CN101090638A - 非粘性口香糖 - Google Patents
非粘性口香糖 Download PDFInfo
- Publication number
- CN101090638A CN101090638A CNA2005800439728A CN200580043972A CN101090638A CN 101090638 A CN101090638 A CN 101090638A CN A2005800439728 A CNA2005800439728 A CN A2005800439728A CN 200580043972 A CN200580043972 A CN 200580043972A CN 101090638 A CN101090638 A CN 101090638A
- Authority
- CN
- China
- Prior art keywords
- chewing gum
- weight
- stick
- resin
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
Abstract
本发明涉及一种包含口香糖成分的口香糖,所述口香糖包含至少一种弹性体和至少一种树脂,所述至少一种树脂包含至少一种合成的生物可降解均聚物树脂,所述口香糖的所述合成的生物可降解均聚物的量为所述口香糖的约1/2%-约60重量%。所获得的结合了可接受的咀嚼感的非粘性质根据本发明的实施方案是通过口香糖中生物可降解均聚物与弹性体的组合获得的。
Description
技术领域
本发明涉及权利要求1的口香糖。
背景技术
几十年来,人们一直希望使口香糖具有非粘性质,并已寻求了若干技术方法。
一种方法是应用各种不同的基于聚醋酸乙烯酯(PVA)的胶基组合物。
另一种方法是在不同的口香糖组合物中使用不同类型的生物可降解聚合物。
在若干其他技术路径中,后一种方法已通过使用环状酯的聚合获得的聚酯得到解决。
但与这类聚合物的使用有关的一个问题在于这类聚酯可能常具有对于口香糖来说不希望有的性质。
例如,L-丙交酯的均聚物(LPLA)为半结晶聚合物。这些类型的材料抗张强度高、伸长率低,因此具有高模量,这使其更适合于口香糖之外的承载应用。
为改进该聚合物的所需性质,人们已通过提供L-丙交酯与D,L-丙交酯的不同共聚物进行了广泛的研究。具体而言,人们已试图通过在聚合物链中使用其他单体(如ε-己内酯)来破坏L-丙交酯的结晶性。
这样的研究已产生适用于口香糖应用的更非晶的聚合物。
遵循相同路径的其他尝试是应用大量的软化剂来改变单个聚合物的性质。
但与上述方法相关的问题在于单个聚合物改进的非晶性质明显可引起聚合物其他结构特点在所希望的非晶性以及较不希望的粘性方面朝典型的常规聚合物方向改变。这可引起使用者咀嚼口香糖时不希望有的粘性。此外,当口香糖被丢弃在环境中时,其倾向于以与常规口香糖相同的方式粘住表面。
本发明的目的是提供好处在于具有可接受的咀嚼感以及改进的非粘性的口香糖。
发明内容
本发明涉及一种包含口香糖成分的非粘性口香糖,所述口香糖包含至少一种弹性体和至少一种树脂,所述至少一种树脂包含至少一种合成的均聚物树脂,所述合成的均聚物是生物可降解的,所述口香糖的所述合成的生物可降解均聚物的量为所述口香糖的约1/2重量%-60重量%。
口香糖的改进的非粘性已通过本发明的合成的均聚物的应用获得,同时在使用过程中具有可接受的咀嚼感。
按本发明的实施方案,通过口香糖中生物可降解均聚物与弹性体的组合获得了非粘性和可接受的咀嚼感。
所得到的结合了可接受的咀嚼感的非粘性根据本发明的实施方案是通过口香糖中生物可降解均聚物和弹性体的组合获得的。
这样,在咀嚼过程中,均聚物的脆性可通过弹性体得到补偿,并且当均聚物在口香糖块中引入脆性时,粘性可消除,尤其是在丢弃后。
已经观察到这样的脆性引入会影响整个口香糖的脆性并抵消粘性。
具体来说,已经观察到改进的非粘性可在其中温度低于或远低于均聚物的玻璃化转变温度的环境中获得。
按本发明,生物可降解的均聚物树脂为具有树脂性质并在口香糖中具有树脂功能的均聚物。
本发明的口香糖可被认为具有改进的非粘性质。
在本发明的实施方案中,所述口香糖的所述合成的均聚物的量为所述口香糖的约2重量%-50重量%,优选为所述口香糖的约2重量%-30重量%。
实验已经表明,与不同的共聚物相比,以显著量存在的合成的生物可降解均聚物使非粘性质得到进一步的改进。
在本发明的实施方案中,所述合成的均聚物是树脂性的。
按本发明的优选实施方案,所述均聚物形成树脂和弹性体混合物的树脂部分,所述混合物形成口香糖胶基的至少一部分。
在本发明的实施方案中,所述合成的均聚物包含聚酯聚合物。
按本发明的实施方案,生物可降解的聚酯均聚物可有利地用作树脂或用作口香糖的主要树脂组分,从而获得改进的非粘性质。
在本发明的实施方案中,所述生物可降解的聚酯聚合物可通过环状单体开环聚合获得。
在本发明的实施方案中,所述生物可降解的聚酯聚合物可通过选自环状酯和环状碳酸酯的环状单体开环聚合获得。
在本发明的实施方案中,所述生物可降解的聚酯聚合物可通过选自D,L-丙交酯、L-丙交酯、乙交酯、ε-己内酯、δ-戊内酯、三亚甲基碳酸酯(TMC)和二烷酮(dioxanone)的环状单体开环聚合获得。
在本发明的实施方案中,所述至少一种均聚物选自聚(D,L-丙交酯)和聚乙交酯。
另一种均聚物如聚(D,L-丙交酯)为更非晶的聚合物,其具有乳酸的两种异构形式的无规分布,因此不能排列成有组织的结晶结构。该材料具有较低的抗张强度、较高的伸长率和快得多的降解时间,有利于用在本发明的口香糖中。
按有利的实施方案,优选避免分别使用L-或D-乳酸作为聚丙交酯的唯一单体。
在本发明的实施方案中,所述至少一种均聚物选自聚(D,L-丙交酯),其中D和L-乳酸单体间的比率为约1∶10到10∶L。
在本发明的实施方案中,所述至少一种均聚物选自聚(D,L-丙交酯),其中D和L-乳酸单体间的比率为约1∶1。
按有利的实施方案,可优选L和D-乳酸单体间一比一的关系以获得适用于口香糖的非晶聚合物。
在本发明的实施方案中,所述均聚物包含通过至少一种二-或多官能度醇或其衍生物与至少一种二-或多官能度酸或其衍生物的反应产生的聚酯。
在本发明的实施方案中,所述酸衍生物包含二-或多元羧酸的酯、酸酐或卤化物。
在本发明的实施方案中,所述酸衍生物包含酸的甲酯或乙酯。
在本发明的实施方案中,所述均聚物包含通过至少一种二-或多官能度羟基羧酸或其衍生物如L-乳酸、D-乳酸或乙醇酸的反应产生的聚酯。
在本发明的实施方案中,所述至少一种均聚物其PD为1.1-20,优选1.3-12。
在本发明的实施方案中,所述均聚物的玻璃化转变温度(Tg)高于20℃,优选高于30℃,最优选高于约35℃。
按本发明的实施方案,改进的非粘性质可通过应用具有较高玻璃化转变温度的均聚物获得,因为当将均聚物用作口香糖的树脂组分时较高的玻璃化转变温度可以是适宜的,此外当丢弃于中等温度的环境中时可增加结构性质的有利改变。
在本发明的实施方案中,所述至少一种树脂的分子量低于400,000g/mol Mn。
在本发明的实施方案中,所述至少一种树脂的分子量低于200,000g/mol Mn。
在本发明的实施方案中,所述至少一种树脂的分子量低于60,000g/mol Mn。
按本发明的实施方案,分子量较低的均聚物可以是获得可接受的质构所适用并优选的。
在本发明的实施方案中,所述至少一种树脂的分子量为约60,000g/mol Mn。
在本发明的实施方案中,所述至少一种树脂的分子量在500g/molMn-60,000g/mol Mn的范围内。
在本发明的实施方案中,所述至少一种树脂的分子量在5000g/molMn-30,000g/mol Mn的范围内。
在本发明的实施方案中,所述口香糖包含量为口香糖的至少5重量%的至少一种树脂。
在本发明的实施方案中,所述口香糖包含量为口香糖的至少8重量%的至少一种树脂。
在本发明的实施方案中,所述口香糖包含量为口香糖的约2-约60重量%的至少一种树脂。
在本发明的实施方案中,所述口香糖包含量为口香糖的约5-约25重量%的至少一种树脂。
在本发明的实施方案中,所述至少一种树脂基本由所述均聚物形成。
按本发明的有利的实施方案,基本上所有树脂均包含一种均聚物或均聚物的组合,从而产生可接受的咀嚼感以及在典型的丢弃条件下有利的非粘性质。
在本发明的实施方案中,所述树脂或树脂聚合物包含至少一种天然树脂、至少一种合成树脂或其任意组合。
按本发明的实施方案,口香糖包含均聚物外的其他树脂。
在本发明的实施方案中,口香糖包含量为所述口香糖的至少3重量%、优选至少5重量%的所述至少一种弹性体。
在本发明的实施方案中,所述口香糖包含量为口香糖的至少8重量%的所述至少一种弹性体。
在本发明的实施方案中,所述口香糖包含量为口香糖的约0.5-约70重量%的所述至少一种弹性体。
在本发明的实施方案中,所述口香糖包含量为口香糖的约2-约20重量%的所述至少一种弹性体。
在本发明的实施方案中,所述弹性体包含苯乙烯-丁二烯、异丁烯-异戊二烯、聚异丁烯、聚异戊二烯或其任意组合。
在本发明的实施方案中,所述弹性体是生物可降解的。
在本发明的实施方案中,所述弹性体包含聚酯。
在本发明的实施方案中,所述弹性体可通过环状单体开环聚合获得。
在本发明的实施方案中,所述弹性体可通过至少一种二-或多官能度醇或其衍生物与至少一种二-或多官能度羧酸或其衍生物的聚合获得。
在本发明的实施方案中,平均分子量为约500-60000g/mol Mn的树脂与平均分子量为约30000g/mol-1000000g/mol Mn的弹性体的重量比在约1∶5-20∶1的范围内。
