AU2004228932B2 - Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications - Google Patents

Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications Download PDF

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Publication number
AU2004228932B2
AU2004228932B2 AU2004228932A AU2004228932A AU2004228932B2 AU 2004228932 B2 AU2004228932 B2 AU 2004228932B2 AU 2004228932 A AU2004228932 A AU 2004228932A AU 2004228932 A AU2004228932 A AU 2004228932A AU 2004228932 B2 AU2004228932 B2 AU 2004228932B2
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AU
Australia
Prior art keywords
iii
paramagnetic
polyaminoacids
polysaccharides
cest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004228932A
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English (en)
Other versions
AU2004228932A1 (en
AU2004228932A2 (en
Inventor
Silvio Aime
Daniela Delli Castelli
Giovanni Battista Giovenzana
Enzo Terreno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
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Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of AU2004228932A1 publication Critical patent/AU2004228932A1/en
Publication of AU2004228932A2 publication Critical patent/AU2004228932A2/en
Application granted granted Critical
Publication of AU2004228932B2 publication Critical patent/AU2004228932B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Iron (AREA)
  • Soft Magnetic Materials (AREA)
AU2004228932A 2003-04-11 2004-04-06 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications Ceased AU2004228932B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03008456.0 2003-04-11
EP03008456A EP1466629A1 (en) 2003-04-11 2003-04-11 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
PCT/EP2004/003684 WO2004089424A1 (en) 2003-04-11 2004-04-06 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications

Publications (3)

Publication Number Publication Date
AU2004228932A1 AU2004228932A1 (en) 2004-10-21
AU2004228932A2 AU2004228932A2 (en) 2004-10-21
AU2004228932B2 true AU2004228932B2 (en) 2009-11-05

Family

ID=32865006

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004228932A Ceased AU2004228932B2 (en) 2003-04-11 2004-04-06 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications

Country Status (9)

Country Link
US (1) US8945512B2 (https=)
EP (3) EP1466629A1 (https=)
JP (1) JP4891763B2 (https=)
CN (1) CN100579583C (https=)
AT (1) ATE444763T1 (https=)
AU (1) AU2004228932B2 (https=)
DE (1) DE602004023492D1 (https=)
WO (1) WO2004089424A1 (https=)
ZA (1) ZA200508155B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006086343A2 (en) * 2005-02-07 2006-08-17 The Johns Hopkins University Chemical exchange saturation transfer based mri using reporter genes and mri methods related thereto
JP5638752B2 (ja) * 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1716870A1 (en) * 2005-04-29 2006-11-02 Bracco Imaging S.p.A. MRI contrast agents endowed with concentration independent responsiveness
EP1907873B1 (en) * 2005-07-21 2015-02-25 Johns Hopkins University Non-invasive mri measurement of tissue glycogen
DE102007039899B3 (de) * 2007-08-23 2009-04-09 Siemens Ag Sensor zum Ermöglichen des Nachweises einer Substanz im Körper eines Lebewesens
WO2011075476A1 (en) * 2009-12-14 2011-06-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Methods and compositions relating to reporter gels for use in mri techniques
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
CN109963839A (zh) * 2016-09-19 2019-07-02 香港理工大学 手性轮环藤宁化合物及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271924A (en) * 1991-10-04 1993-12-21 Nihon Medi-Physics Co., Ltd. Low molecular weight polysaccharide complexes for nuclear magnetic resonance imaging
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
EP1106186A2 (en) * 1999-12-08 2001-06-13 Mallinckrodt Inc. Non-covalent bioconjugates useful for magnetic resonance imaging
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
WO2003013617A2 (de) * 2001-07-20 2003-02-20 Schering Ag Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5050609B1 (en) 1987-10-04 1999-11-02 Us Health Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging
JPH04501723A (ja) * 1988-11-09 1992-03-26 アンガー，エヴァン，シー． リポソーム性放射線造影剤
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
GB9420390D0 (en) * 1994-10-10 1994-11-23 Nycomed Salutar Inc Liposomal agents
JP2002512942A (ja) * 1998-04-28 2002-05-08 ヤーゴウテック アーゲー ヒアルロナン系像形成剤
EP1178837A2 (en) * 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
EP1406669A2 (en) * 2000-10-31 2004-04-14 Bracco International B.V. Conjugates of an antioxidants with metal chelating ligands
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271924A (en) * 1991-10-04 1993-12-21 Nihon Medi-Physics Co., Ltd. Low molecular weight polysaccharide complexes for nuclear magnetic resonance imaging
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
EP1106186A2 (en) * 1999-12-08 2001-06-13 Mallinckrodt Inc. Non-covalent bioconjugates useful for magnetic resonance imaging
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
WO2003013617A2 (de) * 2001-07-20 2003-02-20 Schering Ag Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chem Eur J, 2000, 6(14): 2609-2617 *
Mag Res Med, 2002, 47: 639-48 *

Also Published As

Publication number Publication date
EP2116267A1 (en) 2009-11-11
EP1466629A1 (en) 2004-10-13
US20070036727A1 (en) 2007-02-15
WO2004089424A1 (en) 2004-10-21
EP1613358A1 (en) 2006-01-11
AU2004228932A1 (en) 2004-10-21
DE602004023492D1 (de) 2009-11-19
JP4891763B2 (ja) 2012-03-07
ZA200508155B (en) 2007-01-31
EP1613358B1 (en) 2009-10-07
AU2004228932A2 (en) 2004-10-21
CN100579583C (zh) 2010-01-13
US8945512B2 (en) 2015-02-03
CN1809386A (zh) 2006-07-26
JP2006522761A (ja) 2006-10-05
ATE444763T1 (de) 2009-10-15

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 10 OCT 2005

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired