CN101018788B - 吡咯并[3,2-c]吡啶衍生物及其制备方法 - Google Patents

吡咯并[3,2-c]吡啶衍生物及其制备方法 Download PDF

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Publication number
CN101018788B
CN101018788B CN200580029382XA CN200580029382A CN101018788B CN 101018788 B CN101018788 B CN 101018788B CN 200580029382X A CN200580029382X A CN 200580029382XA CN 200580029382 A CN200580029382 A CN 200580029382A CN 101018788 B CN101018788 B CN 101018788B
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CN
China
Prior art keywords
pyrrolo
pyridine hydrochloride
dimethyl
tetrahydroisoquinoline
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200580029382XA
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English (en)
Chinese (zh)
Other versions
CN101018788A (zh
Inventor
金在圭
安秉乐
李赫雨
尹锡湲
尹永爱
金东勋
琴世薰
申瑛娥
姜熙日
崔龙(已死亡)
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Yuhan Corp
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Yuhan Corp
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Publication of CN101018788A publication Critical patent/CN101018788A/zh
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Publication of CN101018788B publication Critical patent/CN101018788B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200580029382XA 2004-09-03 2005-09-03 吡咯并[3,2-c]吡啶衍生物及其制备方法 Expired - Fee Related CN101018788B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20040070536 2004-09-03
KR1020040070536 2004-09-03
KR10-2004-0070536 2004-09-03
PCT/KR2005/002924 WO2006025714A1 (en) 2004-09-03 2005-09-03 PYRROLO[3,2-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
CN101018788A CN101018788A (zh) 2007-08-15
CN101018788B true CN101018788B (zh) 2010-08-25

Family

ID=36000316

Family Applications (1)

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CN200580029382XA Expired - Fee Related CN101018788B (zh) 2004-09-03 2005-09-03 吡咯并[3,2-c]吡啶衍生物及其制备方法

Country Status (16)

Country Link
US (2) US8148529B2 (enExample)
EP (1) EP1784402B1 (enExample)
JP (1) JP5126830B2 (enExample)
KR (1) KR100946219B1 (enExample)
CN (1) CN101018788B (enExample)
AT (1) ATE518858T1 (enExample)
AU (1) AU2005280738B2 (enExample)
BR (1) BRPI0514843A (enExample)
CA (1) CA2578880C (enExample)
DK (1) DK1784402T3 (enExample)
ES (1) ES2367312T3 (enExample)
MX (1) MX2007002214A (enExample)
PL (1) PL1784402T3 (enExample)
PT (1) PT1784402E (enExample)
RU (1) RU2378275C2 (enExample)
WO (1) WO2006025714A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017466A1 (en) * 2006-08-08 2008-02-14 Nycomed Gmbh Pharmaceutically active tetrahydroisoquinoline-substituted benzimidazole derivatives
JP5802898B2 (ja) 2009-07-09 2015-11-04 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
GB2517908A (en) * 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
CN103626767A (zh) * 2013-12-04 2014-03-12 上海药明康德新药开发有限公司 区域选择性的氮杂吲哚及其合成方法
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
JP7511326B2 (ja) 2015-10-09 2024-07-05 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物およびその方法
SG11201809922YA (en) 2016-05-31 2018-12-28 Kalvista Pharmaceuticals Ltd Pyrazole derivatives as plasma kallikrein inhibitors
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
RS63069B1 (sr) 2017-11-29 2022-04-29 Kalvista Pharmaceuticals Ltd Dozni oblici koji sadrže inhibitor kalikreina plazme
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
CN114206852A (zh) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
DE3269604D1 (en) 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
JP3465827B2 (ja) * 1993-02-24 2003-11-10 株式会社日清製粉グループ本社 アザインドール誘導体およびこれを有効成分とする抗潰瘍薬
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
CN1044811C (zh) * 1994-01-19 1999-08-25 三共株式会社 吡咯并哒嗪衍生物
CN1102144C (zh) 1994-08-13 2003-02-26 株式会社柳韩洋行 新的嘧啶衍生物及其制备方法
EP0849274A1 (en) * 1996-12-20 1998-06-24 Schering Aktiengesellschaft Bissteroidal compounds and their use for the preparation of chiral complexes
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
UA59433C2 (uk) * 1998-01-27 2003-09-15 Авентіс Фармасьютікалс Продактс Інк. ЗАМІЩЕНІ ОКСОАЗАГЕТЕРОЦИКЛІЧНІ ІНГІБІТОРИ ФАКТОРА Хa ТА ПРОМІЖНІ СПОЛУКИ ДЛЯ ЇХ ОТРИМАННЯ
ATE231862T1 (de) 1998-09-23 2003-02-15 Altana Pharma Ag Tetrahydropyridoether
US20040235867A1 (en) 2001-07-24 2004-11-25 Bilodeau Mark T. Tyrosine kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
cassy.4-substituted-1-methyl-1H-pyrrolo.journal of chemical reserach,synopses 1.1986,(1),4. *
ducrocq.azaindoles III.tetrahedron32 7.1976,32(7),773-780. *
girgis.the synthesis of 5-azaindoles.journal of heterocyclic chemistry26 2.1989,26(2),317-325. *

Also Published As

Publication number Publication date
CN101018788A (zh) 2007-08-15
US20090005409A1 (en) 2009-01-01
BRPI0514843A (pt) 2008-06-24
KR20060051002A (ko) 2006-05-19
CA2578880C (en) 2013-01-29
RU2007112108A (ru) 2008-10-10
HK1105977A1 (en) 2008-02-29
US8148529B2 (en) 2012-04-03
EP1784402A1 (en) 2007-05-16
DK1784402T3 (da) 2011-11-14
ES2367312T3 (es) 2011-11-02
JP5126830B2 (ja) 2013-01-23
US8513277B2 (en) 2013-08-20
RU2378275C2 (ru) 2010-01-10
EP1784402A4 (en) 2009-12-23
PT1784402E (pt) 2011-08-23
US20120065224A1 (en) 2012-03-15
CA2578880A1 (en) 2006-03-09
AU2005280738B2 (en) 2010-11-25
ATE518858T1 (de) 2011-08-15
WO2006025714A1 (en) 2006-03-09
MX2007002214A (es) 2007-05-07
PL1784402T3 (pl) 2011-12-30
AU2005280738A1 (en) 2006-03-09
EP1784402B1 (en) 2011-08-03
JP2008511618A (ja) 2008-04-17
KR100946219B1 (ko) 2010-03-08

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