按本发明的优选实施方案,树脂和弹性体间的比率应保持在某个范围内以获得所需的质构。树脂和弹性体的平均分子量分别可通过例如两种或更多树脂的混合物和两种或更多弹性体的混合物获得。因此,例如弹性体为某个值的平均分子量可通过以适当比率混合高和低分子量的弹性体获得。具体而言,约2/3的低分子量弹性体(30000g/mol)与1/3的高分子量弹性体(400000)的混合物可产生约为153000的平均分子量。
在本发明的实施方案中,平均分子量为约500-60000g/mol Mn的树脂与平均分子量为约30000g/mol-1000000g/mol Mn的弹性体的重量比在约1∶3-10∶1的范围内。
按本发明的又一优选实施方案,树脂和弹性体间的比率应保持在1∶3-10∶1的较窄范围内以获得所需的质构。
在本发明的实施方案中,所述口香糖包含一种或多种选自包括调味剂、甜味剂、填料、软化剂、乳化剂和活性成分的集合的口香糖成分。
在本发明的实施方案中,所述调味剂包含天然植物组分、精油、香精、提取物、粉的形式的天然和合成调料,包括能影响味觉特征的酸和其他物质。
在本发明的实施方案中,所述口香糖包含量为0.01-约25重量%、优选0.1-约5重量%的香料,所述百分比基于所述口香糖的总重量。
在本发明的实施方案中,口香糖用约2-15重量%的混合糖浆制备;其中所述混合糖浆包括约25-45%的甘油、约55-75%的氢化淀粉水解物。
按本发明的有利实施方案,口香糖包含非粘性口香糖,其中各成分之间具有优异的内聚强度而不使口香糖粘着到外表面如牙齿和假牙上。按所述实施方案的口香糖通常不具有疏松的质构并不易在加工和处理过程中破坏、断裂或分离。所述口香糖也具有良好的感官品质。
本实施方案的非粘性无糖口香糖中的基本成分为包括甘油和氢化淀粉水解物的共蒸发混合物。该混合糖浆通过混合甘油与可市购的水和氢化淀粉水解物的混合物以形成三组分混合物、然后从混合物中蒸发除去大多数水来制备。该共蒸发混合物在加到所述口香糖中之前呈糖浆形式。已经发现,该混合糖浆起到非粘性口香糖成分(包括胶基成分)间优异的粘结剂的作用而不使其粘着到牙齿或假牙上。混合糖浆可在生产胶基后和生产成品口香糖的过程中加入。混合糖浆应构成口香糖的约2-约15重量%。
如上所述,混合糖浆在生产口香糖的过程中加入。除加入混合糖浆外,基础口香糖组合物可为任何能从其改进的成分间粘结中受益的非粘性口香糖。通常,这样的口香糖可包括任何具有非粘性胶基、可从改进的粘结中受益的口香糖。通常,常规口香糖产品的内聚性或其缺乏取决于口香糖中所用胶基的内聚性或其缺乏。
在本发明的实施方案中,混合糖浆的存在量为口香糖的约2-15重量%。
在本发明的实施方案中,混合糖浆的存在量为口香糖的约5-10重量%。
在本发明的实施方案中,混合糖浆包括约25-45%的甘油、约55-75%的氢化淀粉水解物。
在本发明的实施方案中,混合糖浆包含甘油与氢化淀粉水解物和水混合的共蒸发混合物。
在本发明的实施方案中,口香糖包含量为口香糖的约0-约20重量%、更通常为口香糖的约0-约10重量%的至少一种软化剂。
在本发明的实施方案中,乳化剂的量在口香糖的0-18重量%的范围内。
在本发明的实施方案中,所述甜味剂选自包括填充型甜味剂和高甜度甜味剂和其组合的集合。
在本发明的实施方案中,口香糖包含糖。
在本发明的实施方案中,口香糖是无糖的。
在本发明的实施方案中,所述填充型甜味剂构成口香糖的约5-约95重量%,优选约20-约80重量%。
在本发明的实施方案中,口香糖包含量为口香糖的约0-约1.2重量%、优选约0.1-约0.6重量%的高甜度甜味剂。
在本发明的实施方案中,口香糖包含量为口香糖的约0-约50重量%、更通常为所述口香糖的约5-约20重量%的填料。
在本发明的实施方案中,口香糖包含至少一种着色剂。
在本发明的实施方案中,所述口香糖成分包含活性成分。
在本发明的实施方案中,所述口香糖包覆有选自包括硬包衣、软包衣和可食用膜包衣的集合的外包衣。
在本发明的实施方案中,外包衣包含至少一种选自包括粘结剂、吸湿组分、成膜剂、分散剂、防粘组分、填充剂、调味剂、着色剂、药学或美容活性组分、脂质组分、蜡组分、糖、酸和能加速可降解聚合物的咀嚼后降解的试剂的集合的添加剂组分。
在本发明的实施方案中,口香糖是无蜡的。
在本发明的实施方案中,口香糖通过压片制得。
按本发明的实施方案,由于均聚物具有有利的非粘性质的事实可使最后压缩前口香糖或胶基的粒化变得容易,因此口香糖可有利地被加工和形成压缩口香糖。
具体实施方式
按本发明的生物可降解性的优选定义,生物可降解性是某些有机分子的性质,由此当暴露于自然环境或置于有机体内时,其通过酶或微生物过程并且通常结合化学过程例如水解而反应形成更简单的化合物和最终的二氧化碳、氮氧化物、甲烷、水等。
在本发明内容中,术语“生物可降解聚合物”是指环境或生物可降解的聚合物化合物并且是指口香糖胶基组分,所述组分在口香糖丢弃之后能够经历物理、化学和/或生物降解,由此丢弃的口香糖废弃物变得可更容易从丢弃的位置处除去或最终崩解为不再可认出是口香糖残留物的小块或颗粒。这种可降解聚合物的降解或崩解可以受物理因素如温度、光、湿度等、化学因素如氧化性条件、pH、水解等或生物因素如微生物和/或酶的影响或诱导。降解产物可以是较大的低聚体、三聚物、二聚物和单体。
优选最终降解产物为小分子无机化合物如二氧化碳、氮氧化物、甲烷、氨、水等。
如本文中所指的,玻璃化转变温度(Tg)可通过例如DSC(DSC:差示扫描量热法)来测定。DSC通常可用于测定和研究聚合物的热转变,具体而言,该技术可用于材料的二级转变的测定。Tg处的转变被认为是这种二级转变,即涉及热容的变化但没有潜热的热转变。因此,DSC可用来研究Tg。除非另有说明,否则将采用10℃/分的加热速率。
除非另有说明,当关于聚合物在本文中使用时,术语“分子量”是指数均分子量(Mn),计为g/mol。此外,本文中用到的缩写PD是指聚合物的多分散性,多分散性定义为Mw/Mn,其中Mw为聚合物的重均分子量。表征生物可降解聚合物的公认技术是凝胶渗透色谱法(GPC)。
本文中假定口香糖消费者的口腔内温度约为人体温度,虽然在实际咀嚼过程中其可能较体温要低几度。高于口腔温度的玻璃化转变温度在本文中称为高Tg,而低于口腔温度的Tg在本文中称为低Tg。
本发明的口香糖通常包含水溶性的填充部分、水不溶性的可咀嚼胶基部分和调味剂。所述水溶性的部分随部分调味剂在咀嚼过程中的一段时间内消散。胶基部分在整个咀嚼过程中均保留在口中。术语口香糖广义上指咀嚼型口香糖和泡泡糖。
胶基是口香糖的咀嚼物质,其赋予最终产品以咀嚼特征。胶基通常决定香料和甜味剂的释放特性并在口香糖产品中起重要作用。
口香糖的不溶部分通常可含弹性体、乙烯基聚合物、弹性体增塑剂、蜡、软化剂、填料和其他任选成分(如着色剂和抗氧剂)的任意组合。按本发明,聚合物弹性体增塑剂通常也可称为树脂或树脂性化合物。
胶基配方的组成基本上可随待制备的具体产品以及最终产品所希望的咀嚼和其他感官特征而变。但上述胶基组分的典型范围(重量%)为:5-80重量%的弹性体化合物,5-80重量%的弹性体增塑剂,0-40重量%的蜡,5-35重量%的软化剂,0-50重量%的填料,和0-5重量%的其他组分如抗氧剂、着色剂等。胶基可构成口香糖的约5-约95重量%,更经常的是,胶基构成口香糖的10-约60%。
弹性体为口香糖提供橡胶样的内聚性,其随该成分的化学结构以及其怎样与其他成分复合而异。适宜用于本发明的胶基和口香糖中的弹性体可包括天然或合成类型。
弹性体可为本领域内已知的任何水不溶性的聚合物,包括Foodand Drug Administration,CFR,Title 21,Section 172,615,“Masticatory Substances of Natural Vegetable Origin”和“MastieatorySubstances,Synthetic”中列出的那些用于口香糖和泡泡糖的聚合物。
有用的天然弹性体包括天然橡胶如烟熏或液态胶乳和银胶菊、天然胶如节路顿胶、香豆果胶(Lechi caspi)、perillo、香豆乳、二齿铁线子胶、巧克力铁线子胶、红檀木胶、山榄胶、糖胶树胶、杜仲胶、古塔卡太胶(gutta kataiu)、尼日尔杜仲胶、卡斯德拉胶、托帕匡斯麻风树胶、赤奎巴胶(chiquibul)、古塔杭康胶(gutta hang kang)。
有用的合成弹性体包括高分子量弹性体(如丁二烯-苯乙烯共聚物、聚异戊二烯和异丁烯-异戊二烯共聚物)、低分子量弹性体(如聚丁烯、聚丁二烯、聚异戊二烯和聚异丁烯)、乙烯基聚合物弹性体(如聚醋酸乙烯酯、聚乙烯)、乙烯基共聚物弹性体(如醋酸乙烯酯/月桂酸乙烯酯、醋酸乙烯酯/硬脂酸乙烯酯、乙烯/醋酸乙烯酯)、聚乙烯醇或其混合物。
丁二烯-苯乙烯类型的弹性体(SBR)通常为约20∶80-60∶40的苯乙烯:丁二烯单体的共聚物。这些单体的比率影响SBR的弹性,所述弹性可用门尼粘度评估。随着苯乙烯:丁二烯比率减小,门尼粘度降低。
SBR的结构通常由与苯乙烯共聚的直链1,3-丁二烯组成并具有这些弹性体的非线型分子性质。SBR的平均分子量小于600,000g/mol。
异丁烯-异戊二烯类型的弹性体(丁基橡胶)的异戊二烯摩尔百分数水平为0.2-4.0。与SBR相似,随着异戊二烯:异丁烯比率减小,弹性降低,所述弹性用门尼粘度量度。
丁基橡胶的结构通常由与支链2-甲基丙烯(异丁烯)共聚的支链2-甲基-1,3-丁二烯(异戊二烯)组成,并同SBR一样,这类结构性质上是非线型的。丁基橡胶的平均分子量在150,000g/mol-1,000,000g/mol的范围内。
