CN101062039A - 治疗神经系统疾病的药物组合物 - Google Patents
治疗神经系统疾病的药物组合物 Download PDFInfo
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- CN101062039A CN101062039A CN 200610078667 CN200610078667A CN101062039A CN 101062039 A CN101062039 A CN 101062039A CN 200610078667 CN200610078667 CN 200610078667 CN 200610078667 A CN200610078667 A CN 200610078667A CN 101062039 A CN101062039 A CN 101062039A
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- quetiapine
- citalopram
- paroxetine
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 230000001107 psychogenic effect Effects 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 229940107591 quetiapine 25 mg Drugs 0.000 description 1
- 229940055696 quetiapine 400 mg Drugs 0.000 description 1
- ZTHJULTYCAQOIJ-WXXKFALUSA-N quetiapine fumarate Chemical compound [H+].[H+].[O-]C(=O)\C=C\C([O-])=O.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12.C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 ZTHJULTYCAQOIJ-WXXKFALUSA-N 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229940035004 seroquel Drugs 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- BAZVSMNPJJMILC-UHFFFAOYSA-N triadimenol Chemical compound C1=NC=NN1C(C(O)C(C)(C)C)OC1=CC=C(Cl)C=C1 BAZVSMNPJJMILC-UHFFFAOYSA-N 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别 | 不动时间(s) |
溶媒对照组 | 200±11 |
帕罗西汀0.65mg/kg组 | 191±13 |
帕罗西汀1.3mg/kg组 | 176±16 |
喹硫平3.25mg/kg组 | 182±10 |
喹硫平13mg/kg组 | 153±9 |
帕罗西汀∶喹硫平(1∶5)组 | 121±13** |
帕罗西汀∶喹硫平(1∶10)组 | 119±14** |
帕罗西汀∶喹硫平(1∶20)组 | 89±13*** |
组别 | 不动时间(s) |
溶媒对照 | 205±11 |
西酞普兰0.65mg/kg | 187±10 |
西酞普兰1.3mg/kg | 169±6 |
喹硫平3.25mg/kg | 176±19 |
喹硫平13mg/kg | 147±15 |
西酞普兰∶喹硫平(1∶5)组 | 131±18** |
西酞普兰∶喹硫平(1∶10)组 | 125±16** |
西酞普兰∶喹硫平(1∶20)组 | 109±11*** |
组别 | 不动时间(s) |
溶媒对照 | 189±17 |
S-西酞普兰0.33mg/kg | 167±15 |
S-西酞普兰0.65mg/kg | 159±13 |
喹硫平3.25mg/kg | 166±20 |
喹硫平13mg/kg | 134±17 |
S-西酞普兰∶喹硫平(1∶10)组 | 106±14** |
S-西酞普兰∶喹硫平(1∶20)组 | 79±15** |
S-西酞普兰∶喹硫平(1∶40)组 | 86±8*** |
Claims (12)
Priority Applications (1)
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CN200610078667A CN101062039B (zh) | 2006-04-30 | 2006-04-30 | 治疗神经系统疾病的药物组合物 |
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CN200610078667A CN101062039B (zh) | 2006-04-30 | 2006-04-30 | 治疗神经系统疾病的药物组合物 |
Publications (2)
Publication Number | Publication Date |
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CN101062039A true CN101062039A (zh) | 2007-10-31 |
CN101062039B CN101062039B (zh) | 2010-05-12 |
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Application Number | Title | Priority Date | Filing Date |
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CN200610078667A Active CN101062039B (zh) | 2006-04-30 | 2006-04-30 | 治疗神经系统疾病的药物组合物 |
Country Status (1)
Country | Link |
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CN (1) | CN101062039B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106668024A (zh) * | 2016-12-27 | 2017-05-17 | 郑州郑先医药科技有限公司 | 一种治疗神经衰弱的西药组合物及其应用 |
CN107519157A (zh) * | 2008-09-10 | 2017-12-29 | 原子能和替代能源委员会 | 抗‑连接蛋白剂在调节精神药物分子疗效方面的应用 |
CN109464436A (zh) * | 2019-01-10 | 2019-03-15 | 高智玉 | 西酞普兰或艾司西酞普兰分别和喹硫平联合在制备治疗精神障碍类疾病的复方制剂中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05000294A (es) * | 2002-07-30 | 2005-08-19 | Peter Migaly | Terapia combinada para la depresion, prevencion de suicidios y varias condiciones medicas y psiquiatricas. |
-
2006
- 2006-04-30 CN CN200610078667A patent/CN101062039B/zh active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107519157A (zh) * | 2008-09-10 | 2017-12-29 | 原子能和替代能源委员会 | 抗‑连接蛋白剂在调节精神药物分子疗效方面的应用 |
CN106668024A (zh) * | 2016-12-27 | 2017-05-17 | 郑州郑先医药科技有限公司 | 一种治疗神经衰弱的西药组合物及其应用 |
CN109464436A (zh) * | 2019-01-10 | 2019-03-15 | 高智玉 | 西酞普兰或艾司西酞普兰分别和喹硫平联合在制备治疗精神障碍类疾病的复方制剂中的应用 |
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Publication number | Publication date |
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CN101062039B (zh) | 2010-05-12 |
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