CN101166740B - Imidazo (1,2-a) pyridine derivatives useful as peptide deformylase (PDF) inhibitors - Google Patents

Imidazo (1,2-a) pyridine derivatives useful as peptide deformylase (PDF) inhibitors Download PDF

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CN101166740B
CN101166740B CN2006800140369A CN200680014036A CN101166740B CN 101166740 B CN101166740 B CN 101166740B CN 2006800140369 A CN2006800140369 A CN 2006800140369A CN 200680014036 A CN200680014036 A CN 200680014036A CN 101166740 B CN101166740 B CN 101166740B
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amino
hydroxyl
imidazo
base
ethanamide
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CN101166740A (en
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M·托尔曼
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to compounds of formula (I). These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new antibiotics.

Description

Imidazo [1,2-A] pyridine derivate as peptide deformylase (PDF) inhibitor
The present invention relates to new peptide deformylase (PDF) inhibitor.It is as microbiotic that these compounds make us interested especially.
Peptide deformylase is a kind of ferruginous bacterium metalloenzyme.In all bacteriums, can detect this kind of enzyme and it plays an important role in the metabolism of bacterium.Between synthesis phase, the deformylase polypeptide enzyme catalysis removes deformylase from the N-end of bacterioprotein at albumen.When this enzyme not, bacterium can not produce any functional protein.Peptide deformylase is the point of application of a class new antibiotic, and such microbiotic is called as peptide deformylase inhibitor containing 2.
The objective of the invention is to prepare can be with the synthetic new peptide deformylase inhibitor containing 2 that obtains of plain mode.
The present invention relates to compound or its pharmaceutically useful salt, solvate, hydrate or the pharmaceutically useful preparation of formula (I)
Wherein
Radicals R 1, R 2, R 3And R 4Be hydrogen atom, halogen atom, hydroxyl, amino, nitro or mercaptan (thiole) group, alkyl, alkenyl, alkynyl, assorted alkyl, aryl, heteroaryl, cycloalkyl, alkyl-cycloalkyl, assorted alkyl-cycloalkyl, Heterocyclylalkyl, aralkyl or heteroaralkyl independently of one another, wherein these groups can be substituted independently of one another, perhaps radicals R 1, R 2, R 3And R 4In two can be the part of cycloalkyl, Heterocyclylalkyl, aryl or heteroaryl ring together, and these the ring in each the ring can randomly be substituted;
R 5Be hydrogen atom, halogen atom, hydroxyl, amino, nitro or thiol group, alkyl, alkenyl, alkynyl, assorted alkyl, aryl, heteroaryl, cycloalkyl, alkyl-cycloalkyl, assorted alkyl-cycloalkyl, Heterocyclylalkyl, aralkyl or heteroaralkyl, wherein these groups can randomly be substituted separately;
Radicals R 6And R 7Be hydrogen atom or alkyl, alkenyl, alkynyl, assorted alkyl, aryl, heteroaryl, cycloalkyl, alkyl-cycloalkyl, assorted alkyl-cycloalkyl, Heterocyclylalkyl, aralkyl or heteroaralkyl independently of one another, wherein these groups can randomly be substituted independently of one another; And
X be formula-CS-NHOH ,-CH 2-CO-CH 2-OH ,-CO-CH 2-OH ,-CO-NHOH ,-CNH-NHOH ,-CH 2-NOH-CHS ,-NOH-CHS ,-NOH-CHO ,-CH 2-NOH-CHO ,-CH 2-CHOH-CHO ,-CHOH-CHO ,-CHOH-COOH ,-CH (CH 2-OH)-COOH ,-COOH or-CH 2The group of COOH perhaps is selected from following formula:
Figure S2006800140369D00021
Wherein U is key, CH 2, NH, O or S, V is O, S, NH or CH 2, W is O, S, NH or CH 2, and Y is OH or NH 2, E is key, CH 2, NH, O or S and group D, G and M be N or CH independently of one another.
The statement of alkyl refers to a kind of saturated straight or branched alkyl, it particularly has 1 to 20 carbon atom, preferably has 1 to 12 carbon atom, most preferably has 1 to 6 carbon atom, for example methyl, ethyl, propyl group, sec.-propyl, just-butyl, isobutyl-, tert-butyl, just-hexyl, 2,2-dimethylbutyl or just-octyl group.
The statement of alkenyl and alkynyl refers to the undersaturated straight or branched alkyl of small part, it particularly has 2 to 20 carbon atoms, preferably have 2 to 12 carbon atoms, most preferably have 2 to 6 carbon atoms, for example vinyl, allyl group, ethynyl, propargyl, isopentene group or own-2-thiazolinyl.Alkenyl preferably has one or two (most preferably having one) two keys and alkynyl has one or two (most preferably having one) triple bond.
In addition, the statement of alkyl, alkenyl and alkynyl also refer to wherein for example one or more hydrogen atoms by halogen atom (preferred F or Cl) ,-COOH ,-OH ,-SH ,-NH 2,-NO 2,=O ,=S ,=the displaced group of NH, as 2,2,2-three chloroethyls or trifluoromethyl.
The statement of assorted alkyl refers to wherein one or more (preferred 1,2 or 3) carbon atoms by the displaced alkyl of oxygen, nitrogen, phosphorus, boron, selenium, silicon or sulphur atom (preferred oxygen, sulphur or nitrogen), alkenyl or alkynyl.The statement of assorted alkyl also refers to carboxylic acid or derives from the group of carboxylic acid, as acyl group, acyl group alkyl, alkoxy carbonyl, acyloxy, acyloxy alkyl, carboxyalkyl acid amides or alkoxyl group carbonyl oxygen base.
