CN101085127A - Traditional Chinese medicine composition for treating chronic renal failure - Google Patents

Abstract

The invention relates to a Chinese medicinal combination for treating chronic kidney failure which is prepared from more than ten kinds of Chinese medicinal herbs including oyster shell, raw dragon's bone, fruit of Chinese wolfberry and glutinous rehmannia.

Description

The Chinese medicine composition of treatment chronic kidney hypofunction

Technical field

The present invention relates to treat the Chinese medicine composition of chronic kidney hypofunction, is that a kind of chronic kidney hypofunction for the treatment of is the Chinese medicine composition of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Chronic renal failure (chronic kidney hypofunction) is because the result of kidney damage that a variety of causes causes and the deterioration of carrying out property, body is at the excretion metabolism product, regulate water, electrolyte, acid-base balance, and the clinical syndrome that gets muddled of aspects such as the generation of some endocrine activity material and deactivation.Chronic kidney hypofunction belongs to categories such as " difficulty in urination ", " obstruction and rejection ", " edema ", " asthenia " in the traditional Chinese medical science.Chronic kidney hypofunction can be by multiple kidney disease development such as edema, stranguria, hematuria.The traditional Chinese medical science thinks that with the passing of time various nephropathy, undermine each function, and based on the spleen damage of suffering from a deficiency of the kidney, the state of an illness progressively develops and aggravates disease, and causes the positive deficiency of vital energy to decline at last, and turbid pathogen, blood stasis are stopped up the kidney network that stagnates, cause kidney to lose out entire function, the retention of turbid damp uremic is in body, and the initiation primary disease.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as spleen deficiency of kidney-QI, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, deficiency of both YIN and YANG clinically, obtains very good effect.The research of Chinese medicine chronic kidney hypofunction has had bigger progress.Theoretical side, vital QI being weakened and pathogen being violent, the pathogenic characteristic of carrying throughout must be known together.Differential diagnosis in tcm opinion control Chinese medicine decoction in the delaying chronic kidney hypofunction progress, improve clinical symptoms and cooperate hemodialysis, reduce the dialysis complication, improve dialysis patient life quality aspect and all obtained certain effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the Chinese medicine composition for the treatment of chronic kidney hypofunction.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Fructus Lycii of 1.5～6 portions of Herba Ecliptaes of Radix Rehmanniae

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.5～6 portions of Rhizoma Alismatis of Os Draconis

0.1～2 part of 1.0～4 parts of Cortex Moutan of 1.5～6 parts of Poria of Concha Ostreae

0.1～2 part of 1.0～4 parts of Flos Chrysanthemi of 1.0～4 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Fructus Lycii of 2.5～3.5 portions of Herba Ecliptaes of Radix Rehmanniae

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 2.5～3.5 portions of Rhizoma Alismatis of Os Draconis

0.5～1.5 part of 1.5～2.5 parts of Cortex Moutan of 2.5～3.5 parts of Poria of Concha Ostreae

0.5～1.5 part of 1.5～2.5 parts of Flos Chrysanthemi of 1.5～2.5 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 parts of Fructus Lycii of 3 portions of Herba Ecliptaes of Radix Rehmanniae

1 part of 2 parts of Fructus Corni of 3 portions of Rhizoma Alismatis of Os Draconis

1 part of 2 parts of Cortex Moutan of 3 parts of Poria of Concha Ostreae

1 part of 2 parts of Flos Chrysanthemi of 2 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

Drug action mechanism among the present invention is as follows:

The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

The Os Draconis property of medicine is puckery, sweet, and is flat.GUIXIN, liver, kidney, large intestine channel.Have tranquilizing mind, suppressing the hyperactive liver and subsiding YANG is restrained astringent or styptic treatment for spontaneous sweating effect.Can treat cardiopalmus, palpitation with a distress feeling, insomnia, forgetful, infantile convulsion, demented, dizzy, spontaneous sweating, the seminal emission enuresis, bleeding not during menses, chronic diarrhea chronic dysentery, ulcer do not close up and eczema etc. for a long time.(the 868th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Concha Ostreae property of medicine is salty, is slightly cold.Return liver, kidney channel.Have suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Can treat vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission, metrorrhagia, leukorrhagia etc.(the 1574th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Ligustri Lucidi property of medicine is sweet, bitter, cold.Return liver, kidney channel.Has liver and kidney tonifying, clearind deficient heat, the effect that makes eye bright.Can treat Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision etc.(the 324th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Herba Ecliptae property of medicine is sweet, sour, cold.Return liver, kidney channel.Has liver and kidney tonifying, cooling blood for hemostasis.Can treat deficiency of the liver and kindey, have a dizzy spell, early whitening of beard and hair is spitted blood, spitting of blood, and epistaxis is had blood in stool, dysentery, metrorrhagia, traumatic hemorrhage etc.(the 3690th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Poria property of medicine is sweet, light, and is flat.GUIXIN, spleen, lung, kidney channel.Has promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can treat dysuria, the edema distension, is had loose bowels at phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine etc.(the 2154th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little hardship of the Radix Cyathulae property of medicine, flat.Return liver, kidney channel.Has blood circulation promoting and blood stasis dispelling, the effect of expelling wind and removing dampness.Can treat the blood stasis amenorrhea, difficult labour, retention of placenta, postnatal blood stasis stomachache, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury etc.(the 301st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Lycii property of medicine is sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Can treat caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely etc. of quenching one's thirst.(the 2248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The acid of the Fructus Corni property of medicine, tepor.Return liver, kidney channel.Has liver and kidney tonifying, the effect that convergence is taken off admittedly.Can treat and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding etc.(the 248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).The Flos Chrysanthemi property of medicine is sweet, bitter, is slightly cold.Return lung, Liver Channel.Have wind and heat dispersing, suppressing the hyperactive liver makes eye bright, the effect of removing toxic substances and promoting subsidence of swelling.Can treat affection due to external wind and heat or pathogenic wind-warm from the beginning of, fever and headache, dizzy, conjunctival congestion and swelling pain, furuncle swelling toxin etc.(the 2900th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae, Os Draconis and Concha Ostreae; With Fructus Corni, Fructus Ligustri Lucidi, Herba Ecliptae, Rhizoma Alismatis, Poria and Fructus Lycii is ministerial drug; With Cortex Moutan, Radix Cyathulae and Flos Chrysanthemi is adjuvant.All medicines are harmonious, and are total to the tool nourishing kidney yin, the effect of promoting diuresis to eliminate damp pathogen.The treatment chronic kidney hypofunction has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment chronic kidney hypofunction of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat chronic kidney hypofunction, and the prevention of chronic kidney hypofunction is also had good effect, and the treatment chronic kidney hypofunction has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment chronic kidney hypofunction; Treatment chronic kidney hypofunction patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.Produce effects 7 examples account for 35%, and effective 9 examples account for 45%, and invalid 4 examples account for 20%, and total effective rate reaches 80%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 parts of Fructus Lycii of 3 portions of Herba Ecliptaes of Radix Rehmanniae

1 part of 2 parts of Fructus Corni of 3 portions of Rhizoma Alismatis of Os Draconis

1 part of 2 parts of Cortex Moutan of 3 parts of Poria of Concha Ostreae

1 part of 2 parts of Flos Chrysanthemi of 2 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment chronic kidney hypofunction that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, the Chinese medicine composition of treatment chronic kidney hypofunction is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Fructus Lycii of 1.5～6 portions of Herba Ecliptaes of Radix Rehmanniae

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.5～6 portions of Rhizoma Alismatis of Os Draconis

0.1～2 part of 1.0～4 parts of Cortex Moutan of 1.5～6 parts of Poria of Concha Ostreae

0.1～2 part of 1.0～4 parts of Flos Chrysanthemi of 1.0～4 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

2, the Chinese medicine composition of treatment chronic kidney hypofunction according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 parts of Fructus Lycii of 2.5～3.5 portions of Herba Ecliptaes of Radix Rehmanniae

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 2.5～3.5 portions of Rhizoma Alismatis of Os Draconis

0.5～1.5 part of 1.5～2.5 parts of Cortex Moutan of 2.5～3.5 parts of Poria of Concha Ostreae

0.5～1.5 part of 1.5～2.5 parts of Flos Chrysanthemi of 1.5～2.5 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.

3, the Chinese medicine composition of treatment chronic kidney hypofunction according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 2 parts of Fructus Lycii of 3 portions of Herba Ecliptaes of Radix Rehmanniae

1 part of 2 parts of Fructus Corni of 3 portions of Rhizoma Alismatis of Os Draconis

1 part of 2 parts of Cortex Moutan of 3 parts of Poria of Concha Ostreae

1 part of 2 parts of Flos Chrysanthemi of 2 portions of Radix Cyathulaes of Fructus Ligustri Lucidi.