聚异丁烯(PIB)同SBR和丁基橡胶一样,性质上也是非线型的。低分子量弹性体为聚合物体系提供柔软的咀嚼特征,还像其他弹性体一样提供弹性品质。平均分子量可在约30,000-120,000g/mol的范围内,针入度可在约4毫米-20毫米的范围内。针入度越高,PIB越软。与SBR和丁基橡胶相似,高分子量弹性体为口香糖提供弹性。平均分子量可在120,000-1,000,000g/mol的范围内。需要再次说明的是,如果使用的话,分子量应较低。
乙烯基共聚物类型的聚合物也可用作胶基的辅助聚合物。对于乙烯基共聚物类型,月桂酸乙烯酯/醋酸乙烯酯(VL/VA)、硬脂酸乙烯酯/醋酸乙烯酯(VS/VA)或乙烯/醋酸乙烯酯(EVA)共聚物中存在的月桂酸乙烯酯、硬脂酸乙烯酯或乙烯的量通常分别在共聚物的约10-约60重量%范围内。这些聚合物的平均分子量可在约2,000g/mol-约100,000g/mol的范围内。
乙烯基聚合物如聚乙烯醇和聚醋酸乙烯酯的平均分子量在约5,000g/mol-约65,000g/mol的范围内。
弹性体化合物可为天然的,但优选合成的。
弹性体增塑剂改变胶基的坚实性。其对弹性体分子间链断裂(增塑)的特异性及其不同的软化点导致不同的成品口香糖坚实度和在胶基中使用时不同的相容性。当想要使更多的弹性体链暴露于蜡的烷烃链中时,这一点很重要。
按本发明,口香糖包含一种也称为树脂的增塑剂,所述增塑剂包含一种或多种生物可降解的均聚物。
此外,按本发明,这些生物可降解的聚合物非常适于作为口香糖中与一种或多种弹性体组合使用的树脂性化合物。
按本发明,可用的其他聚合物或非聚合物增塑剂为三醋酸甘油酯、短链脂肪酸的乙酰化甘油一-、二-和三酸酯、中链脂肪酸的乙酰化甘油一-、二-和三酸酯、长链脂肪酸的乙酰化甘油一酸酯、松香甘油酯和低分子量PVAc。在本领域内,后二者也可分别称为天然和合成树脂。
所用增塑剂可为一种类型的或为一种以上类型的组合。通常,一种与另一种之比取决于其各自的软化点、对香味释放的影响以及其各自带给口香糖的粘性度。
这类通常为生物不可降解的合成树脂的实例包括聚醋酸乙烯酯、醋酸乙烯酯-月桂酸乙烯酯共聚物和其混合物。生物不可降解的合成弹性体的实例包括但不限于Food and Drug Administration,CFR,Title21,Section 172,615(the Masticatory Substances,Synthetic)中列出的合成弹性体,如凝胶渗透色谱(GPC)平均分子量在如约10,000-1,000,000范围内(包括50,000-80,000)的聚异丁烯,异丁烯-异戊二烯共聚物(丁基弹性体),苯乙烯-丁二烯比率为如约1∶3-3∶1的苯乙烯-丁二烯共聚物,GPC平均分子量在2,000-90,000范围内(如3,000-80,000范围内,包括30,000-50,000)的聚醋酸乙烯酯(PVA)(其中较高分子量聚醋酸乙烯酯通常用在泡泡糖胶基中),聚异戊二烯,聚乙烯,月桂酸乙烯酯含量为共聚物的约5-50重量%(如10-45重量%)的醋酸乙烯酯-月桂酸乙烯酯共聚物,和其组合。
天然树脂的实例为:天然松香酯(常称为酯胶,实例包括部分氢化松香的甘油酯、聚合松香的甘油酯、部分二聚松香的甘油酯、塔罗油松香的甘油酯、部分氢化松香的季戊四醇酯、松香的甲基酯、松香的部分氢化甲基酯、松香的季戊四醇酯)、合成树脂(如源于α-蒎烯、β-蒎烯和/或d-柠檬烯的萜烯树脂)和天然萜烯树脂。
工业上通常在胶基中组合使用具有高分子量的合成弹性体与具有低分子量的合成弹性体。这样的组合的实例为聚异丁烯和苯乙烯-丁二烯、聚异丁烯和聚异戊二烯、聚异丁烯和异丁烯-异戊二烯共聚物(丁基橡胶)以及聚异丁烯、苯乙烯-丁二烯共聚物和异丁烯异戊二烯共聚物的组合、和全部上述各个合成聚合物分别与聚醋酸乙烯酯、醋酸乙烯酯-月桂酸乙烯酯共聚物的混合物及其混合物。
按本发明的有利实施方案,所述均聚物为聚酯。
按本发明的实施方案,获得用于本发明的口香糖中的生物可降解均聚物或其他合成聚合物的聚合工艺可用引发剂如多官能度醇、胺或含多个羟基或其他反应性基团的其他分子或化合物或其混合物引发。
按本发明的实施方案,适合的多官能度引发剂的实例包括但不限于甘油、三羟甲基丙烷、季戊四醇、二(聚)季戊四醇和乙氧基化或丙氧基化多元胺。
此外,在本发明的优选实施方案中,引发剂可为双官能度的,适用的双官能度引发剂的实例包括二官能度醇,非限制性的实例包括1,2-丙二醇、1,3-丁二醇、其他链烷二醇、乙二醇、含两个羟基的普通醇,和能引发开环聚合的其他双官能度化合物。
按本发明的实施方案,生物可降解聚合物中为双或多官能度的引发剂部分可经调控从而可控制线性和支化度。
在本发明的实施方案中,双官能度引发剂占所用引发剂分子总含量的至少50%摩尔。这样可向本发明的生物可降解聚合物中引入相当的线性度并可获得一定的所希望的结晶度。这样,生物可降解聚酯聚合物可获得作为弹性体增塑剂的非常适宜的性质,并因此可在本发明的口香糖中提供有利的生物可降解树脂。要增大线性度以改善本发明实施方案中口香糖的结晶性、塑性和强度,双官能度引发剂的含量可提高至所用引发剂分子总摩尔含量的例如60%、70%、80%、90%或约100%。
因此,按本发明的实施方案,基本为线型的聚酯聚合物可包含超过例如50或80%的线型聚合物链。
本发明的生物可降解的树脂性均聚物可优选通过开环聚合获得。但在本发明的范围内生产方法不受限制。作为实例,丙交酯的开环聚合较乳酸(如α-羟基丙酸)的缩聚更常被用作生产方法。但这主要是工艺条件和生产容易性的问题。就所得聚合物而论,其可具有基本相同的组成和性质并在本发明的口香糖中同等适用。这类聚合物的命名常被认为是可互换的,因此名称聚(丙交酯)和聚(乳酸)可用来指同一种聚合物。
可用作本发明口香糖中的弹性体的有用的聚合物通常可以由二、三或更高官能度的醇与二、三或更高官能度的脂族或芳族羧酸或其酯的逐步增长聚合来制备。同样,羟基酸或酸酐以及多官能度羧酸的卤化物也可以用作单体。聚合可以涉及直接聚酯化或酯交换并且可经催化。
由于多官能度羧酸通常是在缩聚反应介质中具有非常有限的溶解度的高熔点固体,因此通常使用多官能度羧酸的酯或酸酐来克服这种局限。此外,涉及羧酸或酸酐的缩聚产生缩合产物水,其需要高温去除。因此,涉及多官能度酸的酯的酯交换的缩聚通常是优选的方法。例如,可以使用对苯二甲酸二甲酯来替代对苯二甲酸本身。在这种情况下,缩合产物是甲醇而不是水,前者比水更容易去除。通常,反应以本体方式(没有溶剂)进行并且使用高温和真空以去除副产物并驱使反应完全。
可用于本发明口香糖中的弹性体的制备中的脂族多官能度羧酸的具体实例包括草酸、丙二酸、柠檬酸、琥珀酸、苹果酸、酒石酸、富马酸、马来酸、戊二酸、谷氨酸、己二酸、葡糖二酸、庚二酸、辛二酸、壬二酸、癸二酸、十二烷二酸等。同样,芳族多官能度羧酸的具体实例可为对苯二甲酸、间苯二甲酸、邻苯二甲酸、偏苯三酸、均苯四酸和萘1,4-、2,3-、2,6-二羧酸等。
出于举例说明而非限制的目的,可用来制备用于本发明的口香糖中的弹性体的羧酸衍生物的一些实例包括羟基酸例如3-羟基丙酸和6-羟基己酸以及酸酐、酰卤或酯,如对应于上述酸的二甲酯或二乙酯,这指例如草酸、丙二酸、琥珀酸、富马酸、马来酸、戊二酸、己二酸、庚二酸、辛二酸、壬二酸、癸二酸、十二烷二酸、对苯二甲酸、间苯二甲酸、邻苯二甲酸等的二甲酯或二乙酯。一般来说,甲酯有时比乙酯更为优选,这是由于较高沸点的醇比较低沸点的醇难于去除。通常优选的多官能度醇含有2-100个碳原子,例如聚乙二醇和聚丙三醇。
在用于本发明的口香糖中的弹性体的聚合中,可作为醇本身或作为其衍生物使用的醇的一些可应用实例包括多元醇例如乙二醇、1,2-丙二醇、1,3-丙二醇、1,3-丁二醇、1,4-丁二醇、1,6-己二醇、二甘醇、1,4-环己二醇、1,4-环己二甲醇、新戊二醇、甘油、三羟甲基丙烷、季戊四醇、山梨糖醇、甘露醇等。
通常,本发明的口香糖中使用的弹性体聚合物可为均聚物、共聚物或三元共聚物,包括接枝和嵌段聚合物。
可用于本发明的胶基中的另外的环境或生物可降解口香糖基础聚合物的其他适宜实例包括可降解的聚酯、聚碳酸酯、聚酯酰胺、多肽、氨基酸均聚物如聚赖氨酸、蛋白质包括其衍生物如水解蛋白(包括水解玉米蛋白)。
根据在制造本发明范围内的口香糖中的一般原则,现将各种不同的适宜成分列举和说明如下。
本发明的口香糖可包含着色剂。按本发明的实施方案,口香糖可包含着色剂和增白剂,如FD&C型染料和色淀、水果和植物提取物、二氧化钛和其组合。
其他有用的口香糖基础组分包括抗氧剂,如丁羟甲苯(BHT)、丁羟茴醚(BHA)、没食子酸丙酯和生育酚、及防腐剂。
在本发明的实施方案中,口香糖包含量为口香糖的约0-约18重量%、更通常为口香糖的约0-约12重量%的软化剂。
蜡可根据各个配方的性质任选使用。石油蜡有助于自聚合物体系制得的成品糖果产品的固化,也有助于改善货价寿命和质构。蜡晶尺寸影响香味的释放。那些异构烷烃含量高的蜡的晶体尺寸较那些正构烷烃(特别是碳原子数少于30的正构烷烃)含量高的蜡要小。较小的晶体尺寸使香味释放较慢,原因是较具有较大晶体尺寸的蜡存在更多从蜡中放出香味的障碍。用正构烷烃蜡制得的聚合物体系的相容性较用异构烷烃蜡制得的聚合物体系要低。
此外,在制备口香糖胶基时可用蜡和脂肪来调节稠度和软化口香糖胶基。
石油蜡(精制石蜡和微晶蜡)和石蜡主要由直链正构烷烃和支链异构烷烃组成。正构烷烃与异构烷烃的比率不定。