The example of assorted alkyl has formula R a-O-Y a-, R a-S-Y a-, R a-N (R b)-Y a-, R a-CO-Y a-, R a-O-CO-Y a-, R a-CO-O-Y a-, R a-CO-N (R b)-Y a-, R a-N (R b)-CO-Y a-, R a-O-CO-N (R b)-Y a-, R a-N (R b)-CO-O-Y a-, R a-N (R b)-CO-N (R c)-Y a-, R a-O-CO-O-Y a-, R a-N (R b)-C (=NR d)-N (R c)-Y a-, R a-CS-Y a-, R a-O-CS-Y a-, R a-CS-O-Y a-, R a-CS-N (R b)-Y a-, R a-N (R b)-CS-Y a-, R a-O-CS-N (R b)-Y a-, R a-N (R b)-CS-O-Y a-, R a-N (R b)-CS-N (R c)-Y a-, R a-O-CS-O-Y a-, R a-S-CO-Y a-, R a-CO-S-Y a-, R a-S-CO-N (R b)-Y a, R a-N (R b)-CO-S-Y a-, R a-S-CO-O-Y a-, R a-O-CO-S-Y a-, R a-S-CO-S-Y a-, R a-S-CS-Y a-, R a-CS-S-Y a-, R a-S-CS-N (R b)-Y a-, R a-N (R b)-CS-S-Y a-, R a-S-CS-O-Y a-, R a-O-CS-S-Y a-group, R wherein aBe hydrogen atom, C 1-C 6-alkyl-, C 2-C 6-alkenyl-or C 2-C 6-alkynyl; R bBe hydrogen atom, C 1-C 6-alkyl-, C 2-C 6-alkenyl-or C 2-C 6-alkynyl; R cBe hydrogen atom, C 1-C 6-alkyl-, C 2-C 6-alkenyl-or C 2-C 6-alkynyl; R dBe hydrogen atom, C 1-C 6-alkyl-, C 2-C 6-alkenyl-or C 2-C 6-alkynyl and Y aBe straight key, C 1-C 6-alkylidene group, C 2-C 6-alkylene group or C 2-C 6-alkynylene, wherein each assorted alkyl comprises at least one carbon atom and one or more hydrogen atom can be replaced by the fluorine or chlorine atom.The particular instance of assorted alkyl has methoxyl group; trifluoromethoxy; oxyethyl group; just-propoxy-; isopropoxy; uncle-butoxy; methoxymethyl; ethoxyl methyl; methoxy ethyl; methylamino; ethylamino; dimethylamino; diethylamino; different-the propyl group ethylamino; methyl-amino methyl; the ethylamino methyl; two-different-propyl group amino-ethyl; enol ether; dimethylaminomethyl; dimethyl aminoethyl; ethanoyl; propionyl; butyryl acyloxy; acetoxyl group; methoxycarbonyl; oxyethyl group-carbonyl; N-ethyl-N-methylamino formyl radical or N-methylamino formyl radical.Other examples of assorted alkyl have nitrile, isonitrile, cyanate, thiocyanic ester, isocyanic ester, lsothiocyanates and alkyl nitrile group.
The statement of cycloalkyl refers to saturated or part undersaturated (for example cycloalkenyl group) cyclic group, it comprises one or more (preferred 1 or 2) and has particularly 3 to 14 ring carbon atoms, the ring of preferred 3 to 10 (especially 3,4,5,6 or 7) ring carbon atoms.The statement of cycloalkyl also refer to wherein one or more hydrogen atoms by fluorine, chlorine, bromine or iodine atom or-COOH ,-OH ,=O ,-SH ,=S ,-NH 2,=NH or-NO 2The displaced group of group, that is, for example cyclic ketone such as pimelinketone, 2-cyclonene or cyclopentanone.The concrete example of other of cycloalkyl has cyclopropyl, cyclobutyl, cyclopentyl, volution [4,5] decyl, norborneol alkyl (norbornyl), cyclohexyl, cyclopentenyl, cyclohexadienyl, naphthalane base, cube alkyl (cubanyl), two ring [4.3.0] nonyls, naphthane, cyclopentyl cyclohexyl, fluoro cyclohexyl or hexamethylene-2-thiazolinyl.
The statement of Heterocyclylalkyl refers to wherein one or more (preferred 1,2 or 3) ring carbon atoms by the displaced cycloalkyl as defined above of oxygen, nitrogen, silicon, selenium, phosphorus or sulphur atom (preferred oxygen, sulphur or nitrogen).Heterocyclylalkyl preferably has 1 or 2 ring with 3 to 10 (especially 3,4,5,6 or 7) annular atomses.The statement of Heterocyclylalkyl also refer to wherein one or more hydrogen atoms by fluorine, chlorine, bromine or iodine atom or-COOH ,-OH ,=O ,-SH ,=S ,-NH 2,=NH or-NO 2The displaced group of group.The example has piperidyl, morpholinyl, urotropin, pyrrolidyl, tetrahydro-thienyl, THP trtrahydropyranyl, tetrahydrochysene-furyl, oxa-cyclopropyl, nitrogen heterocyclic propyl group or 2-pyrazolinyl and lactan, lactone, cyclic imide and cyclic acid anhydride.
The statement of alkyl-cycloalkyl refers to the group that comprises cycloalkyl as defined above and alkyl, alkenyl or alkynyl, for example alkyl-cycloalkyl, alkyl cycloalkenyl group, alkenyl cycloalkyl and alkynyl cycloalkyl.Alkyl-cycloalkyl preferably comprises cycloalkyl and one or two alkyl, alkenyl or the alkynyl with 1 or 2 to 6 carbon atoms with one or two ring with 3 to 10 (especially 3,4,5,6 or 7) ring carbon atoms.
The statement of assorted alkyl-cycloalkyl refers to wherein one or more (preferred 1,2 or 3) ring carbon atoms and/or carbon atom by the displaced alkyl-cycloalkyl as defined above of oxygen, nitrogen, silicon, selenium, phosphorus or sulphur atom (preferred oxygen, sulphur or nitrogen).Assorted alkyl-cycloalkyl preferably has 1 or 2 ring with 3 to 10 (especially 3,4,5,6 or 7) annular atomses and has alkyl, alkenyl, alkynyl or the assorted alkyl of 1 or 2 to 6 carbon atoms with one or two.Such examples of groups has alkyl heterocycle alkyl, alkyl heterocycle thiazolinyl, alkenyl Heterocyclylalkyl, alkynyl Heterocyclylalkyl, assorted alkyl-cycloalkyl, assorted alkyl heterocycle alkyl and assorted alkyl heterocycle thiazolinyl, described cyclic group be saturated or single-, two-or three-undersaturated.
The statement of aryl or Ar refers to has one or more particularly 6 to 14 ring carbon atoms that have, the aromatic group of the ring of preferred 6 to 10 (especially 6) ring carbon atoms.The statement of aryl (or Ar) also refer to wherein one or more hydrogen atoms by fluorine, chlorine, bromine or iodine atom or-COOH ,-OH ,-SH ,-NH 2Or-NO 2The displaced group of group.The example has phenyl, naphthyl, xenyl, 2-fluorophenyl, anilino, 3-nitrophenyl or 4-hydroxy phenyl.
