CN100534523C - Health food having delaying senility and beautifying function and preparation method thereof - Google Patents

Abstract

The health food with functions of delaying senility and beautifying is prepared with soybean isoflavone, bupleurum root, angelica, white peony root, mint, white atractylodes rhizome, ginger, tuckahoe, licorice, vet C, vitamin E and excipient. It is prepared through compounding in certain proportion, separate extraction, spray drying, adding excipient, pelletizing in fluidized bed and tabletting.

Description

A kind of health food and preparation method thereof with slow down aging and beautification function

Technical field

The present invention relates to a kind of health food and preparation method thereof, belong to field of health care food with slow down aging and beautification function.

Background technology

Be the aging of delaying female physiological, developed country just brings into use Hormone Replacement Therapy from the fifties, and low dosage is taken the estrogens medicine over a long time, to keep the body inner estrogen in safe and rational level.But long-time clinical use is observed and is found that there is certain side effect in this therapy, and the people as nearly 1% can vaginal hemorrhage occur or vaginal secretions increases, distending pain of the breast, gastrointestinal reaction etc.; Next has potential carcinogenic danger and has more contraindication.Therefore, the natural extract of searching estrogen-like effects becomes one of focus of international research in recent years.

The soybean isoflavone that extracts from Semen sojae atricolor is present universally acknowledged " natural plants estrogen " safely and effectively, is that the product of active ingredient becomes the important dietary supplement of developed country's middle and aged women with the soybean isoflavone.Chinese patent CN1449763A discloses the invention of " soybean isoflavone aglycones composition and method of making the same and purposes ", and the total content of three kinds of isoflavone reaches 90-100% in the said composition, is used for the treatment of climacteric syndrome and person in middle and old age's occlusive cardiovascular and cerebrovascular disease.CN1401320A discloses a kind of by soybean isoflavone or daidzein 1-3 weight portion, the medicine of the treated climacteric syndrome that wolfberry fruit extract 1-3 weight portion is made.CN1416728A discloses with Semen sojae atricolor, Herba Epimedii, the Radix Astragali, Radix Angelicae Sinensis and Fructus Mori are effective ingredient, join again with the adjuvant calcium gluconate, carboxymethyl starch sodium and microcrystalline Cellulose are formed, and have the health food of bone density improving and delaying senility function.

On the other hand, cause that by decrease in estrogen the influence that the female pathology aging is produced is many-sided, the replacement therapy of single estrogen or natural estrogen sample material, though to a certain degree can relief of symptoms, but to endocrine dysfunction that has delayed or formed and the various degeneration variations that bring, the various clinical symptoms relevant with feelings will of lacking of proper care, effect is not satisfactory.

The XIAOYAO POWDER that is widely used in gynecological clinic, record the earliest in " formulary of peaceful benevolent dispensary ", by Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens is formed, this side's composition overwhelming majority is for medicine-food two-purpose or listed healthy food material list Chinese medicine composition in, with and not high, embellish but not dry, has dispersing the stagnated live-QI to relieve the stagnation of QI, the spleen invigorating of nourishing blood, the function of mediation whole body QI and blood, can obviously improve the mental status of human body, pharmacological research proves that this can endocrine regulation, regulate the central nervous system, health invigorating, effects such as hepatoprotective, clinical various gynecological diseases and the degenerative diseases of aged of being used for the treatment of.But onset is slow, need take the long period can take effect.

Summary of the invention

The object of the present invention is to provide a kind of health food with slow down aging and beautification function.

Another object of the present invention has provided the preparation method of this health food.

Technical scheme of the present invention is:

A kind of health food with slow down aging and beautification function, it mainly is to be made by the raw material of following weight portion: soybean isoflavone 1-6 part, Radix Bupleuri 2-6 part, Radix Angelicae Sinensis 2-6 part, Radix Paeoniae Alba 2-6 part, Herba Menthae 0.4-1.2 part, Rhizoma Atractylodis Macrocephalae 2-6 part, Rhizoma Zingiberis Recens 2-6 part, Poria 2-6 part, Radix Glycyrrhizae 1.6-4.8 part, vitamin C 0.6-4 part, vitamin E 0.3-2 part, excipient 0.1-40 part.

Optimized technical scheme has following:

Health food with slow down aging and beautification function, its excipient 7.8-40 part.

Health food with slow down aging and beautification function, its excipient is made up of following materials of weight proportions single or multiple combination: pregelatinized Starch 2.5-10 part, low-substituted hydroxypropyl cellulose 2.5-10 part, microcrystalline Cellulose 2.5-15 part, micropowder silica gel 0.1-2.5 part, hydroxypropyl emthylcellulose 0.2-5 part, cane sugar powder 0-20 part, mannitol 0-10 part.

Health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 10-90%.

Health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 30-50%.

Health food with slow down aging and beautification function, form are tablet, capsule, granule and powder.

