CN101035575B - 用于防止脊髓粘连的由硫酸化透明质酸和吉兰糖胶组成的生物材料 - Google Patents

用于防止脊髓粘连的由硫酸化透明质酸和吉兰糖胶组成的生物材料 Download PDF

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Publication number
CN101035575B
CN101035575B CN2005800340303A CN200580034030A CN101035575B CN 101035575 B CN101035575 B CN 101035575B CN 2005800340303 A CN2005800340303 A CN 2005800340303A CN 200580034030 A CN200580034030 A CN 200580034030A CN 101035575 B CN101035575 B CN 101035575B
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China
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biomaterial
hyaluronic acid
gel
sulfated
sulphated hyaluronic
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Expired - Lifetime
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CN2005800340303A
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Chinese (zh)
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CN101035575A (zh
Inventor
D·贝利尼
C·隆吉诺蒂
V·克雷申齐
A·塔利恩蒂
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Anika Therapeutics SRL
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Fidia Advanced Biopolymers SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN2005800340303A 2004-10-08 2005-10-03 用于防止脊髓粘连的由硫酸化透明质酸和吉兰糖胶组成的生物材料 Expired - Lifetime CN101035575B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITPD2004A000245 2004-10-08
IT000245A ITPD20040245A1 (it) 2004-10-08 2004-10-08 Biomateriali costituiti da acido ialuronico solfatato e gellano utilizzabili nella prevenzione delle adesioni spinali
PCT/EP2005/010645 WO2006037592A1 (en) 2004-10-08 2005-10-03 Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions

Publications (2)

Publication Number Publication Date
CN101035575A CN101035575A (zh) 2007-09-12
CN101035575B true CN101035575B (zh) 2011-12-14

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CN2005800340303A Expired - Lifetime CN101035575B (zh) 2004-10-08 2005-10-03 用于防止脊髓粘连的由硫酸化透明质酸和吉兰糖胶组成的生物材料

Country Status (12)

Country Link
US (2) US8563039B2 (enExample)
EP (1) EP1796752B1 (enExample)
JP (1) JP5385532B2 (enExample)
KR (1) KR20070107658A (enExample)
CN (1) CN101035575B (enExample)
AU (1) AU2005291474B2 (enExample)
BR (1) BRPI0516568A (enExample)
CA (1) CA2583149C (enExample)
IT (1) ITPD20040245A1 (enExample)
MX (1) MX2007004158A (enExample)
RU (1) RU2383336C2 (enExample)
WO (1) WO2006037592A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD20050206A1 (it) * 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
JP5088864B2 (ja) * 2007-03-16 2012-12-05 オリンパス株式会社 生体組織補填材とその製造方法
CA2719666C (en) 2008-04-04 2016-08-16 Glenn Prestwich Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
EP2280739B1 (en) * 2008-06-03 2012-07-04 Actamax Surgical Materials LLC A tissue coating for preventing undesired tissue-to-tissue adhesions
EP2387390B1 (en) 2009-01-13 2012-11-28 PharmaSurgics in Sweden AB Hylauronic acid containing compositions for treatment of wounds, scars, post-surgical adhesion formation
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
EP2688402B1 (en) 2011-03-23 2018-10-24 University of Utah Research Foundation Means for treating or preventing urological inflammation
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
ITMI20130221A1 (it) * 2013-02-18 2014-08-19 Novagenit S R L Formulazione a base di polisaccaridi biocompatibili e biodegradabili da impiegare in chirurgia
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
US11969526B2 (en) 2017-04-03 2024-04-30 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11975123B2 (en) 2018-04-02 2024-05-07 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
WO2020072495A1 (en) 2018-10-01 2020-04-09 The Board Of Trustees Of The Leland Stanford Junior University Injectable hydrogels for controlled release of immunomodulatory compounds
CN111228653A (zh) 2018-11-13 2020-06-05 格莱科米拉治疗公司 用电离辐射加强癌症治疗的方法
RU2744752C1 (ru) * 2020-08-28 2021-03-15 Федеральное государственное бюджетное учреждение науки Институт проблем химико-энергетических технологий Сибирского отделения Российской академии наук (ИПХЭТ СО РАН) Способ получения противоспаечного материала

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1199343A (zh) * 1995-08-29 1998-11-18 菲迪亚高级生物聚合物公司 包括透明质酸衍生物的用于预防手术后粘连的生物材料

Family Cites Families (10)

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US4326053A (en) * 1978-12-04 1982-04-20 Merck & Co., Inc. Polysaccharide S-60 and bacterial fermentation process for its preparation
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
SE9603480L (sv) * 1996-09-23 1998-03-24 Johan Carlfors Beredningsform för svårlösliga läkemedel
AU738788B2 (en) * 1997-04-04 2001-09-27 Fidia Farmaceutici S.P.A. N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
GB0015682D0 (en) * 2000-06-28 2000-08-16 Bristol Myers Squibb Co Sprayable wound care composition
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
US20030219431A1 (en) * 2002-05-24 2003-11-27 Empire Pharmaceuticals, Inc. Treatment of neuronal and neurological damage associated with spinal cord injury

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1199343A (zh) * 1995-08-29 1998-11-18 菲迪亚高级生物聚合物公司 包括透明质酸衍生物的用于预防手术后粘连的生物材料

Also Published As

Publication number Publication date
BRPI0516568A (pt) 2008-09-09
AU2005291474B2 (en) 2011-06-02
RU2007112777A (ru) 2008-10-10
RU2383336C2 (ru) 2010-03-10
ITPD20040245A1 (it) 2005-01-08
CN101035575A (zh) 2007-09-12
CA2583149C (en) 2013-09-10
EP1796752B1 (en) 2012-12-12
US20090202639A1 (en) 2009-08-13
US20130184234A1 (en) 2013-07-18
JP5385532B2 (ja) 2014-01-08
EP1796752A1 (en) 2007-06-20
CA2583149A1 (en) 2006-04-13
KR20070107658A (ko) 2007-11-07
AU2005291474A1 (en) 2006-04-13
JP2008515832A (ja) 2008-05-15
MX2007004158A (es) 2007-10-08
WO2006037592A1 (en) 2006-04-13
US8563039B2 (en) 2013-10-22
US8728524B2 (en) 2014-05-20

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