The statement of heteroaryl refers to and comprises one or more particularly 5 to 14 annular atomses that have, the aromatic group of preferred 5 to 10 (especially 5 or 6) annular atomses and one or more (preferred 1,2,3 or 4) oxygen, nitrogen, phosphorus or sulphur annular atoms (preferred O, S or N).The statement of heteroaryl also refer to wherein one or more hydrogen atoms by fluorine, chlorine, bromine or iodine atom or-COOH ,-OH ,-SH ,-NH 2Or-NO 2The displaced group of group.The example have 4-pyridyl, 2-imidazolyl, 3-phenylpyrrole base, thiazolyl,
Figure 2006800140369_0
Azoles base, triazolyl, tetrazyl, different
Figure 2006800140369_1
Azoles base, indazolyl, indyl, benzimidazolyl-, pyridazinyl, quinolyl, purine radicals, carbazyl, acridyl, pyrimidyl, 2,3 '-Lian furyl, 3-pyrazolyl and isoquinolyl.
The statement of aralkyl refers to the group that wherein comprises aryl defined above and alkyl, alkenyl, alkynyl and/or cycloalkyl, as arylalkyl, alkylaryl, aromatic yl alkenyl, aromatic yl polysulfide yl, cycloalkyl aryl, aryl rings thiazolinyl, alkylaryl cycloalkyl and alkylaryl cycloalkenyl group.The specific examples of aralkyl has toluene, dimethylbenzene, sym-trimethylbenzene, vinylbenzene, benzyl chloride, neighbour-toluene fluoride, 1H-indenes, naphthane, dihydronaphthalene, indone, benzyl ring amyl group, cumene, cyclohexyl phenyl, fluorenes and indane.Aralkyl preferably comprises one or two aromatic ring with 6 to 10 ring carbon atoms and one or two to have alkyl, alkenyl and/or the alkynyl of 1 or 2 to 6 carbon atoms and/or has the cycloalkyl of 5 or 6 ring carbon atoms.
The statement of heteroaralkyl refers to wherein one or more (preferred 1,2,3 or 4) ring carbon atoms and/or carbon atom by the displaced aralkyl as defined above of oxygen, nitrogen, silicon, selenium, phosphorus, boron or sulphur atom (preferred oxygen, sulphur or nitrogen), and promptly it refers to the group that comprises aryl as defined above or heteroaryl and alkyl, alkenyl, alkynyl and/or assorted alkyl and/or cycloalkyl and/or Heterocyclylalkyl.Heteroaralkyl preferably comprises one or two aromatic ring with 5 or 6 to 10 ring carbon atoms and one or two to have alkyl, alkenyl and/or the alkynyl of 1 or 2 to 6 carbon atoms and/or has the cycloalkyl of 5 or 6 ring carbon atoms, and wherein 1,2,3 or 4 in these carbon atoms is replaced by oxygen, sulphur or nitrogen-atoms.
The example has the aryl alkyl of mixing, the aryl-heterocyclic alkyl, the aryl-heterocyclic thiazolinyl, the arylalkyl Heterocyclylalkyl, the aromatic yl alkenyl Heterocyclylalkyl, the aromatic yl polysulfide yl Heterocyclylalkyl, the arylalkyl heterocycloalkenyl, heteroarylalkyl, the heteroaryl alkenyl, the heteroaryl alkynyl, the heteroaryl alkyl of mixing, the heteroaryl ring alkyl, the heteroaryl ring thiazolinyl, the heteroaryl Heterocyclylalkyl, the heteroaryl heterocycloalkenyl, the heteroarylalkyl cycloalkyl, the heteroarylalkyl heterocycloalkenyl, the heteroaryl alkyl-cycloalkyl of mixing, the assorted alkyl heterocycle alkyl of assorted alkyl cycloalkenyl group of heteroaryl and heteroaryl, described cyclic group be saturated or single-, two-or three-undersaturated.Its specific examples has tetrahydro isoquinolyl, benzoyl, 2-or 3-ethylindole base, 4-picoline-1-base (pyridino), 2-, 3-or 4-p-methoxy-phenyl, 4-ethoxyl phenenyl, 2-, 3-or 4-carboxyl phenyl alkyl.
The statement of cycloalkyl, Heterocyclylalkyl, alkyl-cycloalkyl, assorted alkyl-cycloalkyl, aryl, heteroaryl, aralkyl and heteroaralkyl also refer to wherein one or more hydrogen atoms by fluorine, chlorine, bromine or iodine atom or OH ,=O, SH ,=S, NH 2,=NH or NO 2The displaced group of group.
Statement " randomly substituted " refer to wherein one or more hydrogen atoms by fluorine for example, chlorine, bromine or iodine atom or-COOH ,-OH ,=O ,-SH ,=S ,-NH 2,=NH or-NO 2The displaced group of group.This statement also refers to by unsubstituted C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl, C 1-C 6Assorted alkyl, C 3-C 10Cycloalkyl, C 2-C 9Heterocyclylalkyl, C 6-C 10Aryl, C 1-C 9Heteroaryl, C 7-C 12Aralkyl or C 2-C 11The group that heteroaralkyl replaces.
According to its replacement situation, the compound of formula (I) can comprise one or more chiral centres.Therefore, the present invention includes all pure enantiomers and all pure diastereomers, with and the mixture of any ratio.In addition, the present invention also comprise all cis/trans isomer of general formula (I) compound with and composition thereof.In addition, the present invention also comprises all tautomeric forms of formula (I) compound.
Preferred wherein W is that NH and V are formula (I) compounds of O, S or NH.
One, two or three among also preferred wherein group D, G and the M is formula (I) compound of nitrogen-atoms.
Especially preferably wherein X is formula-CH 2-CO-NHOH ,-CO-NHOH ,-CH 2-NOH-CHS ,-NOH-CHS ,-CH 2-NOH-CHO ,-NOH-CHO ,-CH 2-CO-CH 2OH ,-CO-CH 2OH ,-CH 2-CHOH-CHO ,-group of CHOH-CHO or have formula (I) compound of the group of one of following formula:
Figure S2006800140369D00071
X most preferably is the group of formula-CO-NHOH.
In addition, R 1Also preferably hydrogen atom, chlorine atom, bromine atoms, amino, methyl or ethyl; Especially hydrogen atom or amino.
R 2More preferably be hydrogen atom, chlorine atom, bromine atoms, methyl or ethyl; Especially hydrogen atom.
In addition, R 3And R 4Also preferably not hydrogen atom simultaneously.
R 3More preferably be hydrogen atom, chlorine atom, bromine atoms, amino, methyl, ethyl or propyl group, especially chlorine atom, bromine atoms or amino.
R 4Preferably chlorine atom, bromine atoms, methyl, ethyl or propyl group; Especially chlorine atom or bromine atoms.
