CN101072870B - 对真性红细胞增多症中jak2突变的鉴定 - Google Patents

对真性红细胞增多症中jak2突变的鉴定 Download PDF

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CN101072870B
CN101072870B CN2005800420223A CN200580042022A CN101072870B CN 101072870 B CN101072870 B CN 101072870B CN 2005800420223 A CN2005800420223 A CN 2005800420223A CN 200580042022 A CN200580042022 A CN 200580042022A CN 101072870 B CN101072870 B CN 101072870B
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jak2
jak2v617f
variant
seq
sequence
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CN101072870A (zh
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威廉·瓦因切克尔
瓦莱丽·于戈
克洛艾·詹姆斯
让-皮埃尔·勒·库埃迪克
妮科尔·卡萨德瓦尔
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Gustavusi Institute Igr
National Hospital Of Paris (ah-Hp)
Paris Thackeray, University of
VERSAILLES, University of
Institut National de la Santé et de la Recherche Médicale
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Ba Lishiyida
Gustavusi Institute Igr
VERSAILLES, University of
National Hospital Of Paris (ah-Hp)
Institut National de la Santé et de la Recherche Médicale
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Application filed by Ba Lishiyida, Gustavusi Institute Igr, VERSAILLES, University of, National Hospital Of Paris (ah-Hp), Institut National de la Santé et de la Recherche Médicale filed Critical Ba Lishiyida
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CN2005800420223A 2004-10-27 2005-10-26 对真性红细胞增多症中jak2突变的鉴定 Expired - Lifetime CN101072870B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0411480 2004-10-27
FR0411480A FR2877013A1 (fr) 2004-10-27 2004-10-27 Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
PCT/EP2005/055586 WO2006045827A1 (fr) 2004-10-27 2005-10-26 Identification d'une mutation de jak2 impliquée dans la polyglobulie de vaquez

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CN101072870A CN101072870A (zh) 2007-11-14
CN101072870B true CN101072870B (zh) 2013-01-30

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US (9) US7781199B2 (enExample)
EP (2) EP1895000A1 (enExample)
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CN (1) CN101072870B (enExample)
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AU (1) AU2005298636B2 (enExample)
BR (1) BRPI0517398B8 (enExample)
CA (3) CA2647086C (enExample)
DE (1) DE602005004008T2 (enExample)
DK (1) DK1692281T3 (enExample)
ES (1) ES2296229T3 (enExample)
FR (1) FR2877013A1 (enExample)
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MX (1) MX2007005174A (enExample)
PL (1) PL1692281T3 (enExample)
PT (1) PT1692281E (enExample)
SI (1) SI1692281T1 (enExample)
WO (1) WO2006045827A1 (enExample)
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
CN100497657C (zh) * 2006-09-27 2009-06-10 北京大学人民医院 检测JAK2V617F突变的方法及其专用引物与TaqMan-MGB探针
US20080153097A1 (en) * 2006-11-15 2008-06-26 Eragen Biosciences, Inc. Methods and kits for detecting jak2 nucleic acid
US8367078B2 (en) * 2007-06-06 2013-02-05 University Of Florida Research Foundation, Inc. Kinase inhibitor compounds
EP2119796B1 (en) * 2007-07-13 2014-01-15 ARKRAY, Inc. Probe for detecting mutation in jak2 gene and use thereof
GB0820631D0 (en) * 2008-11-11 2008-12-17 London School Hygiene & Tropical Medicine Vectors
EP2272978B1 (en) 2009-07-10 2012-04-18 Biotrin International Limited Highly sensitive rapid isothermal method for the detection of point mutations and SNPs
WO2011067373A1 (fr) * 2009-12-04 2011-06-09 Assistance Publique - Hopitaux De Paris Methode de detection d'une polyglobulie chez un chien
CA2789186A1 (en) * 2010-02-10 2011-08-18 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
US20120021413A1 (en) * 2010-04-30 2012-01-26 Arkray, Inc. Method for Detecting Mutation in Exon 12 of JAK2 Gene, and Nucleic Acid Probe and Kit Therefor
JP6076901B2 (ja) * 2010-07-16 2017-02-15 スティヒティング フェーユーエムセー 被験者の血液サンプル中の疾患マーカーの存在の分析方法
SG193539A1 (en) 2011-03-18 2013-10-30 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg A method of analysing a blood sample of a subject for the presence of a disease marker
JP2013017395A (ja) * 2011-07-07 2013-01-31 Toyobo Co Ltd 骨髄増殖性疾患に関する遺伝子変異を検出するためのプローブおよび該プローブを用いた遺伝子変異の検出方法
GB201116876D0 (en) * 2011-09-30 2011-11-16 Epistem Ltd Mutational analysis of JAK2
CN103243153B (zh) * 2012-02-10 2014-11-05 复旦大学附属华山医院 Jak2 v617f突变的检测应用
WO2014068072A1 (en) 2012-10-31 2014-05-08 Institut Gustave-Roussy Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
US9523084B2 (en) 2012-11-08 2016-12-20 Centre National De La Recherche Scientifique (Cnrs) Phosphodeoxyribosyl transferase mutant enzymes and uses thereof
CA2890658A1 (en) 2012-11-09 2014-05-15 The Johns Hopkins University A genetic assay to determine prognosis in polycythemia vera patients
PT3456333T (pt) 2012-12-07 2020-06-01 Geron Corp Utilização do inibidor de telomerase imetelstate para o tratamento de síndrome mielodisplásica
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
SG11201509556TA (en) 2013-05-16 2015-12-30 Mobelisk Llc Modular tablet case
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
WO2016168612A1 (en) * 2015-04-15 2016-10-20 Promedior, Inc. Methods for treating myeloproliferative disorders
US10519509B2 (en) 2015-04-23 2019-12-31 Quest Diagnostics Investments Incorporated Methods and compositions for the detection of CALR mutations in myeloproliferative diseases
WO2017024171A1 (en) * 2015-08-04 2017-02-09 Acceleron Pharma Inc. Methods for treating myeloproliferative disorders
CN105441573A (zh) * 2016-01-11 2016-03-30 武汉海吉力生物科技有限公司 用于检测人类jak2基因v617f突变的引物、探针及试剂盒
CN109803674A (zh) * 2016-06-10 2019-05-24 Io生物技术公司 Calr和jak2疫苗组合物
EP3658156B1 (en) 2017-07-28 2026-03-25 Geron Corporation Telomerase inhibitor for use in treating a myelodysplastic syndrome
CN113631719A (zh) 2018-11-29 2021-11-09 美国杰龙生物医药公司 治疗骨髓增生异常综合征的方法
EP4061405A1 (en) 2019-11-18 2022-09-28 Janssen Biotech, Inc. Vaccines based on mutant calr and jak2 and their uses
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
IL299612A (en) 2020-07-02 2023-03-01 Incyte Corp Tricyclic urea compounds as JAK2 V617F inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
CA3211748A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
IL315647A (en) 2022-03-17 2024-11-01 Incyte Corp Tricyclic urea compounds as Jak2 and 617f inhibitors
WO2026136827A1 (en) * 2024-12-20 2026-06-25 Incyte Corporation Treatment of clonal hematopoietic disorders using kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914393A (en) * 1995-12-05 1999-06-22 Incyte Pharmaceuticals, Inc. Human Jak2 kinase
CN1440287A (zh) * 2000-06-30 2003-09-03 辉瑞大药厂 治疗外周血管疾病、外周神经病和自主神经病的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5728536A (en) * 1993-07-29 1998-03-17 St. Jude Children's Research Hospital Jak kinases and regulation of Cytokine signal transduction
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5753441A (en) * 1994-08-12 1998-05-19 Myriad Genetics, Inc. 170-linked breast and ovarian cancer susceptibility gene
US5747282A (en) * 1994-08-12 1998-05-05 Myraid Genetics, Inc. 17Q-linked breast and ovarian cancer susceptibility gene
WO1997003358A1 (en) * 1995-07-07 1997-01-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method of identifying inhibitors of the jak-stat signal transduction pathway
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US6821724B1 (en) * 1998-09-17 2004-11-23 Affymetrix, Inc. Methods of genetic analysis using nucleic acid arrays
EP1056889B1 (en) 1998-09-25 2007-06-27 Massachusetts Institute Of Technology Methods related to genotyping and dna analysis
WO2001079555A2 (en) * 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
US20030012788A1 (en) * 2000-07-27 2003-01-16 Jean-Christophe Renauld Method for influencing kinase pathways with IL-22
US20020090622A1 (en) 2000-08-23 2002-07-11 Monisola Adeokun Chemical compounds
US20050235375A1 (en) * 2001-06-22 2005-10-20 Wenqiong Chen Transcription factors of cereals
AU2003299467A1 (en) 2002-05-03 2004-08-10 Gene Logic, Inc. Canine gene microarrays
CA2491637A1 (en) * 2002-07-03 2004-01-15 The Trustees Of Columbia University In The City Of New York Methods for identifying modulators of mda-7 mediated apoptosis
US7537891B2 (en) * 2002-08-27 2009-05-26 Bristol-Myers Squibb Company Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
EP1572957A4 (en) * 2002-08-27 2007-10-10 Bristol Myers Squibb Pharma Co IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING THE ACTIVITY OF COMPOUNDS INTERACTING WITH AND / OR MODULATING TYROSINE KINASE PROTEINS AND / OR TYROSINE KINASE PROTEIN PATHWAYS IN MAMMARY CELLS
US20060019284A1 (en) * 2004-06-30 2006-01-26 Fei Huang Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in lung cancer cells
FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
US7514229B2 (en) * 2005-09-29 2009-04-07 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and evaluating treatment of blood disorders
US20070248961A1 (en) * 2006-04-20 2007-10-25 Maher Albitar Methods for detecting mutations in JAK2 nucleic acid
EP2525651A4 (en) * 2010-01-22 2013-12-11 Chromatin Inc NEW CENTROMERE AND METHOD FOR THEIR USE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914393A (en) * 1995-12-05 1999-06-22 Incyte Pharmaceuticals, Inc. Human Jak2 kinase
CN1440287A (zh) * 2000-06-30 2003-09-03 辉瑞大药厂 治疗外周血管疾病、外周神经病和自主神经病的方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Heike L.Pahl.Towards a molecular understanding of polycythemia rubra vera.Eur.J.Biochem267 12.2000,267(12),p3395-3401.
Heike L.Pahl.Towards a molecular understanding of polycythemia rubra vera.Eur.J.Biochem267 12.2000,267(12),p3395-3401. *
Kawamura et al..Molecular cloning of L-JAK, a Janus family protein-tyrosinekinase expressed in natural killer cells and activated leukocytes.Proc. Nati. Acad. Sci91.1994,91p6374-6378. *
Saltzman et al..Cloning and Characterization of Human Jak-2 Kinase:High mRNA Expression in Immune Cellsand Muscle Tissue.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS246.1998,246p627-633. *
Ugo et al..Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.Experimental Hematology32.2004,32p179-187. *

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