CN101041674A - 肿瘤成像化合物 - Google Patents

肿瘤成像化合物 Download PDF

Info

Publication number
CN101041674A
CN101041674A CNA2007100876699A CN200710087669A CN101041674A CN 101041674 A CN101041674 A CN 101041674A CN A2007100876699 A CNA2007100876699 A CN A2007100876699A CN 200710087669 A CN200710087669 A CN 200710087669A CN 101041674 A CN101041674 A CN 101041674A
Authority
CN
China
Prior art keywords
compound
amino acid
uptake
compounds
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007100876699A
Other languages
English (en)
Chinese (zh)
Inventor
M·M·古德曼
J·麦克科纳西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of CN101041674A publication Critical patent/CN101041674A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNA2007100876699A 2002-04-30 2003-04-24 肿瘤成像化合物 Pending CN101041674A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37712402P 2002-04-30 2002-04-30
US60/377,124 2002-04-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB038098733A Division CN1313436C (zh) 2002-04-30 2003-04-24 肿瘤成像化合物

Publications (1)

Publication Number Publication Date
CN101041674A true CN101041674A (zh) 2007-09-26

Family

ID=29401448

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2007100876699A Pending CN101041674A (zh) 2002-04-30 2003-04-24 肿瘤成像化合物
CNB038098733A Expired - Lifetime CN1313436C (zh) 2002-04-30 2003-04-24 肿瘤成像化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB038098733A Expired - Lifetime CN1313436C (zh) 2002-04-30 2003-04-24 肿瘤成像化合物

Country Status (13)

Country Link
US (2) US7544715B2 (https=)
EP (1) EP1499584B1 (https=)
JP (2) JP4611017B2 (https=)
KR (1) KR100745445B1 (https=)
CN (2) CN101041674A (https=)
AT (1) ATE478041T1 (https=)
AU (1) AU2003231758B2 (https=)
CA (1) CA2479514C (https=)
DE (1) DE60333830D1 (https=)
DK (1) DK1499584T3 (https=)
ES (1) ES2349528T3 (https=)
NZ (1) NZ535333A (https=)
WO (1) WO2003093412A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954097B (zh) * 2009-07-14 2014-06-04 北京师范大学 新型18f标记取代苯并咪唑类化合物及其制备方法和制备肿瘤pet显像剂中的应用
CN111655145A (zh) * 2017-11-21 2020-09-11 索尔维克斯有限公司 包含氘代2-氨基-2-甲基丙酸和/或2-(n-甲基氨基)-2-甲基丙酸用于肿瘤疾病的磁共振诊断的制剂及使用其的诊断方法
CN114163343A (zh) * 2021-12-10 2022-03-11 许昌学院 含氟氨基酸及衍生物含氟多肽的制备方法以及应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
WO2007030571A2 (en) * 2005-09-06 2007-03-15 Molecular Image Inc. Identification of targets and development of reagents for testing and molecular imaging of human disease
WO2007137135A2 (en) * 2006-05-18 2007-11-29 The Regents Of The University Of California Rotenone analogs: method of preparation and use
AU2007202205A1 (en) * 2006-05-18 2007-12-06 Deere & Company Multi-prong conversion tine for a harvester reel
WO2009045535A2 (en) * 2007-10-04 2009-04-09 Sloan-Kettering Institute For Cancer Research Fluorine-18 derivative of dasatinib and uses thereof
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US20110033382A1 (en) 2008-04-14 2011-02-10 Emory University Imaging Agents
US8722014B2 (en) * 2009-05-01 2014-05-13 Washington University 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
AU2011268129A1 (en) * 2010-06-18 2013-01-10 The Regents Of The University Of California Isotopic labeling for the measurement of global protein levels and turnover in vivo
EP2632495A2 (en) 2010-10-28 2013-09-04 GE Healthcare UK Limited Stabilisation of radiopharmaceutical precursors
CA3034757A1 (en) 2016-08-23 2018-03-01 Simon Fraser University 18f labeled amino acids, derivatives thereof and method of making same
EP3293167A1 (en) * 2016-09-09 2018-03-14 Université Catholique De Louvain [18f]-labelled lactate derivative as pet radiotracer
EP3892612B1 (en) * 2018-12-05 2025-05-14 Otsuka Chemical Co., Ltd. Method for producing organic tellurium compound and method for producing vinyl polymer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855208A (en) * 1971-05-24 1974-12-17 Becton Dickinson Co Derivatives of digoxigenin
US4325961A (en) * 1977-06-01 1982-04-20 Merck & Co., Inc. Fluorinated amino acids
US4695588A (en) * 1977-06-01 1987-09-22 Merck & Co., Inc. Fluorinated amino acids
US4743691A (en) * 1977-07-11 1988-05-10 Merrell Dow France Et Cie 2-halomethyl derivatives of 2-amino acids
US4483870A (en) * 1978-07-24 1984-11-20 Merck & Co., Inc. α-Difluoromethyl amino acids and hypertension treating compositions thereof
US4390517A (en) * 1979-12-19 1983-06-28 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
US4358434A (en) * 1979-12-19 1982-11-09 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US4760091A (en) * 1985-10-01 1988-07-26 The Dow Chemical Company Method of controlling phytopathogenic fungus
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5637759A (en) * 1992-07-30 1997-06-10 The Regents Of The University Of California Metal-ligating amino acid derivatives for MRI and for peptide synthesis
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
FR2748475B1 (fr) 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
US6344179B1 (en) * 1999-04-22 2002-02-05 Emory University Fluoralkenyl nortropanes
US6399042B1 (en) * 1999-04-26 2002-06-04 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
US6843979B2 (en) * 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
US6933042B2 (en) * 2003-07-30 2005-08-23 Hitachi Global Storage Technologies Netherlands B.V. Ballistic GMR structure using nanoconstruction in self pinned layers