Especially preferred is R wherein 3Be bromine atoms and R 4Be methyl or R wherein 3Be hydrogen atom and R 4It is formula (I) compound of chlorine atom or bromine atoms.
More preferably be radicals R 1, R 2, R 3And R 4In two be the part of cycloalkyl, Heterocyclylalkyl, aryl or heteroaryl ring together, and these rings can randomly be substituted separately.
R 5Tert-butyl, sec.-propyl, neo-pentyl or just-hexyl preferably; Especially tert-butyl, neo-pentyl or just-hexyl.
Radicals R 6And R 7More preferably be hydrogen atom, hydroxymethyl or methyl independently of one another.
The example of formula (I) compound pharmacologically acceptable salt has the salt of the acceptable mineral acid example hydrochloric acid of physiology, sulfuric acid and phosphoric acid; Organic acid such as methylsulfonic acid, right-toluenesulphonic acids, lactic acid, formic acid, acetate, trifluoroacetic acid, citric acid, succsinic acid, fumaric acid, toxilic acid and salicylic salt.The compound of formula (I) can be by solvation, particularly can be by hydration.Hydration can be for example takes place in preparation process or can be that water absorbability by initial water-free formula (I) compound produces.
Pharmaceutical composition of the present invention comprises at least a formula as activeconstituents (I) compound and randomly comprises carrier and/or auxiliary agent.
The prodrug that is the object of the invention equally (can be referring to for example R.B.Silverman for its definition and example; Medizinische Chemie; VCH Weinheim; 1995; the 8th chapter; the 361ff page or leaf) comprise the compound and the acceptable blocking group of at least a pharmacology cleaved under physiological conditions of formula (I), for example hydroxyl, alkoxyl group, aralkoxy, acyl group or acyloxy are as methoxyl group, oxyethyl group, benzyloxy, ethanoyl or acetoxyl group.
It is purpose of the present invention equally that the treatment of formula (I) compound, the acceptable salt of its pharmacology or solvate and hydrate and preparation and pharmaceutical composition is used.
The compound of formula (I) very interesting especially as the inhibitor of metalloprotease (particularly PDF).These activeconstituentss prevent and/or treat disease in preparation, also are purposes of the present invention by the application in the medicine of the disease of PDF mediation especially.Generally speaking, the compound of formula (I) carries out administration with known acceptable method, and it is by independent administration or with any other therapeutical agent Combined Preparation.For example can finish administration with a kind of in the following mode: oral administration, for example with the form oral administration of dragee, coating tablet, pill, semisolid, soft or hard capsule, solution, emulsion or suspension; Parenteral admin is for example with the form parenteral admin of Injectable solution; Form rectal administration with suppository; Carry out administration by suction, for example with powder formulation or Sprayable, through skin or intranasal administration.For the preparation of such tablet, pill, semisolid, coating tablet, dragee and hard gelatin capsule, can for example lactose, sucrose, glucose, gelatin, maltose, silica gel, starch or derivatives thereof, talcum powder, stearic acid or its salt, dry skimmed milk etc. be admixed together with treating the product of application and the inorganic or organic pharmaceutical carrier of pharmacology inert.For preparation of soft capsule, can use the pharmaceutical carrier such as vegetables oil, oil, animal or synthetic oil, wax, fat, polyvalent alcohol.For liquor and syrupy preparation, can use the pharmaceutical carrier such as water, alcohols, aqueous salt solution, moisture dextrose, polyvalent alcohol, glycerine, vegetables oil, oil, animal or synthetic oil.For suppository, can use the pharmaceutical carrier such as vegetables oil, oil, animal or synthetic oil, wax, fat and polyvalent alcohol.For aerosol, can use the pressurized gas that is applicable to this purpose, as oxygen, nitrogen and carbonic acid gas.Pharmaceutically useful material also can comprise anticorrosion and stabilization additives, emulsifying agent, sweeting agent, perfume compound, the salt that is used to change osmotic pressure, buffer reagent, dressing additive and oxidation inhibitor.
X=-COOCH 3Formula (I) compound can by will be wherein the aforesaid formula of definition (II), (III) and the compound (IV) of each group react and prepare.
Figure S2006800140369D00091
By its reaction product and azanol are reacted, can prepare formula (I) compound of X=-CO-NHOH in methyl alcohol.
Embodiment
General operation:
The solution of 50 0.2Ms of μ l amine (II) in methyl alcohol is assigned to (amine that is insoluble to methyl alcohol carries out manual allocation) on the 96-orifice plate.The solution that adds 50 0.2Ms of μ l aldehyde (III) in methyl alcohol.With this plate jolting at room temperature 2 hours.Subsequently, to acetic acid/methanol solution of solution that wherein adds 50 0.2Ms of μ l isocyanide (IV) in methyl alcohol and 50 μ l 0.4M.With one night of this plate jolting at room temperature, solvent evaporated, resistates is dissolved in the NH of 150 μ l 0.5M 2In the OH/ methanol solution.With this plate one night of jolting more at room temperature.
With suitable parent material, prepare following compound and it is identified with mass spectrum according to described general operation.All compounds have all been carried out studying (for this test as the activity of PDF inhibitor, referring to people such as D.Chen, antiseptic-germicide and chemotherapy (Antimicrobial Agents andChemotherapy), in January, 2004,250-261 page or leaf) and these compounds have the IC that scope is 1nmol to 50 μ mol 50Value.
