CN101084208A - 作为c－fms激酶抑制剂的芳族酰胺 - Google Patents

作为c－fms激酶抑制剂的芳族酰胺 Download PDF

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Publication number
CN101084208A
CN101084208A CNA2005800437031A CN200580043703A CN101084208A CN 101084208 A CN101084208 A CN 101084208A CN A2005800437031 A CNA2005800437031 A CN A2005800437031A CN 200580043703 A CN200580043703 A CN 200580043703A CN 101084208 A CN101084208 A CN 101084208A
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Prior art keywords
methyl
phenyl
carboxylic acid
cyano
piperidin
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Chinese (zh)
Inventor
C·R·伊利格
S·K·巴伦泰恩
J·陈
S·米加拉
J·鲁多尔夫
M·J·沃尔
K·J·威尔逊
R·德斯亚莱斯
C·L·曼泰
C·M·弗洛尔斯
C·J·莫洛伊
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN101084208A publication Critical patent/CN101084208A/zh
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  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
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CNA2005800437031A 2004-10-22 2005-10-20 作为c－fms激酶抑制剂的芳族酰胺 Pending CN101084208A (zh)

Applications Claiming Priority (2)

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US62119204P 2004-10-22 2004-10-22
US60/621,192 2004-10-22

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CN201410019923.1A Pending CN103788035A (zh) 2004-10-22 2005-10-20 作为c-fms激酶抑制剂的芳族酰胺

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US (1) US7705042B2 (enExample)
EP (1) EP1807407B1 (enExample)
JP (1) JP5008569B2 (enExample)
CN (2) CN101084208A (enExample)
AT (1) ATE437864T1 (enExample)
AU (1) AU2005299501B2 (enExample)
DE (1) DE602005015742D1 (enExample)
WO (1) WO2006047504A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520295A (zh) * 2012-08-07 2015-04-15 詹森药业有限公司 用于制备c-fms激酶抑制剂的方法
CN112638431A (zh) * 2018-06-26 2021-04-09 约翰霍普金斯大学 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂
CN115707699A (zh) * 2021-08-18 2023-02-21 中国医学科学院医药生物技术研究所 一组抗骨质疏松的化合物及其应用
CN118027009A (zh) * 2024-04-15 2024-05-14 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790724B2 (en) 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
CA2536964A1 (en) 2003-04-25 2004-11-11 Ortho-Mcneil Pharmaceutical, Inc. C-fms kinase inhibitors
US7427683B2 (en) 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
UA88648C2 (en) * 2004-10-22 2009-11-10 Янссэн Фармацэвтика Н.В. Inhibitors of c-fms kinase
EP1676842A1 (en) * 2004-12-30 2006-07-05 Laboratorios Del Dr. Esteve, S.A. Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments
EP1853586B1 (en) 2005-02-18 2013-07-24 AstraZeneca AB Antibacterial piperidine derivatives
CN101171247A (zh) * 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
NL2000284C2 (nl) * 2005-11-04 2007-09-28 Pfizer Ltd Pyrazine-derivaten.
KR20090004976A (ko) * 2006-04-19 2009-01-12 아스테라스 세이야쿠 가부시키가이샤 아졸카르복사미드 유도체
AU2007240439B2 (en) * 2006-04-20 2012-10-11 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
AU2006342509A1 (en) * 2006-04-20 2007-11-01 Janssen Pharmaceutica, N.V. c-fms kinase inhibitors
US7414050B2 (en) * 2006-04-20 2008-08-19 Janssen Pharmaceutica, N.V. Inhibitors of c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
EP2016070B1 (en) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
EP2206707B1 (en) 2007-10-24 2014-07-23 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
MX2011006503A (es) 2008-12-19 2011-09-06 Vertex Pharma Derivados de pirazina utiles como inhibidores de la cinasa de atr.
US20120238547A1 (en) * 2009-09-07 2012-09-20 Neurosearch A/S 2, 3, 6 - triamino substituted pyridines as kv7 (kcnq) channel modulators
WO2011143425A2 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
NZ603477A (en) 2010-05-12 2014-09-26 Vertex Pharma Compounds useful as inhibitors of atr kinase
JP2013529200A (ja) * 2010-05-12 2013-07-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
EP2627650A2 (en) * 2010-05-26 2013-08-21 Merck Sharp & Dohme Corp. N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
CN106496173A (zh) 2011-09-30 2017-03-15 沃泰克斯药物股份有限公司 用于制备可用作atr激酶抑制剂的化合物的方法
CA2850491C (en) 2011-09-30 2020-10-27 Vertex Pharmaceuticals Incorporated Treating pancreatic cancer and non-small cell lung cancer with atr inhibiors
WO2013152298A1 (en) 2012-04-05 2013-10-10 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
US9303046B2 (en) 2012-08-07 2016-04-05 Janssen Pharmaceutica Nv Process for the preparation of heterocyclic ester derivatives
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
WO2015063793A1 (en) * 2013-11-01 2015-05-07 Srf Limited Process for the preparation of pyrazole derivatives
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
US10959987B2 (en) 2019-04-15 2021-03-30 King Abdulaziz University Imidazole-based compounds as hepatitis C virus inhibitors
WO2021144360A1 (en) 2020-01-17 2021-07-22 F. Hoffmann-La Roche Ag Small molecule csf-1r inhibitors in therapeutic and cosmetic uses
WO2022238327A1 (en) 2021-05-12 2022-11-17 Boehringer Ingelheim International Gmbh Pyridine derivatives with n-linked cyclic substituents as cgas inhibitors
WO2024035950A1 (en) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibitors of kif18a and uses thereof
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
HUP0303841A2 (hu) * 2001-02-20 2004-03-01 Bristol-Myers Squibb Company 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk
AU2003242131A1 (en) * 2002-06-05 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Immunity-related protein kinase inhibitors
CA2536964A1 (en) * 2003-04-25 2004-11-11 Ortho-Mcneil Pharmaceutical, Inc. C-fms kinase inhibitors
US20050113566A1 (en) * 2003-04-25 2005-05-26 Player Mark R. Inhibitors of C-FMS kinase
US7427683B2 (en) * 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
US20050165015A1 (en) * 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments
UA88648C2 (en) * 2004-10-22 2009-11-10 Янссэн Фармацэвтика Н.В. Inhibitors of c-fms kinase

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520295A (zh) * 2012-08-07 2015-04-15 詹森药业有限公司 用于制备c-fms激酶抑制剂的方法
CN104520295B (zh) * 2012-08-07 2017-07-18 詹森药业有限公司 用于制备c‑fms激酶抑制剂的方法
TWI646090B (zh) * 2012-08-07 2019-01-01 比利時商健生藥品公司 製備ｃ-ｆｍｓ激酶抑制劑的方法
CN112638431A (zh) * 2018-06-26 2021-04-09 约翰霍普金斯大学 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂
CN115707699A (zh) * 2021-08-18 2023-02-21 中国医学科学院医药生物技术研究所 一组抗骨质疏松的化合物及其应用
CN118027009A (zh) * 2024-04-15 2024-05-14 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用

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