CN101166740B - 用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物 - Google Patents

用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物 Download PDF

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Publication number
CN101166740B
CN101166740B CN2006800140369A CN200680014036A CN101166740B CN 101166740 B CN101166740 B CN 101166740B CN 2006800140369 A CN2006800140369 A CN 2006800140369A CN 200680014036 A CN200680014036 A CN 200680014036A CN 101166740 B CN101166740 B CN 101166740B
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CN
China
Prior art keywords
imidazo
hydroxy
ylamino
acetamide
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800140369A
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English (en)
Chinese (zh)
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CN101166740A (zh
Inventor
M·托尔曼
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Novartis AG
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Novartis AG
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Filing date
Publication date
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Publication of CN101166740A publication Critical patent/CN101166740A/zh
Application granted granted Critical
Publication of CN101166740B publication Critical patent/CN101166740B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006800140369A 2005-04-25 2006-04-24 用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物 Expired - Fee Related CN101166740B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019180.0 2005-04-25
DE102005019180 2005-04-25
PCT/EP2006/003765 WO2006114261A1 (en) 2005-04-25 2006-04-24 Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (2)

Publication Number Publication Date
CN101166740A CN101166740A (zh) 2008-04-23
CN101166740B true CN101166740B (zh) 2010-12-29

Family

ID=36686088

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800140369A Expired - Fee Related CN101166740B (zh) 2005-04-25 2006-04-24 用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物

Country Status (10)

Country Link
EP (1) EP1877407A1 (https=)
JP (1) JP2008538776A (https=)
KR (1) KR20080002866A (https=)
CN (1) CN101166740B (https=)
AU (1) AU2006239546B2 (https=)
BR (1) BRPI0610842A2 (https=)
CA (1) CA2606251A1 (https=)
MX (1) MX2007013237A (https=)
RU (1) RU2409575C2 (https=)
WO (1) WO2006114261A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008027812A2 (en) 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
EP2074121B1 (en) * 2006-10-06 2016-11-30 Boehringer Ingelheim International GmbH Chymase inhibitors
RU2748833C2 (ru) * 2016-11-28 2021-05-31 Цзянсу Хэнжуй Медсин Ко., Лтд. Производное пиразоло-гетероарила, способ его получения и медицинское применение
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
EP4214207A4 (en) 2020-09-15 2024-10-02 1st Biotherapeutics, Inc. 2-AMINO-3-CARBONYL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE COMPOUNDS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
JPH0717971A (ja) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途
DE69729007T2 (de) * 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
AU2003296960A1 (en) * 2002-12-11 2004-06-30 Smithkline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chafiq Hamdouchi, et al..A Novel Application of the Ullmann Coupling Reaction for theAlkylsulfenylation of 2-Amino-Imidazo[1,2-a]pyridine.Terahedron55.1999,55541-548. *
ChafiqHamdouchi et al..A Novel Application of the Ullmann Coupling Reaction for theAlkylsulfenylation of 2-Amino-Imidazo[1
Winkelmann, E. et al..Chemotherapeutically effective nitrocompounds.Part3:nitropyridine, nitroimidazopyridine andrelatedcompounds.Arzneim.-Forsch.27 1.1977,27(1),82-89.
Winkelmann, E. et al..Chemotherapeutically effective nitrocompounds.Part3:nitropyridine, nitroimidazopyridine andrelatedcompounds.Arzneim.-Forsch.27 1.1977,27(1),82-89. *

Also Published As

Publication number Publication date
KR20080002866A (ko) 2008-01-04
WO2006114261A1 (en) 2006-11-02
RU2007143501A (ru) 2009-06-10
AU2006239546A1 (en) 2006-11-02
BRPI0610842A2 (pt) 2010-07-27
AU2006239546B2 (en) 2010-04-15
CA2606251A1 (en) 2006-11-02
EP1877407A1 (en) 2008-01-16
CN101166740A (zh) 2008-04-23
JP2008538776A (ja) 2008-11-06
RU2409575C2 (ru) 2011-01-20
MX2007013237A (es) 2008-01-24

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20101229

Termination date: 20120424