Embodiment Calculated value [M+H] Measured value [M+H]
2-(6-fluoro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 225.09 225.08
2-(6-bromo-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 299.03 299.04
2-(6-bromo-3,5-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 313.05 313.08
N-hydroxyl-2-(6-iodo-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 389.07 389.10
2-(6-bromo-3,5-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 327.07 327.10
2-(3-tert-butyl-6-iodo-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 389.07 389.11
2-(6-bromo-3-ethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 327.07 327.10
2-(6-chloro-3-cyclopropyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 295.12 295.14
2-(6-chloro-3-sec.-propyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 297.14 297.18
2-(6-bromo-3-ethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 341.09 341.12
2-(6-bromo-3-sec.-propyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.12
2-[6-bromo-5-methyl-3-((E)-propenyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 339.07 339.11
2-(6-chloro-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 297.14 297.17
2-(3-tert-butyl-6-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 297.14 297.16
2-(3-tert-butyl-6-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 311.16 311.23
2-(3-tert-butyl-6-fluoro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 281.17 281.15
2-(6-fluoro-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 281.17 281.19
N-hydroxyl-2-(3-isobutyl--5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 277.20 277.21
2-(6-bromo-5-methyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.12
2-(6-bromo-3-isobutyl--5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.14
2-(3-tert-butyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.20
N-hydroxyl-2-(6-iodo-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-propionic acid amide 403.09 403.12
2-(6-bromo-8-methyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 355.11 355.08
2-(6-bromo-3-tert-butyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.13
2-(6-chloro-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 297.14 297.16
2-(3-tert-butyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 291.22 291.22
2-(6-chloro-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 311.16 311.17
2-(6-bromo-5-methyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 355.11 355.13
2-(6-bromo-3-tert-butyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 369.13 369.16
2-(6-bromo-3-isobutyl--8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 369.13 369.15
2-(6-bromo-3-isobutyl--5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 369.13 369.15
N-hydroxyl-2-(3-hydroxymethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 251.14 251.15
2-(5-ethyl-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 265.16 265.17
2-(5-ethyl-3-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 249.16 249.17
N-hydroxyl-2-[3-(1H-imidazoles-2-yl)-5-methyl-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 287.15 287.16
2-(3,5-diethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 263.18 263.19
2-[5-ethyl-3-(1H-imidazoles-2-yl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 301.16 301.18
2-(5-ethyl-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-propionic acid amide 279.17 279.26
2-[5-ethyl-3-((E)-propenyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 275.18 0.00
2-[7-ethyl-3-(1H-imidazoles-2-yl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 301.16 301.18
2-(3-furans-2-base-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 287.13 287.15
N-hydroxyl-2-[8-methyl-3-(1H-pyrazole-3-yl)-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 287.15 287.16
2-(3-cyclopropyl-5-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 275.18 275.18
N-hydroxyl-2-(8-hydroxy-3-methyl-imidazo [1,2-a] pyridine-2-base is amino)-3-phenyl-propionic acid amide 327.17 327.10
N-hydroxyl-2-(5-methyl-3-phenyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 297.16 297.17
N-hydroxyl-2-(7-methyl-imidazo [1,2-a] pyridine-2-base is amino)-3-phenyl-propionic acid amide 311.18 311.15
2-(3-butyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.22
2-(3-ethyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.19
N-hydroxyl-2-(3-isobutyl--5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 305.24 305.14
N-hydroxyl-2-(3-hydroxymethyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 279.17 279.17
2-(3-benzyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 339.22 339.22
N-hydroxyl-2-(3-amyl group-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 319.26 319.25
N-hydroxyl-2-(3-methyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 263.18 263.17
3-[2-(hydroxyl amino formyl radical methyl-amino)-5-propyl group-imidazo [1,2-a] pyridin-3-yl]-propionic acid 321.19 321.18
2-(3,5-dipropyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.21
N-hydroxyl-2-[3-(2-methylthio group-ethyl)-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 323.19 323.18
2-(3-tert-butyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.22
2-[3-(2,2-dimethyl-propyl group)-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 319.26 319.25
2-(3-heptan-1-alkynyl-5-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 343.26 343.25
N-hydroxyl-2-(3-amyl group-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 345.18 345.20
2-[3-(2,2-dimethyl-propyl group)-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 345.18 345.20
2-(3-heptan-1-alkynyl-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.18 369.11
2-(6-fluoro-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 295.19 295.20
2-[3-(2,2-dimethyl-propyl group)-6-fluoro-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 295.19 295.19
2-(3-butyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.19
2-(3-benzyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 311.18 311.19
N-hydroxyl-2-(5-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 291.22 291.22
N-hydroxyl-2-[5-methyl-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 295.15 295.09
2-(3-tert-butyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.21
2-[3-(2,2-dimethyl-propyl group)-5-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 291.22 291.22
2-(3-heptan-1-alkynyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 315.22 315.23
2-(1-butyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 313.20 313.21
2-(1-benzyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 347.18 347.20
N-hydroxyl-2-(1-amyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 327.22 327.23
N-hydroxyl-2-(1-propyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 299.18 299.21
N-hydroxyl-2-[1-(2-methylthio group-ethyl)-imidazo [1,2-a] quinoline-2-base is amino]-ethanamide 331.15 331.18
2-(1-tert-butyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 313.20 313.21
2-[1-(2,2-dimethyl-propyl group)-imidazo [1,2-a] quinoline-2-base is amino]-N-hydroxyl-ethanamide 327.22 327.23
2-(1-heptan-1-alkynyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 351.22 351.23
2-(6-bromo-3-isobutyl--8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.03
2-[6-bromo-3-(2,2-dimethyl-propyl group)-8-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 369.13 369.15
2-(6-bromo-3-heptan-1-alkynyl-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 393.13 393.14
2-(6-chloro-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 311.16 311.17
2-[6-chloro-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 311.16 311.17
2-(6-chloro-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 335.16 335.17
2-(3-butyl-6-nitro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 308.16 308.15
N-hydroxyl-2-(3-isobutyl--6-nitro-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 308.16 308.11
2-(3-benzyl-6-nitro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 342.14 342.17
N-hydroxyl-2-(6-nitro-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 322.18 322.19
2-[3-(2,2-dimethyl-propyl group)-6-nitro-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 322.18 322.20
2-(3-heptan-1-alkynyl-6-nitro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 346.18 346.20