Another object of the present invention is the preparation method that discloses the health food with slow down aging and beautification function, and the health food preparation of its tablet form is operated by following step:

(1) extract of prefabricated Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, Rhizoma Zingiberis Recens: get Radix Bupleuri by weight ratio, Radix Angelicae Sinensis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, add in the decoction pot, add 30-60 part water, soaked overnight, behind the heating extraction volatile oil C, decocting liquid filters, and medicinal residues add water 40-50 part again, heated and boiled 1 hour, the filtrate extract merges filtrate twice, leaves standstill cooling, filter, filtrate heating is condensed into the extractum that proportion is 1.0-1.3, and drying is the prefabricated extract A of Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, Rhizoma Zingiberis Recens;

(2) extract of the prefabricated Radix Paeoniae Alba, Poria, Radix Glycyrrhizae: get the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae by weight ratio, add in the Decocting pot, add the water of 15-30 part, soaked overnight, heating decocted 2 hours, the filtrate extract, medicinal residues add water 20-25 part again, heated and boiled 1 hour, filtrate extract, merge filtrate twice, leave standstill cooling, filter, the filtrate heating is condensed into the extractum that proportion is 1.0-1.3, drying promptly gets the prefabricated extract B of the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae;

(3) with the soybean isoflavone powder behind the crushing screening, prefabricated extract A, prefabricated extract B, vitamin E, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, pregelatinized Starch and vitamin C, divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer, its control process parameters is as follows: air intake 30-50 ℃, vibrate atomizing pressure 0.10-0.2bar, hydrojet speed 50-70g/ minute 2-6 time/minute, air door pressure 0.05-0.2mpa, auxiliary pneumatics 0.10-0.2mpa when treating that shaping particles is better, enters dry for the first time, inlet temperature is elevated to 60-90 ℃, vibrate air door pressure 0.1-0.3mpa, aux. pressure 0.10-0.2mpa 2-6 time/minute, when the granule water content is controlled at 0.5-3.5%, take out granule;

(4) granule that makes sifts out the parts of fine granule by 16 mesh sieve granulate with 60 order dusting covers, adds the volatile oil C that extract (1), mixing the back thoroughly adds in the material, add micropowder silica gel again, abundant airtight spending the night behind the mixing, put 21 in the rotary tablet machine tabletting, sift out fine powder, remove useless sheets such as loose sheet, sliver, stain, sampling inspection changes in the coating pan after qualified, with hydroxypropyl emthylcellulose coating materials coating, obtain finished product.

By the health food that prescription of the present invention is made, have the effect and the functions of removing chloasma of slow down aging and improve the beautification function of skin moisture, and health is had no adverse effects.

The invention has the advantages that: with soybean isoflavone and Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens reasonable compatibility, natural estrogen sample effect by soybean isoflavone, be equipped with XIAOYAO POWDER prescription endocrine regulation system and central nervous system functions such as Radix Bupleuri, Radix Angelicae Sinensis, simultaneously an amount of forced for vitamins C and vitamin E, reach treating both the principal and secondary aspects of a disease, can prevent the decline of women's ovarian function, postpone climacteric or improve menopause syndrome, prevention or postponement skin aging, prevention of osteoporosis and cardiovascular disease.

Soybean isoflavone raw material powder and XIAOYAO POWDER extract all have stronger hygroscopicity, and easily bonding is agglomerating after the moisture absorption, and phenomenons such as loose sheet, sliver, sticking appear in the very difficulty of operation of granulating easily in the tabletting process, and the disintegration of tablet time of extrusion surpasses the pharmacopeia regulation.The preparation technology that additional benefit of the present invention provides has successfully solved the problems referred to above, not only granulate, the tabletting process is smooth, and the hardness that is pressed into tablet can reach more than 4 kilograms, and the disintegration time of plain sheet is in 10 minutes.

By the further capable beneficial effect of setting forth health food of the present invention of following test.

Health food deferring senility experimental result of the present invention:

Sample source and processing: the health food tablet that anthology inventive embodiments 2 provides, the 0.6g/ sheet, it is 2.4g/ people/sky that human body is recommended daily intaking amount.Sample directly is mixed with the suspension of desired concn with distilled water, is provided with down test and uses.

1, drosophila survival experiment:

1.1 laboratory animal: OregonK wild type Drosophila melanogaster (Drosophila melanogaster) 1.2 method for breeding: adopt flat cultivation vial to cultivate, 20 of every pipes, in the constant temperature culture chamber that to put 25 ± 1 ℃ of relative humiditys be 45-75%, changed a subculture in per four days.Basal medium prescription following (is example with the 100ml cultivation):

Table 1

1.3 dosage: establish 1 blank group and 0.027%, 0.08%, 0.24%, 0.72% 4 dosage group.

1.4 experimental technique: collect in eight hours the new fruit bat adult that sprouts wings, etherization is distinguished the male and female random packet down, is experimentized after weighing respectively.Use 400 of fruit bats, male and female half and half for every group.Matched group gives conventional corn powder culture medium: conventional raise the culture medium that test group after 25 days contains sample 0.027%, 0.08%, 0.24%, 0.72% respectively.Every day observed and recorded drosophila survival number and death toll, till the whole death of fruit bat.Calculate three indexs such as the dead natural law of half, average life and average maximum life span.

