CN101099784A - Traditional Chinese medicine suppository and preparation method thereof - Google Patents
Traditional Chinese medicine suppository and preparation method thereof Download PDFInfo
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- CN101099784A CN101099784A CNA2007100168040A CN200710016804A CN101099784A CN 101099784 A CN101099784 A CN 101099784A CN A2007100168040 A CNA2007100168040 A CN A2007100168040A CN 200710016804 A CN200710016804 A CN 200710016804A CN 101099784 A CN101099784 A CN 101099784A
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Abstract
The invention is concerned with the Chinese traditional medicine suppository and the preparation method for treating and defending intestine paralysis, intestine conglutination and intestinal obstruction, composes of bark of official magnolia, rhubarb and fruit of immature citron that compounds with weight, which is by distill, filtration, concentration, dryness, crush to get dry cream powder, melts and mixes with the suppository base, irrigate module, cooling, gets the suppository. The invention is fast effect and dramatic curative effect.
Description
Technical field
The present invention relates to medicine and preparation method, particularly a kind of treatment enteroparalysis, the prescription and the preparation method of prevention and treatment intestinal adhesion and intestinal obstruction suppository belong to field of medicaments.
Background technology
For a long time, enteroparalysis, intestinal adhesion, intestinal obstruction are multiple diseases behind common acute abdomen and the abdominal surgery, sickness rate height, mortality rate height, serious harm patient's healthy and life.There is the interior adhesion of abdomen in various degree in the patient of abdominal postoperative about 94%.In causing ileac factor, owing to accounting for about 40% that adhesion in the abdomen causes.Patient's abdominal distention, stomachache, feel sick, vomiting, constipation, not aerofluxus, very painful, Therapeutic Method adopts fasting, instillation antibiotic, medicinal liquid coloclysis more, irritates stomach clinically, it is very inconvenient with medication to cause suffering to patient, influence therapeutic effect, or adopt acupuncture, external application of Chinese medicine treatment, but the course of treatment is long, and therapeutic effect is poor.
Abdominal operation, enteroparalysis, the inflammatory reaction that bacterial infection, tissue ischemia etc. causes are that adhesion forms modal factor.After present known enterokinesia recovers, partial blood fortune be improved significantly, the hydrops in abdominal cavity absorbs to be accelerated, inflammatory resolution is accelerated, the nutritional status of intestinal and barrier function improve.These effects all help the reparation of serous coat, the absorption of exudate and the minimizing of oozing out.Therefore, " suddenly attacking early down " is one important in the intestinal adhesion preventive measure.
Tcm clinical practice is used compound decoctions such as Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Semen Raphani, the Radix Aucklandiae always and is treated enteroparalysis, prevention and treatment intestinal adhesion, intestinal obstruction, but decoction is taken after need decocting, bring a lot of inconvenience to patient and medical personnel, after the doctor leaves prescription, arrive the pharmacy again and take medicine by the side, decoct again, so promptly lose time, waste fuel again, also unhygienic, for acute abdomen such as enteroparalysis, intestinal adhesion, intestinal obstruction, be difficult to medication treatment at once, and because many patients do not grasp decocting for Chinese herbal medicine knowledge, drug effect can not be stablized, can not bring into play due effect.It is one of treatment enteroparalysis, intestinal adhesion, ileac measure that water is prohibited in fasting, and decoction is irritated stomach and also do not met the Therapeutic Principle.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of middle stype and preparation method for the treatment of enteroparalysis, prevention and treatment intestinal adhesion and intestinal obstruction disease is provided.Easy to use, the efficacy stability of the present invention, to the patient bring treatment during disease rapider effectively and the assurance of health.
