CN100579583C - 用于＂cest＂应用的磁共振位移试剂和包含可交换质子的底物的加合物 - Google Patents

用于＂cest＂应用的磁共振位移试剂和包含可交换质子的底物的加合物 Download PDF

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Publication number
CN100579583C
CN100579583C CN200480009565.0A CN200480009565A CN100579583C CN 100579583 C CN100579583 C CN 100579583C CN 200480009565 A CN200480009565 A CN 200480009565A CN 100579583 C CN100579583 C CN 100579583C
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iii
cest
paramagnetic
free
iron
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CN200480009565.0A
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Chinese (zh)
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CN1809386A (zh
Inventor
S·艾梅
E·泰雷诺
D·德利卡斯泰利
G·B·焦文扎纳
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Bracco Imaging SpA
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Bracco Imaging SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Iron (AREA)
  • Soft Magnetic Materials (AREA)
CN200480009565.0A 2003-04-11 2004-04-06 用于＂cest＂应用的磁共振位移试剂和包含可交换质子的底物的加合物 Expired - Fee Related CN100579583C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03008456.0 2003-04-11
EP03008456A EP1466629A1 (en) 2003-04-11 2003-04-11 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications

Publications (2)

Publication Number Publication Date
CN1809386A CN1809386A (zh) 2006-07-26
CN100579583C true CN100579583C (zh) 2010-01-13

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CN200480009565.0A Expired - Fee Related CN100579583C (zh) 2003-04-11 2004-04-06 用于＂cest＂应用的磁共振位移试剂和包含可交换质子的底物的加合物

Country Status (9)

Country Link
US (1) US8945512B2 (https=)
EP (3) EP1466629A1 (https=)
JP (1) JP4891763B2 (https=)
CN (1) CN100579583C (https=)
AT (1) ATE444763T1 (https=)
AU (1) AU2004228932B2 (https=)
DE (1) DE602004023492D1 (https=)
WO (1) WO2004089424A1 (https=)
ZA (1) ZA200508155B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006086343A2 (en) * 2005-02-07 2006-08-17 The Johns Hopkins University Chemical exchange saturation transfer based mri using reporter genes and mri methods related thereto
JP5638752B2 (ja) * 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1716870A1 (en) * 2005-04-29 2006-11-02 Bracco Imaging S.p.A. MRI contrast agents endowed with concentration independent responsiveness
EP1907873B1 (en) * 2005-07-21 2015-02-25 Johns Hopkins University Non-invasive mri measurement of tissue glycogen
DE102007039899B3 (de) * 2007-08-23 2009-04-09 Siemens Ag Sensor zum Ermöglichen des Nachweises einer Substanz im Körper eines Lebewesens
WO2011075476A1 (en) * 2009-12-14 2011-06-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Methods and compositions relating to reporter gels for use in mri techniques
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
CN109963839A (zh) * 2016-09-19 2019-07-02 香港理工大学 手性轮环藤宁化合物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
WO2003013617A2 (de) * 2001-07-20 2003-02-20 Schering Ag Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5050609B1 (en) 1987-10-04 1999-11-02 Us Health Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging
JPH04501723A (ja) * 1988-11-09 1992-03-26 アンガー，エヴァン，シー． リポソーム性放射線造影剤
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤
GB9420390D0 (en) * 1994-10-10 1994-11-23 Nycomed Salutar Inc Liposomal agents
JP2002512942A (ja) * 1998-04-28 2002-05-08 ヤーゴウテック アーゲー ヒアルロナン系像形成剤
EP1178837A2 (en) * 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
CA2322344A1 (en) * 1999-12-08 2001-06-08 Mallinckrodt Inc. Non-covalent bioconjugates useful for magnetic resonance imaging
EP1406669A2 (en) * 2000-10-31 2004-04-14 Bracco International B.V. Conjugates of an antioxidants with metal chelating ligands
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
WO2003013617A2 (de) * 2001-07-20 2003-02-20 Schering Ag Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie

Also Published As

Publication number Publication date
EP2116267A1 (en) 2009-11-11
EP1466629A1 (en) 2004-10-13
US20070036727A1 (en) 2007-02-15
WO2004089424A1 (en) 2004-10-21
EP1613358A1 (en) 2006-01-11
AU2004228932A1 (en) 2004-10-21
DE602004023492D1 (de) 2009-11-19
AU2004228932B2 (en) 2009-11-05
JP4891763B2 (ja) 2012-03-07
ZA200508155B (en) 2007-01-31
EP1613358B1 (en) 2009-10-07
AU2004228932A2 (en) 2004-10-21
US8945512B2 (en) 2015-02-03
CN1809386A (zh) 2006-07-26
JP2006522761A (ja) 2006-10-05
ATE444763T1 (de) 2009-10-15

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