2-(3-butyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.18
N-hydroxyl-2-(6-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 291.22 291.22
2-[3-(2,2-dimethyl-propyl group)-6-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 291.22 291.22
2-(3-heptan-1-alkynyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 315.22 315.22
2-(3-butyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.23
N-hydroxyl-2-(3-isobutyl--5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 291.22 291.21
N-hydroxyl-2-(3-hydroxymethyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 265.16 265.16
2-(3-benzyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 325.20 325.21
2-(5,7-dimethyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.24
3-[2-(hydroxyl amino formyl radical methyl-amino)-5,7-dimethyl-imidazo [1,2-a] pyridin-3-yl]-propionic acid 307.17 307.10
2-(5,7-dimethyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.26
2-[5,7-dimethyl-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 309.17 309.18
2-(3-tert-butyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.22
2-[3-(2,2-dimethyl-propyl group)-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 305.24 305.24
2-(in 3-heptan-1-alkynyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 329.24 329.24
2-(6,8-two bromo-3-butyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 419.00 419.03
2-(6,8-two bromo-3-isobutyl--imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 419.00 419.03
2-(6,8-two bromo-3-hydroxymethyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 392.93 393.00
2-(3-benzyl-6,8-two bromo-imidazos [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 452.97 453.02
2-(6,8-two bromo-3-amyl group-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 433.02 433.05
2-[6,8-two bromo-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 436.95 436.97
2-[6,8-two bromo-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 433.02 433.02
2-(6,8-two bromo-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 457.01 457.03
2-(3-butyl-8-chloro-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 365.12 365.14
2-(8-chloro-3-hydroxymethyl-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 339.06 339.03
2-(3-benzyl-8-chloro-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 399.10 399.15
2-(8-chloro-3-amyl group-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 379.14 379.15
2-[8-chloro-3-(2,2-dimethyl-propyl group)-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 379.14 379.15
2-(8-chloro-3-heptan-1-alkynyl-6-trifluoromethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 403.14 403.14
2-(6-bromo-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.09
2-(6-bromo-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.10
2-(6-bromo-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.09
2-[6-bromo-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 355.11 355.11
2-(6-bromo-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 379.11 379.12
2-(1-butyl-9-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 329.19 329.19
2-(1-ethyl-9-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 301.15 301.16
N-hydroxyl-2-(9-hydroxyl-1-isobutyl--imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 329.19 329.19
2-(1-benzyl-9-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 363.17 363.18
N-hydroxyl-2-(9-hydroxyl-1-amyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 343.21 343.21
N-hydroxyl-2-(9-hydroxyl-1-propyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 315.17 315.17
N-hydroxyl-2-[9-hydroxyl-1-(2-methylthio group-ethyl)-imidazo [1,2-a] quinoline-2-base is amino]-ethanamide 347.14 347.15
2-(1-tert-butyl-9-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 329.19 329.19
2-[1-(2,2-dimethyl-propyl group)-9-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino]-N-hydroxyl-ethanamide 343.21 343.21
2-(8-bromo-3-butyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.11
2-(8-bromo-6-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.13 369.12
2-[8-bromo-3-(2,2-dimethyl-propyl group)-6-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 369.13 369.12
2-(8-bromo-3-heptan-1-alkynyl-6-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 393.13 393.13
2-(3-butyl-5-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 297.14 297.14
2-(5-chloro-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 269.10 269.14
2-(5-chloro-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 297.14 297.14
2-(5-chloro-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 271.07 271.09
2-(3-benzyl-5-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 331.12 331.13
2-(5-chloro-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 311.16 311.16
2-(5-chloro-3-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 255.08 255.09
3-[5-chloro-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridin-3-yl]-propionic acid 313.09 313.13
2-(5-chloro-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 283.12 283.18
2-[5-chloro-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 315.09 315.10
2-(3-tert-butyl-5-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 297.14 297.14
2-[5-chloro-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 311.16 311.16
2-(5-chloro-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 335.16 335.17
N-hydroxyl-2-(5-methyl-6-nitro-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 308.16 308.14
2-[3-(2,2-dimethyl-propyl group)-5-methyl-6-nitro-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 336.20 336.25
2-(5-bromo-3-propyl group-imidazo [1,2-b] isoquinoline 99.9-2-base is amino)-N-hydroxyl-ethanamide 377.09 377.13
2-[5-bromo-3-(2-methylthio group-ethyl)-imidazo [1,2-b] isoquinoline 99.9-2-base is amino]-N-hydroxyl-ethanamide 409.06 409.08
2-(6,8-two bromo-3-butyl-5-methyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 433.02 433.05
2-(6,8-two bromo-3-ethyl-5-methyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 404.98 405.00
2-(6,8-two bromo-3-isobutyl--5-methyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 433.02 433.03
2-(6,8-two bromo-3-hydroxymethyl-5-methyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 406.95 406.98
2-(3-benzyl-6,8-two bromo-5-methyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 466.99 466.96
2-(6,8-two bromo-5-methyl-3-amyl group-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 447.03 447.04
2-(6,8-two bromo-3,5-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 390.96 390.98
2-(6,8-two bromo-5-methyl-3-propyl group-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 419.00 419.01
2-[6,8-two bromo-5-methyl-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 450.97 451.02
2-[6,8-two bromo-3-(2,2-dimethyl-propyl group)-5-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 447.03 447.05
2-(6,8-two bromo-3-heptan-1-alkynyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 471.03 471.08
2-(1-butyl-5-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 329.19 329.20
N-hydroxyl-2-(5-hydroxyl-1-isobutyl--imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 329.19 329.20
2-(1-benzyl-5-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino)-N-hydroxyl-ethanamide 363.17 363.17
N-hydroxyl-2-(5-hydroxyl-1-amyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 343.21 343.19
N-hydroxyl-2-(5-hydroxyl-1-propyl group-imidazo [1,2-a] quinoline-2-base is amino)-ethanamide 315.17 315.23
N-hydroxyl-2-[5-hydroxyl-1-(2-methylthio group-ethyl)-imidazo [1,2-a] quinoline-2-base is amino]-ethanamide 347.14 347.15
2-[1-(2,2-dimethyl-propyl group)-5-hydroxyl-imidazo [1,2-a] quinoline-2-base is amino]-N-hydroxyl-ethanamide 343.21 343.21
2-(3-butyl-6,8-two fluoro-imidazos [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 299.16 299.16
2-(6,8-two fluoro-3-isobutyl--imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 299.16 299.16
2-(6,8-two fluoro-3-amyl group-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 313.18 313.18
2-[6,8-two fluoro-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 317.11 317.12
2-[3-(2,2-dimethyl-propyl group)-6,8-two fluoro-imidazos [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 313.18 313.18
2-(6-bromo-3-isobutyl--7,8-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.13 369.13
