DE602004023492D1 - Adducte zwischen nmr vershibungsreagenzen und substraten mit austauschbaren protonen für die "cest" anwendung - Google Patents

Adducte zwischen nmr vershibungsreagenzen und substraten mit austauschbaren protonen für die "cest" anwendung

Info

Publication number
DE602004023492D1
DE602004023492D1 DE602004023492T DE602004023492T DE602004023492D1 DE 602004023492 D1 DE602004023492 D1 DE 602004023492D1 DE 602004023492 T DE602004023492 T DE 602004023492T DE 602004023492 T DE602004023492 T DE 602004023492T DE 602004023492 D1 DE602004023492 D1 DE 602004023492D1
Authority
DE
Germany
Prior art keywords
iii
cest
protones
sharpening
adducts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004023492T
Other languages
German (de)
English (en)
Inventor
Silvio Aime
Enzo Terreno
Castelli Daniela Delli
Giovanni Battista Giovenzana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of DE602004023492D1 publication Critical patent/DE602004023492D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Iron (AREA)
  • Soft Magnetic Materials (AREA)
DE602004023492T 2003-04-11 2004-04-06 Adducte zwischen nmr vershibungsreagenzen und substraten mit austauschbaren protonen für die "cest" anwendung Expired - Lifetime DE602004023492D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03008456A EP1466629A1 (en) 2003-04-11 2003-04-11 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
PCT/EP2004/003684 WO2004089424A1 (en) 2003-04-11 2004-04-06 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications

Publications (1)

Publication Number Publication Date
DE602004023492D1 true DE602004023492D1 (de) 2009-11-19

Family

ID=32865006

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004023492T Expired - Lifetime DE602004023492D1 (de) 2003-04-11 2004-04-06 Adducte zwischen nmr vershibungsreagenzen und substraten mit austauschbaren protonen für die "cest" anwendung

Country Status (9)

Country Link
US (1) US8945512B2 (https=)
EP (3) EP1466629A1 (https=)
JP (1) JP4891763B2 (https=)
CN (1) CN100579583C (https=)
AT (1) ATE444763T1 (https=)
AU (1) AU2004228932B2 (https=)
DE (1) DE602004023492D1 (https=)
WO (1) WO2004089424A1 (https=)
ZA (1) ZA200508155B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006086343A2 (en) * 2005-02-07 2006-08-17 The Johns Hopkins University Chemical exchange saturation transfer based mri using reporter genes and mri methods related thereto
JP5638752B2 (ja) * 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1716870A1 (en) * 2005-04-29 2006-11-02 Bracco Imaging S.p.A. MRI contrast agents endowed with concentration independent responsiveness
EP1907873B1 (en) * 2005-07-21 2015-02-25 Johns Hopkins University Non-invasive mri measurement of tissue glycogen
DE102007039899B3 (de) * 2007-08-23 2009-04-09 Siemens Ag Sensor zum Ermöglichen des Nachweises einer Substanz im Körper eines Lebewesens
WO2011075476A1 (en) * 2009-12-14 2011-06-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Methods and compositions relating to reporter gels for use in mri techniques
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
CN109963839A (zh) * 2016-09-19 2019-07-02 香港理工大学 手性轮环藤宁化合物及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5050609B1 (en) 1987-10-04 1999-11-02 Us Health Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging
JPH04501723A (ja) * 1988-11-09 1992-03-26 アンガー，エヴァン，シー． リポソーム性放射線造影剤
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤
GB9420390D0 (en) * 1994-10-10 1994-11-23 Nycomed Salutar Inc Liposomal agents
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
JP2002512942A (ja) * 1998-04-28 2002-05-08 ヤーゴウテック アーゲー ヒアルロナン系像形成剤
EP1178837A2 (en) * 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
CA2322344A1 (en) * 1999-12-08 2001-06-08 Mallinckrodt Inc. Non-covalent bioconjugates useful for magnetic resonance imaging
EP1406669A2 (en) * 2000-10-31 2004-04-14 Bracco International B.V. Conjugates of an antioxidants with metal chelating ligands
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Also Published As

Publication number Publication date
EP2116267A1 (en) 2009-11-11
EP1466629A1 (en) 2004-10-13
US20070036727A1 (en) 2007-02-15
WO2004089424A1 (en) 2004-10-21
EP1613358A1 (en) 2006-01-11
AU2004228932A1 (en) 2004-10-21
AU2004228932B2 (en) 2009-11-05
JP4891763B2 (ja) 2012-03-07
ZA200508155B (en) 2007-01-31
EP1613358B1 (en) 2009-10-07
AU2004228932A2 (en) 2004-10-21
CN100579583C (zh) 2010-01-13
US8945512B2 (en) 2015-02-03
CN1809386A (zh) 2006-07-26
JP2006522761A (ja) 2006-10-05
ATE444763T1 (de) 2009-10-15

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