CN101090711A - 治疗肺部感染的颗粒 - Google Patents

治疗肺部感染的颗粒 Download PDF

Info

Publication number
CN101090711A
CN101090711A CNA2005800449753A CN200580044975A CN101090711A CN 101090711 A CN101090711 A CN 101090711A CN A2005800449753 A CNA2005800449753 A CN A2005800449753A CN 200580044975 A CN200580044975 A CN 200580044975A CN 101090711 A CN101090711 A CN 101090711A
Authority
CN
China
Prior art keywords
formulation
capreomycin
treatment
particle
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800449753A
Other languages
English (en)
Chinese (zh)
Inventor
大卫·A·爱德华兹
珍妮弗·菲格尔
琼·孙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of CN101090711A publication Critical patent/CN101090711A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800449753A 2004-10-29 2005-10-19 治疗肺部感染的颗粒 Pending CN101090711A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62373804P 2004-10-29 2004-10-29
US60/623,738 2004-10-29

Publications (1)

Publication Number Publication Date
CN101090711A true CN101090711A (zh) 2007-12-19

Family

ID=37667331

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800449753A Pending CN101090711A (zh) 2004-10-29 2005-10-19 治疗肺部感染的颗粒

Country Status (11)

Country Link
US (1) US8846607B2 (enExample)
EP (1) EP1809252A2 (enExample)
JP (1) JP2008518007A (enExample)
CN (1) CN101090711A (enExample)
AU (1) AU2005334514B2 (enExample)
BR (1) BRPI0517374A (enExample)
CA (1) CA2585859C (enExample)
IL (1) IL182785A0 (enExample)
RU (1) RU2007119721A (enExample)
WO (1) WO2007011396A2 (enExample)
ZA (1) ZA200703452B (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225058A (zh) * 2011-06-22 2011-10-26 中国药科大学 磷酸奥司他韦吸入粉雾剂及其制备方法
CN108697790A (zh) * 2015-09-03 2018-10-23 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
CN109260180A (zh) * 2017-07-17 2019-01-25 北京盈科瑞创新药物研究有限公司 一种盐酸莫西沙星雾化吸入用溶液制剂及其制备方法
CN113907360A (zh) * 2021-07-30 2022-01-11 湖南达侑科技有限公司 植物甾醇磷脂组合物及其制备方法
US11278612B2 (en) 2018-03-19 2022-03-22 Novavax, Inc. Multivalent influenza nanoparticle vaccines
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
CN117083278A (zh) * 2021-02-01 2023-11-17 结核病药物开发全球联盟公司 普托马尼无定形形式
CN117083063A (zh) * 2020-05-14 2023-11-17 兴和株式会社 新型吸入剂
US12083228B2 (en) 2017-07-24 2024-09-10 Novavax, Inc. Methods and compositions for treating respiratory disease
US12357684B2 (en) 2008-12-09 2025-07-15 Novavax, Inc. Modified RSV F proteins and methods of their use

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2399385C1 (ru) * 2009-03-10 2010-09-20 Общество с ограниченной ответственностью "Научно-производственная фирма "НОРД" Способ профилактической обработки животных и птиц
JP2012524817A (ja) * 2009-04-24 2012-10-18 シェーリング コーポレイション 標的粒子サイズを有する、活性医薬を含む凝集体配合物
CN105832678A (zh) 2009-05-27 2016-08-10 株式会社三养生物制药 生物利用度提高的包含难溶性药物的微球及其制备方法
CN102573886A (zh) * 2009-09-17 2012-07-11 相互制药公司 用抗病毒剂治疗哮喘的方法
ES2814336T3 (es) 2012-04-13 2021-03-26 Glaxosmithkline Ip Dev Ltd Partículas de agregado
RU2562550C2 (ru) * 2013-12-19 2015-09-10 Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт бруцеллеза и туберкулеза животных" (ФГБНУ ВНИИБТЖ) Способ специфической профилактики туберкулеза
WO2018226949A1 (en) 2017-06-08 2018-12-13 Pai Life Sciences Inc. Cpzen compositions and uses
MX2021000796A (es) * 2018-07-24 2021-06-15 Univ Texas Composiciones de partículas terapéuticamente activas con superficie modificada por congelación ultra-rápida.
IL297852A (en) * 2020-05-01 2023-01-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd E protein channel blockers, and orf3 inhibitors, against covid 19
US20250268857A1 (en) * 2020-08-28 2025-08-28 Shigadry With Earth Co., Ltd. Method and device for infection prevention
JP2024049405A (ja) * 2021-02-22 2024-04-10 興和株式会社 新規吸入剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
JP2930421B2 (ja) 1994-02-28 1999-08-03 メディノヴァ メディカル コンサルティング ゲゼルシャフト ミット ベシュレンクテル ハフツング 薬剤組成物、その製造方法及びその使用方法
ATE264096T1 (de) 1994-03-07 2004-04-15 Nektar Therapeutics Verfahren und mittel zur verabreichung von insulin über die lunge
US5814617A (en) 1994-10-07 1998-09-29 The United States Of America As Represented By The Secretary Of The Navy Protective 17 KDA malaria hepatic and erythrocytic stage immunogen and gene
DK0752245T3 (da) 1995-07-05 2002-09-09 Europ Economic Community Biokompatible og bionedbrydelige nanopartikler udviklet til absorption og afgivelse af proteinholdige lægemidler
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6517860B1 (en) * 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
CN1188111C (zh) 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
EP1458361A4 (en) * 2001-11-20 2007-04-25 Advanced Inhalation Res Inc COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
WO2004024213A2 (en) * 2002-09-12 2004-03-25 The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services Aerosolized capreomycin for inhibition of pulmonary tuberculosis
CN1694689A (zh) 2002-09-30 2005-11-09 阿库斯菲尔公司 供吸入的缓释多孔微粒
ATE482706T1 (de) 2003-02-10 2010-10-15 Bayer Schering Pharma Ag Behandlung bakterieller erkrankungen der atmungsorgane durch lokale applikation von fluorchinolonen

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12357684B2 (en) 2008-12-09 2025-07-15 Novavax, Inc. Modified RSV F proteins and methods of their use
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
CN102225058A (zh) * 2011-06-22 2011-10-26 中国药科大学 磷酸奥司他韦吸入粉雾剂及其制备方法
CN108697790A (zh) * 2015-09-03 2018-10-23 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
US11253585B2 (en) 2015-09-03 2022-02-22 Novavax, Inc. Vaccine compositions having improved stability and immunogenicity
US12257297B2 (en) 2015-09-03 2025-03-25 Novavax, Inc. Vaccine compositions having improved stability and immunogenicity
CN109260180A (zh) * 2017-07-17 2019-01-25 北京盈科瑞创新药物研究有限公司 一种盐酸莫西沙星雾化吸入用溶液制剂及其制备方法
US12083228B2 (en) 2017-07-24 2024-09-10 Novavax, Inc. Methods and compositions for treating respiratory disease
US11896662B2 (en) 2018-03-19 2024-02-13 Novavax, Inc. Multivalent influenza nanoparticle vaccines
US11278612B2 (en) 2018-03-19 2022-03-22 Novavax, Inc. Multivalent influenza nanoparticle vaccines
CN117083063A (zh) * 2020-05-14 2023-11-17 兴和株式会社 新型吸入剂
CN117083278A (zh) * 2021-02-01 2023-11-17 结核病药物开发全球联盟公司 普托马尼无定形形式
CN113907360A (zh) * 2021-07-30 2022-01-11 湖南达侑科技有限公司 植物甾醇磷脂组合物及其制备方法

Also Published As

Publication number Publication date
CA2585859C (en) 2012-03-06
IL182785A0 (en) 2007-09-20
WO2007011396A3 (en) 2007-05-03
RU2007119721A (ru) 2008-12-10
US8846607B2 (en) 2014-09-30
WO2007011396A2 (en) 2007-01-25
BRPI0517374A (pt) 2008-10-07
US20080213373A1 (en) 2008-09-04
AU2005334514B2 (en) 2009-11-26
JP2008518007A (ja) 2008-05-29
EP1809252A2 (en) 2007-07-25
CA2585859A1 (en) 2007-01-25
ZA200703452B (en) 2008-06-25
AU2005334514A1 (en) 2007-01-25

Similar Documents

Publication Publication Date Title
CN101090711A (zh) 治疗肺部感染的颗粒
JP5989750B2 (ja) フルオロキノロンの肺送達
Patil et al. A novel approach for lung delivery of rifampicin-loaded liposomes in dry powder form for the treatment of tuberculosis
KR100652532B1 (ko) 유동 저항이 조절된 에어로졸화 활성 약물의 송달
US7442388B2 (en) Phospholipid-based powders for drug delivery
Hamishehkar et al. The role of carrier in dry powder inhaler
US20140212504A1 (en) Phospholipid-based powders for drug delivery
JP2009510077A (ja) 抗生物質製剤、単位用量、キットおよび方法
JP2009106790A (ja) 乾燥粉末を調整するための噴霧乾燥法
AU2020203437B2 (en) Dry powder formulations for inhalation
CN111228244A (zh) 一种利巴韦林吸入制剂及其在制备治疗新冠肺炎中的用途
CN116585272A (zh) 喷雾冷冻干燥法制备融合蛋白吸入微粉剂
Scherließ et al. Novel formulation concept for particulate uptake of vaccines via the nasal associated lymphoid tissue
CN118845721A (zh) 可吸入团聚纳米颗粒干粉药物组合物、及其制备方法和用途
MX2007005139A (es) Particulas para el tratamiento de infeccion pulmonar
TUTOR Pulmonary drug delivery systems based on polymeric micro and nanoparticles for the treatment of cystic fibrosis
Auriemma et al. Gentamicin and particle engineering: from an old molecule to innovative drug delivery systems
Kaye Development of Microparticulate Formulations for the Delivery of Therapeutic Antibodies to the Respiratory Tract
Gadgil A comparative study between high potency dry powder inhalation and nebulized solution of vancomycin hydrochloride for lung delivery
Kandil Spray drying as a method for fabrication of particulate pulmonary delivery systems
Stigliani Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models.
Cook Sustained release microparticles for pulmonary drug delivery
HK1240081A1 (en) Dry powder formulations for inhalation
HK1240081B (en) Dry powder formulations for inhalation
WO2003061668A1 (en) Use of pulmonary surfactant for the prevention of infectious diseases

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20071219