2-(6-bromo-7,8-dimethyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 383.15 383.14
2-[6-bromo-3-(2,2-dimethyl-propyl group)-7,8-dimethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 383.15 383.14
2-(in 6-bromo-3-heptan-1-alkynyl-7,8-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 407.15 407.15
2-[3-(2,2-dimethyl-propyl group)-7-methyl-6-nitro-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 336.20 336.21
2-(5-bromo-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.09
2-(5-bromo-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 313.05 313.06
2-(5-bromo-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.10
2-(5-bromo-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 315.02 315.04
2-(3-benzyl-5-bromo-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 375.07 374.98
2-(5-bromo-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.06
2-(5-bromo-3-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 299.03 299.04
3-[5-bromo-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridin-3-yl]-propionic acid 357.04 357.06
2-(5-bromo-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 327.07 327.07
2-[5-bromo-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 359.04 359.06
2-(5-bromo-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 341.09 341.17
2-[5-bromo-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 355.11 355.11
2-(5-bromo-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 379.11 379.12
2-(3-butyl-8-ethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.23
2-(8-ethyl-3-hydroxymethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 279.17 279.18
2-(3-benzyl-8-ethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 339.22 339.22
2-(8-ethyl-5-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 319.26 319.25
2-[3-(2,2-dimethyl-propyl group)-8-ethyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 319.26 319.25
2-(8-ethyl-3-heptan-1-alkynyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 343.26 343.26
2-(6,8-two chloro-3-hydroxymethyl-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 305.03 305.06
2-(6,8-two chloro-3-amyl group-imidazo [1,2-a] pyridines-2-base is amino)-N-hydroxyl-ethanamide 345.12 345.12
2-(6-bromo-3-isobutyl--7-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.11
2-[6-bromo-3-(2,2-dimethyl-propyl group)-7-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 369.13 369.12
2-(3-butyl-5-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.22
2-(5-ethyl-3-isobutyl--imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.21
2-(5-ethyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.23
3-[5-ethyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridin-3-yl]-propionic acid 307.17 307.17
2-(5-ethyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.19
2-[5-ethyl-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 309.17 309.18
2-(3-tert-butyl-5-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.22
2-[3-(2,2-dimethyl-propyl group)-5-ethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 305.24 305.24
2-(5-ethyl-3-heptan-1-alkynyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 329.24 329.24
2-(6-bromo-3-butyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.11 355.11
2-(3-benzyl-6-bromo-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 389.09 389.06
2-(6-bromo-5-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.13 369.13
3-[6-bromo-2-(hydroxyl amino formyl radical methyl-amino)-5-methyl-imidazo [1,2-a] pyridin-3-yl]-propionic acid 371.06 371.10
2-[6-bromo-5-methyl-3-(2-methylthio group-ethyl)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 373.06 373.08
2-[6-bromo-3-(2,2-dimethyl-propyl group)-5-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 369.13 369.14
2-(6-bromo-3-heptan-1-alkynyl-5-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 393.13 393.03
2-(3,7-two-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 267.13 267.13
N-hydroxyl-2-(7-hydroxymethyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 279.17 279.17
2-(3-tert-butyl-7-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 293.19 293.18
2-(3-cyclohexyl-7-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 319.21 319.20
3-butyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-6-benzoic acid amides 306.19 306.18
2-(hydroxyl amino formyl radical methyl-amino)-3-hydroxymethyl-imidazo [1,2-a] pyridine-6-benzoic acid amides 280.12 280.14
3-tert-butyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-6-benzoic acid amides 306.19 306.18
2-(hydroxyl amino formyl radical methyl-amino)-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-6-benzoic acid amides 346.13 346.15
3-cyclohexyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-6-benzoic acid amides 332.21 332.20
2-(6,8-two bromo-3-butyl-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 447.03 447.05
2-(6,8-two bromo-3-ethyls-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 419.00 419.02
2-(7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino for 3-benzyl-6,8-two bromo-5)-N-hydroxyl-ethanamide 481.01 481.05
2-(6,8-two bromo-5,7-dimethyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 461.05 461.08
3-[6,8-two bromo-2-(hydroxyl amino formyl radical methyl-amino)-5,7-dimethyl-imidazo [1,2-a] pyridin-3-yl]-propionic acid 462.98 463.01
2-[6,8-two bromo-3-(2,2-dimethyl-propyl group)-5,7-dimethyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 461.05 461.10
2-[6,8-two bromo-5,7-dimethyl-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 486.98 487.04
2-(8-bromo-6-chloro-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 347.01 347.10
2-[8-bromo-6-chloro-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 389.07 389.07
2-(8-bromo-6-chloro-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 401.07 401.08
2-(8-amino-3-butyl-6-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 312.15 312.16
2-(8-amino-6-chloro-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 284.11 284.12
2-(8-amino-6-chloro-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 286.09 286.02
2-(8-amino-3-benzyl-6-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 346.13 346.15
2-(8-amino-6-chloro-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 326.17 326.18
3-[8-amino-6-chloro-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridin-3-yl]-propionic acid 328.10 328.12
2-(8-amino-6-chloro-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 298.13 298.06
2-(8-amino-3-tert-butyl-6-chloro-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 312.15 312.16
2-[8-amino-6-chloro-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 326.17 326.18
2-[8-amino-6-chloro-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 352.10 352.05
2-(8-amino-6-chloro-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 338.17 338.18
2-(8-amino-6-bromo-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 356.10 356.12
2-(8-amino-6-bromo-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 328.06 328.08
2-(8-amino-6-bromo-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 330.04 330.06
2-(8-amino-3-benzyl-6-bromo-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 390.08 390.11
2-(8-amino-6-bromo-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 370.12 370.13
2-(8-amino-6-bromo-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 342.08 342.10
2-(8-amino-6-bromo-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 356.10 356.11
2-[8-amino-6-bromo-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 370.12 370.13
2-[8-amino-6-bromo-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 396.04 396.05
2-[8-amino-6-bromo-3-(2,2,2-three fluoro-ethyls)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 382.03 382.06
2-(8-amino-6-bromo-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 382.12 382.13
2-(6-amino-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.19
2-(6-amino-3-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 250.15 250.15
2-(6-amino-3-benzyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 312.17 312.25
2-(6-amino-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 292.21 292.20
3-[6-amino-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridin-3-yl]-propionic acid 294.14 294.15
2-(6-amino-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 264.17 264.27
2-(6-amino-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.18
2-[6-amino-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 292.21 292.20
2-[6-amino-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 318.14 318.15
2-[6-amino-3-(2,2,2-three fluoro-ethyls)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 304.12 304.11
2-(6-amino-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 304.21 304.20
2-(8-amino-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.19
2-(8-amino-3-benzyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 312.17 312.18
2-(8-amino-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 292.21 292.20
2-(8-amino-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 264.17 264.20
2-(8-amino-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.19
2-[8-amino-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 292.21 292.20
2-[8-amino-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 318.14 318.15
2-(5-amino-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.25
2-(5-amino-3-benzyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 312.17 312.19
2-(5-amino-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 292.21 292.20
2-(5-amino-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 264.17 264.17
2-(5-amino-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 278.19 278.19
2-[5-amino-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 318.14 318.16
2-[5-amino-3-(2,2,2-three fluoro-ethyls)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 304.12 304.10
2-(5-amino-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 304.21 304.21
2-(3-butyl-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 277.20 277.22
N-hydroxyl-2-(3-hydroxymethyl-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 251.14 251.13
2-(3-benzyl-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 311.18 311.11
N-hydroxyl-2-(8-methyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 291.22 291.21
2-[3-(2,2-dimethyl-propyl group)-8-methyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 291.22 291.21
N-hydroxyl-2-[8-methyl-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 317.14 317.15
2-(3-cyclohexyl-8-methyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 303.22 303.21
2-(3-butyl-7-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 291.22 291.21
2-(7-ethyl-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 265.16 265.07
2-(3-benzyl-7-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 325.20 325.20
2-(7-ethyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.24 305.23
2-(3-cyclohexyl-7-ethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 317.24 317.23
2-(3-butyl-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 279.17 279.20
2-(3-ethyl-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 251.14 251.14
N-hydroxyl-2-(8-hydroxyl-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 253.11 253.12
2-(3-benzyl-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 313.15 313.17
N-hydroxyl-2-(8-hydroxyl-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 293.19 293.19
N-hydroxyl-2-(8-hydroxyl-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-ethanamide 265.16 265.16
2-(3-tert-butyl-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 279.17 279.17
2-[3-(2,2-dimethyl-propyl group)-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 293.19 293.19
N-hydroxyl-2-[8-hydroxyl-3-(3,3,3-three fluoro-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-ethanamide 319.12 319.13
2-(3-cyclohexyl-8-hydroxyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 305.19 305.19
2-(3-butyl-imidazo [2,1-a] isoquinoline 99.9-2-base is amino)-N-hydroxyl-ethanamide 313.20 313.20
2-(3-benzyl-imidazo [2,1-a] isoquinoline 99.9-2-base is amino)-N-hydroxyl-ethanamide 347.18 347.19
N-hydroxyl-2-(3-amyl group-imidazo [2,1-a] isoquinoline 99.9-2-base is amino)-ethanamide 327.22 327.22
2-[3-(2,2-dimethyl-propyl group)-imidazo [2,1-a] isoquinoline 99.9-2-base is amino]-N-hydroxyl-ethanamide 327.22 327.22
2-(3-cyclohexyl-imidazo [2,1-a] isoquinoline 99.9-2-base is amino)-N-hydroxyl-ethanamide 339.22 339.21
2-(8-benzyloxy-3-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.23 369.23
2-(8-benzyloxy-3-hydroxymethyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 343.17 343.18
2-(8-benzyloxy-3-amyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 383.25 383.23
2-(8-benzyloxy-3-propyl group-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 355.21 355.22
2-(8-benzyloxy-3-tert-butyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 369.23 369.25
2-[8-benzyloxy-3-(2,2-dimethyl-propyl group)-imidazo [1,2-a] pyridine-2-base is amino]-N-hydroxyl-ethanamide 383.25 383.25
2-(8-benzyloxy-3-cyclohexyl-imidazo [1,2-a] pyridine-2-base is amino)-N-hydroxyl-ethanamide 395.25 395.25
2-(hydroxyl amino formyl radical methyl-amino)-3-amyl group-imidazo [1,2-a] pyridine-6-formic acid 321.19 321.14
3-butyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-8-formic acid 307.17 307.20
2-(hydroxyl amino formyl radical methyl-amino)-3-amyl group-imidazo [1,2-a] pyridine-8-formic acid 321.19 321.17
3-(2,2-dimethyl-propyl group)-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-8-formic acid 321.19 321.19
3-cyclohexyl-2-(hydroxyl amino formyl radical methyl-amino)-imidazo [1,2-a] pyridine-8-formic acid 333.19 333.20

Claims (13)

1. formula (I) compound or its pharmaceutically useful salt
Wherein
Radicals R 1, R 2, R 3And R 4The C that is hydrogen atom, halogen atom, hydroxyl, amino, nitro independently of one another, is randomly replaced by halogen atom or hydroxyl 1-C 12Alkyl, R wherein aBe hydrogen atom and Y aBe the R of straight key a-O-CO-Y a-, R wherein aAnd R bBe hydrogen atom and Y aBe the R of straight key a-N (R b)-CO-Y a-or heteroaralkyl, described heteroaralkyl comprise the aromatic ring of 6 ring carbon atoms and one and have 2 to 6 carbon atoms and one of them carbon atom by the displaced alkyl of Sauerstoffatom, perhaps radicals R 1, R 2, R 3And R 4In two can be the part of benzyl ring together;
R 5The C that is hydrogen atom, is randomly replaced by halogen atom or hydroxyl 1-C 12Alkyl, C 2-C 12Alkenyl, C 2-C 12Alkynyl, phenyl, comprise heteroaryl, benzyl, a C with 5 annular atomses and one or two oxygen or azo-cycle atom 3-C 7Cycloalkyl, R wherein aBe hydrogen atom and Y aBe C 1-C 6The R of-alkylidene group a-O-CO-Y a-or R wherein aBe C 1-C 6-alkyl-and Y aBe C 1-C 6The R of-alkylidene group a-S-Y a-;
Radicals R 6And R 7Be hydrogen atom or C independently of one another 1-C 6Alkyl; And
X is the group of formula-CO-NHOH.
2. compound as claimed in claim 1, wherein R 1Be hydrogen atom, chlorine atom, bromine atoms, amino, methyl or ethyl.
3. the described compound of claim 1, wherein R 2Be hydrogen atom, chlorine atom, bromine atoms, methyl or ethyl.
4. compound as claimed in claim 1, wherein R 3And R 4Not hydrogen atom simultaneously.
5. compound as claimed in claim 1, wherein R 3Be hydrogen atom, chlorine atom, bromine atoms, amino, methyl, ethyl or propyl group.
6. compound as claimed in claim 1, wherein R 4Be chlorine atom, bromine atoms, methyl, ethyl or propyl group.
7. compound as claimed in claim 1, wherein R 3Be bromine atoms and R 4Be methyl, perhaps R wherein 3Be hydrogen atom and R 4Be chlorine atom or bromine atoms.
8. compound as claimed in claim 1, wherein R 5It is tert-butyl, sec.-propyl, neo-pentyl or just-hexyl.
9. compound as claimed in claim 1, wherein radicals R 6And R 7Be hydrogen atom or methyl independently of one another.
10. comprise the pharmaceutical composition that also randomly comprises carrier as each the described compound in the claim 1 to 9.
11. be used for the application of the medicine of inhibiting peptide deformylase in preparation as each the described compound in the claim 1 to 9.
12. be used for preventing and/or treating application in preparation by the medicine of the disease of deformylase polypeptide enzymic activity mediation as each the described compound in the claim 1 to 9.
13. preparing as the application in the antibiotic medicine as each the described compound in the claim 1 to 9.
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