CN100584341C - The concealing method of the stench flavor of animal tcm granule - Google Patents
The concealing method of the stench flavor of animal tcm granule Download PDFInfo
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- CN100584341C CN100584341C CN200710134316A CN200710134316A CN100584341C CN 100584341 C CN100584341 C CN 100584341C CN 200710134316 A CN200710134316 A CN 200710134316A CN 200710134316 A CN200710134316 A CN 200710134316A CN 100584341 C CN100584341 C CN 100584341C
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Abstract
The present invention relates to the concealing method of the stench flavor of a kind of animal tcm granule, belong to animal tcm granule preparing technical field.Described method comprises following process: animal tcm dry extract, micropowder silica gel, pregelatinized Starch, Herba Menthae essence and Fructus Citri Limoniae essence are fully mixed, add 90% ethanol system granule, oven dry, make the animal tcm granule that does not have stench flavor, the weight portion of wherein said each raw material composition is: 100 parts of animal tcm dry extracts, micropowder silica gel 0.1-0.5 part, pregelatinized Starch 1-3 part, Herba Menthae essence 0.5-2 part, Fructus Citri Limoniae essence 0.5-2 part, 90% ethanol 15-30 part.The present invention can cover the stink of animal tcm granule raw meat.
Description
Technical field
The present invention relates to the animal tcm granule, especially the concealing method of the stench flavor of animal tcm granule.Belong to animal tcm granule preparing technical field.
Background technology
Chinese medicinal granule is to be raw material with the prepared slices of Chinese crude drugs, the granule that adopts methods such as extraction, cryoconcentration, drying to make.It both can supply clinical flexible prescription, and allotment is taken after mixing it with water, and can be used as the raw material of industry of Chinese medicine preparation again.
Animal kind medicine mainly contains compositions such as protein, alkaloid.The protease that protein produces via microbial reproduction decomposes generation aminoacid, deamination, decarboxylating and Oxidation take place and form intermediate product and the little product of molecular weight in aminoacid again, as indole, putrescine, tyramine, histamine, fatty acid etc., generate hydrogen sulfide, methane, ammonia, mercaptan etc. at last, meanwhile, also with fatty acid and sugared decomposition, Zhi Fang oxidation Decomposition particularly, can produce intensive foul smell, therefore, animal medicinal material all has unpleasant stench flavor.Animal medicinal material is in concocting the course of processing, though the stench flavors of place to go part such as process processed with wine, vinegar system,, make granule through water extraction, drying, still have strong stench the flavor.When hospital clinical was filled a prescription, intensive stench flavor made patient be difficult to accept, and was difficult to take, even the vomiting phenomenon occurred, had a strong impact on the particularly clinical practice of animal tcm granule of Chinese medicinal granule.
Chinese medicine preparation is traditional covers stench flavor method two kinds usually, and coating (tablet) is covered stench flavor behind a kind of employing tabletting, a kind of make granule after encapsulated (capsule) cover stench flavor.Above-mentioned two kinds of dosage forms all adopt hot water to take, and medicine does not disperse in the oral cavity, has avoided the stop of stench flavor in the oral cavity, and the patient is easy to receive.And the instructions of taking of Chinese medicinal granule is taken for behind the hot water dissolving, and medicine disperses in hot water earlier, and the stench flavor of animal tcm granule discharges in water simultaneously, and when taking, stench flavor causes the discomfort of olfactory sensation, the sense of taste, is difficult to take.Therefore, above-mentioned two kinds of dosage forms are not suitable for especially animal tcm granule of Chinese medicinal granule.
The concealing method of the stench flavor of animal tcm granule does not appear in the newspapers.
Summary of the invention
The objective of the invention is to overcome above-mentioned deficiency, a kind of concealing method that is applicable to the stench flavor of animal tcm granule is provided.
The present invention is realized by following technical proposals: the concealing method of the stench flavor of a kind of animal tcm granule, described method comprises following process: animal tcm dry extract, micropowder silica gel, pregelatinized Starch, Herba Menthae essence and Fructus Citri Limoniae essence are fully mixed, add 90% ethanol system granule, oven dry, make the animal tcm granule that does not have stench flavor, the weight portion of wherein said each raw material composition is:
100 parts of animal tcm dry extracts
Micropowder silica gel 0.1-0.5 part
Pregelatinized Starch 1-3 part
Herba Menthae essence 0.5-2 part
Fructus Citri Limoniae essence 0.5-2 part
90% ethanol 15-30 part.
The concealing method of the stench flavor of animal tcm granule of the present invention, the weight portion of described each raw material composition is:
100 parts of animal tcm dry extracts
Micropowder silica gel 0.2-0.4 part
Pregelatinized Starch 1.5-2.5 part
Herba Menthae essence 0.5-1 part
Fructus Citri Limoniae essence 0.5-1 part
90% ethanol 15-25 part.
Micropowder silica gel is the anhydrous powder of lightweight white colloidal silica gel, and odorless, tasteless has good flowability, can make powder or particulate mobile increasing, and can make the medicated powder mix homogeneously.
Pregelatinized Starch, disintegrate is rapid, and good water solubility can be accelerated the dissolving of granule in water.
