CN101080417B - 吉西他滨的酰胺前体药物、其组合物以及应用 - Google Patents

吉西他滨的酰胺前体药物、其组合物以及应用 Download PDF

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Publication number
CN101080417B
CN101080417B CN2005800431815A CN200580043181A CN101080417B CN 101080417 B CN101080417 B CN 101080417B CN 2005800431815 A CN2005800431815 A CN 2005800431815A CN 200580043181 A CN200580043181 A CN 200580043181A CN 101080417 B CN101080417 B CN 101080417B
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China
Prior art keywords
compound
gemcitabine
administration
formula
oral
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Expired - Fee Related
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CN2005800431815A
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English (en)
Chinese (zh)
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CN101080417A (zh
Inventor
D·M·本德尔
D·M·雷米克
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Eli Lilly and Co
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Eli Lilly and Co
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CN2005800431815A 2004-12-17 2005-11-30 吉西他滨的酰胺前体药物、其组合物以及应用 Expired - Fee Related CN101080417B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17
US60/637,422 2004-12-17
PCT/US2005/043125 WO2006065525A1 (en) 2004-12-17 2005-11-30 Amide prodrug of gemcitabine, compositions and use thereof

Publications (2)

Publication Number Publication Date
CN101080417A CN101080417A (zh) 2007-11-28
CN101080417B true CN101080417B (zh) 2011-01-19

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800431815A Expired - Fee Related CN101080417B (zh) 2004-12-17 2005-11-30 吉西他滨的酰胺前体药物、其组合物以及应用

Country Status (32)

Country Link
US (1) US7691827B2 (xx)
EP (1) EP1831237B1 (xx)
JP (1) JP5022911B2 (xx)
KR (1) KR100874052B1 (xx)
CN (1) CN101080417B (xx)
AR (1) AR055009A1 (xx)
AT (1) ATE405573T1 (xx)
AU (1) AU2005316922B2 (xx)
BR (1) BRPI0519117A2 (xx)
CA (1) CA2589850C (xx)
CY (1) CY1108447T1 (xx)
DE (1) DE602005009255D1 (xx)
DK (1) DK1831237T3 (xx)
EA (1) EA011868B1 (xx)
ES (1) ES2310860T3 (xx)
HK (1) HK1109903A1 (xx)
HR (1) HRP20080529T3 (xx)
IL (1) IL183666A (xx)
MA (1) MA29154B1 (xx)
MX (1) MX2007007228A (xx)
MY (1) MY143677A (xx)
NO (1) NO20073368L (xx)
NZ (1) NZ554732A (xx)
PE (1) PE20060771A1 (xx)
PL (1) PL1831237T3 (xx)
PT (1) PT1831237E (xx)
RS (1) RS50629B (xx)
SI (1) SI1831237T1 (xx)
TW (1) TWI326687B (xx)
UA (1) UA86119C2 (xx)
WO (1) WO2006065525A1 (xx)
ZA (1) ZA200705019B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000198A (es) * 2006-06-21 2009-01-22 Lilly Co Eli Formas cristalinas de profarmaco amida de gemcitabina, composiciones y usos del mismo.
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN104955458A (zh) 2012-11-07 2015-09-30 Z·索 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法
KR20150082606A (ko) 2012-11-13 2015-07-15 보옌 테라퓨틱스, 인크. 겜시타빈 전구약물 및 그의 용도
US10059733B2 (en) 2014-03-03 2018-08-28 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
WO2019139920A1 (en) 2018-01-10 2019-07-18 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
MX2020008188A (es) 2018-02-02 2020-11-18 Maverix Oncology Inc Conjugados de fármacos de molécula pequeña de monofosfato de gemcitabina.
CN113166189A (zh) * 2018-04-26 2021-07-23 纳米医学控股有限公司 吉西他滨两亲性前体药物
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
EP3817732A4 (en) * 2018-08-03 2022-06-08 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
US12110311B2 (en) 2019-07-17 2024-10-08 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
WO2021216427A1 (en) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
PL186888B1 (pl) * 1997-01-24 2004-03-31 Conpharma As Pochodne gemcytabiny
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
AU2003291726A1 (en) 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
US20090156547A1 (en) 2009-06-18
EA200701300A1 (ru) 2007-10-26
PL1831237T3 (pl) 2009-01-30
EP1831237A1 (en) 2007-09-12
PT1831237E (pt) 2008-09-22
TW200634023A (en) 2006-10-01
KR20070086308A (ko) 2007-08-27
MA29154B1 (fr) 2008-01-02
CN101080417A (zh) 2007-11-28
BRPI0519117A2 (pt) 2008-12-23
ES2310860T3 (es) 2009-01-16
CY1108447T1 (el) 2014-04-09
CA2589850A1 (en) 2006-06-22
DK1831237T3 (da) 2008-10-27
US7691827B2 (en) 2010-04-06
EP1831237B1 (en) 2008-08-20
AU2005316922B2 (en) 2011-08-25
KR100874052B1 (ko) 2008-12-12
IL183666A0 (en) 2007-09-20
HK1109903A1 (en) 2008-06-27
CA2589850C (en) 2012-05-01
ZA200705019B (en) 2008-10-29
ATE405573T1 (de) 2008-09-15
WO2006065525A1 (en) 2006-06-22
JP2008524218A (ja) 2008-07-10
UA86119C2 (xx) 2009-03-25
DE602005009255D1 (de) 2008-10-02
HRP20080529T3 (en) 2008-12-31
AU2005316922A1 (en) 2006-06-22
NZ554732A (en) 2010-09-30
EA011868B1 (ru) 2009-06-30
MX2007007228A (es) 2007-08-14
SI1831237T1 (sl) 2009-02-28
JP5022911B2 (ja) 2012-09-12
AR055009A1 (es) 2007-08-01
NO20073368L (no) 2007-07-16
RS50629B (sr) 2010-06-30
TWI326687B (en) 2010-07-01
PE20060771A1 (es) 2006-09-23
MY143677A (en) 2011-06-30
IL183666A (en) 2011-09-27

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