 2016-09-12 Yeda Res & Dev Utilização de células t de memória central anti-terceiros no tratamento anti-leucemia/linfoma
RU2636503C2 (ru) 2011-09-08 2017-11-23 Иеда Рисеч Энд Девелопмент Ко. Лтд. Т-клетки центральной памяти против третьей стороны, способы их получения и их применение в трансплантации и лечении заболеваний
SMT202000091T1 (it) 2011-10-13 2020-05-08 Bristol Myers Squibb Co Polipeptidi anticorpali che antagonizzano cd40l
WO2014160822A1 (en) * 2013-03-28 2014-10-02 Bristol-Myers Squibb Company Methods for identifying patients at risk for costimulation blockade resistant rejection
CN106132429A (zh) 2014-03-19 2016-11-16 百时美施贵宝公司 使用针对cd40l的域抗体治疗移植物排斥的方法
MA41459A (fr) * 2015-02-03 2017-12-12 Als Therapy Development Inst Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
PT3283508T (pt) 2015-04-17 2021-06-21 Alpine Immune Sciences Inc Proteínas imuno modulatórias com afinidades afináveis
CN108135938A (zh) 2015-07-16 2018-06-08 耶达研究及发展有限公司 基因修饰的抗第三方中央型记忆t细胞及其在免疫疗法中的用途
US10751368B2 (en) 2017-01-18 2020-08-25 Yeda Research And Development Co. Ltd. Methods of transplantation and disease treatment
CN110392736A (zh) 2017-01-18 2019-10-29 耶达研究及发展有限公司 遗传修饰的反抑细胞及其在免疫治疗中的用途
US10286036B2 (en) 2017-05-12 2019-05-14 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2019136179A1 (en) 2018-01-03 2019-07-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
WO2019246577A1 (en) 2018-06-22 2019-12-26 Mayo Foundation For Medical Education And Research Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality
WO2020010259A1 (en) * 2018-07-06 2020-01-09 Mayo Foundation For Medical Education And Research Methods and materials for improving transplant outcomes
KR20230031981A (ko) 2019-05-14 2023-03-07 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
KR20240122658A (ko) 2023-02-03 2024-08-13 이뮤노바이옴 주식회사 이식 거부 반응의 예방 또는 치료용 조성물
WO2024211211A1 (en) 2023-04-03 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104673822A (zh) * 2013-11-27 2015-06-03 深圳先进技术研究院 一种重组载体及其制备方法和应用
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CN111801347A (zh) * 2017-10-10 2020-10-20 高山免疫科学股份有限公司 Ctla-4变体免疫调节蛋白和其用途
CN115089718A (zh) * 2021-11-30 2022-09-23 杭州瑞普晨创科技有限公司 用于异种移植的免疫抑制剂组合和免疫抑制方法
CN115089718B (zh) * 2021-11-30 2024-05-28 杭州瑞普晨创科技有限公司 用于异种移植的免疫抑制剂组合和免疫抑制方法

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PT1868635T (pt) 2017-07-27
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JP2008535841A (ja) 2008-09-04
AU2006231622A1 (en) 2006-10-12
AU2006231622B2 (en) 2012-07-05
HRP20171121T1 (hr) 2017-10-06
NO342966B1 (no) 2018-09-10
WO2006108035A1 (en) 2006-10-12
HRP20171121T8 (hr) 2017-11-03
EP1868635B1 (en) 2017-05-17
PL1868635T3 (pl) 2017-10-31
SI1868635T1 (sl) 2017-07-31
NZ561655A (en) 2010-01-29
US20100041602A1 (en) 2010-02-18
KR20070119728A (ko) 2007-12-20
NZ576434A (en) 2010-06-25
CY1119145T1 (el) 2018-02-14
IL186189A0 (en) 2008-01-20
NO20075078L (no) 2008-01-04
US20070009511A1 (en) 2007-01-11
EA013122B1 (ru) 2010-02-26
CA2603970A1 (en) 2006-10-12
RS56138B1 (sr) 2017-10-31
US7482327B2 (en) 2009-01-27
ES2634260T3 (es) 2017-09-27
KR101235484B1 (ko) 2013-02-22
MX2007012222A (es) 2007-12-06
DK1868635T3 (en) 2017-09-11
EP1868635A1 (en) 2007-12-26
ME02930B (me) 2018-04-20
EA200702180A1 (ru) 2008-10-30
IL186189A (en) 2015-11-30
AR055052A1 (es) 2007-08-01

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