正构烷烃蜡的碳链长度通常大于C-18但主要不超过C-30。支链和环状结构位于那些主要为正构烷烃的蜡的链端附近。正构烷烃蜡的粘度小于10mm2/s(100℃),总的数均分子量低于600g/mol。
异构烷烃蜡的碳链长度通常主要大于C-30。支链和环状结构在那些主要为异构烷烃的蜡内沿碳链无规分布。异构烷烃蜡的粘度高于10mm2/s(100℃),总的数均分子量高于600g/mol。
合成蜡通过非典型的石油蜡生产途径生产,因此不认为是石油蜡。合成蜡可包括含支链烷烃并与单体例如但不限于丙烯共聚合的蜡和聚乙烯及Fischer Tropsch型蜡。聚乙烯蜡为含不同长度的烷烃单元、其上连接有乙烯单体的合成蜡。
天然蜡可包括米糠蜡、蜂蜡、巴西棕榈蜡或小烛树蜡。
至于本发明,可以使用任何常用的和适合类型的蜡和脂肪,例如米糠蜡、聚乙烯蜡、石油蜡(精制石蜡和微晶蜡)、石蜡、蜂蜡、巴西棕榈蜡、小烛树蜡、可可油、脱脂可可粉以及任何适宜的油或脂肪,例如完全或部分氢化的植物油或完全或部分氢化的动物脂肪。
按本发明,软化剂/乳化剂可加到口香糖和胶基中。
软化剂的选择对胶基的柔软性有影响。软化剂改变质构,使胶基的疏水和亲水组分可混溶,并可进一步增塑聚合物体系的合成聚合物。属于软化剂组的乳化剂为聚合物体系提供水结合性,水结合性赋予聚合物体系令人愉快的平滑表面并降低其粘着性。
适用于聚合物体系中的软化剂包括非氢化、部分氢化和完全氢化的植物油和牛油、可可油和脱脂可可粉的甘油三酸酯,除这些外,还包括乳化剂。
甘油三酸酯组包括棉籽油、棕榈油、棕榈仁油、椰油、红花油、菜籽油、向日葵油、牛油、大豆油、可可油、中链甘油三酸酯等。
甘油三酸酯的己酸、辛酸、癸酸、肉豆蔻酸、月桂酸和棕榈脂肪酸较主要含硬脂酸的甘油三酸酯增塑合成弹性体的趋势更强。
乳化剂组中包含甘油一酸酯、甘油二酸酯、乙酰化甘油一酸酯和甘油二酸酯、馏得的甘油一酸酯和甘油二酸酯、单硬脂酸甘油酯、单硬脂酸丙二醇酯、Na-、K-、Mg-和Ca-硬脂酸盐、三乙酸甘油酯、脂肪酸单甘油酯(如硬脂酸、棕榈酸、油酸和亚油酸)、甘油一酸酯和甘油二酸酯的乳酸酯和乙酸酯、可食用脂肪酸的糖酯(也称蔗糖聚酯,包括WO00/25598中公开的那些,该专利申请通过引用结合到本文中)、卵磷脂和羟基化卵磷脂,其大多数可含少于2重量%来自其生产工艺的甘油三酸酯。
软化剂(包括乳化剂)可单独使用或以至少两种或多种组合使用。
聚合物体系中使用的填料改变聚合物体系的质构并有助于加工。粒径影响聚合物体系的内聚性、密度和加工特性及其配混。粒径越小,最终聚合物体系的密度越大,内聚性越高。通过基于其粒径分布选择填料,可改变初始物质配混,从而可以改变聚合物体系加工过程中初始物质的配混特征并最终改变自这些聚合物体系制得的口香糖的最终咀嚼特征。
适用于聚合物体系中的填料包括碳酸镁和碳酸钙、重质碳酸钙、硅酸盐类如硅酸镁和硅酸铝、高岭土和粘土、氧化铝、氧化硅、滑石、以及氧化钛、磷酸一钙、磷酸二钙和磷酸三钙、硫酸钠、纤维素聚合物如乙基纤维素、甲基纤维素和木材及其混合物。
滑石填料可用于本发明的聚合物体系和糖果产品中,其可与酸香料接触或采用酸香料或提供所需的酸性环境以阻止人造甜味剂通过与碳酸钙型填料反应而降解。碳酸钙和滑石填料的平均粒径通常在约0.1微米-约15微米的范围内。
填料也可包括天然有机纤维如水果植物纤维、谷物、稻谷、纤维素和其组合。
在本发明的实施方案中,口香糖包含量为口香糖的约0-约50重量%、更通常为口香糖的约5-约20重量%的填料。
除通常为水不溶性的胶基部分外,典型的口香糖还包括水溶性的填充部分和一种或多种调味剂。所述水溶性部分可包括填充型甜味剂、高甜度甜味剂、调味剂、软化剂、乳化剂、着色剂、酸化剂、填料、抗氧剂和提供所希望属性的其他组分。
适合的填充型甜味剂包括糖或非糖增甜组分。填充型甜味剂通常构成口香糖的约5-约95重量%,更通常构成口香糖的约20-约80重量%,例如30-60重量%。
可用的糖甜味剂为口香糖领域中公知的含糖组分,包括但不限于蔗糖、葡萄糖、麦芽糖、糊精、海藻糖、D-塔格糖、干转化糖、果糖、左旋糖、半乳糖、淀粉糖浆干粉等,单独或组合使用。
山梨糖醇可用作非糖甜味剂。其他可用的非糖甜味剂包括但不限于其他糖醇如甘露醇、木糖醇、氢化淀粉水解物、麦芽糖醇、异麦芽酚、赤藓糖醇、乳糖醇等,单独或组合使用。
高甜度人造甜味剂可单独使用或结合上述甜味剂一起使用。优选的高甜度甜味剂包括但不限于三氯蔗糖、阿斯巴甜、丁磺氨的盐、阿力甜、纽甜、双甜、糖精及其盐、环拉酸及其盐、甘草甜素、双氢查耳酮、索马甜、莫内林、蛇菊苷等,单独或组合使用。为提供更持久的甜味和香味,可能希望的是包封或以其他方式控制至少一部分的人造甜味剂的释放。可以使用诸如湿造粒、蜡造粒、喷雾干燥、喷雾冷却、流化床涂覆、凝聚、酵母泡腔包封以及纤维挤出等技术实现所希望的释放特征。甜味剂的包封还可用另一种口香糖组分如树脂性化合物来提供。
高甜度人造甜味剂的使用水平变化明显并取决于诸如甜味剂的效能、释放速率、产品所希望的甜味、所用香料的水平和类型以及成本考虑的因素。因此,高效人造甜味剂的有效水平可在约0-约8重量%范围内变化,优选0.001-约5重量%。当包括用于包封的载体时,包封的甜味剂的用量水平将成比例地更高。
糖和/或非糖甜味剂的组合可用于根据本发明加工的口香糖配方中。此外,软化剂还可提供另外的甜味,如糖或醛醇的水溶液。
如果需要低卡路里口香糖,可以使用低卡路里填充剂。低卡路里填充剂的实例包括聚葡萄糖、Raftilose(低聚果糖)、Raftilin(菊粉)、寡聚果糖(NutraFlora)、低聚帕拉金糖、水解瓜尔胶(例如SunFiber)或难消化的糊精(例如Fibersol)。但是,可以使用其他低卡路里填充剂。
本发明的口香糖可含香味剂和调味剂,包括例如天然植物组分、精油、香精、提取物、粉末形式的天然和合成调料,包括能影响味道特征的酸和其他物质。液态和粉末调料的实例包括椰子、咖啡、巧克力、香草、葡萄果实、桔子、酸橙、薄荷醇、甘草、焦糖香、蜜香、花生、胡桃、腰果、榛子、杏仁、菠萝、草莓、悬钩子、热带水果、樱桃、肉桂、胡椒薄荷、冬青、留兰香、桉树和薄荷、诸如来自苹果、梨、桃、草莓、杏、悬钩子、樱桃、菠萝的果香精以及李子香精。精油包括胡椒薄荷、留兰香、薄荷醇、桉树、丁香油、月桂油、茴香、百里香、雪松叶油、肉豆蔻以及上述水果的油。
口香糖香料可以是冻干的天然调味剂,优选粉末、薄片或块或其组合的形式。粒径(按颗粒的最长维度计算)可小于3mm、小于2mm或更优选小于1mm。天然调味剂可以是粒径为约3μm-2mm的形式,如粒径为约4μm-1mm。优选的天然调味剂包括来自水果例如来自草莓、黑莓和悬钩子的种子。
各种合成香料例如混合水果香料也可用于本发明的口香糖芯中。如上所述,与传统使用的那些相比,可以使用更少量的香味剂。可以使用量为成品的0.01-约30重量%的香味剂和/或香料,这取决于所用香味剂和/或香料的所希望的强度。优选香味剂和/或香料的含量为总组合物的0.2-3重量%。
在本发明的实施方案中,调味剂包含天然植物组分、精油、香精、提取物、粉末形式的天然和合成调料,包括能影响味道特征的酸和其他物质。
可以包括在本发明的口香糖中的其他口香糖成分包括表面活性剂和/或增溶剂,特别是当存在药学或生物活性成分时。作为用作本发明口香糖组合物中的增溶剂的表面活性剂类型的实例,参考H.P.Fiedler,Lexikon der Hilfstoffe für Pharmacie,Kosmetik undAngrenzende Gebiete,63-64页(1981)以及各个国家批准的食品乳化剂的清单。可以使用阴离子、阳离子、两性或非离子增溶剂。合适的增溶剂包括卵磷脂、聚氧乙烯硬脂酸酯、聚氧乙烯失水山梨醇脂肪酸酯、脂肪酸盐、可食用脂肪酸的甘油一酯和甘油二酯的单乙酰和二乙酰酒石酸酯、可食用脂肪酸的甘油一酯和甘油二酯的柠檬酸酯、脂肪酸蔗糖酯、脂肪酸聚甘油酯、互酯化蓖麻油酸的聚甘油酯(E476)、硬脂酰基乳酰乳酸钠、月桂基硫酸钠和脂肪酸的失水山梨醇酯以及聚氧乙基化氢化蓖麻油(例如以商品名CREMOPHOR出售的产品)、环氧乙烷和环氧丙烷的嵌段共聚物(例如以商品名PLURONIC和POLOXAMER出售的产品)、聚氧乙烯脂肪醇醚、聚氧乙烯失水山梨醇脂肪酸酯、脂肪酸的失水山梨醇酯以及聚氧乙烯硬脂酸酯。
特别适合的增溶剂为聚氧乙烯硬脂酸酯,例如聚氧乙烯(8)硬脂酸酯和聚氧乙烯(40)硬脂酸酯、以商品名TWEEN出售的聚氧乙烯失水山梨醇脂肪酸酯例如TWEEN 20(单月桂酸酯)、TWEEN 80(单油酸酯)、TWEEN 40(单棕榈酸酯)、TWEEN 60(单硬脂酸酯)或TWEEN65(三硬脂酸酯)、可食用脂肪酸的甘油一酯和甘油二酯的单乙酰和二乙酰酒石酸酯、可食用脂肪酸的甘油一酯和甘油二酯的柠檬酸酯、硬脂酰基乳酰乳酸钠、月桂基硫酸钠、聚氧乙基化氢化蓖麻油、环氧乙烷和环氧丙烷的嵌段共聚物以及聚氧乙烯脂肪醇醚。增溶剂可以是单一化合物或是几种化合物的组合。在活性成分存在下,口香糖可优选还包含本技术领域中已知的载体。
用作软化剂的乳化剂可包括牛油、氢化牛油、氢化和部分氢化的植物油、可可油、单硬脂酸甘油酯、三乙酸甘油酯、卵磷脂、甘油一、二和三酸酯、乙酰化甘油单酸酯、脂肪酸(如硬脂酸、棕榈酸、油酸和亚油酸)和其组合。
按本发明的实施方案,口香糖可包含药学、美容或生物活性物质。这类活性物质的实例的综合清单可在例如WO00/25598中找到,该专利申请通过引用结合到本文中。
待用于本发明中的活性剂可为任何希望从口香糖中释放的物质。如果想要加快释放速率(对应于香料所获得的效果),首要物质为具有有限水溶性(通常低于10g/100ml,包括完全不水溶)的那些。实例为药物、营养强化剂、口服组合物、戒烟剂、高效甜味剂、pH调节剂等。
活性成分的其他实例包括扑热息痛、苯佐卡因、桂利嗪、薄荷醇、香芹酮、咖啡因、乙酸氯己定、盐酸赛克利嗪、1,8-桉油醇、南诺龙、咪康唑、mystatine、阿斯巴甜、氟化钠、尼古丁、糖精、西吡氯胺、其他季铵化合物、维生素E、维生素A、维生素D、格列苯脲或其衍生物、黄体酮、乙酰水杨酸、茶苯海明、赛克利嗪、甲硝唑、碳酸氢钠、来自银杏的活性组分、来自蜂胶的活性组分、来自人参的活性组分、美沙酮、胡椒薄荷油、水杨酰胺、氢化可的松或阿斯咪唑。
营养强化剂形式的活性剂的实例为例如具有维生素B2(核黄素)、B12、叶酸、烟酸、维生素H、难溶的甘油磷酸酯、氨基酸、维生素A、D、E和K、盐形式的矿物质、含钙、磷、镁、铁、锌、铜、碘、锰、铬、硒、钼、钾、钠或钴的络合物和化合物的营养作用的盐和化合物。
此外可参考各国主管机构认可的营养素清单,如US Code ofFederal Regulations,Title 21,Section 182.5013.182 5997和182.8013-182.8997。
用来护理或治疗口腔和牙齿的化合物形式的活性剂的实例为例如结合过氧化氢和能在咀嚼过程中释放脲的化合物。
防腐剂形式的活性剂的实例为例如胍和双胍的盐和化合物(例如乙酸氯己定)以及具有有限水溶性的下述类型的物质:季铵化合物(例如神经胺(ceramine)、氯二甲酚、结晶紫、氯胺)、醛(例如多聚甲醛)、地喹胺(dequaline)化合物、聚羟甲脲(polynoxyline)、酚(例如百里酚、对氯酚、甲酚)、六氯酚、水杨酸苯胺化合物(salicylic anilidecompounds)、三氯生、卤素类(碘、碘酊、氯胺、二氯氰尿酸盐)、醇(3,4二氯苯甲醇、苯甲醇、苯氧乙醇、苯乙醇),此外参考Martindale,The Extra Pharmacopoeia,28th edition,547-578页;应该包括具有有限水溶性的金属盐、络合物以及化合物,例如铝盐(如硫酸铝钾AlK(SO4)2·12H2O)以及硼、钡、锶、铁、钙、锌(醋酸锌、氯化锌、葡糖酸锌)、铜(氯化铜、硫酸铜)、铅、银、镁、钠、钾、锂、钼、钒的盐、络合物和化合物;护理口腔和牙齿的其他组合物:例如含氟的盐、络合物和化合物(如氟化钠、一氟磷酸钠、氨基氟化物、氟化亚锡)、磷酸盐、碳酸盐以及硒。
此外参考J.Dent.Res.Vol.28 No.2,160-171页,1949,其中提到了多种经过试验的化合物。
口腔中pH调节剂形式的活性剂的实例包括例如:可接受的酸,例如己二酸、琥珀酸、富马酸,或其盐,或柠檬酸、酒石酸、苹果酸、乙酸、乳酸、磷酸和戊二酸的盐,和可接受的碱,例如钠、钾、铵、镁或钙的碳酸盐、碳酸氢盐、磷酸盐、硫酸盐或氧化物,特别是镁和钙的碳酸盐、碳酸氢盐、磷酸盐、硫酸盐或氧化物。
戒烟剂形式的活性剂的实例包括例如:尼古丁、烟草粉末或银盐,例如醋酸银、碳酸银和硝酸银。
活性剂的其他实例为任何类型的药物。
药物形式的活性剂的实例包括咖啡因、水杨酸、水杨酰胺和相关物质(乙酰水杨酸、胆碱水杨酸盐、水杨酸镁、水杨酸钠)、扑热息痛、镇痛新的盐(盐酸镇痛新和乳酸镇痛新)、盐酸丁丙诺啡、盐酸可待因和磷酸可待因、吗啡和吗啡盐(盐酸盐、硫酸盐、酒石酸盐)、盐酸美沙酮、凯托米酮和凯托米酮的盐(盐酸盐)、β-阻断剂(普萘洛尔)、钙拮抗剂、盐酸维拉帕米、硝苯地平及Pharm.Int.,Nov.85,pages 267-271,Barney H.Hunter and Robert L.Talbert中提到的适合的物质及其盐、硝化甘油、丁四硝酯、马钱子碱及其盐、利多卡因、盐酸丁卡因、盐酸埃托啡、阿托品、胰岛素、酶(例如木瓜蛋白酶、胰蛋白酶、淀粉葡萄糖苷酶、葡萄糖氧化酶、链激酶、链道酶、葡聚糖酶、α-淀粉酶)、多肽(缩宫素、促性激素释放素、(LH.RH)、醋酸去氨加压素(DDAVP))、盐酸异舒普林、麦角胺化合物、氯喹(磷酸盐、硫酸盐)、异山梨醇、去氨缩宫素、肝素。
其他活性成分包括β-羽扇醇、Letigen、柠檬酸西地那非和其衍生物。
牙科产品包括尿素(Carbami)、CPP酪蛋白磷肽、氯己定、醋酸氯己定、盐酸氯己定、葡萄糖氯己定、Hexetedine、氯化锶、氯化钾、碳酸氢钠、碳酸钠、含氟成分、氟化物、氟化钠、氟化铝、氟化铵、氟化钙、氟化亚锡、其他含氟成分氟硅酸铵、氟硅酸钾、氟硅酸钠、一氟磷酸铵、一氟磷酸钙、一氟磷酸钾、一氟磷酸钠、十八酰氟化铵、硬脂酰三羟乙基丙二胺二氢氟化物、维生素包括A、B1、B2、B6、B12、叶酸、烟酸、泛酸(Pantothensyre)、维生素H、C、D、E、K。
矿物质包括钙、磷、镁、铁、锌、铜、铅、锰、铬、硒、钼。其他活性成分包括:Q10@,酶。天然药物包括银杏、姜和鱼油。本发明也涉及偏头痛药物的使用,如5-羟色胺拮抗剂:舒马曲坦、佐米曲普坦、那拉曲坦、利扎曲普坦、依来曲普坦;抗恶心药物如赛克利嗪、桂利嗪、茶苯海明、苯海拉明(Difenhydrinat);抗花粉热药物如西替利嗪、氯雷他定(Loratidin);疼痛缓解药物,如丁丙诺啡、曲马多;抗口腔疾病药物如咪康唑、两性霉素B、丙酮去炎松(Triamcinolonaceton);和药物Cisaprid、多潘立酮、灭吐灵。
活性成分可包含但不限于下述化合物或其衍生物:对乙酰氨基酚、乙酰水杨酸、丁丙诺啡、溴己新、塞来昔布、可待因、苯海拉明、双氯芬酸、依托昔布、异丁苯丙酸、吲哚美辛、酮洛芬、鲁米昔布、吗啡、萘普生、羟可待酮(Oxycodon)、帕瑞昔布、吡罗西康、伪麻黄碱、罗非昔布、替诺昔康、曲马多、戊地昔布、碳酸钙、氢氧化镁铝、双硫仑(Disulfiram)、安非他酮、烟碱、阿奇霉素、克拉霉素、克雷唑、红霉素、四环素、格拉司琼、昂丹司琼、异丙嗪(Prometazin)、托烷司琼、溴苯那敏、西替利嗪、左西替利嗪(leco-Ceterizin)、氯环嗪、氯苯那敏、苯海拉明、多西拉敏、非诺非那定(Fenofenadin)、愈创甘油醚、氯雷他定、右氯雷他定、苯托沙敏、异丙嗪、Pyridamine、特非那定、曲克芦丁、甲基多巴、哌醋甲酯、苯扎氯铵、苄索氯铵、西吡氯铵、氯己定、依卡倍特钠、氟哌啶醇、别嘌醇、秋冰仙碱(Colchinine)、茶碱、普萘洛尔、强的松龙、强的松、氟化物、脲、咪康唑、爱妥糖(Actot)、格列本脲、格列吡嗪、甲福明、米格列醇、瑞格列奈、罗格列酮、阿扑吗啡、西力士(Cialis)、西地那非、瓦地那非、地芬诺酯、二甲硅油、甲氰咪胍、法莫替丁、雷尼替丁、Ratinidine、西替利嗪、氯雷他定、阿斯匹林、苯佐卡因、右甲吗喃、麻黄碱、苯丙醇胺(Phenylpropanolamine)、伪麻黄碱、西沙比利、多潘立酮、胃复安、无环鸟苷、二辛基硫琥珀酸、酚酞、阿莫曲坦、依拉曲普坦、麦角胺、托芬那酸(Migea)、那拉曲坦、利扎曲坦、舒马曲坦、佐米曲坦、铝盐、钙盐、铁盐、银盐、锌盐、两性霉素B、氯己定、咪康唑、曲安奈德、梅拉通宁、苯巴比妥、咖啡因、苯二氮平、羟嗪、甲丙氨酯、吩噻嗪、布克利嗪、布洛他嗪、桂利嗪、赛克利嗪、苯海拉明、茶苯海明、丁咯地尔、安非他明、咖啡因、麻黄碱、奥利司他、苯福林、苯丙醇胺、伪麻黄碱、西布曲明、酮康唑、硝化甘油、制霉菌素、孕酮、睾丸激素、维生素B12、维生素C、维生素A、维生素D、维生素E、毛果芸香碱、氨基乙酸铝(Aluminumaminoacetat)、甲氰咪胍、埃索美拉唑、法莫替丁、兰索拉唑、氧化镁、尼扎替丁和/或雷替尼丁。
在本发明的一个实施方案中,香料可在包含活性成分的口香糖中用作掩味剂,其中所述活性成分自身具有不受欢迎的味道或改变配方的味道。
口香糖可任选含常见的添加剂,如粘结剂、酸化剂、填料、着色剂、防腐剂和抗氧剂。
用于甜味剂的上述包封方法的材料可包括例如明胶、小麦蛋白、大豆蛋白、酪蛋白酸钠、酪蛋白、阿拉伯胶、改性淀粉、水解淀粉(麦芽糊精)、藻酸盐、果胶、角叉菜胶、黄原胶、槐豆胶、壳聚糖、蜂蜡、小烛树蜡、巴西棕榈蜡、氢化植物油、玉米蛋白和/或蔗糖。
通常,口香糖可通过向本领域内已知的可市购混合器中顺序加入各种口香糖成分生产。
口香糖和胶基的混合通常可通过间歇或连续加工法进行。基本的适用混合原理的实例在下面描述。
在初始成分经彻底混合后,口香糖体从混合器中放出并通过例如轧成片和切成条、挤成块或铸成粒成型为所希望的形式。
通常,各成分可通过首先熔融胶基再将其加到运转的混合器中而混合。着色剂、活性剂和/或乳化剂也可在此时加入。软化剂如甘油也可在此时随糖浆和一部分填充剂/甜味剂一起加入。其他部分的填充剂/甜味剂可然后加到混合器中。调味剂通常与最后部分的填充剂/甜味剂一起加入。高甜度甜味剂优选在最后部分的填充剂和香料已经加入之后加入。
整个混合程序通常需要五到十五分钟,但有时需要更长的混合时间。本领域熟练技术人员会理解可按上述程序的许多变体进行,包括美国专利申请2004/0115305中所述的一步法,该文通过引用结合到本文中。
成品口香糖通过挤出、压缩、轧制形成,并可中心填充以任何形式的液体和/或固体。
本发明的口香糖可形成为传统的粒、中心填充的粒等。
也可为本发明的口香糖提供外包衣,外包衣可为硬包衣、软包衣、膜包衣或本领域内已知的任何类型的包衣或这类包衣的组合。所述包衣通常可构成包衣口香糖块的0.1-75重量%。
一种优选的外包衣类型为硬包衣,术语硬包衣包括糖包衣和无糖(或不含糖的)包衣及其组合。硬包衣的目的是获得甜的脆性层(这是消费者喜欢的)和保护口香糖芯。在为口香糖芯提供保护性糖包衣的典型工艺中,口香糖芯依次在适合的包衣设备中用可结晶的糖(如蔗糖或葡萄糖)的水溶液处理,取决于所达到的包衣阶段,所述水溶液中可含其他功能成分如填料、着色剂等。