1.5 result: see Table 1 as seen, sample tablet 0.08%, 0.24%, 0.72% dosage group can obviously prolong the average life of hero, female fruit bat, with the matched group comparing difference significance P＜0.01, P＜0.01, P＜0.05, P＜0.01, P＜0.01, P＜0.01 is arranged; 0.027%, 0.08%, 0.24%, 0.72% dosage group can obviously prolong the maximum life span of male drosophila, than difference significance is arranged compared with the control, P＜0.01, P＜0.01, P＜0.01, P＜0.05; 0.08%, 0.24%, 0.72% dosage group can obviously prolong the maximum life span of female fruit bat, the difference of comparing with matched group has significance, P＜0.05, P＜0.01, P＜0.01,0.08%, 0.24% dosage group male drosophila half death time respectively greater than matched group 6 days, 10 days, 0.08%, 0.24%, female fruit bat half death time of 0.72% dosage group respectively greater than matched group 7 days, 8 days, 8 days.

The influence that table 2 sample is tested drosophila survival (X ± SD)

Compare * P＜0.05 * * P＜0.01 with matched group

The average maximum life span of a is calculated by 20 fruit bats of longest-lived.

2, biochemical indicator detects:

2,1 test animal: SPF level Kunming kind female 12 the monthly age 40 of mices, 10 of 1 monthly age male mices, the animal feeding room temperature is 22-24 ℃, humidity is 65-80%.

2,2 dosage grouping: press MDA level grouping in the blood before the test, aged mouse is divided into 1 aged control and basic, normal, high dosage group at random.Recommend 5,10,20 times of human body daily intaking amount (2.4g/560kg.BW) to be equivalent to manufacturer, as basic, normal, high dosage group (corresponding actual dose be 0.20,0.40,0.80g/kg.BW).Basic, normal, high dosage group is pressed 0.10ml/10g.BW capacity per os with the sample distilled water preparation liquid of variable concentrations respectively and is irritated stomach; Matched group is irritated stomach and is given with the volume distilled water.

2,3 experimental techniques: after animal was fed one month continuously, eyeball was got blood, prepared 2% hemolysate, made 2% hemolysate MDA content and whole blood GSH-PX and measured, and preparation erythrocyte extract is made the erythrocyte sod vitality test.

2,4 statistical method: adopt EXCELL software to carry out the T check.

2,5 results: see Table 3,4, the basic, normal, high dosage group of this product can obviously reduce aged mouse 2% hemolysate MDA content, with aged matched group comparing difference remarkable P＜0.01, P＜0.01, P＜0.01 is arranged; The basic, normal, high dosage group aged mouse whole blood GSH-PX activity that can obviously raise has significance P＜0.01, P＜0.01, P＜0.01 with aged matched group comparing difference; The basic, normal, high dosage group red SOD activity of aged mouse that can obviously raise has significance P＜0.05, P＜0.01, P＜0.01 with aged matched group comparing difference.

The influence of table 3 pair aged mouse body weight (X ± S)

Table 4 sample is to the influence of MDA content in the aged mouse blood (X ± S)

Compare * * P＜0.01 with aged matched group

Table 5 sample is to the influence of aged mouse erythrocyte, SOD, whole blood GSH-PX (X ± S)

Compare * P＜0.05 * * P＜0.01 with aged matched group

The result shows that as seen drosophila survival experiment and biochemical indicator detect, and with the matched group comparing difference significance are arranged, and according to health food function assessment assessment process regulation, this is tried thing delaying senility function.

Health food beauty treatment of the present invention (functions of removing chloasma) effect clinical observation:

Sample source and processing: the health food tablet that anthology inventive embodiments 2 provides, 0.6g/ sheet.

The report of beauty treatment (functions of removing chloasma) experimental check:

Sample source and processing: derive from the sample that embodiment 1 provides, sample is made 0.6 gram/sheet, is provided with down test and uses.

30 satisfactory chloasma experimenters take sample, and each 2, every day 2 times, continuous 30 days.The chloasma area 6.79 ± 8.19cm2 that on average descends as a result, color obviously shoals, and colour atla on average reduces by 0.30 ± 0.36 degree, in 30 examples, produce effects 3 examples, effective 16 examples, total effective rate 63.33%.Routine blood test, routine urinalysis and bloodization are given birth to index all in normal range before and after the test-meal, can think, sample has beauty treatment (functions of removing chloasma) effect, and the healthy nothing of examination trencherman is obviously influenced.

Object and method:

Tried thing: the sample that embodiment 1 method provides.

Study subject: press the principle of voluntariness and select 18-65 year, have chloasma experimenter 30 examples.

Diagnostic criteria: the visible brown spot of women's head-ornaments portion perusal is mainly in and cheekbone, cheek, volume, nose, lip week etc. locates symptoms such as no sufferings.

The person's of including in standard: all volunteers that chloasma is arranged, all can carry out test-meal through medical fitness and observe.

Eliminator's standard:

1 age, gestation or women breast-feeding their children were to these health product allergy sufferers under-18s or over-65s person.

