GB790762A - A hydrate of lignocaine hydrochloride and process for making it - Google Patents

A hydrate of lignocaine hydrochloride and process for making it

Info

Publication number
GB790762A
GB790762A GB2388853A GB2388853A GB790762A GB 790762 A GB790762 A GB 790762A GB 2388853 A GB2388853 A GB 2388853A GB 2388853 A GB2388853 A GB 2388853A GB 790762 A GB790762 A GB 790762A
Authority
GB
United Kingdom
Prior art keywords
hydrochloride
monohydrate
lignocaine
water
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2388853A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB2388853A priority Critical patent/GB790762A/en
Publication of GB790762A publication Critical patent/GB790762A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises diethylaminoacetyl-2:6 - dimethylanilide ("lignocaine") hydrochloride monohydrate in the form of discrete particles and processes for its manufacture by combining lignocaine hydrochloride with sufficient water to form the monohydrate. The manufacture may suitably be carried out by precipitating the monohydrate from an aqueous solution of the hydrochloride by adding a water-miscible organic solvent, or by crystallizing the monohydrate from a solution of the hydrochloride in a solvent consisting of a mixture of water and a water-miscible liquid (e.g. acetone, methyl ethyl ketone or dioxane), or by bringing the hydrochloride into contact with water vapour, e.g. by treating it with humid air, until the hydrochloride has taken up sufficient water to form the monohydrate and which is then recrystallized from a solvent in order to form discrete particles. In examples: (1) lignocaine is dissolved in 33 per cent hydrochloric acid, acetone is added and the monohydrate is crystallized from the solution; (2) lignocaine hydrochloride formed by subjecting a solution of lignocaine in dilute hydrochloric acid to azeotropic distillation with benzene is recrystallized from methyl ethyl ketone containing a small quantity of water, to give the monohydrate and (3) lignocaine hydrochloride is exposed to humid air and the resulting hydrate is recrystallized from methyl ethyl ketone.
GB2388853A 1953-08-28 1953-08-28 A hydrate of lignocaine hydrochloride and process for making it Expired GB790762A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2388853A GB790762A (en) 1953-08-28 1953-08-28 A hydrate of lignocaine hydrochloride and process for making it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2388853A GB790762A (en) 1953-08-28 1953-08-28 A hydrate of lignocaine hydrochloride and process for making it

Publications (1)

Publication Number Publication Date
GB790762A true GB790762A (en) 1958-02-19

Family

ID=10202948

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2388853A Expired GB790762A (en) 1953-08-28 1953-08-28 A hydrate of lignocaine hydrochloride and process for making it

Country Status (1)

Country Link
GB (1) GB790762A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004006894A1 (en) * 2002-07-16 2004-01-22 Bayer Healthcare Ag Medicaments containing vardenafil hydrochloride trihydrate
EP1891010A2 (en) 2005-06-17 2008-02-27 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A A process for the preparation of an injectable solution of (2s)-n-(2;6-dimethyl-phenyl)-1-propyl-2-piperidincarboxamide
US8613950B2 (en) 2005-03-01 2013-12-24 Bayer Intellectual Property Gmbh Pharmaceutical forms with improved pharmacokinetic properties
CN114524749A (en) * 2022-03-01 2022-05-24 遂成药业股份有限公司 N-diethyl acetyl-2, 6-dimethylaniline crystal and preparation method thereof

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004006894A1 (en) * 2002-07-16 2004-01-22 Bayer Healthcare Ag Medicaments containing vardenafil hydrochloride trihydrate
AU2003249942B2 (en) * 2002-07-16 2009-10-29 Bayer Intellectual Property Gmbh Medicaments containing vardenafil hydrochloride trihydrate
CN1681481B (en) * 2002-07-16 2010-12-15 拜耳先灵制药股份公司 Medicaments containing vardenafil hydrochloride trihydrate
EP2272505A1 (en) * 2002-07-16 2011-01-12 Bayer Schering Pharma AG Pharmaceutical compositions containing vardenafil hydrochloride trihydrate
US8273876B2 (en) 2002-07-16 2012-09-25 Bayer Intellectual Property Gmbh Medicaments containing vardenafil hydrochloride trihydrate
HRP20050143B1 (en) * 2002-07-16 2014-01-31 Bayer Intellectual Property Gmbh Medicaments containing vardenafil hydrochloride trihydrate
CN102210689B (en) * 2002-07-16 2014-07-30 拜耳知识产权有限责任公司 Medicaments containing vardenafil hydrochloride trihydrate
EP2272505B1 (en) 2002-07-16 2016-10-12 Bayer Intellectual Property GmbH Tablets containing vardenafil hydrochloride trihydrate
HRP20120418B1 (en) * 2002-07-16 2018-01-26 Bayer Intellectual Property Gmbh Pharmaceutical compositions containing vardenafil hydrochloride trihydrate
US8613950B2 (en) 2005-03-01 2013-12-24 Bayer Intellectual Property Gmbh Pharmaceutical forms with improved pharmacokinetic properties
EP1891010A2 (en) 2005-06-17 2008-02-27 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A A process for the preparation of an injectable solution of (2s)-n-(2;6-dimethyl-phenyl)-1-propyl-2-piperidincarboxamide
CN114524749A (en) * 2022-03-01 2022-05-24 遂成药业股份有限公司 N-diethyl acetyl-2, 6-dimethylaniline crystal and preparation method thereof

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