AU2006239546B2 - Imidazo(1,2-A)pyridine derivatives useful as peptide deformylase (PDF) inhibitors - Google Patents

Imidazo(1,2-A)pyridine derivatives useful as peptide deformylase (PDF) inhibitors Download PDF

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Publication number
AU2006239546B2
AU2006239546B2 AU2006239546A AU2006239546A AU2006239546B2 AU 2006239546 B2 AU2006239546 B2 AU 2006239546B2 AU 2006239546 A AU2006239546 A AU 2006239546A AU 2006239546 A AU2006239546 A AU 2006239546A AU 2006239546 B2 AU2006239546 B2 AU 2006239546B2
Authority
AU
Australia
Prior art keywords
hydroxy
imidazo
acetamide
pyridin
ylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006239546A
Other languages
English (en)
Other versions
AU2006239546A1 (en
Inventor
Michael Thormann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2006239546A1 publication Critical patent/AU2006239546A1/en
Application granted granted Critical
Publication of AU2006239546B2 publication Critical patent/AU2006239546B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2006239546A 2005-04-25 2006-04-24 Imidazo(1,2-A)pyridine derivatives useful as peptide deformylase (PDF) inhibitors Ceased AU2006239546B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019180.0 2005-04-25
DE102005019180 2005-04-25
PCT/EP2006/003765 WO2006114261A1 (en) 2005-04-25 2006-04-24 Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (2)

Publication Number Publication Date
AU2006239546A1 AU2006239546A1 (en) 2006-11-02
AU2006239546B2 true AU2006239546B2 (en) 2010-04-15

Family

ID=36686088

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006239546A Ceased AU2006239546B2 (en) 2005-04-25 2006-04-24 Imidazo(1,2-A)pyridine derivatives useful as peptide deformylase (PDF) inhibitors

Country Status (10)

Country Link
EP (1) EP1877407A1 (https=)
JP (1) JP2008538776A (https=)
KR (1) KR20080002866A (https=)
CN (1) CN101166740B (https=)
AU (1) AU2006239546B2 (https=)
BR (1) BRPI0610842A2 (https=)
CA (1) CA2606251A1 (https=)
MX (1) MX2007013237A (https=)
RU (1) RU2409575C2 (https=)
WO (1) WO2006114261A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008027812A2 (en) 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
EP2074121B1 (en) * 2006-10-06 2016-11-30 Boehringer Ingelheim International GmbH Chymase inhibitors
RU2748833C2 (ru) * 2016-11-28 2021-05-31 Цзянсу Хэнжуй Медсин Ко., Лтд. Производное пиразоло-гетероарила, способ его получения и медицинское применение
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
EP4214207A4 (en) 2020-09-15 2024-10-02 1st Biotherapeutics, Inc. 2-AMINO-3-CARBONYL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE COMPOUNDS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
JPH0717971A (ja) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途
DE69729007T2 (de) * 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
AU2003296960A1 (en) * 2002-12-11 2004-06-30 Smithkline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Winkelmann et al et, Arzneim-Forsch./Drug Res. 27(I), Nr. 1 (1977) *

Also Published As

Publication number Publication date
KR20080002866A (ko) 2008-01-04
WO2006114261A1 (en) 2006-11-02
RU2007143501A (ru) 2009-06-10
AU2006239546A1 (en) 2006-11-02
BRPI0610842A2 (pt) 2010-07-27
CN101166740B (zh) 2010-12-29
CA2606251A1 (en) 2006-11-02
EP1877407A1 (en) 2008-01-16
CN101166740A (zh) 2008-04-23
JP2008538776A (ja) 2008-11-06
RU2409575C2 (ru) 2011-01-20
MX2007013237A (es) 2008-01-24

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired