CN101028371A - Chinese medicinal decoction for treating hives - Google Patents

Abstract

A Chinese medicine in the form of decoction for treating urticaria is prepared from more than 10 Chinese-medicinal materials including astragalus root, ledebouriella root, rehmannia root, liquorice root, etc.

Description

The urticarial Chinese medicine decoction of a kind of treatment

Technical field

The present invention relates to the urticarial Chinese medicine decoction of a kind of treatment, is that a kind of urticaria for the treatment of is the Chinese medicine decoction of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Urticaria is owing to skin, the little vascular reactivity expansion of mucosa and permeability increase a kind of localized edema reaction that produces.Primary disease is more common, and the people of about 15%-25% was taken place once in life at least.The urticaria traditional Chinese medical science is called urticaria, rubella, red rash, miliaria alba, acute angioneurotic edema, urticaria etc.Be commonly called as terrible wind pimple, rubella wheal, bellows chamber etc.As saying that " the evil exopathogenic heat of husband is skin, meets wind and cold and hinders and then play urticaria, and overabundant heat is red complexion then, and wind color at most is white, and very the person itches bitterly, and that scratches then becomes skin ulcer in " Standards of Diagnosis and Treatment air door "." " urticaria person, the sound granule is had a nightmare among skin, the loathing of cold pruritus all over of generating heat and for example " surgery great achievement urticaria ".Classical prescription: exposure to the wind after sweating due to overstrain, Nai Cuo Rush.The little red complexion of heat, heat is darkish complexion very., control and should lung heat clearing fall expectorant and induce sweat at lung by expectorant heat.”

The urticaria clinical manifestation is the localized edema welt that differs in size.The welt color can be cerise, pale red, pale asphyxia or skin-color, and form can rounded, oval, annular or irregular shape.Welt can take place suddenly in several minutes, can disappear in several minutes to a few hours, did not stay any vestige, but this plays that again, outbreak repeatedly.Its Clinical symptoms is stepped back no vestige for taking place rapidly and disappearing, and itches with play.Severe patient can be with headache, dizziness, arthralgia, stomachache, nausea,vomiting,diarrhea, uncomfortable in chest, nervous, hoarseness, dyspnea, severe patient can occur that laryngeal edema, pale complexion, heart rate quicken, anaphylactic shock such as pulse is thin and delicate, blood pressure drops, confusion, threat to life.Clinical in course of disease length, generally anxious onset, the course of disease was called acute urticaria at three months with interior person, and its morbidity is hurried, the welt number is more, how with General Symptoms; Welt shows effect repeatedly and is called chronic urticaria above person more than three months, and is few for a long time during its welt, but most welt is less, and General Symptoms is lighter.

The common cause of disease of urticaria has: 1. food: as fish, shrimp, Eriocheir sinensis, egg or milk etc.2. medicine: penicillin, furazolidone, serum, vaccine etc.3. infect: tonsillitis, viral hepatitis, Enterozoa etc.4. animal and plant factor: as sucking scurf, feather or the pollen etc. of animal.5. physics and chemical factor: as hot and cold, daylight, friction and pressure etc.6. internal organs and general disease and nervously all can bring out primary disease.

Urticaria also has specific type urticaria, (1) peptone urticaria (acute protein anaphylaxis urticaria) except that being divided into acute urticaria and chronic urticaria.(2) cold urticaria is divided into again: familial cold urticaria and acquired cold urticaria.(3) heat urticaria.(4) cholinergic urticaria.(5) solar urticaria.(6) pressure urticaria.(7) aquagenic urticaria.(8) serum sickness urticaria.(9) autoimmunity Progesterone urticaria.(10) angioedema (huge urticaria).(11) factitial urticaria.Acute urticaria disappeared through a few days or several weeks, and reason is more easily traced, and disappeared rapidly after dispeling the cause of disease.Chronic urticaria is shown effect repeatedly, does not heal throughout the year.Cause of disease complexity is difficult to find out, lives, brings mentally very big misery and inconvenience to the patient.Serious symptom when its acute attack can cause the shock of suffocating, threat to life.Therefore, the problem of relevant prevention minimizing chronic urticaria recurrence is the difficult point of present clinical treatment aspect.

The Chinese traditional treatment acute urticaria is single can to obtain good curative effect with treatment by Chinese herbs.Clinical syndrome differentiation is based on excess syndrome, heat syndrome, and common card has pattern of syndrome such as wind heat, blood hot air wind producing, the intestines and stomach be damp and hot, and ailment said due to cold or exposure is a main external cause, treats antipruritic based on dispelling wind; Be equipped with the medicine of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, clearing away heat and cooling blood, heat clearing away purging FU-organs intestinal stasis relieving respectively.The chronic urticaria Chinese medical discrimination is many with deficiency syndrome, blood stasis syndrome.Common pattern of syndrome has: insufficiency of the spleen catching cold, weakened defensive QI; Deficiency of qi and blood; Give birth in the hepatic and renal YIN deficiency, wind syndrome caused by deficiency; Qi depression to blood stasis; Chong and Ren channel disorder etc.Treat respectively with invigorating the spleen and benefiting QI the cold expelling consolidating superficial resistance; Benefiting QI and nourishing blood, dispelling wind is antipruritic; Adjusting and reinforcing liver and kidney, nourishing blood to stop wind syndrome; Blood circulation promoting and blood stasis dispelling, dispelling wind for relieving itching; Regulating thoroughfare and controlling vessel is a method.

Doctor trained in Western medicine thinks that urticaria will prevent its recurrence, at first when finding clear and definite its cause of disease, is removed.But often the cause of disease is difficult to find clinically.So present western medical treatment is symptomatic treatment mostly.Traditional antihistaminic has stronger maincenter inhibition ability easily to produce the drowsiness side effect that waits, and the antihistaminic of a new generation does not have side effect such as drowsiness as astemizole, loratadine, cetirizine etc., and its short term effect is better, but late result is relatively poor.This is concerning treatment of Chronic Urticaria and reduce its relapse rate, and curative effect is often not ideal enough.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the urticarial Chinese medicine decoction of a kind of treatment.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Radix Rehmanniae Preparata of 1.5～6 parts of Poria of the Radix Astragali

1.0～4 parts of 1.0～4 parts of Radix Glycyrrhizae Preparatas of 1.5～6 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

0.1～2 part of 1.0～4 parts of Zaocys of 1.5～6 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

0.1～2 part of 0.1～2 portion of Bombyx Batryticatus of 1.0～4 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae Preparata of 2.5～3.5 parts of Poria of the Radix Astragali

1.5～2.5 parts of 1.5～2.5 parts of Radix Glycyrrhizae Preparatas of 2.5～3.5 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

0.5～1.5 part of 1.5～2.5 parts of Zaocys of 2.5～3.5 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

0.5～1.5 part of 0.5～1.5 portion of Bombyx Batryticatus of 1.5～2.5 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 parts of Radix Rehmanniae Preparata of 3 parts of Poria of the Radix Astragali

2 parts of 2 parts of Radix Glycyrrhizae Preparatas of 3 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

1 part of 2 parts of Zaocys of 3 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

1 part of 1 portion of Bombyx Batryticatus of 2 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

Drug action mechanism among the present invention is as follows:

Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.What be used for that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).

Radix Saposhnikoviae nature and flavor suffering, sweet, temperature.Return bladder, liver, spleen channel.Have inducing diaphoresis to dispel wind, win and wet, the effect of relieving convulsion.Can treat headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus etc.(the 117th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Rhizoma Atractylodis Macrocephalae property of medicine hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Paeoniae Alba nature and flavor hardship, acid, be slightly cold.Return liver, spleen channel.Effect with suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, antibiotic, thrombocytosis.Can treat that the pain over the hypochondriac region, dysentery stomachache, night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, headache are dizzy, limb pain twin, blood deficiency and yellow complexion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 432nd page).

The Poria nature and flavor are sweet, flat, light.GUIXIN, lung, spleen, kidney channel.Has eliminating dampness and diuresis, the effect of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Can treat that dysuria, edema distension, phlegm retention cough with dyspnea, brain are throbbed with fear, have loose bowels in the loose stool, irritability, palpitation with fear, insomnia, forgetful, seminal emission, stranguria with turbid discharge, insufficiency of the spleen, stop that drink is not eaten, gastral cavity is vexed, three YIN malaria (malaria pathogen in three YIN) disease, heating do not heal, end empty YANG-depletion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 898th page).

Ramulus Cinnamomi property of medicine suffering, sweet, temperature.Return bladder, the heart, lung meridian.Has expelling cold and relieving exterior syndrome, warming the meridian, the effect of activating yang.Can treat exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.(the 2522nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Paeoniae Rubra nature and flavor suffering, hardship, flavor are trembled with fear.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, traumatic injury, carbuncle skin infection etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 659th page).

The Radix Rehmanniae Preparata nature and flavor are sweet, tepor.Return liver, kidney channel.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair etc.(the 95th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Radix Glycyrrhizae Preparata property of medicine is sweet, and is flat.Return spleen, stomach, the heart, lung meridian.Have and middle emergency lung moistening, detoxifcation, the effect of coordinating the actions of various ingredients in a prescription.Can treat weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, consumptive lung disease cough; Give birth to controlling laryngopharynx swelling and pain, the carbuncle pyogenic infections from tumour or sore, infantile carbuncle reaches medicine, alimentary toxicosis etc.(the 792nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Periostracum Cicadae nature and flavor are sweet, salty, cold.Return lung, Liver Channel.Has diffusing wind heat extraction, sore-throat relieving, rash, nebula removing, the effect of spasmolytic.Can treat anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1254th page).

The Zaocys property of medicine is sweet, and is flat.Return lung, spleen, Liver Channel.Has wind-damp dispelling, the meridian dredging, the effect of relieving convulsion.Can treat rheumatoid arthritis stubborn, numbness of the skin, the contracture of muscle arteries and veins, quadriplegia, tetanus, leprosy, rubella scabies etc.(the 667th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Bombyx Batryticatus property of medicine suffering, salty, flat.Return liver, lung, stomach warp.Have and expelling wind and relieving convulsion, dissipating phlegm and resolving masses, the effect of resolving toxin and disinhibiting the throat.Infantile convulsion be can treat and apoplexy facial hemiparalysis, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore etc. twitched.(the 1021st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Flos Lonicerae, Cortex Mori and Fructus Forsythiae; With Herba Houttuyniae, Fructus Arctii, Radix Isatidis, Herba Schizonepetae, Herba Spirodelae and Fructus Gardeniae is ministerial drug; With Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi) and Concha Margaritifera is adjuvant.All medicines are harmonious, tool invigorating the spleen and benefiting QI altogether, the effect of the consolidating superficial resistance that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.The treatment urticaria has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment urticaria of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat urticaria, and urticarial prevention is also had good effect, and the treatment urticaria has determined curative effect, has no side effect taking convenience, cheap characteristics.

Further specify medicine of the present invention to treating urticarial therapeutic effect below by the clinical practice example.The urticaria curative effect determinate standard: 1. cure: welt disappears, and clinical sign disappears, and the person does not reaccess.2. take a turn for the better: welt disappear 30% or the back recurrent interval time that disappears prolong sx persons such as pruritus.3. do not heal: welt and pruritus do not have obvious improver, or the less than 30% that disappears.(the 859th page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).

For showing medicine of the present invention, as follows through clinical test results to treating urticarial therapeutic effect; Treatment urticaria patient 45 examples, male's 22 examples, women's 23 examples, the age is 18～55 years old.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.36 examples of fully recovering account for 80%, and 6 examples that take a turn for the better account for 13.3%, and more 3 examples do not account for 6.7%, and total effective rate reaches 93.3%.After three course of therapy, symptoms such as patient's welt and pruritus all have clear improvement or fully recover.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 parts of Radix Rehmanniae Preparata of 3 parts of Poria of the Radix Astragali

2 parts of 2 parts of Radix Glycyrrhizae Preparatas of 3 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

1 part of 2 parts of Zaocys of 3 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

1 part of 1 portion of Bombyx Batryticatus of 2 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The urticaria decoction plastic packaging that the present invention makes is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.One month is a course of treatment.

Claims (3)

1, the urticarial Chinese medicine decoction of a kind of treatment is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Radix Rehmanniae Preparata of 1.5～6 parts of Poria of the Radix Astragali

1.0～4 parts of 1.0～4 parts of Radix Glycyrrhizae Preparatas of 1.5～6 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

0.1～2 part of 1.0～4 parts of Zaocys of 1.5～6 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

0.1～2 part of 0.1～2 portion of Bombyx Batryticatus of 1.0～4 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

2, the urticarial Chinese medicine decoction of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae Preparata of 2.5～3.5 parts of Poria of the Radix Astragali

1.5～2.5 parts of 1.5～2.5 parts of Radix Glycyrrhizae Preparatas of 2.5～3.5 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

0.5～1.5 part of 1.5～2.5 parts of Zaocys of 2.5～3.5 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

0.5～1.5 part of 0.5～1.5 portion of Bombyx Batryticatus of 1.5～2.5 portions of Periostracum Cicadaes of the Radix Paeoniae Alba

3, the urticarial Chinese medicine decoction of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 2 parts of Radix Rehmanniae Preparata of 3 parts of Poria of the Radix Astragali

2 parts of 2 parts of Radix Glycyrrhizae Preparatas of 3 parts of Ramulus Cinnamomi of Radix Saposhnikoviae

1 part of 2 parts of Zaocys of 3 parts of Radix Paeoniae Rubra of the Rhizoma Atractylodis Macrocephalae

1 part of 1 portion of Bombyx Batryticatus of 2 portions of Periostracum Cicadaes of the Radix Paeoniae Alba