AU2005280738B2 - Pyrrolo(3,2-c)pyridine derivatives and processes for the preparation thereof - Google Patents

Pyrrolo(3,2-c)pyridine derivatives and processes for the preparation thereof Download PDF

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Publication number
AU2005280738B2
AU2005280738B2 AU2005280738A AU2005280738A AU2005280738B2 AU 2005280738 B2 AU2005280738 B2 AU 2005280738B2 AU 2005280738 A AU2005280738 A AU 2005280738A AU 2005280738 A AU2005280738 A AU 2005280738A AU 2005280738 B2 AU2005280738 B2 AU 2005280738B2
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AU
Australia
Prior art keywords
pyrrolo
pyridine hydrochloride
tetrahydroisoquinolin
dimethyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005280738A
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English (en)
Other versions
AU2005280738A1 (en
Inventor
Byung-Nak Ahn
Ryong Choi
Heui-Il Kang
Se-Hoon Keum
Dong-Hoon Kim
Jae-Gyu Kim
Hyouk-Woo Lee
Young-Ah Shin
Suk-Won Yoon
Young-Ae Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of AU2005280738A1 publication Critical patent/AU2005280738A1/en
Application granted granted Critical
Publication of AU2005280738B2 publication Critical patent/AU2005280738B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2005280738A 2004-09-03 2005-09-03 Pyrrolo(3,2-c)pyridine derivatives and processes for the preparation thereof Ceased AU2005280738B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040070536 2004-09-03
KR10-2004-0070536 2004-09-03
PCT/KR2005/002924 WO2006025714A1 (en) 2004-09-03 2005-09-03 PYRROLO[3,2-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
AU2005280738A1 AU2005280738A1 (en) 2006-03-09
AU2005280738B2 true AU2005280738B2 (en) 2010-11-25

Family

ID=36000316

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005280738A Ceased AU2005280738B2 (en) 2004-09-03 2005-09-03 Pyrrolo(3,2-c)pyridine derivatives and processes for the preparation thereof

Country Status (16)

Country Link
US (2) US8148529B2 (enExample)
EP (1) EP1784402B1 (enExample)
JP (1) JP5126830B2 (enExample)
KR (1) KR100946219B1 (enExample)
CN (1) CN101018788B (enExample)
AT (1) ATE518858T1 (enExample)
AU (1) AU2005280738B2 (enExample)
BR (1) BRPI0514843A (enExample)
CA (1) CA2578880C (enExample)
DK (1) DK1784402T3 (enExample)
ES (1) ES2367312T3 (enExample)
MX (1) MX2007002214A (enExample)
PL (1) PL1784402T3 (enExample)
PT (1) PT1784402E (enExample)
RU (1) RU2378275C2 (enExample)
WO (1) WO2006025714A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017466A1 (en) * 2006-08-08 2008-02-14 Nycomed Gmbh Pharmaceutically active tetrahydroisoquinoline-substituted benzimidazole derivatives
EP2452680B1 (en) 2009-07-09 2019-12-18 RaQualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB2517908A (en) * 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
CN103626767A (zh) * 2013-12-04 2014-03-12 上海药明康德新药开发有限公司 区域选择性的氮杂吲哚及其合成方法
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
MA46427A (fr) 2015-10-09 2018-08-15 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
ME03794B (me) 2016-05-31 2021-04-20 Kalvista Pharmaceuticals Ltd Derivati pirazola kao inhibitori kalikreina plazme
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
PL3716952T3 (pl) 2017-11-29 2022-05-02 Kalvista Pharmaceuticals Limited Postacie dawkowania zawierające inhibitor kalikreiny osoczowej
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068378B1 (en) 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
JP3465827B2 (ja) * 1993-02-24 2003-11-10 株式会社日清製粉グループ本社 アザインドール誘導体およびこれを有効成分とする抗潰瘍薬
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
HU225920B1 (en) * 1994-01-19 2008-01-28 Sankyo Co Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0775120B1 (en) 1994-08-13 2003-06-04 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof
EP0849274A1 (en) * 1996-12-20 1998-06-24 Schering Aktiengesellschaft Bissteroidal compounds and their use for the preparation of chiral complexes
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) * 1997-11-28 1997-11-28 Astra Ab New compounds
YU47600A (sh) * 1998-01-27 2002-09-19 Aventis Pharmaceuticals Products Inc. SUPSTITUISANI OKSOAZAHETEROCIKLIL INHIBITORI FAKTORA Xa
WO2000017200A1 (en) 1998-09-23 2000-03-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyridoethers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CASY, A. F. et al: "4-Substituted-1-methyl-1H-pyrrolo[3,2-c]pyridines", J. Chem. Research, Synopses, 1986, 1, 4. *
DUCROCQ C. et al: "Azaindoles - III Synthese De L'Amino-4- Aza-5 Indole Et Du N-5 Ribonucleoside Correspondant (Iso-Deaza-1 Tubercidine)", Tetrahedron, 1976, 32(7), 773-780. *
GIRGIS N. S. et al: "The Synthesis of 5-Azaindoles by Substitution-Rearrangement of 7-Azaindoles upon Treatment with Certain Primary Amines", J. Heterocyclic Chem., 1989, 26(2), 317-325. *

Also Published As

Publication number Publication date
EP1784402A4 (en) 2009-12-23
PT1784402E (pt) 2011-08-23
ATE518858T1 (de) 2011-08-15
AU2005280738A1 (en) 2006-03-09
RU2007112108A (ru) 2008-10-10
EP1784402A1 (en) 2007-05-16
CN101018788A (zh) 2007-08-15
US20120065224A1 (en) 2012-03-15
CA2578880A1 (en) 2006-03-09
RU2378275C2 (ru) 2010-01-10
US8513277B2 (en) 2013-08-20
HK1105977A1 (en) 2008-02-29
KR100946219B1 (ko) 2010-03-08
JP2008511618A (ja) 2008-04-17
EP1784402B1 (en) 2011-08-03
US20090005409A1 (en) 2009-01-01
PL1784402T3 (pl) 2011-12-30
WO2006025714A1 (en) 2006-03-09
JP5126830B2 (ja) 2013-01-23
MX2007002214A (es) 2007-05-07
CA2578880C (en) 2013-01-29
KR20060051002A (ko) 2006-05-19
CN101018788B (zh) 2010-08-25
US8148529B2 (en) 2012-04-03
DK1784402T3 (da) 2011-11-14
ES2367312T3 (es) 2011-11-02
BRPI0514843A (pt) 2008-06-24

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired