ES2349528T3 - Compuestos para la imagen de tumores. - Google Patents

Compuestos para la imagen de tumores. Download PDF

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Publication number
ES2349528T3
ES2349528T3 ES03747599T ES03747599T ES2349528T3 ES 2349528 T3 ES2349528 T3 ES 2349528T3 ES 03747599 T ES03747599 T ES 03747599T ES 03747599 T ES03747599 T ES 03747599T ES 2349528 T3 ES2349528 T3 ES 2349528T3
Authority
ES
Spain
Prior art keywords
baselineskip
minutes
tumor
response
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03747599T
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English (en)
Spanish (es)
Inventor
Jonathan Mcconathy
Mark M. Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Application granted granted Critical
Publication of ES2349528T3 publication Critical patent/ES2349528T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES03747599T 2002-04-30 2003-04-24 Compuestos para la imagen de tumores. Expired - Lifetime ES2349528T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37712402P 2002-04-30 2002-04-30
US377124P 2002-04-30

Publications (1)

Publication Number Publication Date
ES2349528T3 true ES2349528T3 (es) 2011-01-04

Family

ID=29401448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03747599T Expired - Lifetime ES2349528T3 (es) 2002-04-30 2003-04-24 Compuestos para la imagen de tumores.

Country Status (13)

Country Link
US (2) US7544715B2 (https=)
EP (1) EP1499584B1 (https=)
JP (2) JP4611017B2 (https=)
KR (1) KR100745445B1 (https=)
CN (2) CN101041674A (https=)
AT (1) ATE478041T1 (https=)
AU (1) AU2003231758B2 (https=)
CA (1) CA2479514C (https=)
DE (1) DE60333830D1 (https=)
DK (1) DK1499584T3 (https=)
ES (1) ES2349528T3 (https=)
NZ (1) NZ535333A (https=)
WO (1) WO2003093412A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
WO2007030571A2 (en) * 2005-09-06 2007-03-15 Molecular Image Inc. Identification of targets and development of reagents for testing and molecular imaging of human disease
WO2007137135A2 (en) * 2006-05-18 2007-11-29 The Regents Of The University Of California Rotenone analogs: method of preparation and use
AU2007202205A1 (en) * 2006-05-18 2007-12-06 Deere & Company Multi-prong conversion tine for a harvester reel
WO2009045535A2 (en) * 2007-10-04 2009-04-09 Sloan-Kettering Institute For Cancer Research Fluorine-18 derivative of dasatinib and uses thereof
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US20110033382A1 (en) 2008-04-14 2011-02-10 Emory University Imaging Agents
US8722014B2 (en) * 2009-05-01 2014-05-13 Washington University 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
CN101954097B (zh) * 2009-07-14 2014-06-04 北京师范大学 新型18f标记取代苯并咪唑类化合物及其制备方法和制备肿瘤pet显像剂中的应用
AU2011268129A1 (en) * 2010-06-18 2013-01-10 The Regents Of The University Of California Isotopic labeling for the measurement of global protein levels and turnover in vivo
EP2632495A2 (en) 2010-10-28 2013-09-04 GE Healthcare UK Limited Stabilisation of radiopharmaceutical precursors
CA3034757A1 (en) 2016-08-23 2018-03-01 Simon Fraser University 18f labeled amino acids, derivatives thereof and method of making same
EP3293167A1 (en) * 2016-09-09 2018-03-14 Université Catholique De Louvain [18f]-labelled lactate derivative as pet radiotracer
CA3083111C (en) * 2017-11-21 2022-09-20 Solvex Limited Liability Company Preparation for magnetic resonance diagnostics for oncological diseases, comprising deuterated 2-amino-2-methylpropionic acid and/or 2-(n-methylamino)-2-methylpropionic acid, and diagnostic method using said preparation
EP3892612B1 (en) * 2018-12-05 2025-05-14 Otsuka Chemical Co., Ltd. Method for producing organic tellurium compound and method for producing vinyl polymer
CN114163343A (zh) * 2021-12-10 2022-03-11 许昌学院 含氟氨基酸及衍生物含氟多肽的制备方法以及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855208A (en) * 1971-05-24 1974-12-17 Becton Dickinson Co Derivatives of digoxigenin
US4325961A (en) * 1977-06-01 1982-04-20 Merck & Co., Inc. Fluorinated amino acids
US4695588A (en) * 1977-06-01 1987-09-22 Merck & Co., Inc. Fluorinated amino acids
US4743691A (en) * 1977-07-11 1988-05-10 Merrell Dow France Et Cie 2-halomethyl derivatives of 2-amino acids
US4483870A (en) * 1978-07-24 1984-11-20 Merck & Co., Inc. α-Difluoromethyl amino acids and hypertension treating compositions thereof
US4390517A (en) * 1979-12-19 1983-06-28 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
US4358434A (en) * 1979-12-19 1982-11-09 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US4760091A (en) * 1985-10-01 1988-07-26 The Dow Chemical Company Method of controlling phytopathogenic fungus
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5637759A (en) * 1992-07-30 1997-06-10 The Regents Of The University Of California Metal-ligating amino acid derivatives for MRI and for peptide synthesis
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
FR2748475B1 (fr) 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
US6344179B1 (en) * 1999-04-22 2002-02-05 Emory University Fluoralkenyl nortropanes
US6399042B1 (en) * 1999-04-26 2002-06-04 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
US6843979B2 (en) * 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
US6933042B2 (en) * 2003-07-30 2005-08-23 Hitachi Global Storage Technologies Netherlands B.V. Ballistic GMR structure using nanoconstruction in self pinned layers

Also Published As

Publication number Publication date
KR20050005425A (ko) 2005-01-13
AU2003231758B2 (en) 2009-10-22
US7544715B2 (en) 2009-06-09
US20090240041A1 (en) 2009-09-24
HK1073296A1 (en) 2005-09-30
CA2479514C (en) 2011-07-26
JP2005523941A (ja) 2005-08-11
US7989649B2 (en) 2011-08-02
ATE478041T1 (de) 2010-09-15
EP1499584A2 (en) 2005-01-26
EP1499584B1 (en) 2010-08-18
CN1313436C (zh) 2007-05-02
WO2003093412A3 (en) 2004-04-01
JP4611017B2 (ja) 2011-01-12
DK1499584T3 (da) 2010-09-20
CA2479514A1 (en) 2003-11-13
CN1649828A (zh) 2005-08-03
EP1499584A4 (en) 2007-08-15
CN101041674A (zh) 2007-09-26
NZ535333A (en) 2007-02-23
US20050192458A1 (en) 2005-09-01
JP2009149678A (ja) 2009-07-09
DE60333830D1 (de) 2010-09-30
AU2003231758A1 (en) 2003-11-17
WO2003093412A2 (en) 2003-11-13
KR100745445B1 (ko) 2007-08-03

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