CN101084208A - 作为c－fms激酶抑制剂的芳族酰胺 - Google Patents

作为c－fms激酶抑制剂的芳族酰胺 Download PDF

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Publication number
CN101084208A
CN101084208A CNA2005800437031A CN200580043703A CN101084208A CN 101084208 A CN101084208 A CN 101084208A CN A2005800437031 A CNA2005800437031 A CN A2005800437031A CN 200580043703 A CN200580043703 A CN 200580043703A CN 101084208 A CN101084208 A CN 101084208A
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Prior art keywords
methyl
phenyl
carboxylic acid
cyano
piperidin
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CNA2005800437031A
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Chinese (zh)
Inventor
C·R·伊利格
S·K·巴伦泰恩
J·陈
S·米加拉
J·鲁多尔夫
M·J·沃尔
K·J·威尔逊
R·德斯亚莱斯
C·L·曼泰
C·M·弗洛尔斯
C·J·莫洛伊
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN101084208A publication Critical patent/CN101084208A/zh
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  • Pulmonology (AREA)
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  • Diabetes (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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CNA2005800437031A 2004-10-22 2005-10-20 作为c－fms激酶抑制剂的芳族酰胺 Pending CN101084208A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62119204P 2004-10-22 2004-10-22
US60/621,192 2004-10-22

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CNA2005800437031A Pending CN101084208A (zh) 2004-10-22 2005-10-20 作为c－fms激酶抑制剂的芳族酰胺
CN201410019923.1A Pending CN103788035A (zh) 2004-10-22 2005-10-20 作为c-fms激酶抑制剂的芳族酰胺

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Country Link
US (1) US7705042B2 (enExample)
EP (1) EP1807407B1 (enExample)
JP (1) JP5008569B2 (enExample)
CN (2) CN101084208A (enExample)
AT (1) ATE437864T1 (enExample)
AU (1) AU2005299501B2 (enExample)
DE (1) DE602005015742D1 (enExample)
WO (1) WO2006047504A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520295A (zh) * 2012-08-07 2015-04-15 詹森药业有限公司 用于制备c-fms激酶抑制剂的方法
CN112638431A (zh) * 2018-06-26 2021-04-09 约翰霍普金斯大学 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂
CN115707699A (zh) * 2021-08-18 2023-02-21 中国医学科学院医药生物技术研究所 一组抗骨质疏松的化合物及其应用
CN118027009A (zh) * 2024-04-15 2024-05-14 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790724B2 (en) 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
US7427683B2 (en) * 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
MXPA05011503A (es) 2003-04-25 2006-05-31 Johnson & Johnson Inhibidores de la c-fms cinasa.
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
CN101437514B (zh) * 2004-10-22 2012-04-25 詹森药业有限公司 C-fms激酶抑制剂
EP1676842A1 (en) * 2004-12-30 2006-07-05 Laboratorios Del Dr. Esteve, S.A. Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments
ES2430569T3 (es) 2005-02-18 2013-11-21 Astrazeneca Ab Compuestos antibacterianos derivados de piperidina
US20080269214A1 (en) * 2005-03-04 2008-10-30 Astrazeneca Ab Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
NL2000284C2 (nl) * 2005-11-04 2007-09-28 Pfizer Ltd Pyrazine-derivaten.
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
EP2016070B1 (en) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
KR101367645B1 (ko) 2006-04-20 2014-02-27 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물
JP2009534380A (ja) * 2006-04-20 2009-09-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ｃ−ｆｍｓキナーゼインヒビター
EP2021329B1 (en) * 2006-04-20 2016-04-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
SI2206707T1 (sl) 2007-10-24 2014-11-28 Astellas Pharma Inc. Azolkarboksamidna spojina ali njena sol
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
PL3354650T3 (pl) 2008-12-19 2022-06-13 Vertex Pharmaceuticals Incorporated Związki przydatne jako inhibitory kinazy atr
EP2475656A1 (en) * 2009-09-07 2012-07-18 NeuroSearch A/S 2, 3, 6 -triamino substituted pyridines as kv7 (kcnq) channel modulators
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
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