Be associated with serious primary disease such as conscience kidney and hemopoietic system, the psychotic.

Do not meet the standard of including in,, can't judge effect or data not umbra sound effect or safety judgement person not in accordance with regulations with being tried thing.

Contrast form: adopt self cross-reference form.

Taking dose and time; Each 2, every day 2 times, continuous 30 days.The experimenter cuts out medicine or other health product and the cosmetics of relevant face-beautifying and spot-removing at experimental session.

Instrument and reagent: F-820 type blood counting instrument, ten analyses of MIDIRON urine (Germany produces), Olympus automatic clinical chemistry analyzer (Japan produces), model AU600, Institute of Geography, Academia Sinica's development and design, Mapping Press published " practical standard colour atla " (front page) in 1992, and the biochemical reagents box is all provided by middle living company.

Observation index:

Each is checked once before and after the experiment.

The effect observation:

Ordinary circumstance:

Detailed medical history-taking is understood experimenter's diet situation, observes main clinic symptoms: feeling of fatigue, agitation, sleep etc.Before and after test-meal, add up integrated value by symptom weight (serious symptom 3 minutes, moderate 2 minutes, light disease 1 minute), and improve (2 fens produce effects of each doing well,improving are improved 1 and are divided into effectively), calculate the improvement rate with regard to its cardinal symptom.

The head chloasma detects:

The area size changes: the major diameter and the wide footpath of same chloasma before and after being tried with tape measure, reference area (cm2).

Shade changes:

According to Institute of Geography, Academia Sinica's development and design, brown (Y+M+BK i.e. Huang+magenta+black folded color) colour atla in " practical standard colour atla " (front page) that Mapping Press published in 1992 is the criterion of chloasma shade: I degree (15,20,5), II degree (30,40,10), III degree (40,60,15).

Spot-removal function is judged:

Produce effects: chloasma color decline II degree, or area dwindle 〉=30%, do not produce new chloasma.

Effectively: chloasma color decline I degree, or 10%＜area dwindle＜30% do not produce new chloasma.

Invalid: the chloasma area dwindles＜and 10%, color does not have significant change.

Therapeutic outcome (see Table 6, table 7, table 8, table 9 and table 10):

Table 6 chloasma shade after treating changes

**P＜0.01

Table 7 is chloasma area size variation after treating

**P＜0.01

The evaluation of table 8 effect

Table 9 cardinal symptom is improved situation

Table 10 symptom integral changes

**P＜0.01

As a result, 30 routine chloasma experimenters took 30 days on request continuously, and the chloasma area on average dwindles 6.79 ± 8.19cm ²P＜0.01, color shoals, and colour atla on average reduces by 0.30 ± 0.36 degree, P＜0.05, produce effects 3 examples wherein, effective 16 examples, total effective rate 63.33% shows beauty treatment is arranged (functions of removing chloasma) effect, and symptoms such as chloasma experimenter's feeling of fatigue, agitation, sleep are had the improvement effect.

The specific embodiment

Embodiment 1

The preparation of tablet of the present invention:

1 part of soybean isoflavone, 2 parts of Radix Bupleuri, 2 parts of Radix Angelicae Sinensis, 0.4 part of Herba Menthae, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts in Rhizoma Zingiberis Recens, 2 parts of the Radix Paeoniae Albas, 2 parts in Poria, 1.6 parts in Radix Glycyrrhizae, 0.6 part of vitamin C, 0.3 part of vitamin E, 10 parts of pregelatinized Starch, 10 parts of low-substituted hydroxypropyl celluloses, 2.5 parts of microcrystalline Cellulose, 0.1 part of micropowder silica gel, 0.2 part of hydroxypropyl emthylcellulose.

Preparation method: (1). prefabricated Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the extract of Rhizoma Zingiberis Recens: by the Radix Bupleuri of described weight proportion, Radix Angelicae Sinensis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, add in the decoction pot, add 30 parts of water, soaked overnight, behind the heating extraction volatile oil C, decocting liquid filters, medicinal residues add 45 parts in water again, heated and boiled 1 hour, the filtrate extract merges filtrate twice, leave standstill cooling, filter, it is 1.1 extractum that the filtrate heating is condensed into proportion, stops heating, standing over night, get supernatant and advance spray dryer, 120 ℃ of inlet temperature controls, 113 ℃ of leaving air temps, 50,000 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, and spray-dired powder is crossed 100 mesh sieves, is Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the prefabricated extract A of Rhizoma Zingiberis Recens;

(2) extract of the prefabricated Radix Paeoniae Alba, Poria, Radix Glycyrrhizae: get the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae by weight ratio, add in the Decocting pot, add 15 parts water, soaked overnight, heating decocted 2 hours, the filtrate extract, medicinal residues add 20 parts in water again, heated and boiled 1 hour, filtrate extract, merge filtrate twice, leave standstill cooling, filter, it is 1.0 extractum that the filtrate heating is condensed into proportion, drying promptly gets the prefabricated extract B of the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae;

