CN101141950B - 具有改进的药物代谢动力学特性的药物 - Google Patents

具有改进的药物代谢动力学特性的药物 Download PDF

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Publication number
CN101141950B
CN101141950B CN200680006596XA CN200680006596A CN101141950B CN 101141950 B CN101141950 B CN 101141950B CN 200680006596X A CN200680006596X A CN 200680006596XA CN 200680006596 A CN200680006596 A CN 200680006596A CN 101141950 B CN101141950 B CN 101141950B
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CN
China
Prior art keywords
vardenafil
pharmaceutical preparation
preparation according
acid
hydrochloric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN200680006596XA
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English (en)
Chinese (zh)
Other versions
CN101141950A (zh
Inventor
P·瑟诺
R·黑尼格
K·波利
早内丰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Bayer Intellectual Property GmbH
Original Assignee
Bayer Healthcare AG
Bayer Schering Pharma AG
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Application filed by Bayer Healthcare AG, Bayer Schering Pharma AG filed Critical Bayer Healthcare AG
Publication of CN101141950A publication Critical patent/CN101141950A/zh
Application granted granted Critical
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Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200680006596XA 2005-03-01 2006-02-16 具有改进的药物代谢动力学特性的药物 Expired - Lifetime CN101141950B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005009240A DE102005009240A1 (de) 2005-03-01 2005-03-01 Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DE102005009240.3 2005-03-01
PCT/EP2006/001393 WO2006092207A1 (de) 2005-03-01 2006-02-16 Arzneiformen mit verbesserten pharmakokinetischen eigenschaften

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110078538.0A Division CN102198140B (zh) 2005-03-01 2006-02-16 具有改进的药物代谢动力学特性的药物

Publications (2)

Publication Number Publication Date
CN101141950A CN101141950A (zh) 2008-03-12
CN101141950B true CN101141950B (zh) 2011-06-08

Family

ID=36264023

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200680006596XA Expired - Lifetime CN101141950B (zh) 2005-03-01 2006-02-16 具有改进的药物代谢动力学特性的药物
CN201110078538.0A Expired - Lifetime CN102198140B (zh) 2005-03-01 2006-02-16 具有改进的药物代谢动力学特性的药物

Family Applications After (1)

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CN201110078538.0A Expired - Lifetime CN102198140B (zh) 2005-03-01 2006-02-16 具有改进的药物代谢动力学特性的药物

Country Status (38)

Country Link
US (2) US8613950B2 (OSRAM)
EP (2) EP1858490B1 (OSRAM)
JP (1) JP5122984B2 (OSRAM)
KR (1) KR101360526B1 (OSRAM)
CN (2) CN101141950B (OSRAM)
AR (2) AR053552A1 (OSRAM)
AT (1) ATE552828T1 (OSRAM)
AU (1) AU2006220100B2 (OSRAM)
BR (1) BRPI0609375A2 (OSRAM)
CA (1) CA2599617C (OSRAM)
CR (2) CR9339A (OSRAM)
CY (1) CY1112874T1 (OSRAM)
DE (1) DE102005009240A1 (OSRAM)
DK (1) DK1858490T3 (OSRAM)
DO (1) DOP2006000049A (OSRAM)
ES (1) ES2384109T3 (OSRAM)
GT (1) GT200600097A (OSRAM)
HN (1) HN2006009000A (OSRAM)
HR (1) HRP20120545T1 (OSRAM)
IL (2) IL185552A (OSRAM)
MA (1) MA29376B1 (OSRAM)
MX (1) MX2007010527A (OSRAM)
MY (2) MY148698A (OSRAM)
NO (2) NO332368B1 (OSRAM)
NZ (1) NZ561004A (OSRAM)
PE (2) PE20100740A1 (OSRAM)
PL (1) PL1858490T3 (OSRAM)
PT (1) PT1858490E (OSRAM)
RS (1) RS52374B (OSRAM)
RU (2) RU2423970C2 (OSRAM)
SG (1) SG160330A1 (OSRAM)
SI (1) SI1858490T1 (OSRAM)
TN (1) TNSN07336A1 (OSRAM)
TW (1) TWI387465B (OSRAM)
UA (1) UA93200C2 (OSRAM)
UY (1) UY29395A1 (OSRAM)
WO (1) WO2006092207A1 (OSRAM)
ZA (1) ZA200707320B (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
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DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
FR2906140B1 (fr) * 2006-09-22 2008-12-05 Philippe Perovitch Forme galenique pour l'administration par voie trans-muqueuse de principes actifs
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
DE102009020888A1 (de) 2009-05-12 2010-11-18 Ratiopharm Gmbh Schmelztablette, enthaltend ein Vardenafil-Salz
US8920839B2 (en) 2009-05-20 2014-12-30 Sumitomo Dainippon Pharma Co., Ltd. Dry-coated orally-disintegrating tablet
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CN102727455B (zh) * 2012-07-03 2016-06-29 北京科信必成医药科技发展有限公司 一种他达那非口腔崩解片及其制备方法
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
CN110193015A (zh) * 2018-02-27 2019-09-03 广州朗圣药业有限公司 一种盐酸伐地那非口腔崩解片及其制备方法
CN108272765B (zh) * 2018-04-26 2021-02-02 江西杏林白马药业股份有限公司 含盐酸伐地那非的药物组合物、口崩片及其制备、应用
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CN110840851A (zh) * 2019-08-16 2020-02-28 天津仁卫生物医药科技有限公司 一种盐酸伐地那非口腔崩解片及其制备方法
IT201900020350A1 (it) 2019-11-05 2021-05-05 Alpex Pharma Sa Formulazione orodispersibile di vardenafil
EP4096791A1 (en) 2020-01-31 2022-12-07 Nanocopoeia LLC Amorphous nilotinib microparticles and uses thereof
IL297776A (en) 2020-04-30 2022-12-01 Nanocopoeia Llc Orally disintegrating tablets containing an amorphous solid dispersion of nalotinib
IL298432A (en) * 2020-05-26 2023-01-01 Strategic Drug Solutions Inc Formulations and methods for treating erectile dysfunction
CN114848603B (zh) * 2022-04-25 2023-12-12 湖北菲瑞生物药业有限公司 一种伐地那非冻干闪释片及其制备工艺

Citations (1)

* Cited by examiner, † Cited by third party
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DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel

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