在本发明的一个优选实施方案中,硬包衣工艺中所用的包衣剂为无糖包衣剂,如多元醇,包括例如山梨糖醇、麦芽糖醇、甘露醇、木糖醇、赤藻糖醇、乳糖醇和异麦芽酮糖醇,或例如单糖、二糖,包括例如海藻糖。
或可采用无糖软包衣,如包含交替地向芯施加多元醇或单糖、二糖的糖浆,所述多元醇或单糖、二糖包括例如山梨糖醇、麦芽糖醇、甘露醇、木糖醇、赤藻糖醇、乳糖醇、异麦芽酮糖醇和海藻糖。
在另外的可用实施方案中通过成膜剂如纤维素衍生物、改性淀粉、糊精、明胶、玉米蛋白、虫胶、阿拉伯树胶、植物胶、合成聚合物等或其组合提供膜包衣。
在本发明的实施方案中,外包衣包含至少一种选自包括粘结剂、吸湿组分、成膜剂、分散剂、防粘组分、填充剂、调味剂、着色剂、药学或美容活性组分、脂质组分、蜡组分、糖和酸的集合的添加剂组分。
本发明的包衣口香糖芯可具有允许口香糖芯用任何常规的包衣法包衣的任何形式、形状或尺寸。
本发明的包衣口香糖单元的口香糖芯可具有允许口香糖芯用任何常规的包衣法包衣的任何形式、形状或尺寸。因此,口香糖芯可为例如选自粒、垫形粒、棒、片、块、锭、丸、球和半球的形状,且通常口香糖芯的重量可为0.5-5克。
注意,说明书和具体的权利要求书中记例如1000为1,000,记1/2为0.5。
下面的非限制性实施例说明本发明口香糖的制造。
实施例1
通过开环聚合制备聚酯弹性体
如下在干N2手套箱内合成弹性体样品。在干N2气体吹扫下将3.143g季戊四醇和0.5752g Sn(Oct)2(2.0ml的1.442g Sn(Oct)2/5mL二氯甲烷)充入装有顶置机械搅拌器的500ml树脂釜中。使二氯甲烷在N2吹扫下蒸发15分钟。然后加入ε-己内酯(1144g,10mol)、三亚甲基碳酸酯(31g,0.30mol)和δ-戊内酯(509g,5.1mol)。将树脂釜浸没在130℃恒温油浴中并搅拌13.9小时。随后将釜从油浴中移出并冷却到室温。利用小刀一小块一小块地将固体、弹性产物取下,并放入塑料容器中。
产物的特征为Mn=56,000g/mol和Mw=98,700g/mol(凝胶渗透色谱法,在线MALLS检测器),Tg=-58.9℃(DSC,加热速率10℃/分钟)。
实施例2
通过开环聚合制备聚酯弹性体
如下在干N2手套箱内合成弹性体样品。在干N2气体吹扫下将3.152g季戊四醇和0.5768g Sn(Oct)2(2.0ml的1.442g Sn(Oct)2/5mL二氯甲烷)充入装有顶置机械搅拌器的500ml树脂釜中。使二氯甲烷在N2吹扫下蒸发15分钟。然后加入ε-己内酯(1148g,10mol)、三亚甲基碳酸酯(31g,0.30mol)和δ-戊内酯(511g,5.1mol)。将树脂釜浸没在130℃恒温油浴中并搅拌13.4小时。随后将釜从油浴中移出并冷却到室温。利用小刀一小块一小块地将固体、弹性产物取下,并放入塑料容器中。
产物的特征为Mn=88,800g/mol和Mw=297,000g/mol(凝胶渗透色谱法,在线MALLS检测器),Tg=-59.4℃(DSC,加热速率10℃/分钟)。
实施例3
通过开环聚合制备聚酯树脂
利用装配有玻璃搅拌轴和特氟隆搅拌叶片和底部出口的圆筒玻璃、带夹套的10L的试验反应器来生产树脂样品。利用硅油循环通过夹套恒温在130℃下来实现反应器内容物的加热。将ε-己内酯(358.87g,3.145mol)和1,2-丙二醇(79.87g,1.050mol)与作为催化剂的辛酸亚锡(1.79g,4.42×10-3mol)一起充入反应器并在130℃下反应约30分钟。然后加入熔融的D,L-丙交酯(4.877kg,33.84mol),反应持续约2小时。反应结束后,打开底部出口,使熔融聚合物排入到特氟隆衬里的涂料罐中。
产物特征为Mn=6,000g/mol和Mw=7,000g/mol(凝胶渗透色谱法,在线MALLS检测器),Tg=25-30℃(DSC,加热速率10℃/分钟)。
实施例4
通过逐步增长聚合制备聚酯弹性体
利用500mL树脂釜来生产弹性体样品,该树脂釜装配有顶置搅拌器、氮气进口管、温度计以及用于去除甲醇的蒸馏头。将83.50g(0.43摩尔)对苯二甲酸二甲酯、99.29g(0.57摩尔)己二酸二甲酯、106.60g(1.005摩尔)二(乙二醇)和0.6g乙酸钙一水合物充入釜中。在氮气下缓慢加热混合物同时搅拌,直到所有组分熔融(120-140℃)。继续加热和搅拌,连续蒸馏甲醇。温度缓慢升到150-200℃,直到甲醇的释放停止。停止加热并使内容物冷却到约100℃。移开反应器盖并小心地将熔融聚合物倒入接收容器中。
产物特征为Mn=40,000g/mol和Mw=190,000g/mol(凝胶渗透色谱法,在线MALLS检测器),Tg=-30℃(DSC,加热速率10℃/分钟)。
实施例5
以NatureWorksPLA 4060D(非晶)聚D,L-丙交酯均聚物作为树脂。该均聚物的Tg为约56℃(Mn~100,000)。
实施例6
以NatureWorksPLA 5500D(非晶)聚D,L-丙交酯均聚物作为树脂。该均聚物的Tg为约50℃(Mn~50,000)。
实施例7
制备胶基
按照下列路线来实施制备胶基的方法:将胶基组分加入混合釜中,该混合釜装配有混合装置例如水平放置的Z型臂。釜已预热到约140℃的温度。将混合物混合30-120分钟,直到整个混合物变得均匀。然后将混合物充入平底锅并使其冷却到室温。
制备了如表1所示的九种不同的胶基。
胶基组分 | 对照胶基001 | 胶基002 | 胶基003 | 胶基004 | 胶基005 | 胶基006 | 胶基007 | 胶基008 | 胶基009 |
常规弹性体 | 15 | 15 | 15 | 15 | |||||
常规天然树脂 | 20 | ||||||||
常规合成树脂 | 20 | ||||||||
实施例1的聚酯 | 15 | 15 | |||||||
实施例4的聚酯 | 15 | 15 | 15 | ||||||
实施例3的聚酯 | 40 | 40 | 40 | ||||||
实施例5的聚酯 | 40 | 40 | |||||||
实施例6的聚酯 | 40 | 40 | 40 | ||||||
填料 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 |
乳化剂 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
脂肪 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 |
表1:胶基组合物,组分以重量%表示。
实施例8
制备口香糖
实施例7的胶基被用于制备具有如表2中所示基本配方的胡椒薄荷味口香糖配方1001-1009,其中,胶基001用于制备口香糖1001,胶基002用于制备口香糖1002,依此类推。
表2:胡椒薄荷味口香糖配方。成分浓度以重量百分数给出。
实施例9:
表2口香糖的评价
建立了评价表2口香糖的非粘性质的试验程序。该试验涉及步骤
-在咀嚼机中将表2口香糖配方的口香糖块咀嚼8分钟,
-将口香糖块紧固到混凝土板上,
-在三种不同的受控气候条件下评价口香糖块:
(a)0℃
(b)21℃/55%RH
(c)30℃/70%RH
对口香糖块进行视觉评价并用刮铲试图清除掉口香糖块。
普遍观察到在试验(a)的低测试温度0℃下非粘性的受试样品比对照样品1001具有改进的非粘性。
还得出结论,口香糖配方1003、1004、1006、1008和1009在所有温度(a)、(b)和(c)下均具有改进的非粘性,从而表明这样的非粘性不那么取决于环境温度。
关于口香糖配方1003、1004、1006、1008和1009的质构的试验表明可通过使用最低分子量的树脂获得最佳的质构,即口香糖样品1004、1006和1009。
实施例10
制备胶基
按实施例7中所述方法再制备一批胶基,但组成稍有所改变,这里的胶基包含常规弹性体和均聚物作为树脂。
表3示出了胶基202-209。
胶基组分 | 胶基202 | 胶基203 | 胶基204 | 胶基205 | 胶基206 | 胶基207 | 胶基208 | 胶基209 |
常规弹性体 | 1 | 5 | 8 | 15 | 30 | 35 | 40 | 45 |
实施例6的聚酯 | 54 | 50 | 47 | 40 | 25 | 25 | 25 | 10 |
树脂/弹性体比例 | 54∶1 | 10∶1 | 47∶8 | 40∶15 | 25∶30 | 25∶35 | 25∶40 | 10∶45 |
填料 | 20 | 20 | 20 | 20 | 20 | 15 | 10 | 20 |
乳化剂 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
脂肪 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 |
表3:胶基组合物,组分浓度以重量百分数给出。
实施例11
基于实施例10的胶基的口香糖配方在表4中示出。
表4:胡椒薄荷味口香糖配方。成分浓度以重量百分数给出。
实施例12
表4口香糖的评价
基于胶基209形成的口香糖2009中弹性体占主要。该口香糖的胶基中的弹性体含量为约45%(w/w),以该含量与均聚物结合被认为太高,但可通过弹性体共混物的进一步软化和改性得以补偿。具体而言,可以考虑降低分子量。
另一方面观察到,当树脂和弹性体之间的比率低于约1∶5时,口香糖所期望的非粘性较差。
