JPH0491029A - Galenical drug blended chewable tablet - Google Patents

Abstract

PURPOSE:To stimulate the feeling of taste and smell in addition to direct action on gastric mucosa and enhance the secretion of saliva and gastric juice and the motility of alimentary canal by preparing a chewable tablet obtained by blending one or more kinds of galenical ordinary stomachics therein. CONSTITUTION:A medicine obtained by combining and blending one or more kinds of galenical drugs such as Cinnamini Cortex, Zingiberis Rhizoma, Atratylodis Lanceae Rhizoma, Menthae Herba, Curcumae Rhizoma, Swertiae Herba or Piscrasmae Lignum is blended with a sugar alcohol, cane sugar, lactose, etc., which are used as additives and the blend is prepared in the form of a chewable tablet. The chewable tablet disintegrates quickly in mouth by chewing and can be administered without water. Hardness thereof is preferably 5-15kg/cm<2>. The tablet is useful as a stomachic because the tablet enhances motility of stomach immediately after administration and the enhancing action id further long-active.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to Chugamma tablets containing crude drugs. More specifically, the present invention relates to chewable tablets that enhance the usefulness of stomach medicines containing herbal medicines.

[Conventional technology] Stomach medicines are drugs that stimulate the sense of taste and smell with bitterness and aroma, stimulate the reflex production of saliva and gastric juice, and increase the movement of digestive organs such as the stomach, and are made from crude drugs. (Pharmaceutical Encyclopedia, 1982, Section 175), and is a commonly used oral preparation (Clinically) for the treatment of anorexia, poor secretion of digestive juices, etc.
It is used as tablets, granules, powders, liquids, etc.).

Many of the herbal medicines used as health medicines contain aromatic, pungent, or bitter ingredients, and these ingredients have no effect other than directly stimulating the gastric mucosa, promoting the release of gastrin, and promoting the secretion of gastric juice. It is known that it stimulates the sense of taste and smell, promotes the secretion of saliva and gastric juice via the medulla oblongata, and promotes the movement of the gastrointestinal tract (Internal Medicine, Kaneko et al., L., 65).
(1987), Pharmacy, Seyo et al., AE, 39 (1984)
).

On the other hand, tinable tablets are tablets that are taken by chewing or dissolving in the mouth, and are only used in some sedatives and vitamin preparations.

[NHH to be solved by the invention] In the conventional oral preparations of general gastric medicines, the medicine reaches the stomach quickly after taking it, so it mainly acts directly on the gastric mucosa, stimulating the sense of taste and smell. I could hardly expect any effect.

Therefore, it has been desired to develop a preparation that can fully and sustainably exert the inherent pharmacological action of stomach medicines and enhance the usefulness of conventional stomach medicines.

[Means for Solving the Problems] The present inventors have discovered that in addition to having a direct effect on the gastric mucosa,
As a result of examining various formulations of stomach medicine that has the effect of stimulating the sense of smell and increasing the secretion of saliva and gastric juices as well as the movement of the gastrointestinal tract, the above-mentioned problem was solved by creating a medicine containing crude drugs in the form of Chicoable tablets. They discovered this and completed the present invention.

That is, the present invention relates to a chewable tablet containing a herbal medicine, and provides a chewable tablet that has strong, fast-acting, and long-lasting effects on the stomach.

In the present invention, herbal medicines are those containing one or more conventional stomachic medicines. Typical stomach medicines include, for example, Uiki Hokutsu, Keihi, /lI Ukirou, Soujikok,
Herbal medicines containing aromatic ingredients such as 100% maggot, 100% chimpanzee, 1x chimpi, scutellariae, and 100% sardine, 1x straw oil, 100% cinnamon oil, 1x raw mushroom oil, 1x oil, 1x chili
Essential oils such as uno oil, spruce oil, pepper oil, and lemon oil, herbal medicines containing pungent ingredients such as turmeric and chili pepper, orientale, gentian, koubok, sembuha bittern,
Examples include crude drugs containing bitter components such as hops.

