CN101068826A - 有效抑制hif-1a表达的lna寡核苷酸 - Google Patents
有效抑制hif-1a表达的lna寡核苷酸 Download PDFInfo
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- CN101068826A CN101068826A CN200580041216.1A CN200580041216A CN101068826A CN 101068826 A CN101068826 A CN 101068826A CN 200580041216 A CN200580041216 A CN 200580041216A CN 101068826 A CN101068826 A CN 101068826A
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Images
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Abstract
Description
SEQ ID NO.1 | 5′-TsGsGscsasasgscsastscscsTsGsTsa-3′ |
SEQ ID NO.2 | 5′-GsTsTsascstsgscscststscsTsTsAsc-3′ |
SEQ ID NO.3 | 5′-( T x)GxGxcsasasgscsastscscsTxGx( T)-3′ |
SEQ ID NO.4 | 5′-( G x)TxTxascstsgscscststscsTxTx( A)-3′ |
SEQ ID NO.5 | 5′-TGGcsasasgscsastscscsTGTa-3′ |
SEQ ID NO.6 | 5′-TGGcaagcatccTGTa-3′ |
SEQ ID NO.7 | FAM-TsGsGscsasasgscsastscscsTsGsTsa-3′ |
SEQ ID NO.8 | 5′-CsGsTscsasgstsastsgscsgsAsAsTsc-3′ |
SEQ ID NO.9 | 5′-TsGsGscsasasascsastscscsTsGsTsa-3′ |
SEQ ID NO.10 | 5′-TsGsAscsasasgscsastscscsAsGsTsa-3′ |
SEQ ID NO.11 | 5′-TGGTgsasgsgscstsgstsCCGA-3′ |
SEQ ID NO.12 | 5′-TTGCgsgsascstscsgsgsATGG-3′ |
SEQ ID NO.13 | 5′-tsgsgscsasasgscsastscscstsgstsa-3′ |
SEQ ID NO.14 | 5′-TsTs mCscstsastsgscstsgstsAsTs mCsc-3′ |
SEQ ID NO.15 | 5′-TsGsGscsasasgscsastscscsTsGsT-3′ |
SEQ ID NO.16 | 5′-GsGscsasasgscsastscscsTsGst-3′ |
SEQ ID NO.17 | 5′-GsTsTsascstsgscscststscsTsTsAs-3′ |
SEQ ID NO.18 | 5′-TsTsascstsgscscststscsTsTsa-3′ |
SEQ ID NO.19 | 5′-TsGsGscsasasgscsastscscsTsGst-3′ |
SEQ ID NO.20 | FAM-CsGsTscsasgstsastsgscsgsAsAsTsc-3′ |
序列Tm | DNA | RNA |
SEQ ID NO.1TsGsGscsasasgscsastscscsTsGsTsa | 64.2℃ | 68.4℃ |
Claims (35)
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Application Number | Priority Date | Filing Date | Title |
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US62656304P | 2004-11-09 | 2004-11-09 | |
US60/626,563 | 2004-11-09 | ||
US64718605P | 2005-01-25 | 2005-01-25 | |
US60/647,186 | 2005-01-25 | ||
US69972105P | 2005-07-15 | 2005-07-15 | |
US60/699,721 | 2005-07-15 | ||
US72462105P | 2005-10-07 | 2005-10-07 | |
US60/724,621 | 2005-10-07 | ||
PCT/DK2005/000721 WO2006050734A2 (en) | 2004-11-09 | 2005-11-09 | Potent lna oligonucleotides for the inhibition of hif-1a expression |
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CN101068826A true CN101068826A (zh) | 2007-11-07 |
CN101068826B CN101068826B (zh) | 2011-11-16 |
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CN2005800412161A Expired - Fee Related CN101068826B (zh) | 2004-11-09 | 2005-11-09 | 有效抑制hif-1a表达的lna寡核苷酸 |
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CN (1) | CN101068826B (zh) |
ES (1) | ES2348247T3 (zh) |
UA (1) | UA93188C2 (zh) |
ZA (1) | ZA200704253B (zh) |
Cited By (1)
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CN104586794A (zh) * | 2014-12-25 | 2015-05-06 | 海南卫康制药(潜山)有限公司 | 一种氨鲁米特组合物冻干片及其制备方法 |
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JP4338527B2 (ja) * | 2002-04-05 | 2009-10-07 | サンタリス ファーマ アー/エス | HIF−1α発現を調節するオリゴマー化合物 |
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2005
- 2005-11-09 UA UAA200706383A patent/UA93188C2/ru unknown
- 2005-11-09 CN CN2005800412161A patent/CN101068826B/zh not_active Expired - Fee Related
- 2005-11-09 ZA ZA200704253A patent/ZA200704253B/xx unknown
- 2005-11-09 ES ES05800760T patent/ES2348247T3/es active Active
Cited By (1)
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