口香糖2002(即基于胶基中仅1%的弹性体含量形成的口香糖)缺乏所希望的咀嚼感。据推定,之所以缺乏所希望的咀嚼感是因为弹性体含量非常低。
口香糖2003-2008在咀嚼感和粘性方面被认为是可接受的。
按本发明的有利实施方案,口香糖可用约2-15重量%的混合糖浆制备;其中所述混合糖浆含约25-45%的甘油、约55-75%的氢化淀粉水解物。
Claims (61)
1.包含口香糖成分的非粘性口香糖,所述口香糖包含至少一种弹性体和至少一种树脂,所述至少一种树脂包含至少一种合成的均聚物树脂,所述合成的均聚物是生物可降解的,所述口香糖的所述合成的均聚物的量为所述口香糖的约1/2重量%-约60重量%。
2.权利要求1的非粘性口香糖,其中所述口香糖的所述合成的均聚物的量为所述口香糖的约2重量%-50重量%,优选为所述口香糖的约2重量%-30重量%。
3.权利要求1或2的非粘性口香糖,其中所述合成的均聚物是树脂性的。
4.权利要求1-3中任一项的非粘性口香糖,其中所述合成的均聚物包含聚酯聚合物。
5.权利要求1-4中任一项的非粘性口香糖,其中所述聚酯聚合物可通过环状单体开环聚合获得。
6.权利要求1-5中任一项的非粘性口香糖,其中所述聚酯聚合物可通过选自环状酯和环状碳酸酯的环状单体开环聚合获得。
7.权利要求1-6中任一项的非粘性口香糖,其中所述聚酯聚合物可通过选自D,L-丙交酯、L-丙交酯、乙交酯、ε-己内酯、δ-戊内酯、三亚甲基碳酸酯(TMC)和二烷酮的环状单体开环聚合获得。
8.权利要求1-7中任一项的非粘性口香糖,其中所述至少一种均聚物选自聚(D,L-丙交酯)和聚乙交酯。
9.权利要求1-8中任一项的非粘性口香糖,其中所述至少一种均聚物选自聚(D,L-丙交酯),其中D和L-乳酸单体间的比率在约1∶10-10∶1之间。
10.权利要求1-9中任一项的非粘性口香糖,其中所述至少一种均聚物选自聚(D,L-丙交酯),其中D和L-乳酸单体间的比率为约1∶1。
11.权利要求1-10中任一项的非粘性口香糖,其中所述均聚物包含通过至少一种二-或多官能度醇或其衍生物与至少一种二-或多官能度酸或其衍生物的反应产生的聚酯。
12.权利要求1-11中任一项的非粘性口香糖,其中所述酸衍生物包含二-或多元羧酸的酯、酸酐或卤化物。
13.权利要求1-12中任一项的非粘性口香糖,其中所述酸衍生物包含酸的甲酯或乙酯。
14.权利要求1-13中任一项的非粘性口香糖,其中所述均聚物包含通过至少一种二-或多官能度羟基羧酸或其衍生物的缩合反应产生的聚酯。
15.权利要求1-14中任一项的非粘性口香糖,其中所述至少一种均聚物的PD为1.1-20,优选1.3-12。
16.权利要求1-15中任一项的非粘性口香糖,其中所述均聚物的玻璃化转变温度(Tg)高于20℃,优选高于30℃,最优选高于约35℃。
17.权利要求1-16中任一项的非粘性口香糖,其中所述至少一种树脂的分子量低于400,000g/mol Mn。
18.权利要求1-17中任一项的非粘性口香糖,其中所述至少一种树脂的分子量低于200,000g/mol Mn。
19.权利要求1-18中任一项的非粘性口香糖,其中所述至少一种树脂的分子量低于60,000g/mol Mn。
20.权利要求1-19中任一项的非粘性口香糖,其中所述至少一种树脂的分子量为约60,000g/mol Mn。
21.权利要求1-20中任一项的非粘性口香糖,其中所述至少一种树脂的分子量在500g/mol Mn-60,000g/mol Mn的范围内。
22.权利要求1-21中任一项的非粘性口香糖,其中所述至少一种树脂的分子量在5000g/mol Mn-30,000g/mol Mn的范围内。
23.权利要求1-22中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的至少5重量%的至少一种树脂。
24.权利要求1-23中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的至少8重量%的至少一种树脂。
25.权利要求1-24中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约2-约60重量%的至少一种树脂。
26.权利要求1-25中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约5-约25重量%的至少一种树脂。
27.权利要求1-26中任一项的非粘性口香糖,其中所述至少一种树脂基本由所述均聚物形成。
28.权利要求1-27中任一项的非粘性口香糖,其中所述树脂或树脂性聚合物包含至少一种天然树脂、至少一种合成树脂或其任意组合。
29.权利要求1-28中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的至少3重量%、优选至少5重量%的所述至少一种弹性体。
30.权利要求1-29中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的至少8重量%的所述至少一种弹性体。
31.权利要求1-30中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约0.5-约70重量%的所述至少一种弹性体。
32.权利要求1-31中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约2-约20重量%的所述至少一种弹性体。
33.权利要求1-32中任一项的非粘性口香糖,其中所述至少一种弹性体包含丁二烯-苯乙烯、异丁烯-异戊二烯、聚异丁烯、聚异戊二烯或其任意组合。
34.权利要求1-33中任一项的非粘性口香糖,其中所述至少一种弹性体是生物可降解的。
35.权利要求1-34中任一项的非粘性口香糖,其中所述至少一种弹性体包含聚酯。
36.权利要求1-35中任一项的非粘性口香糖,其中所述至少一种弹性体可通过环状单体开环聚合获得。
37.权利要求1-36中任一项的非粘性口香糖,其中所述至少一种弹性体可通过至少一种二-或多官能度醇或其衍生物与至少一种二-或多官能度羧酸或其衍生物聚合获得。
38.权利要求1-37中任一项的非粘性口香糖,其中平均分子量为约500-60,000g/mol Mn的树脂与平均分子量为约30,000g/mol-1,000,000g/mol Mn的弹性体的重量比在约1∶5-20∶1的范围内。
39.权利要求1-38中任一项的非粘性口香糖,其中平均分子量为约500-60,000g/mol Mn的树脂与平均分子量为约30,000g/mol-1,000,000g/mol Mn的弹性体的重量比在约1∶3-10∶1的范围内。
40.权利要求1-39中任一项的非粘性口香糖,其中所述口香糖包含一种或多种选自包括调味剂、甜味剂、填料、软化剂、乳化剂和活性成分的集合的口香糖成分。
41.权利要求1-40中任一项的非粘性口香糖,其中所述调味剂包含天然植物组分、精油、香精、提取物、粉的形式的天然和合成调料,包括酸和能影响味觉特征的其他物质。
42.权利要求1-41中任一项的非粘性口香糖,其中所述口香糖包含量为0.01-约25重量%、优选0.1-约5重量%的香料,所述百分比基于所述口香糖的总重量。
43.权利要求1-42中任一项的非粘性口香糖,其中所述口香糖用约2-15重量%的混合糖浆制备;其中所述混合糖浆包括约25-45重量%的甘油、约55-75重量%的氢化淀粉水解物。
44.权利要求1-43中任一项的非粘性口香糖,其中所述混合糖浆的存在量为所述口香糖的约2-15重量%。
45.权利要求1-44中任一项的非粘性口香糖,其中所述混合糖浆的存在量为所述口香糖的约5-10重量%。
46.权利要求1-45中任一项的非粘性口香糖,其中所述混合糖浆包括约25-45重量%的甘油、约55-75重量%的氢化淀粉水解物。
47.权利要求1-46中任一项的非粘性口香糖,其中所述混合糖浆包含甘油与氢化淀粉水解物和水混合的共蒸发混合物。
48.权利要求1-47中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约0-约20重量%、更通常为所述口香糖的约0-约10重量%的至少一种软化剂。
49.权利要求1-48中任一项的非粘性口香糖,其中乳化剂的量为所述口香糖的0-18重量%。
50.权利要求1-49中任一项的非粘性口香糖,其中所述甜味剂选自包括填充型甜味剂和高甜度甜味剂和其组合的集合。
51.权利要求1-50中任一项的非粘性口香糖,其中所述口香糖包含糖。
52.权利要求1-51中任一项的非粘性口香糖,其中所述口香糖是无糖的。
53.权利要求1-52中任一项的非粘性口香糖,其中所述填充型甜味剂构成所述口香糖的约5-约95重量%,优选约20-约80重量%。
54.权利要求1-53中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约0-约1.2重量%、优选约0.1-约0.6重量%的高甜度甜味剂。
55.权利要求1-54中任一项的非粘性口香糖,其中所述口香糖包含量为所述口香糖的约0-约50重量%、更通常为所述口香糖的约5-约20重量%的填料。
56.权利要求1-55中任一项的非粘性口香糖,其中所述口香糖包含至少一种着色剂。
57.权利要求1-56中任一项的非粘性口香糖,其中所述口香糖成分包含活性成分。
58.权利要求1-57中任一项的非粘性口香糖,其中所述口香糖包有选自包括硬包衣、软包衣和可食用膜包衣的集合的外包衣。
59.权利要求1-58中任一项的非粘性口香糖,其中所述外包衣包含至少一种选自包括粘结剂、吸湿组分、成膜剂、分散剂、防粘组分、填充剂、调味剂、着色剂、药学或美容活性组分、脂质组分、蜡组分、糖、酸和能加速可降解聚合物的咀嚼后降解的试剂的集合的添加剂组分。
60.权利要求1-59中任一项的非粘性口香糖,其中所述口香糖是无蜡的。
61.权利要求1-60中任一项的非粘性口香糖,其中所述口香糖通过压片制得。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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PCT/DK2004/000906 WO2006066572A2 (en) | 2004-12-22 | 2004-12-22 | Biodegradable chewing gum comprising biodegradable polymer with high glass transition temperature |
DKPCT/DK2004/000906 | 2004-12-22 | ||
PCT/DK2005/000629 WO2006066576A1 (en) | 2004-12-22 | 2005-10-03 | Non-tack chewing gum |
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CN101090638A true CN101090638A (zh) | 2007-12-19 |
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CNA2005800443456A Pending CN101090639A (zh) | 2004-12-22 | 2005-09-30 | 包含具有高玻璃化转变温度的生物可降解聚合物的生物可降解口香糖 |
CNA2005800439728A Pending CN101090638A (zh) | 2004-12-22 | 2005-10-03 | 非粘性口香糖 |
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CNA2005800443456A Pending CN101090639A (zh) | 2004-12-22 | 2005-09-30 | 包含具有高玻璃化转变温度的生物可降解聚合物的生物可降解口香糖 |
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US (2) | US20080166448A1 (zh) |
EP (2) | EP1827125B1 (zh) |
JP (2) | JP2008523826A (zh) |
CN (2) | CN101090639A (zh) |
AT (2) | ATE479337T1 (zh) |
DE (2) | DE602005023338D1 (zh) |
DK (2) | DK1827125T3 (zh) |
ES (1) | ES2345264T3 (zh) |
RU (2) | RU2007128063A (zh) |
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2004
- 2004-12-22 WO PCT/DK2004/000906 patent/WO2006066572A2/en not_active Application Discontinuation
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2005
- 2005-09-30 AT AT05786768T patent/ATE479337T1/de not_active IP Right Cessation
- 2005-09-30 US US11/793,957 patent/US20080166448A1/en not_active Abandoned
- 2005-09-30 DK DK05786768.1T patent/DK1827125T3/da active
- 2005-09-30 DE DE602005023338T patent/DE602005023338D1/de active Active
- 2005-09-30 JP JP2007547177A patent/JP2008523826A/ja not_active Withdrawn
- 2005-09-30 EP EP05786768A patent/EP1827125B1/en active Active
- 2005-09-30 WO PCT/DK2005/000626 patent/WO2006066575A1/en active Application Filing
- 2005-09-30 CN CNA2005800443456A patent/CN101090639A/zh active Pending
- 2005-09-30 RU RU2007128063/13A patent/RU2007128063A/ru not_active Application Discontinuation
- 2005-10-03 DE DE602005020846T patent/DE602005020846D1/de active Active
- 2005-10-03 JP JP2007547178A patent/JP2008523827A/ja not_active Withdrawn
- 2005-10-03 EP EP05789115A patent/EP1830661B1/en active Active
- 2005-10-03 AT AT05789115T patent/ATE464790T1/de not_active IP Right Cessation
- 2005-10-03 US US11/793,958 patent/US20080107770A1/en not_active Abandoned
- 2005-10-03 WO PCT/DK2005/000629 patent/WO2006066576A1/en active Application Filing
- 2005-10-03 DK DK05789115.2T patent/DK1830661T3/da active
- 2005-10-03 CN CNA2005800439728A patent/CN101090638A/zh active Pending
- 2005-10-03 RU RU2007128076/13A patent/RU2384201C2/ru not_active IP Right Cessation
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114456452A (zh) * | 2022-03-02 | 2022-05-10 | 西北农林科技大学 | 一种杜仲胶/改性松香热塑性复合材料的制备方法 |
CN114456452B (zh) * | 2022-03-02 | 2023-08-15 | 西北农林科技大学 | 一种杜仲胶/改性松香热塑性复合材料的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2006066576A1 (en) | 2006-06-29 |
ATE464790T1 (de) | 2010-05-15 |
RU2007128076A (ru) | 2009-01-27 |
DE602005023338D1 (de) | 2010-10-14 |
US20080107770A1 (en) | 2008-05-08 |
RU2384201C2 (ru) | 2010-03-20 |
JP2008523826A (ja) | 2008-07-10 |
RU2007128063A (ru) | 2009-01-27 |
CN101090639A (zh) | 2007-12-19 |
EP1830661B1 (en) | 2010-04-21 |
EP1827125A1 (en) | 2007-09-05 |
US20080166448A1 (en) | 2008-07-10 |
ES2345264T3 (es) | 2010-09-20 |
WO2006066572A2 (en) | 2006-06-29 |
DK1827125T3 (da) | 2011-01-10 |
WO2006066575A1 (en) | 2006-06-29 |
DK1830661T3 (da) | 2010-08-09 |
EP1830661A1 (en) | 2007-09-12 |
JP2008523827A (ja) | 2008-07-10 |
DE602005020846D1 (de) | 2010-06-02 |
ATE479337T1 (de) | 2010-09-15 |
EP1827125B1 (en) | 2010-09-01 |
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