CN101084896A - 阿曲库铵冷冻干燥组合物 - Google Patents
阿曲库铵冷冻干燥组合物 Download PDFInfo
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- CN101084896A CN101084896A CN 200710127756 CN200710127756A CN101084896A CN 101084896 A CN101084896 A CN 101084896A CN 200710127756 CN200710127756 CN 200710127756 CN 200710127756 A CN200710127756 A CN 200710127756A CN 101084896 A CN101084896 A CN 101084896A
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- atracurium
- injection
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Abstract
Description
实施例 | 贮存时间 | 2-8℃ | 20℃ | 30℃ |
1 | 0hr | 2.68% | ||
1 | 24hr | 2.66% | 2.69% | 2.70% |
1 | 1月 | 2.72% | 2.71% | 3.56% |
2 | 0hr | 1.94% | ||
2 | 24hr | 1.95% | 1.96% | 1.96% |
2 | 1月 | 1.98% | 1.94% | 2.01% |
3 | 0hr | 1.31% |
3 | 24hr | 1.32% | 1.33% | 1.34% |
3 | 1月 | 1.29% | 1.35% | 1.62% |
4 | 0hr | 1.62% | ||
4 | 24hr | 1.64% | 1.61% | 1.60% |
4 | 1月 | 1.65% | 1.66% | 2.01% |
对比例1 | 0hr | 1.53% | ||
对比例1 | 14hr | 1.60%(0℃) | 30.5% | 53.2% |
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2007101277562A CN100531734C (zh) | 2007-03-13 | 2007-06-26 | 阿曲库铵冷冻干燥组合物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN200710020588.7 | 2007-03-13 | ||
CN200710020588 | 2007-03-13 | ||
CNB2007101277562A CN100531734C (zh) | 2007-03-13 | 2007-06-26 | 阿曲库铵冷冻干燥组合物 |
Publications (2)
Publication Number | Publication Date |
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CN101084896A true CN101084896A (zh) | 2007-12-12 |
CN100531734C CN100531734C (zh) | 2009-08-26 |
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CNB2007101277562A Active CN100531734C (zh) | 2007-03-13 | 2007-06-26 | 阿曲库铵冷冻干燥组合物 |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8293912B2 (en) | 2007-05-01 | 2012-10-23 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
US8354537B2 (en) | 2007-10-29 | 2013-01-15 | Chemagis Ltd. | R,R1-atracurium salts |
US8357805B2 (en) | 2007-06-18 | 2013-01-22 | Chemagis Ltd. | (1R,1′R)-atracurium salts separation process |
US8357807B2 (en) | 2007-05-01 | 2013-01-22 | Chemagis Ltd. | Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
CN103070832A (zh) * | 2012-10-27 | 2013-05-01 | 江苏华泰晨光药业有限公司 | 一种常温稳定的苯磺酸顺阿曲库铵冻干制剂组合物及其制备方法 |
US8461338B2 (en) | 2007-03-08 | 2013-06-11 | Chemagis Ltd. | (1R, 1′R)-atracurium salts separation process |
CN104434822A (zh) * | 2014-12-12 | 2015-03-25 | 海南先通药业有限公司 | 一种注射用苯磺顺阿曲库铵组合物及其制备方法与应用 |
CN104983694A (zh) * | 2015-06-01 | 2015-10-21 | 东英(江苏)药业有限公司 | 25℃贮存运输使用的注射用苯磺顺阿曲库铵生产工艺 |
CN105078909A (zh) * | 2015-09-18 | 2015-11-25 | 江苏盈科生物制药有限公司 | 一种注射用苯磺顺阿曲库铵冷冻干燥组合物及其制备方法 |
CN107184583A (zh) * | 2017-05-17 | 2017-09-22 | 广东艾时代生物科技有限责任公司 | 阿曲库胺的新医药用途及其药物组合物 |
CN108703953A (zh) * | 2018-08-27 | 2018-10-26 | 海南皇隆制药股份有限公司 | 一种注射用苯磺顺阿曲库铵冻干粉针剂及其制备方法 |
CN108938573A (zh) * | 2017-05-26 | 2018-12-07 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂组合物及其制备方法和用途 |
-
2007
- 2007-06-26 CN CNB2007101277562A patent/CN100531734C/zh active Active
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8461338B2 (en) | 2007-03-08 | 2013-06-11 | Chemagis Ltd. | (1R, 1′R)-atracurium salts separation process |
US8293912B2 (en) | 2007-05-01 | 2012-10-23 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
US8357807B2 (en) | 2007-05-01 | 2013-01-22 | Chemagis Ltd. | Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
US8357805B2 (en) | 2007-06-18 | 2013-01-22 | Chemagis Ltd. | (1R,1′R)-atracurium salts separation process |
US8354537B2 (en) | 2007-10-29 | 2013-01-15 | Chemagis Ltd. | R,R1-atracurium salts |
CN103070832A (zh) * | 2012-10-27 | 2013-05-01 | 江苏华泰晨光药业有限公司 | 一种常温稳定的苯磺酸顺阿曲库铵冻干制剂组合物及其制备方法 |
CN104434822A (zh) * | 2014-12-12 | 2015-03-25 | 海南先通药业有限公司 | 一种注射用苯磺顺阿曲库铵组合物及其制备方法与应用 |
CN104434822B (zh) * | 2014-12-12 | 2017-06-06 | 海南先通药业有限公司 | 一种注射用苯磺顺阿曲库铵组合物及其制备方法与应用 |
CN104983694A (zh) * | 2015-06-01 | 2015-10-21 | 东英(江苏)药业有限公司 | 25℃贮存运输使用的注射用苯磺顺阿曲库铵生产工艺 |
CN104983694B (zh) * | 2015-06-01 | 2018-05-04 | 上药东英(江苏)药业有限公司 | 25℃贮存运输使用的注射用苯磺顺阿曲库铵生产工艺 |
CN105078909A (zh) * | 2015-09-18 | 2015-11-25 | 江苏盈科生物制药有限公司 | 一种注射用苯磺顺阿曲库铵冷冻干燥组合物及其制备方法 |
CN107184583A (zh) * | 2017-05-17 | 2017-09-22 | 广东艾时代生物科技有限责任公司 | 阿曲库胺的新医药用途及其药物组合物 |
CN108938573A (zh) * | 2017-05-26 | 2018-12-07 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂组合物及其制备方法和用途 |
CN108938573B (zh) * | 2017-05-26 | 2021-08-10 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂组合物及其制备方法和用途 |
CN108703953A (zh) * | 2018-08-27 | 2018-10-26 | 海南皇隆制药股份有限公司 | 一种注射用苯磺顺阿曲库铵冻干粉针剂及其制备方法 |
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Address after: 226000 No. 8 Zhongtian Road, Nantong economic and Technological Development Zone, Jiangsu Patentee after: On the East (Jiangsu) Pharmaceutical Co. Ltd. Address before: 226009 Nantong economic and Technological Development Zone, Jiangsu Zhongtian Road, No. 8 Patentee before: Sinobiopharma Inc. |