CN101031604B - 聚乙二醇化合物及其制备方法 - Google Patents

聚乙二醇化合物及其制备方法 Download PDF

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Publication number
CN101031604B
CN101031604B CN2005800328299A CN200580032829A CN101031604B CN 101031604 B CN101031604 B CN 101031604B CN 2005800328299 A CN2005800328299 A CN 2005800328299A CN 200580032829 A CN200580032829 A CN 200580032829A CN 101031604 B CN101031604 B CN 101031604B
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CN
China
Prior art keywords
polyethylene glycol
reaction mixture
molecular weight
compound
weight
Prior art date
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Expired - Fee Related
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CN2005800328299A
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English (en)
Chinese (zh)
Other versions
CN101031604A (zh
Inventor
E·D·道格斯
R·B·阿佩尔
J·G·希普勒
B·T·基恩
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Dow Global Technologies LLC
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Dr Reddys Laboratories Ltd
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Publication of CN101031604A publication Critical patent/CN101031604A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2005800328299A 2004-09-28 2005-09-27 聚乙二醇化合物及其制备方法 Expired - Fee Related CN101031604B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/952,198 2004-09-28
US10/952,198 US7199193B2 (en) 2004-09-28 2004-09-28 Polyethylene glycol compounds and process of making
PCT/US2005/034251 WO2006036825A1 (en) 2004-09-28 2005-09-27 Polyethylene glycol compounds and process for making

Publications (2)

Publication Number Publication Date
CN101031604A CN101031604A (zh) 2007-09-05
CN101031604B true CN101031604B (zh) 2010-08-11

Family

ID=35432615

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800328299A Expired - Fee Related CN101031604B (zh) 2004-09-28 2005-09-27 聚乙二醇化合物及其制备方法

Country Status (8)

Country Link
US (2) US7199193B2 (https=)
EP (1) EP1797131B1 (https=)
JP (1) JP4987719B2 (https=)
KR (1) KR101279664B1 (https=)
CN (1) CN101031604B (https=)
AT (1) ATE552286T1 (https=)
ES (1) ES2384979T3 (https=)
WO (1) WO2006036825A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004059489C5 (de) † 2004-12-10 2011-12-08 Clariant Produkte (Deutschland) Gmbh Verfahren zur Herstellung von reinen alpha-Alkoxy-omega-hydroxy-Polyalkylenglykolen
EP2150568B1 (en) * 2007-05-29 2016-03-23 Youl Chon Chemical Co. Ltd. Chain-end functionalized methoxy poly(ethylene glycol)and metal nano-particles using the same
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
DK2348064T3 (da) 2008-11-11 2013-09-08 Nof Corp Fremgangsmåde til fremstilling af polyalkylenglycolderivater
JP5569787B2 (ja) * 2009-03-31 2014-08-13 日油株式会社 高分子量ポリエチレングリコール化合物の精製方法
JP5713274B2 (ja) * 2009-03-31 2015-05-07 日油株式会社 高分子量ポリオキシアルキレン誘導体の精製方法
ATE545673T1 (de) * 2009-06-18 2012-03-15 Basf Se Verfahren zur herstellung von monohydroxypolyalkylenoxiden
EP2840103A4 (en) * 2012-04-18 2015-09-23 Asahi Glass Co Ltd PROCESS FOR PREPARING POLYETHERES
WO2014117148A1 (en) 2013-01-28 2014-07-31 New York University Treatment methods using atoxic neurotoxin derivatives
JP6106104B2 (ja) 2014-01-16 2017-03-29 信越化学工業株式会社 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法
US9708350B2 (en) 2014-12-04 2017-07-18 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator
JP6460937B2 (ja) 2014-12-04 2019-01-30 信越化学工業株式会社 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法
US10377775B2 (en) 2014-12-04 2019-08-13 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end
EP3230457B1 (en) 2014-12-09 2021-06-30 New York University Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
WO2019035090A1 (en) * 2017-08-17 2019-02-21 Sabic Global Technologies B.V. PROCESS FOR THE PREPARATION OF A POLYOXYETHYLENE FATTY ACID MONOESTER, ESTER THEREOF, AND CORRESPONDING USES THEREOF
EP4089133A1 (en) * 2021-05-14 2022-11-16 Johannes Gutenberg-Universität Mainz Poly(ethylene glycol) having c1 to c3-alkyloxymethyl side chains, bioconjugates thereof, process for its preparation and its use.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0985697A1 (en) * 1998-03-24 2000-03-15 Nof Corporation Oxirane derivatives and process for producing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
US6280745B1 (en) * 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
JP3050228B2 (ja) * 1998-03-24 2000-06-12 日本油脂株式会社 オキシラン誘導体及びその製造方法
DE10121807A1 (de) * 2001-05-04 2002-11-07 Bayer Ag Verfahren zur Herstellung von Polyetherpolyolen
ES2341960T3 (es) 2003-07-22 2010-06-30 Nektar Therapeutics Procedimientos para preparar polimeros funcionalizados a partir de alcoholes polimericos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0985697A1 (en) * 1998-03-24 2000-03-15 Nof Corporation Oxirane derivatives and process for producing the same

Also Published As

Publication number Publication date
US20070213479A1 (en) 2007-09-13
EP1797131A1 (en) 2007-06-20
ATE552286T1 (de) 2012-04-15
US7199193B2 (en) 2007-04-03
KR20070058534A (ko) 2007-06-08
CN101031604A (zh) 2007-09-05
ES2384979T3 (es) 2012-07-16
US20060074200A1 (en) 2006-04-06
KR101279664B1 (ko) 2013-06-27
JP2008514763A (ja) 2008-05-08
WO2006036825A1 (en) 2006-04-06
EP1797131B1 (en) 2012-04-04
JP4987719B2 (ja) 2012-07-25

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Granted publication date: 20100811

Termination date: 20210927

CF01 Termination of patent right due to non-payment of annual fee