(3) with the soybean isoflavone powder behind the crushing screening, prefabricated extract A, prefabricated extract B, vitamin E, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, pregelatinized Starch and vitamin C, divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer, its control process parameters is as follows: 30 ℃ of air intakes, vibrate atomizing pressure 0.10bar, hydrojet speed 50g/ minute 2 times/minute, air door pressure 0.05mpa, auxiliary pneumatics 0.10mpa when treating that shaping particles is better, enters dry for the first time, inlet temperature is elevated to 60 ℃, vibrate air door pressure 0.1mpa, aux. pressure 0.10mpa 2 times/minute, the granule water content was controlled at 0.5% o'clock, took out granule;

(4) granule that makes sifts out the parts of fine granule by 16 mesh sieve granulate with 60 order dusting covers, adds the volatile oil C that extract (1), mixing the back thoroughly adds in the material, add micropowder silica gel again, abundant airtight spending the night behind the mixing, put 21 in the rotary tablet machine tabletting, sift out fine powder, remove useless sheets such as loose sheet, sliver, stain, sampling inspection changes in the coating pan after qualified, with hydroxypropyl emthylcellulose coating materials coating, obtain finished product.

Carry out conventional tablet detection with obtaining finished tablet, hardness can reach more than 4 kilograms, and the disintegration time of plain sheet is in 10 minutes.Conform to quality requirements.

Embodiment 2

The preparation of tablet of the present invention:

2 parts of soybean isoflavone, 3 parts of Radix Bupleuri, 3 parts of Radix Angelicae Sinensis, 0.5 part of Herba Menthae, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts in Rhizoma Zingiberis Recens, 4 parts of the Radix Paeoniae Albas, 4 parts in Poria, 3 parts in Radix Glycyrrhizae, 1 part of vitamin C, 0.5 part of vitamin E, 5 parts of pregelatinized Starch, 5 parts of low-substituted hydroxypropyl celluloses, 5 parts of microcrystalline Cellulose, 0.5 part of micropowder silica gel, 1 part of hydroxypropyl emthylcellulose.

Preparation method: (1). prefabricated Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the extract of Rhizoma Zingiberis Recens: by the Radix Bupleuri of described weight proportion, Radix Angelicae Sinensis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, add in the decoction pot, add 40 parts of water, soaked overnight, behind the heating extraction volatile oil C, decocting liquid filters, medicinal residues add 45 parts in water again, heated and boiled 1.5 hours, the filtrate extract merges filtrate twice, leave standstill cooling, filter, it is 1.2 extractum that the filtrate heating is condensed into proportion, stops heating, standing over night, get supernatant and advance spray dryer, 130 ℃ of inlet temperature controls, 120 ℃ of leaving air temps, 20,000 rev/mins of nebulizer rotating speeds, charging rate is 2ml/ minute, and spray-dired powder is crossed 100 mesh sieves, is Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the prefabricated extract A of Rhizoma Zingiberis Recens;

(2) the prefabricated Radix Paeoniae Alba, Poria, the extract of Radix Glycyrrhizae: get the Radix Paeoniae Alba by weight ratio, Poria, Radix Glycyrrhizae adds in the Decocting pot, adds 20 parts water, soaked overnight, heating decocted 2 hours, and filtrate extract, medicinal residues add 23 parts in water again, heated and boiled 2 hours, the filtrate extract merges filtrate twice, leaves standstill cooling, filter, it is 1.2 extractum that filtrate heating is condensed into proportion, and standing over night is got supernatant and advanced spray dryer, 150 ℃ of inlet temperature controls, 95 ℃ of leaving air temps, 20,000 rev/mins of nebulizer rotating speeds, charging rate is 2ml/ minute, spray-dired powder is crossed 100 mesh sieves, is the Radix Paeoniae Alba, Poria, the prefabricated extract B of Radix Glycyrrhizae;

(3) with the soybean isoflavone powder behind the crushing screening, prefabricated extract A, prefabricated extract B, 0.5 part of vitamin E, 5 parts of microcrystalline Cellulose, 5 parts of low-substituted hydroxypropyl celluloses, 1 part of 5 parts of pregelatinized Starch and vitamin C, divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer, its control process parameters is as follows: 40 ℃ of air intakes, vibrate atomizing pressure 0.2bar, hydrojet speed 60g/ minute 4 times/minute, air door pressure 0.1mpa, auxiliary pneumatics 0.15mpa when treating that shaping particles is better, enters dry for the first time, inlet temperature is elevated to 70 ℃, vibrate air door pressure 0.2mpa, aux. pressure 0.15mpa 4 times/minute, the granule water content was controlled at 1.5% o'clock, took out granule;

(4) the granule granulate that makes, sift out the parts of fine granule with 60 order dusting covers, add the volatile oil C that extract (1), mix the back thoroughly and add in the material, add 0.01 part of micropowder silica gel again, fully airtight spending the night behind the mixing, put 21 in the rotary tablet machine tabletting, sift out fine powder,, obtain finished product with hydroxypropyl emthylcellulose coating materials coating.

Embodiment 3

The preparation of tablet of the present invention:

6 parts of soybean isoflavone, 6 parts of Radix Bupleuri, 6 parts of Radix Angelicae Sinensis, 1.2 parts of Herba Menthaes, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts in Rhizoma Zingiberis Recens, 6 parts of the Radix Paeoniae Albas, 6 parts in Poria, 4.8 parts in Radix Glycyrrhizae, 4 parts of vitamin Cs, 2 parts of vitamin Es, 2.5 parts of pregelatinized Starch, 2.5 parts of low-substituted hydroxypropyl celluloses, 2.5 parts of microcrystalline Cellulose, 0.1 part of micropowder silica gel, 5 parts of hydroxypropyl emthylcelluloses.

Preparation method: (1). prefabricated Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the extract of Rhizoma Zingiberis Recens: by the Radix Bupleuri of described weight proportion, Radix Angelicae Sinensis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, add in the decoction pot, add 60 parts of water, soaked overnight, behind the heating extraction volatile oil C, decocting liquid filters, medicinal residues add 50 parts in water again, heated and boiled 2 hours, the filtrate extract merges filtrate twice, leave standstill cooling, filter, it is 1.3 extractum that the filtrate heating is condensed into proportion, stops heating, standing over night, get supernatant and advance spray dryer, 150 ℃ of inlet temperature controls, 125 ℃ of leaving air temps, 50,000 rev/mins of nebulizer rotating speeds, charging rate is 8ml/ minute, and spray-dired powder is crossed 100 mesh sieves, is Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, the prefabricated extract A of Rhizoma Zingiberis Recens;

(2) the prefabricated Radix Paeoniae Alba, Poria, the extract of Radix Glycyrrhizae: get 6 parts of the Radix Paeoniae Albas by weight ratio, 6 parts in Poria, 4.8 parts in Radix Glycyrrhizae adds in the Decocting pot, adds 30 parts water, soaked overnight, heating decocted 2 hours, and filtrate extract, medicinal residues add 25 parts in water again, heated and boiled 2.5 hours, the filtrate extract merges filtrate twice, leaves standstill cooling, filter, it is 1.3 extractum that filtrate heating is condensed into proportion, and standing over night is got supernatant and advanced spray dryer, 150 ℃ of inlet temperature controls, 125 ℃ of leaving air temps, 50,000 rev/mins of nebulizer rotating speeds, charging rate is 8ml/ minute, spray-dired powder is crossed 100 mesh sieves, is the Radix Paeoniae Alba, Poria, the prefabricated extract B of Radix Glycyrrhizae;

(3) with the soybean isoflavone powder behind the crushing screening, prefabricated extract A, prefabricated extract B, 2 parts of vitamin Es, 2.5 parts of microcrystalline Cellulose, 2.5 parts of low-substituted hydroxypropyl celluloses, 4 parts of 2.5 parts of pregelatinized Starch and vitamin Cs, divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer, its control process parameters is as follows: 50 ℃ of air intakes, vibrate atomizing pressure 0.2bar, hydrojet speed 70g/ minute 6 times/minute, air door pressure 0.2mpa, auxiliary pneumatics 0.2mpa when treating that shaping particles is better, enters dry for the first time, inlet temperature is elevated to 90 ℃, vibrate air door pressure 0.3mpa, aux. pressure 0.2mpa 6 times/minute, the granule water content was controlled at 3.5% o'clock, took out granule;

(4) granule that makes is by 16 mesh sieve granulate, sift out the parts of fine granule with dusting cover, add the volatile oil C that extract (1), mix the back thoroughly and add in the material, add 0.1 part of micropowder silica gel again, fully airtight spending the night behind the mixing, put 21 in the rotary tablet machine tabletting, sift out fine powder,, obtain finished product with hydroxypropyl emthylcellulose coating materials coating.

Embodiment 4

The preparation of granule of the present invention:

2 parts of soybean isoflavone, 3 parts of Radix Bupleuri, 3 parts of Radix Angelicae Sinensis, 0.5 part of Herba Menthae, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts in Rhizoma Zingiberis Recens, 4 parts of the Radix Paeoniae Albas, 4 parts in Poria, 3 parts in Radix Glycyrrhizae, 1 part of vitamin C, 0.5 part of vitamin E, 5 parts of cane sugar powders.

Preparation method:

(1) presses embodiment prefabricated extract A of 1 described method and extract B;

(2) with 2 parts in the soybean isoflavone powder behind the crushing screening; prefabricated extract A, prefabricated extract B, 0.5 part of vitamin E; 1 part of 5 parts of cane sugar powders and vitamin C; divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer; its control process parameters is as follows: 40 ℃ of air intakes; vibrate atomizing pressure 0.10bar, hydrojet speed 60g/ minute 3-5 time/minute; air door pressure 0.1mpa; auxiliary pneumatics 0.10mpa when treating that shaping particles is better, enters dry for the first time; inlet temperature is elevated to 80 ℃; vibrate air door pressure 0.2mpa, aux. pressure 0.152mpa 3 times/minute; the granule water content was controlled at 1.5% o'clock; take out granule, behind the 16 mesh sieve granulate, remove fine powder with 60 mesh sieves sieve.