These crude drugs may be used alone or in combination of two or more. Further, these crude drugs may be used in combination with other pharmaceutically active ingredients.

In the tinable tablets of the present invention, additives used in the production of general tablets can be used as appropriate, unless there is any particular problem. For example, lactose, sugar alcohol, reduced maltose starch syrup, corn starch, Avicel, powdered sugar, excipients such as magnenium stearate, tenfun, /11 sugar, gelatin,
Binder such as gum arabic powder, methylcellulose, sodium dimethylcellulose, hydroquinopropylmethylcellulose, polyvinylpyrrolid 7, disintegrants such as carboxydimethylcellulose, L-hydroquinopropylcellulose, other flavoring agents, Adsorbents, preservatives, wetting agents, disintegration prolonging agents, etc. can be added as appropriate.

Chewable tablets need to be in a dosage form that quickly disintegrates in the mouth when chewed and can be taken without water, so additives include sugar alcohols such as mannitol, sorbitol, and quinlitol, white sugar, lactose, and powdered reduced maltose starch syrup. etc. are preferably blended.

In addition, if necessary, the formulation is designed to be easy to take in terms of taste by adding artificial sweeteners or the like.

The crude drug is usually added at a ratio of 1 to 30%, preferably 1 to 10%, to these additives.

There are no particular restrictions on the method of producing the chewable tablets of the present invention, and the chewable tablets can be produced by a direct tableting method, an indirect tableting method, etc., which are ordinary tablet manufacturing methods.

The hardness of the chewable tablet of the present invention is preferably 5 to 15 kg/cm 2 because it needs to be hard enough to be easily chewed.

[Effect] Next, the usefulness of the present invention will be explained by the effect on gastric motility in rats.

Male SD rats (approximately 200 g) were pre-fed for one week and used. After 24 hours of administration, the abdomen was opened under ether anesthesia, a small incision was made in the anterior and dorsal region, and a rubber balloon connected to a catheter and an intragastric injection force table were inserted and ligated and fixed. Furthermore, 1 ml of water was injected into the balloon, and the balloon catheter was connected to a low pressure transducer (LPU-0,1-
350°TM+).

After the rat was fully awake, changes in intragastric pressure due to spontaneous movement were amplified using an amplifier (TYPE 1236: Sanei v).
Recorder (to RECTT-HORIZ-8: Sanei!
8+). The drug was administered after the generation of spontaneous movements stabilized, and changes in intragastric pressure were recorded for 40 minutes.

The drug was prepared by suspending the ingredients of the following formulation in 0.4 ml of purified water to prepare a test solution.

The effectiveness was determined by comparing the frequency of cap contractions between simultaneous administration in the oral cavity and stomach, assuming the administration of Chicoable tablets, and administration only in the stomach, assuming a conventional oral formulation as a control example.

Prescription 2.5mg Wiki linseed oil 3.0mg Cinnamon oil 1.0mg Citrus chinensis oil 1.0mg Shibatsu Hanbatsu dried extract 5.0mg Hops dried extract 5.0mg Licorice extract powder 23
．． 0mg Prescription 2 Wiki-Kotsu Oil 2.5mg Cinnamon Oil
3. Omg butterfly oil
1.0mgm Licorice Dried Extract 5.0mg Soju Dry Extract 12.0mg Licorice Extract Powder
The 23.0 mg administration method was to simultaneously administer 0.2 to 1 of the test liquid into the oral cavity and further 0.2 to 1 into the stomach assuming a chewable tablet. As a control, 0.4 ml of the test solution was administered directly into the stomach assuming a conventional oral preparation.

Analysis of gastric motility is performed using methods such as TAKEUCH1 (Take
uchi et al., Dig, Dis, Se4. , 31
．． 1114-1122, (19g+1)), the contraction frequency per 10 minutes was measured. That is, 20CmH2
The number of contraction spikes showing 0 or more was measured at 10 minute intervals.

