CN100537556C - 单糖的端基异构衍生物 - Google Patents

单糖的端基异构衍生物 Download PDF

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Publication number
CN100537556C
CN100537556C CNB038073757A CN03807375A CN100537556C CN 100537556 C CN100537556 C CN 100537556C CN B038073757 A CNB038073757 A CN B038073757A CN 03807375 A CN03807375 A CN 03807375A CN 100537556 C CN100537556 C CN 100537556C
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CN
China
Prior art keywords
hydrogen
compound
group
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB038073757A
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English (en)
Chinese (zh)
Other versions
CN1642932A (zh
Inventor
维姆·莫特曼斯
迈克尔·利奥·韦斯特
江·青丽
乔治·亚当森
卡尔·谢弗
乔瓦尼·阿贝南特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chwast Biotech Pte Ltd
Original Assignee
Alchemia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN1642932A publication Critical patent/CN1642932A/zh
Application granted granted Critical
Publication of CN100537556C publication Critical patent/CN100537556C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
CNB038073757A 2002-03-28 2003-03-28 单糖的端基异构衍生物 Expired - Lifetime CN100537556C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPS1434A AUPS143402A0 (en) 2002-03-28 2002-03-28 Anomeric derivatives of monosaccharides
AUPS1434 2002-03-28

Publications (2)

Publication Number Publication Date
CN1642932A CN1642932A (zh) 2005-07-20
CN100537556C true CN100537556C (zh) 2009-09-09

Family

ID=3835023

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038073757A Expired - Lifetime CN100537556C (zh) 2002-03-28 2003-03-28 单糖的端基异构衍生物

Country Status (8)

Country Link
US (1) US7737287B2 (enExample)
EP (1) EP1487812A4 (enExample)
JP (1) JP4610197B2 (enExample)
CN (1) CN100537556C (enExample)
AU (1) AUPS143402A0 (enExample)
CA (1) CA2480578C (enExample)
DE (1) DE03745223T1 (enExample)
WO (1) WO2003082846A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138531B2 (en) 2001-10-15 2006-11-21 Kemin Pharma B.V.B.A. Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
AU2002950657A0 (en) 2002-08-08 2002-09-12 Alchemia Limited Derivatives of monosaccharides for drug discovery
AU2002951995A0 (en) 2002-10-11 2002-10-31 Alchemia Limited Classes of compounds that interact with gpcrs
US7125854B2 (en) 2003-01-07 2006-10-24 Kemin Pharma B.V.B.A. Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites
JP4707397B2 (ja) 2003-01-07 2011-06-22 ケミン・ファーマ・ヨーロッパ・ビー・ブイ・ビー・エイ Ｃ型肝炎及びウシウイルス性下痢のウイルスのようなフラビウイルス科に分類される種によって引き起こされる感染の治療に有用な二環式炭水化物化合物
US7368475B2 (en) 2003-03-12 2008-05-06 Kemin Pharma Bvba Furanose-type bicyclic carbohydrates with biological activity
US7098243B2 (en) 2003-09-16 2006-08-29 Kemin Pharma Europe B.V.B.A. Bicyclic carbohydrates as antiviral bioactives for the treatment of infections caused by the alphaherpesvirinae HSV-1 and HSV-2
AU2006209794B2 (en) * 2005-02-04 2010-07-08 Alchemia Limited Classes of compounds that interact with integrins
DE06704810T1 (de) * 2005-02-04 2008-05-21 Alchemia Ltd., Eight Mile Plains Mit integrinen interagierende verbindungsklassen
PL1934388T3 (pl) * 2005-10-04 2013-04-30 Alchemia Ltd Sposób projektowania leków
WO2007070947A1 (en) * 2005-12-22 2007-06-28 Alchemia Ltd Antibacterial agents
WO2021155317A1 (en) 2020-01-31 2021-08-05 Avilar Therapeutics, Inc. Asgpr-binding compounds for the degradation of extracellular proteins
KR20240017423A (ko) 2021-05-03 2024-02-07 아빌라 테라퓨틱스, 인크. 이뮤노글로불린 및 다른 단백질의 분해를 위한 강력한 asgpr-결합 화합물
US12116382B2 (en) 2022-11-28 2024-10-15 Hongene Biotech Corporation Functionalized N-acetylgalactosamine analogs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008799A1 (en) * 1996-08-26 1998-03-05 Alchemia Pty. Ltd. Oligosaccharide synthesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331664A (en) * 1976-09-02 1978-03-25 Suami T Production of novel nitroso urea derivatives
DE3347522A1 (de) * 1983-12-30 1985-07-11 Troponwerke GmbH & Co KG, 5000 Köln N-glycosylierte carbonsaeureamid-derivate als mittel bei der bekaempfung von erkrankungen des rheumatischen formenkreises
DE3521994A1 (de) * 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
HU208146B (en) * 1989-11-14 1993-08-30 Biogal Gyogyszergyar Process for producing aminobenzoic acid-n-glycoside derivatives
US5449785A (en) * 1991-07-24 1995-09-12 Hoffmann-La Roche Inc. Cyclohexane derivatives
JPH07242684A (ja) * 1994-03-02 1995-09-19 Japan Tobacco Inc 新規なグルクロン酸化合物
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
WO1997014709A1 (en) * 1995-10-13 1997-04-24 F. Hoffmann-La Roche Ag Antisense oligomers
JP2002502393A (ja) * 1997-05-29 2002-01-22 インカラ・ファーマシューティカルズ・コーポレーション 炭水化物骨格化合物及びライブラリー
US6197963B1 (en) * 1998-08-13 2001-03-06 The Trustees Of The University Of Pennsylvania Non-peptide peptidomimetics
CA2415368A1 (en) * 2000-07-13 2002-01-31 Yi Jin Synthesis and antiviral evaluation of nucleic acid based (nab) libraries
AUPR079700A0 (en) * 2000-10-17 2000-11-09 Alchemia Pty Ltd Combinatorial libraries of monosaccharides
AUPR084400A0 (en) 2000-10-18 2000-11-09 Alchemia Pty Ltd Immunoadjuvant systems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008799A1 (en) * 1996-08-26 1998-03-05 Alchemia Pty. Ltd. Oligosaccharide synthesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
'Carbohydrate based mimetics in drug design: sugar aminoacids and carbohydrate scaffolds'. GRUNER S.A.W. ET AL.CHEM. REVIEWS,Vol.102 . 2002 *
'Synthesis of oligomers of tetrahydrofuran amino acids:Furanose carbopeptides'. SMITH ET AL.CHEM. COMMUN.. 1998 *

Also Published As

Publication number Publication date
US7737287B2 (en) 2010-06-15
JP2005526813A (ja) 2005-09-08
WO2003082846A1 (en) 2003-10-09
JP4610197B2 (ja) 2011-01-12
EP1487812A1 (en) 2004-12-22
CN1642932A (zh) 2005-07-20
EP1487812A4 (en) 2006-07-26
CA2480578C (en) 2013-01-08
DE03745223T1 (de) 2007-05-03
AUPS143402A0 (en) 2002-05-09
CA2480578A1 (en) 2003-10-09
US20050245746A1 (en) 2005-11-03

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Effective date of registration: 20150911

Address after: Queensland, Australia

Patentee after: Chwast biotech Pte. Ltd.

Address before: Queensland, Australia

Patentee before: ALCHEMIA LTD.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20090909