Herba Menthae essence, Fructus Citri Limoniae essence are edible powdered essence, and pleasant fragrance is distributed in easily dissolving in water, and joyful olfactory sensation, the sense of taste can make the popular feeling refreshing frank; Can also cover the abnormal smells from the patient of component unhappiness (stench flavor), be easy to receive, be convenient to take.
Ethanol on the one hand as the wetting agent of granulating, has the effect of removing stench flavor on the other hand.
The invention has the advantages that:
1, this invention supplementary product consumption is few, and technology is simple, and is easy to operate, and the granule stability of making is good, dissolves in water, meets Chinese medicinal granule water towards instant medication characteristics.
2, the Herba Menthae essence and the Fructus Citri Limoniae essence of this invention use are edible essence, and soluble in water, fragrance is pleasant, can cover the unhappy abnormal smells from the patients such as stench flavor of animal tcm; The granule of making does not have stench flavor, and patient is easy to receive, and makes things convenient for clinical practice.
The specific embodiment:
Embodiment 1:
Get dried Pheretima extract powder 1000g, add micropowder silica gel 3.2g, pregelatinized Starch 19g, Herba Menthae essence 7g, Fructus Citri Limoniae essence 9g, fully mix, add 90% ethanol 200g, make granule, the Pheretima granule that does not have stench flavor is made in 60 ℃ of oven dry.
Embodiment 2:
Get Eupolyphaga Seu Steleophaga dry extract 1000g, add micropowder silica gel 3.5g, pregelatinized Starch 17g, Herba Menthae essence 8g, Fructus Citri Limoniae essence 7g, fully mix, add 90% ethanol 210g, make granule, the Eupolyphaga Seu Steleophaga granule that does not have stench flavor is made in 60 ℃ of oven dry.
Embodiment 3:
Get Bombyx Batryticatus dry extract 1000g, add micropowder silica gel 3.3g, pregelatinized Starch 18g, Herba Menthae essence 9g, Fructus Citri Limoniae essence 6g, fully mix, add 90% ethanol 220g, make granule, the Bombyx Batryticatus granule that does not have stench flavor is made in 60 ℃ of oven dry.
Claims (2)
1, the concealing method of the stench flavor of a kind of animal tcm granule, it is characterized in that described method is: animal tcm dry extract, micropowder silica gel, pregelatinized Starch, Herba Menthae essence and Fructus Citri Limoniae essence are fully mixed, add 90% ethanol system granule, oven dry, make the animal tcm granule that does not have stench flavor, the weight portion of wherein said each raw material composition is:
100 parts of animal tcm dry extracts
Micropowder silica gel 0.1-0.5 part
Pregelatinized Starch 1-3 part
Herba Menthae essence 0.5-2 part
Fructus Citri Limoniae essence 0.5-2 part
90% ethanol 15-30 part.
2, the concealing method of the stench flavor of a kind of animal tcm granule according to claim 1 is characterized in that the weight portion of described each raw material composition is:
100 parts of animal tcm dry extracts
Micropowder silica gel 0.2-0.4 part
Pregelatinized Starch 1.5-2.5 part
Herba Menthae essence 0.5-1 part
Fructus Citri Limoniae essence 0.5-1 part
90% ethanol 15-25 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710134316A CN100584341C (en) | 2007-10-10 | 2007-10-10 | The concealing method of the stench flavor of animal tcm granule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710134316A CN100584341C (en) | 2007-10-10 | 2007-10-10 | The concealing method of the stench flavor of animal tcm granule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101167744A CN101167744A (en) | 2008-04-30 |
| CN100584341C true CN100584341C (en) | 2010-01-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200710134316A Active CN100584341C (en) | 2007-10-10 | 2007-10-10 | The concealing method of the stench flavor of animal tcm granule |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100702B (en) * | 2011-01-20 | 2013-03-06 | 鲁南厚普制药有限公司 | Method for covering stinking smells of animal medicines |
| CN104740642A (en) * | 2015-03-05 | 2015-07-01 | 济南康众医药科技开发有限公司 | Preparation method of animal medicine powder |
| CN109043386A (en) * | 2018-06-21 | 2018-12-21 | 中国水产科学研究院南海水产研究所 | A kind of method that jewfish removes flavor and enhancing flavor |
| CN113908175B (en) * | 2021-10-21 | 2024-04-05 | 山西振东五和堂制药有限公司 | Spleen and kidney two-aid pill for removing fishy smell and production process thereof |
| CN114946892A (en) * | 2022-04-25 | 2022-08-30 | 广州至信药业股份有限公司 | Modified atmosphere curing agent for animal traditional Chinese medicine and preparation method thereof |
-
2007
- 2007-10-10 CN CN200710134316A patent/CN100584341C/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 掩盖药物不良臭味的研究进展. 张小滨等.中国医院药学杂志，第23卷第1期. 2003 |
| 掩盖药物不良臭味的研究进展. 张小滨等.中国医院药学杂志，第23卷第1期. 2003 * |
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| CN101167744A (en) | 2008-04-30 |
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Inventor after: Xu Yiliang Inventor after: Zhou Jialin Inventor after: Li Song Inventor after: Tang Bo Inventor before: Xu Yiliang Inventor before: Zhou Jialin Inventor before: Li Song Inventor before: Tang Bo |