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954097B (zh) * 2009-07-14 2014-06-04 北京师范大学 新型18f标记取代苯并咪唑类化合物及其制备方法和制备肿瘤pet显像剂中的应用
CN111655145A (zh) * 2017-11-21 2020-09-11 索尔维克斯有限公司 包含氘代2-氨基-2-甲基丙酸和/或2-(n-甲基氨基)-2-甲基丙酸用于肿瘤疾病的磁共振诊断的制剂及使用其的诊断方法
CN111655145B (zh) * 2017-11-21 2023-12-26 索尔维克斯有限公司 用于肿瘤疾病的磁共振诊断的制剂及使用其的诊断方法
CN114163343A (zh) * 2021-12-10 2022-03-11 许昌学院 含氟氨基酸及衍生物含氟多肽的制备方法以及应用

Also Published As

Publication number Publication date
KR20050005425A (ko) 2005-01-13
AU2003231758B2 (en) 2009-10-22
US7544715B2 (en) 2009-06-09
US20090240041A1 (en) 2009-09-24
HK1073296A1 (en) 2005-09-30
CA2479514C (en) 2011-07-26
JP2005523941A (ja) 2005-08-11
US7989649B2 (en) 2011-08-02
ATE478041T1 (de) 2010-09-15
EP1499584A2 (en) 2005-01-26
EP1499584B1 (en) 2010-08-18
CN1313436C (zh) 2007-05-02
WO2003093412A3 (en) 2004-04-01
JP4611017B2 (ja) 2011-01-12
DK1499584T3 (da) 2010-09-20
CA2479514A1 (en) 2003-11-13
CN1649828A (zh) 2005-08-03
EP1499584A4 (en) 2007-08-15
ES2349528T3 (es) 2011-01-04
NZ535333A (en) 2007-02-23
US20050192458A1 (en) 2005-09-01
JP2009149678A (ja) 2009-07-09
DE60333830D1 (de) 2010-09-30
AU2003231758A1 (en) 2003-11-17
WO2003093412A2 (en) 2003-11-13
KR100745445B1 (ko) 2007-08-03

Similar Documents

Publication Publication Date Title
US7989649B2 (en) Tumor imaging compounds
CA2612187C (en) Stereoselective synthesis of amino acid analogs for tumor imaging
CN1033143C (zh) 放射性药物制剂的制备方法
TW200920407A (en) [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, their derivatives and their use and processes for their preparation
CN1342141A (zh) Dtpa衍生物的区域选择性合成
WO2007001940A2 (en) Imaging agents
CN1118160A (zh) 作为放射保护剂的多胺衍生物
US8722014B2 (en) 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
JP2011522799A (ja) 新規な［ｆ−１８］−ラベル化ｌ−グルタミン酸およびｌ−グルタミン誘導体（ｉｉ）、それらの使用及びその調製法
CN1234680C (zh) 新的成像剂及其前体与制备方法
TW201023900A (en) Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation
WO2022219569A1 (en) Folate receptor-targeted radiotherapeutic agents and their use
CN1158621A (zh) 用于血管疾病诊断的配位化合物
RU2395489C2 (ru) [f-18] меченная l-глютаминовая кислота, [f-18] меченный l-глютамин, их производные и их применение, а также способ их получения
HK1073296B (en) Tumor imaging compounds
CN102448931A (zh) 蛋氨酸的放射标记的氟衍生物
CN100340300C (zh) 放射性过渡金属－亚氨杂二膦络合物、它们的制备以及其放射性药物组合物
WO2026012457A1 (zh) 骨靶向放射性药物及其用途
HK1069380B (en) Regioselective synthesis of dtpa derivatives
HK1043587A (en) Regioselective synthesis of dtpa derivatives

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070926