Note that the number of contractions before administration of the test solution was taken as 100%, and the change in frequency after administration was calculated.

The results are shown in the table below.

*; P<0. 05 As is clear from the table, there is a tendency to transiently suppress gastric motility when the drug is administered directly into the stomach in the form of a conventional oral preparation, whereas simultaneous intraoral and intragastric administration in the form of a chewable tablet Immediately after administration, gastric motility was altered, and furthermore, the drug showed a sustained action to increase motility. From this, the main point is that the administration method using chewable tablets is superior to the administration method using conventional oral preparations in terms of the strength, speed of onset (fast-acting), and sustainability of the gastric motility-promoting effect, and is extremely useful as a stomachic drug. It was done.

[Example] Next, the present invention will be specifically described with reference to Examples, but the present invention is not limited to these in any way.

In addition, the hardness of the tablets in the examples is /Uroinigel hardness Mt
(2E 'Jl: Dr. R. Sehlenuige
r & Co,). The disintegration time was determined in accordance with the Japanese Pharmacopoeia General Test Method Disintegration Test Method (2) Tablet section.

Example 1 Fennel oil 0.25%, cinnamon bark oil 03%, clove oil 0. ] 2% synthetic aluminum silicate and 1% magnesium stearate were added to a homogeneous mixture of reduced maltose starch syrup containing 0.5% hop dry extract and 0.5% hop dry extract to make 15 mm
Chewable tablets each weighing 1000 mg were prepared using a punch with a diameter of 100 mL.

The hardness of this chewable tablet is lO~13K g/c
m2 and disintegration time was 10-15 minutes.

Example 2 Mannitol mixed with 0.5% Wikitau oil, 0.6% cinnamon oil, 0.2% Chi, Maggot oil, and 59 1-menthol, 10% Macrogol 6000, 3% synthetic aluminum silicate, and stearin. A 500 mg chewable tablet was prepared by blending 1% magnesium/um acid with a 10 mm diameter punch.

The hardness of this chewable tablet is 8~I OK g/c
m2, disintegration time was 12-16 minutes.

Example 3 170 ml of purified water was added to a homogeneous mixture of 15 g of Nunjun dry extract, 10 g of 7m cow dry extract, 250 g of lactose, 680 g of mannitol, and log of hydrobovine/propyl cellulose and granulated.

After drying, 14 g of Wiki B, 2 Q g of cinnamon and Ig of magnesium/ium stearate were blended, and each 1000 mg Chicoable tablet was made using a 15 mm diameter punch.

The hardness of this chiniable tablet is 9-12 Kg/c
tn'', the disintegration time was 8-13 minutes.

Example 4 18 g of dried extract of Orensis oleracea, 170 g of dried extract of Kobokko, 75 g of dried extract of C. oleracea, 35 g of dried carrot extract, 1200 g of white sugar, lactose zoo
and 102 g of starch, and 40 g of purified water.
Add 0ml, granulate and dry. To 2000g of this granules,
5g of cinnamon bark oil and 2g of cinnamon oil and 2g of aluminum silicate
After adding 10 g of the mixed bed powdered at 0 g and 2 g of magnesium stearate and mixing uniformly, chewable tablets each weighing 900 mg were prepared using a 13 mm diameter pestle.

The hardness of this chairable tablet is lO~13K g/c
m2, disintegration time was 12-15 minutes.

[Effects of the invention] The chewable tablet containing the herbal medicine of the present invention not only has a direct effect on the gastric mucosa, but also stimulates the sense of taste and smell and strongly, rapidly, and sustainably stimulates saliva and gastric juice secretion and gastrointestinal motility. It also has a stimulating effect, making it extremely useful as a stomachic medicine.

Claims (1)

[Claims] Chewable tablets characterized by containing crude drugs