It is 4.8g/ people/sky that human body is recommended daily intaking amount.

By do the deferring senility experiment with quadrat method:

The result: 0.16%, 0.48%, 1.44% granule dosage group also can obviously prolong the average life of hero, female fruit bat, and male drosophila group and matched group comparing difference have significance, P＜0.01, P＜0.05, P＜0.01, P＜0.01; Female fruit bat group has significance than difference, P＜0.01, P＜0.01, P＜0.01, P＜0.05 compared with the control; 0.16%, 0.48%, 1.44% dosage group male drosophila half death time is respectively greater than matched group 2 days, 6 days, 7 days.0.16%, the female fruit bat half death time of 0.48%, 1.44% dosage group is respectively greater than matched group 1 day, 5 days, 5 days.

The result shows the compatibility science in the corresponding mixture ratio scope of soybean isoflavone and Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae, and granule and Tabules all have the function of slow down aging.

But tablet carry take more convenient.

Embodiment 5

A kind of health food with slow down aging and beautification function, it mainly is to be made by the raw material of following weight portion: 2.5 parts of pregelatinized Starch, 2.5 parts of low-substituted hydroxypropyl celluloses, 2.5 parts of microcrystalline Cellulose, 0.1 part of micropowder silica gel, 0.2 part of hydroxypropyl emthylcellulose.All the other are with embodiment 1.

Embodiment 6

A kind of health food with slow down aging and beautification function, its excipient mainly is to be made by the raw material of following weight portion: 10 parts of pregelatinized Starch, 10 parts of low-substituted hydroxypropyl celluloses, 15 parts of microcrystalline Cellulose, 2.5 parts of micropowder silica gels, 2.5 parts of hydroxypropyl emthylcelluloses.All the other are with embodiment 2.

Embodiment 7

A kind of health food with slow down aging and beautification function, its excipient are 0.1 part of micropowder silica gels.All the other are with embodiment 2.

Embodiment 8

A kind of health food with slow down aging and beautification function, its excipient are 20 parts of cane sugar powders.All the other are with embodiment 4.

Embodiment 9

A kind of health food with slow down aging and beautification function, its excipient are 10 parts in mannitol.All the other are with embodiment 4.

Embodiment 10

A kind of health food with slow down aging and beautification function, its excipient are 2 parts in mannitol, cane sugar powder 10.All the other are with embodiment 4.

Embodiment 11

A kind of health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 10%.All the other are with embodiment 2.

Embodiment 12

A kind of health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 90%.All the other are with embodiment 2.

Embodiment 13

A kind of health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 30%.All the other are with embodiment 2.

Embodiment 14

A kind of health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 50%.All the other are with embodiment 2.

Embodiment 15

A kind of health food with slow down aging and beautification function, the total isoflavone content of soybean isoflavone is 40%.All the other are with embodiment 2.

A kind of health food with slow down aging and beautification function, form are capsule, routinely the prepared of capsule.All the other are with embodiment 2.

Embodiment 16

A kind of health food with slow down aging and beautification function, form are powder, routinely the prepared of powder.All the other are with embodiment 2.

Embodiment 17

The granule water content was controlled at 0.1% o'clock, took out granule; All the other are with embodiment 1.

Because of moisture content is too dried, the finished product that obtains is easy-formation not, and the sliver phenomenon is serious, can't 21 in the rotary tablet machine compression molding.

Embodiment 18

The granule water content was controlled at 4.0% o'clock, took out granule; All the other are with embodiment 1.

Because of moisture content is too damp, the finished product that obtains easily is clamminess, and behind the compression molding, the finished tablet that obtains is carried out conventional tablet detect, and hardness has only 2.5 kilograms.Tablet strength is not enough, and it is undesirable to chew mouthfeel.

Embodiment 19

A kind of tablet that contains soybean isoflavone, be the tablet of making by the following weight proportion raw material: 10 parts of soybean isoflavone, 2 parts of Radix Bupleuri, 2 parts of Radix Angelicae Sinensis, 0.4 part of Herba Menthae, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts in Rhizoma Zingiberis Recens, 2 parts of the Radix Paeoniae Albas, 2 parts in Poria, 1.6 parts in Radix Glycyrrhizae, 0.6 part of vitamin C, 0.3 part of vitamin E, 10 parts of pregelatinized Starch, 10 parts of low-substituted hydroxypropyl celluloses, 2.5 parts of microcrystalline Cellulose, 0.1 part of micropowder silica gel, 0.2 part of hydroxypropyl emthylcellulose.All the other are with embodiment 2.

Do the deferring senility experiment in the same way:

Result: 0.08%, 0.24%, 0.72%; But the also average life of proper extension hero, female fruit bat of 0.48%, 1.44% tablet dose group 0.16%,, male drosophila group and matched group comparing difference have significance, P＜0.05, P＜0.01, P＜0.01; Female fruit bat group has significance than difference, P＜0.01, P＜0.01, P＜0.01 compared with the control; 0.08%, 0.24%, 0.72% dosage group male drosophila half death time is respectively greater than matched group 2 days, 3 days, 3 days.0.16%, the female fruit bat half death time of 0.48%, 1.44% dosage group is respectively greater than matched group 1 day, 3 days, 4 days.