The traditional Chinese medical science is thought " six mansions with logical be usefulness ", the sick the intestines and stomach of enteroparalysis, intestinal adhesion and intestinal obstruction, and mechanism of qi pent-up, the imbalance of the intestines and stomach ascending or descending movement of vital Qi, spleen-QI failing to rise up, failure of stomach-QI to descend, fortuneization is obstructed, and intestinal loses and is subjected to widely spread the merit of leading, and ties obstructed and cause the internal organs stagnation of QI.Stagnation of QI and blood may bring about pain, then bloated, failure of stomach-QI to descend is then vomitted.
Medicine of the present invention contains Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus.These drug regimens produce synergism, improve curative effect.We reuse the effect that Cortex Magnoliae Officinalis is got its regulating the flow of QI to ease the stomach, removed full relieving distension, are applicable to the card of the gastrointestinal stagnation of QI.The logical intestinal removing blood stasis of Radix Et Rhizoma Rhei bitter cold wherein expels the heat-evil that it is long-pending to swing, and can stagnate by removing mass; The Fructus Aurantii Immaturus removing food stagnancy painful abdominal mass of loosing, therapeutic method to keep the adverse QI flowing downwards intestinal stasis relieving; Two medicines assist Cortex Magnoliae Officinalis to cleanse gastrointestinal excess-heat, blood stasis-eliminating and stagnation-dissipating; Three medicines share and play the circulation of qi promoting dissipating blood stasis, and the knot that expels the heat-evil is brokenly cleansed the gastrointestinal effect, make the QI and blood must be capable, and it is logical that internal organs is so incensed that, pyretic toxicity must be let out gastrointestinal function and be recovered.The modern pharmacological research prompting: the Cortex Magnoliae Officinalis effective ingredient is a magnolol, can excited intestinal tube smooth muscle.According to another report, Cortex Magnoliae Officinalis has tangible analgesia, antiinflammatory action, and especially antibacterial action is stronger, has a broad antifungal spectrum, and antibacterial properties is stable.Radix Et Rhizoma Rhei can increase gastrointestinal smooth muscle cell electrical activity, reduces the antibacterial displacement and takes place, and reduces level of endotoxin in the blood, also has microcirculation improvement, the effect of removing antibacterial, toxin and poisonous substance in the gastrointestinal in addition.Fructus Aurantii Immaturus can make gastrointestinal shrink the rhythm and pace of moving things to be increased.Three medicines share has stronger synergism, plays the promotion gastrointestinal peristalsis jointly, discharges toxin and antibacterial, protects from infection, and waits effect.
The present invention proposes a kind of Chinese medicine suppository, it is characterized in that, comprises the Chinese medicine of following weight proportion;
Cortex Magnoliae Officinalis 200-320 part Radix Et Rhizoma Rhei 80-160 part Fructus Aurantii Immaturus 100-220 part
Preferable range:
Cortex Magnoliae Officinalis 220-300 part Radix Et Rhizoma Rhei 100-140 part Fructus Aurantii Immaturus 130-180 part
Optimum range:
150 parts of 120 parts of Fructus Aurantii Immaturuss of 240 parts of Radix Et Rhizoma Rhei of Cortex Magnoliae Officinalis
Suppository of the present invention prepares by the following method:
(a) Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei and the Fructus Aurantii Immaturus with described weight proportion decocts with water twice, adds 8-10 times of water gaging for the first time, decocts 1-2 hour, adds 6-8 times of water gaging for the second time, decocts 1-2 hour.Merge decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃);
(b) clear paste is pulverized 60-100 ℃ of drying, and powder gets dry extract.
(c) with gained dried cream powder and an amount of suppository base mixing that dissolves, moulding, cooling makes suppository.
In the above-mentioned preparation method, when in the preferred steps (a) medicine being decocted with water, add 9 times of water gagings for the first time, decocted 2 hours, add 7 times of water gagings the second time, decocted 1 hour.
In the above-mentioned preparation method, used suppository base is semi-synthetic fatty acid glyceride or Polyethylene Glycol.
If weight is unit with the gram, this composition can be made into 100 suppositorys, 2g/ grain among the present invention.Can or reduce in corresponding ratio increase during production, but weight proportion constant rate between each component.
The present invention has the circulation of qi promoting dissipating blood stasis, and the knot that expels the heat-evil is brokenly cleansed the gastrointestinal effect, makes the QI and blood must be capable, and it is logical that internal organs is so incensed that, plays the promotion gastrointestinal peristalsis jointly, treatment enteroparalysis, prevention and treatment intestinal adhesion and ileac effect.
Suppository of the present invention is by rectally, 1 time 1,1-2 time on the 1st.Have the following advantages: 1. medicine is not subjected to the destruction of gastrointestinal tract pH or enzyme; 2. rectally meets fasting and prohibits water treatment enteroparalysis, intestinal adhesion, ileac Therapeutic Principle; 3. medicine absorbs from rectum, is subjected to the destruction of liver first-pass effect 4. easy to use in the time of can avoiding oral; 5. technology is preferred through test of many times, but suitability for industrialized production, steady quality, efficacy stability.
For a better understanding of the present invention, treat enteroparalysis, intestinal adhesion and ileac beneficial effect by testing the further the present invention of elaboration of example below.Test is intended to further specify effect of the present invention below, but not restriction of the present invention.
Test example one. Pharmacodynamic test of active extract of the present invention
1) test objective: experimental observation suppository of the present invention is to the effect of the propulsive distance of mouse small intestine carbon powder, small intestinal contraction intensity and frequency.
2) test material
Be subjected to the reagent thing: suppository of the present invention is provided by Jinan Kangzhong Medicin Science ﹠ Technology Co., Ltd.
3) test method and result
Suppository of the present invention is to the effect of mouse small intestine carbon powder advance distance
Get mice, 18～22g, male and female half and half, be divided into 4 groups behind the fasting 24h at random, every group 8: suppository base group (suppository base 0.80g/kg), the heavy dose of group of suppository of the present invention (being equivalent to the 1.60g/kg crude drug), middle dosage group (being equivalent to the 0.80g/kg crude drug), small dose group (being equivalent to the 0.40g/kg crude drug), each group is only irritated stomach with carbon powder suspension (0.1g/ml) 0.5ml/ earlier respectively, anum administration after 10 minutes, taking off cervical vertebra after 2 hours puts to death, the clip upper end is to pylorus, the lower end places on the glass plate to the intestinal tube of ileocecus, gently draws small intestinal to be in line, measure intestinal tube length, distance from pylorus to the carbon powder forward position is the propulsive distance of carbon powder, calculates the propulsive distance of intestinal propulsion rate=carbon powder/small intestinal total length * 100%.Propelling rate: suppository base group 48%, heavy dose of group 79%, middle dosage group 71%, small dose group 62%.
The result shows that suppository of the present invention can obviously increase mouse small intestine carbon powder propelling rate in the 0.40-1.6g/kg dosage range, strengthens the mouse small intestine wriggling.
Test example two. clinical trial of the present invention.
Case 1
Liu, the woman, 76 years old, because of the pulmonary carcinoma radiotherapy, cause enteroparalysis, constipation influences diet, must every day coloclysis 2-3 time, continue 10 surplus the sky, use suppository of the present invention, 1 time on the 1st, 1 time 1, with back 6 hours defecations.
Case 2
Zhang, man, 50 years old, because of abdominal operation, suffered from intestinal adhesion before 30 years, annual generation intestinal obstruction 4-5 time, stomachache, vomiting, not defecation, not aerofluxus, all hospitalization of at every turn falling ill are inserted stomach tube, coloclysis, transfusion, water is prohibited in fasting, could alleviate in 5-7 days, very painful, once morbidity before 2 years, use suppository of the present invention, final vacuum in 4 hours as a result, defecation after 8 hours voluntarily.Each later on morbidity is all used suppository of the present invention, the not hospitalization of falling ill over 2 years.
Case 3
Lee so-and-so, the man, 40 years old, did Appendectomy before half a year, the preceding bottom right of first quarter moon abdomen is often latent, heavyly when light during pain increases the weight of pain relief after the aerofluxus, inappetence gradually.Be diagnosed as postoperative intestinal adhesion.Use suppository of the present invention, 2 times on the 1st, 1 time 1, pain relief after 1 day, the stomachache number of times reduces, stomachache disappears after 5 days.Follow up a case by regular visits to not recurrence in 1 year.
The specific embodiment
Below further specify preparation method of the present invention by specific embodiment
Embodiment 1
Take by weighing following traditional Chinese medicines
Cortex Magnoliae Officinalis 320g Radix Et Rhizoma Rhei 80g Fructus Aurantii Immaturus 180g
Three flavor Chinese medicines are decocted with water twice, add 10 times of water gagings for the first time, decocted 1 hour, add 6 times of water gagings for the second time, decocted 1 hour, and merged decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃), 60 ℃ of dryings, pulverizes, the powder that gets dry extract is weighed, and it is an amount of to take by weighing semi-synthetic fatty acid glyceride, heat and dissolve, add the dried cream powder stirring and evenly mixing, moulding, cooling is made 100, every heavy 2g.
Embodiment 2
Take by weighing following traditional Chinese medicines
Cortex Magnoliae Officinalis 220g Radix Et Rhizoma Rhei 140g Fructus Aurantii Immaturus 130g
Three flavor Chinese medicines are decocted with water twice, add 8 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, and merged decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃), 100 ℃ of dryings, pulverizes, the powder that gets dry extract is weighed, and it is an amount of to take by weighing Polyethylene Glycol, heat and dissolve, add the dried cream powder stirring and evenly mixing, moulding, cooling is made 100, every heavy 2g
Embodiment 3
Take by weighing following traditional Chinese medicines
Cortex Magnoliae Officinalis 200g Radix Et Rhizoma Rhei 100g Fructus Aurantii Immaturus 100g
Three flavor Chinese medicines are decocted with water twice, add 8 times of water gagings for the first time, decocted 1 hour, add 8 times of water gagings for the second time, decocted 2 hours, and merged decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃), 80 ℃ of dryings, pulverizes, the powder that gets dry extract is weighed, and it is an amount of to take by weighing Polyethylene Glycol, heat and dissolve, add the dried cream powder stirring and evenly mixing, moulding, cooling is made 100, every heavy 2g.
Embodiment 4
Take by weighing following traditional Chinese medicines
Cortex Magnoliae Officinalis 300g Radix Et Rhizoma Rhei 160g Fructus Aurantii Immaturus 220g
Three flavor Chinese medicines are decocted with water twice, add 9 times of water gagings for the first time, decocted 2 hours, add 7 times of water gagings for the second time, decocted 1 hour, and merged decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃), 80 ℃ of dryings, pulverizes, the powder that gets dry extract is weighed, and it is an amount of to take by weighing semi-synthetic fatty acid glyceride, heat and dissolve, add the dried cream powder stirring and evenly mixing, moulding, cooling is made 100, every heavy 2g.
Embodiment 5
Take by weighing following traditional Chinese medicines
Cortex Magnoliae Officinalis 240g Radix Et Rhizoma Rhei 120g Fructus Aurantii Immaturus 150g
Three flavor Chinese medicines are decocted with water twice, add 9 times of water gagings for the first time, decocted 2 hours, add 7 times of water gagings for the second time, decocted 1 hour, and merged decocting liquid twice, filter, concentrated filtrate to relative density is the clear paste of 1.20-1.35 (70-80 ℃), 80 ℃ of dryings, pulverizes, the powder that gets dry extract is weighed, and it is an amount of to take by weighing semi-synthetic fatty acid glyceride, heat and dissolve, add the dried cream powder stirring and evenly mixing, moulding, cooling is made 100, every heavy 2g.
