CN101035522B - Dpp-ⅳ抑制剂、ppar抗糖尿病剂和二甲双胍的组合 - Google Patents

Dpp-ⅳ抑制剂、ppar抗糖尿病剂和二甲双胍的组合 Download PDF

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Publication number
CN101035522B
CN101035522B CN2005800343814A CN200580034381A CN101035522B CN 101035522 B CN101035522 B CN 101035522B CN 2005800343814 A CN2005800343814 A CN 2005800343814A CN 200580034381 A CN200580034381 A CN 200580034381A CN 101035522 B CN101035522 B CN 101035522B
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China
Prior art keywords
metformin
dpp
pharmaceutically acceptable
rosiglitazone
pioglitazone
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Expired - Fee Related
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CN2005800343814A
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Chinese (zh)
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CN101035522A (zh
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B·布尔凯
T·E·休斯
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN2005800343814A 2004-10-25 2005-10-21 Dpp-ⅳ抑制剂、ppar抗糖尿病剂和二甲双胍的组合 Expired - Fee Related CN101035522B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62189104P 2004-10-25 2004-10-25
US60/621,891 2004-10-25
PCT/US2005/037819 WO2006047248A1 (en) 2004-10-25 2005-10-21 Combination of dpp-iv inhibitor, ppar antidiabetic and metformin

Publications (2)

Publication Number Publication Date
CN101035522A CN101035522A (zh) 2007-09-12
CN101035522B true CN101035522B (zh) 2011-12-07

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Application Number Title Priority Date Filing Date
CN2005800343814A Expired - Fee Related CN101035522B (zh) 2004-10-25 2005-10-21 Dpp-ⅳ抑制剂、ppar抗糖尿病剂和二甲双胍的组合

Country Status (11)

Country Link
US (2) US20090253752A1 (https=)
EP (1) EP1807066A1 (https=)
JP (1) JP2008517921A (https=)
KR (1) KR20070068407A (https=)
CN (1) CN101035522B (https=)
AU (2) AU2005299808B2 (https=)
BR (1) BRPI0518409A2 (https=)
CA (1) CA2581298A1 (https=)
MX (1) MX2007004934A (https=)
RU (1) RU2007119320A (https=)
WO (1) WO2006047248A1 (https=)

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Also Published As

Publication number Publication date
US20090253752A1 (en) 2009-10-08
RU2007119320A (ru) 2008-11-27
AU2009222515A1 (en) 2009-10-22
CN101035522A (zh) 2007-09-12
MX2007004934A (es) 2007-06-12
KR20070068407A (ko) 2007-06-29
JP2008517921A (ja) 2008-05-29
BRPI0518409A2 (pt) 2008-11-18
AU2005299808A1 (en) 2006-05-04
US20110301172A1 (en) 2011-12-08
EP1807066A1 (en) 2007-07-18
CA2581298A1 (en) 2006-05-04
AU2005299808B2 (en) 2009-08-20
WO2006047248A1 (en) 2006-05-04

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