The consumption that increases soybean isoflavone in the prescription reaches 10 parts, and the deferring senility experiment shows that super scope dosage uses the effect of soybean isoflavone poor slightly.

The too high deferring senility on the contrary of the consumption of soybean isoflavone effect is undesirable, and the consumption of soybean isoflavone too high being unfavorable for controls cost.Therefore under the fixed prerequisite of other composition consumptions, it is more reasonable that soybean isoflavone is controlled at 1-6 part.

Claims (7)

1, a kind of health food with slow down aging and beautification function, it is characterized in that it is to be made by the raw material of following weight portion: soybean isoflavone 1-6 part, Radix Bupleuri 2-6 part, Radix Angelicae Sinensis 2-6 part, Radix Paeoniae Alba 2-6 part, Herba Menthae 0.4-1.2 part, Rhizoma Atractylodis Macrocephalae 2-6 part, Rhizoma Zingiberis Recens 2-6 part, Poria 2-6 part, Radix Glycyrrhizae 1.6-4.8 part, vitamin C 0.6-4 part, vitamin E 0.3-2 part, excipient 0.1-40 part.

2, the health food with slow down aging and beautification function according to claim 1 is characterized in that excipient 7.8-40 part.

3, the health food with slow down aging and beautification function according to claim 1, it is characterized in that excipient is made up of following materials of weight proportions single or multiple combination: pregelatinized Starch 2.5-10 part, low-substituted hydroxypropyl cellulose 2.5-10 part, microcrystalline Cellulose 2.5-15 part, micropowder silica gel 0.1-2.5 part, hydroxypropyl emthylcellulose 0.2-5 part, cane sugar powder 0-20 part, mannitol 0-10 part.

4, the health food with slow down aging and beautification function according to claim 1, the total isoflavone content that it is characterized in that soybean isoflavone is 10-90%.

5, the health food with slow down aging and beautification function according to claim 4, the total isoflavone content that it is characterized in that soybean isoflavone is 30-50%.

6, the health food with slow down aging and beautification function according to claim 1, the form that it is characterized in that described health food is tablet, capsule, granule and powder.

7, as having the preparation method of the health food of slow down aging and beautification function as described in the claim 3, the food preparation that it is characterized in that tablet form is by the poly-operation of following step:

(1) extract of prefabricated Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, Rhizoma Zingiberis Recens: get Radix Bupleuri by weight ratio, Radix Angelicae Sinensis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, add in the decoction pot, add 30-60 part water, soaked overnight, behind the heating extraction volatile oil C, decocting liquid filters, and medicinal residues add water 40-50 part again, heated and boiled 1-2 hour, the filtrate extract merges filtrate twice, leaves standstill cooling, filter, filtrate heating is condensed into the extractum that proportion is 1.0-1.3, and drying is the prefabricated extract A of Radix Bupleuri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, Rhizoma Zingiberis Recens;

(2) extract of the prefabricated Radix Paeoniae Alba, Poria, Radix Glycyrrhizae: get the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae by weight ratio, add in the Decocting pot, add the water of 15-30 part, soaked overnight, heating decocted 1-2.5 hour, the filtrate extract, medicinal residues add water 20-25 part again, heated and boiled 1 hour, filtrate extract, merge filtrate twice, leave standstill cooling, filter, the filtrate heating is condensed into the extractum that proportion is 1.0-1.3, drying promptly gets the prefabricated extract B of the Radix Paeoniae Alba, Poria, Radix Glycyrrhizae;

(3) with the soybean isoflavone powder behind the crushing screening, prefabricated extract A, prefabricated extract B, vitamin E, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, pregelatinized Starch and vitamin C, divide another name fixed, put be mixed to the color and luster uniformity in the V-type blender after, put pelletize in the fluidized bed pelletizer, its control process parameters is as follows: air intake 30-50 ℃, vibrate atomizing pressure 0.10-0.2bar, hydrojet speed 50-70g/ minute 2-6 time/minute, air door pressure 0.05-0.2mpa, auxiliary pneumatics 0.10-0.2mpa when treating that shaping particles is better, enters dry for the first time, inlet temperature is elevated to 60-90 ℃, vibrate air door pressure 0.1-0.3mpa, aux. pressure 0.10-0.2mpa 2-6 time/minute, when the granule water content is controlled at 0.5-3.5%, take out granule;

(4) granule that makes sifts out the parts of fine granule by 16 mesh sieve granulate with 60 order dusting covers, adds the volatile oil C that extract (1), mixing the back thoroughly adds in the material, add micropowder silica gel again, abundant airtight spending the night behind the mixing, put 21 in the rotary tablet machine tabletting, sift out fine powder, remove useless sheets such as loose sheet, sliver, stain, sampling inspection changes in the coating pan after qualified, with hydroxypropyl emthylcellulose coating materials coating, obtain finished product.