Claims (5)
1. treatment enteroparalysis, prevention and treatment intestinal adhesion and ileac Chinese medicine suppository is characterized in that it is to be made by following materials of weight proportions medicine:
Cortex Magnoliae Officinalis 200-320 part Radix Et Rhizoma Rhei 80-160 part Fructus Aurantii Immaturus 100-220 part
2. according to the described treatment enteroparalysis of claim 1, prevention and treatment intestinal adhesion and ileac Chinese medicine suppository is characterized in that wherein the weight proportion of each raw material is:
Cortex Magnoliae Officinalis 220-300 part Radix Et Rhizoma Rhei 100-140 part Fructus Aurantii Immaturus 130-180 part
3. according to claim 1 or 2 described treatment enteroparalysis, prevention and treatment intestinal adhesion and ileac Chinese medicine suppository is characterized in that wherein the weight proportion of each raw material is:
150 parts of 120 parts of Fructus Aurantii Immaturuss of 240 parts of Radix Et Rhizoma Rhei of Cortex Magnoliae Officinalis
4. according to claim 1 or 2 or 3 described treatment enteroparalysis, prevent and treat the preparation method of intestinal adhesion and ileac Chinese medicine suppository, it comprises the following steps:
(a) Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei and the Fructus Aurantii Immaturus with described weight proportion decocts with water twice, adds water 8-10 for the first time and doubly measures, and decocts 1-2 hour, adds water 6-8 for the second time and doubly measures, and decocts 1-2 hour.Merge decocting liquid twice, filter, concentrated filtrate to relative density is 1.20-1.35 (70-80 a ℃), gets clear paste;
(b) clear paste is pulverized 60-100 ℃ of drying, and powder gets dry extract.
(c) with gained dried cream powder and the suppository base mixing that dissolves, moulding, cooling makes suppository.
5. according to the preparation method of the Chinese medicine suppository of the described treatment enteropathy of claim 4, when wherein in step (a), medicine being decocted with water, add 9 times of amounts of water for the first time, decocted 2 hours, add 7 times of amounts of water the second time, decocted 1 hour.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100168040A CN101099784A (en) | 2007-07-09 | 2007-07-09 | Traditional Chinese medicine suppository and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100168040A CN101099784A (en) | 2007-07-09 | 2007-07-09 | Traditional Chinese medicine suppository and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445130C2 (en) * | 2009-05-04 | 2012-03-20 | Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию" | Method for prevention of postoperative enteroparesis |
| CN102688325A (en) * | 2012-06-25 | 2012-09-26 | 西安新通药物研究有限公司 | Chinese medicinal composition for gastroenteropathy and preparation method thereof |
| CN104197646A (en) * | 2014-08-25 | 2014-12-10 | 济南康众医药科技开发有限公司 | Drying method of magnolia officinalis and application of magnolia officinalis product |
| CN106491974A (en) * | 2016-11-03 | 2017-03-15 | 陈英杰 | A kind of Chinese medicine composition for treating enteroparalysis and Chinese medicine decoction |
-
2007
- 2007-07-09 CN CNA2007100168040A patent/CN101099784A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445130C2 (en) * | 2009-05-04 | 2012-03-20 | Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию" | Method for prevention of postoperative enteroparesis |
| CN102688325A (en) * | 2012-06-25 | 2012-09-26 | 西安新通药物研究有限公司 | Chinese medicinal composition for gastroenteropathy and preparation method thereof |
| CN104197646A (en) * | 2014-08-25 | 2014-12-10 | 济南康众医药科技开发有限公司 | Drying method of magnolia officinalis and application of magnolia officinalis product |
| CN106491974A (en) * | 2016-11-03 | 2017-03-15 | 陈英杰 | A kind of Chinese medicine composition for treating enteroparalysis and Chinese medicine decoction |
| CN106491974B (en) * | 2016-11-03 | 2020-01-03 | 陈英杰 | Traditional Chinese medicine composition and traditional Chinese medicine decoction for treating enteroparalysis |
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Open date: 20080109 |