CN101072764B - 抑制蛋白酶体的(-)-表没食子儿茶素没食子酸酯衍生物 - Google Patents

抑制蛋白酶体的(-)-表没食子儿茶素没食子酸酯衍生物 Download PDF

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Publication number
CN101072764B
CN101072764B CN2005800354787A CN200580035478A CN101072764B CN 101072764 B CN101072764 B CN 101072764B CN 2005800354787 A CN2005800354787 A CN 2005800354787A CN 200580035478 A CN200580035478 A CN 200580035478A CN 101072764 B CN101072764 B CN 101072764B
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cells
egcg
proteasome
nmr
compound
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CN2005800354787A
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English (en)
Chinese (zh)
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CN101072764A (zh
Inventor
陈德恒
林惠霞
周铭祥
窦庆平
德博拉·乔伊斯·库恩
阿斯拉姆扎曼·卡齐
万升标
克里斯廷·R·兰迪斯－比沃华尔
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McGill University
Hong Kong Polytechnic University HKPU
Wayne State University
University of South Florida St Petersburg
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McGill University
Hong Kong Polytechnic University HKPU
Wayne State University
University of South Florida St Petersburg
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Priority claimed from US10/921,332 external-priority patent/US7544816B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
CN2005800354787A 2004-08-19 2005-08-15 抑制蛋白酶体的(-)-表没食子儿茶素没食子酸酯衍生物 Expired - Fee Related CN101072764B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/921,332 US7544816B2 (en) 2004-08-19 2004-08-19 (−)-Epigallocatechin gallate derivatives for inhibiting proteasome
US10/921,332 2004-08-19
US64956905P 2005-02-04 2005-02-04
US60/649,569 2005-02-04
PCT/CN2005/001262 WO2006017981A1 (en) 2004-08-19 2005-08-15 (-)-epigallocatechin gallate derivatives for inhibiting proteasome

Publications (2)

Publication Number Publication Date
CN101072764A CN101072764A (zh) 2007-11-14
CN101072764B true CN101072764B (zh) 2013-07-10

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CN2005800354787A Expired - Fee Related CN101072764B (zh) 2004-08-19 2005-08-15 抑制蛋白酶体的(-)-表没食子儿茶素没食子酸酯衍生物

Country Status (6)

Country Link
US (4) US8193377B2 (https=)
EP (1) EP1778663B1 (https=)
JP (1) JP5265915B2 (https=)
CN (1) CN101072764B (https=)
ES (1) ES2660339T3 (https=)
WO (1) WO2006017981A1 (https=)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
EP1778663B1 (en) 2004-08-19 2017-12-13 The Hong Kong Polytechnic University (-)-epigallocatechin gallate derivatives for inhibiting proteasome
EP2088205A1 (en) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10: A diagnosis marker and therapeutic target of chronic rejection.
US8784873B2 (en) * 2009-07-22 2014-07-22 Naturewise Biotech & Medicals Corporation Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly
US9126997B1 (en) 2010-09-07 2015-09-08 Northwestern University Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
GB2500136B (en) 2010-10-15 2015-02-18 Microsoft Corp Parasitic folded loop antenna
CN102078316A (zh) * 2011-01-24 2011-06-01 广西医科大学 表没食子儿茶素没食子酸酯衍生物在抗肿瘤药物中的应用
CN102153535A (zh) * 2011-03-04 2011-08-17 中国海洋大学 一种抗肿瘤多药耐药抑制剂苯并吡喃-3-醇酯化衍生物及其制备方法和应用
EP2557079A1 (en) * 2011-08-09 2013-02-13 Nestec S.A. Synthesis of catechin and epicatechin conjugates
WO2017132775A1 (en) * 2016-02-05 2017-08-10 Viteava Pharmaceuticals Inc. Novel compositions and methods for the treatment of leiomyoma
CN108129438A (zh) * 2017-12-25 2018-06-08 中国海洋大学 一种含2-苯色满母核的化合物及其制备方法
KR102057773B1 (ko) 2018-03-30 2019-12-19 건국대학교 산학협력단 에피갈로카테킨 갈레이트 유도체를 포함하는 유방암 예방 또는 치료용 약학적 조성물
JP2021527048A (ja) * 2018-06-05 2021-10-11 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 癌治療のためのアシル化カテキンポリフェノールおよびその使用方法
CN116162078B (zh) * 2022-12-27 2024-10-29 佛山病原微生物研究院 一种表没食子儿茶素没食子酸酯类化合物及其制备方法和应用

Citations (1)

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WO1999022728A1 (en) * 1997-10-31 1999-05-14 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity

Family Cites Families (7)

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JPS57118580A (en) * 1981-01-16 1982-07-23 Kanebo Ltd Novel catechin derivative
JPS57120584A (en) * 1981-01-20 1982-07-27 Kanebo Ltd Production of catechin derivative
JPH10254087A (ja) * 1997-03-14 1998-09-25 Konica Corp ハロゲン化銀写真感光材料
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
US7122573B2 (en) * 2002-12-06 2006-10-17 Sri International Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents
US7544816B2 (en) * 2004-08-19 2009-06-09 The Hong Kong Polytechnic University (−)-Epigallocatechin gallate derivatives for inhibiting proteasome
EP1778663B1 (en) * 2004-08-19 2017-12-13 The Hong Kong Polytechnic University (-)-epigallocatechin gallate derivatives for inhibiting proteasome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999022728A1 (en) * 1997-10-31 1999-05-14 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DANNE A ET AL:.Flavan-3-ols, prodelphinidins and further polyphenols fromCistus salvifolius.PHYTOCHEMISTRY37 2.1994,37(2),pages 553- 538. *
DE GROOT A ET AL:.Advantages of long range INEPT measurement for structuredetermination of catechin esters.BULLETIN OF MAGNETIC RESONANCE17 1-4.1995,17(1-4),pages 242-243. *
FREUDENBERG, K., et.al..SYNTHESE DES 3-GALLOYL-CATECHIN-ACETATS.LIEBIGS ANN. CHEM.603.1957,603pages 177-182. *
LAM W H ET AL:.A protential prodrug for a green tea polyphenol proteasomeinhibitor: evaluation of the peracetate ester of(-)-epigallocatechin gallate [(-)-EGCG].BIOORGANIC & MEDICINAL CHEMISTRY12 21.2004,12(21),pages 5587- 5596. *

Also Published As

Publication number Publication date
US9169230B2 (en) 2015-10-27
JP5265915B2 (ja) 2013-08-14
JP2008509939A (ja) 2008-04-03
US8193377B2 (en) 2012-06-05
CN101072764A (zh) 2007-11-14
US20080176931A1 (en) 2008-07-24
WO2006017981A9 (en) 2006-05-11
WO2006017981A1 (en) 2006-02-23
EP1778663A4 (en) 2008-08-06
US20160068503A1 (en) 2016-03-10
ES2660339T3 (es) 2018-03-21
US20140213802A1 (en) 2014-07-31
EP1778663A1 (en) 2007-05-02
US8710248B2 (en) 2014-04-29
US20120232135A1 (en) 2012-09-13
EP1778663B1 (en) 2017-12-13

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