CN109289005A - Has effects that composition of resolving stagnation for tranquilization and preparation method thereof - Google Patents
Has effects that composition of resolving stagnation for tranquilization and preparation method thereof Download PDFInfo
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- CN109289005A CN109289005A CN201811397627.XA CN201811397627A CN109289005A CN 109289005 A CN109289005 A CN 109289005A CN 201811397627 A CN201811397627 A CN 201811397627A CN 109289005 A CN109289005 A CN 109289005A
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- parts
- tranquilization
- composition
- resolving stagnation
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K35/586—Turtles; Tortoises, e.g. terrapins
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Abstract
The present invention relates to a kind of compositions and preparation method thereof with resolving stagnation for tranquilization, raw material components are by weight, comprising: 5-10 parts of semen ziziphi spinosae, 3-5 parts of lily, 3-5 parts of Poria cocos, 3-5 parts of fructus lycii, 3-5 parts of mulberry fruit, 3-5 parts of radix polygonati officinalis, 4-8 parts of hawthorn, 3-5 parts of rose, 3-5 parts of jujube, 4-6 parts of wheat, 3-5 parts of Radix Glycyrrhizae, 1-3 parts of fingered citron, 0.5-3 parts of fructus amomi.The present invention extracts raw material active constituent using dual-purpose of drug and food material as primary raw material, with modern advanced technology, and the composition being refining to obtain has " nourishing yin and supplementing blood, relieving restlessness and restlessness, liver soothing and depression relief, mental-tranquilization " four large effects, treating both manifestation and root cause of disease, it makes overall plans, good effect takes safety.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of to have effects that the composition of resolving stagnation for tranquilization and its preparation side
Method.
Background technique
With social progress and development, people's lives and operating pressure are increasing, and frequent overtime work is stayed up late and led to
Night amusement becomes normality so that sleep quality is not high caused by many people are overstrain one's nerves, feel depressed, solitarily, anxiety it is irritated,
Irritability, thus body is chronically at sub-health state.Insomnia refers to that patient was unsatisfactory for and influences on sleeping time and (or) quality
In the daytime a kind of subjective experience of social function；Clinical common insomnia has difficulty falling asleep, the frequent, poor sleeping quality of night awakening etc..
Depression is as caused by a variety of causes, using depression as a kind of mood disorder of cardinal symptom；Clinical manifestation is depressive mood, thinking
Slow, speech movement is reduced, and self-assessment is too low, and with somatizations such as appetite stimulator, hypogona dism, sleep disturbance,
Clinically break out in chronic, repeatability.There is the product of many relieve stagnations and/or tranquilizing the mind in the market, treats the Chinese patent drug master of insomnia
There are resolving stagnation for tranquilization, clearing away the heart fire and tranquillizing, transquilization with heavy material three classes, however, often effect is not significant enough for existing product, patient compliance
Difference, or there are certain side effects, are not met by the demand of user.
Summary of the invention
For the defects in the prior art, it is an object of that present invention to provide it is a kind of have effects that the composition of resolving stagnation for tranquilization and
Preparation method is primary raw material by using dual-purpose of drug and food material, extracts raw material active constituent with modern advanced technology,
The composition being refining to obtain has " nourishing yin and supplementing blood, relieving restlessness and restlessness, liver soothing and depression relief, mental-tranquilization " four large effects, treating both manifestation and root cause of disease, system
It raises and takes into account, good effect takes safety.
To achieve the above object, technical solution provided by the invention are as follows:
Has effects that the composition of resolving stagnation for tranquilization the present invention provides a kind of, raw material components are by weight, comprising: wild jujube
5-10 parts of benevolence, 3-5 parts of lily, 3-5 parts of Poria cocos, 3-5 parts of fructus lycii, 3-5 parts of mulberry fruit, 3-5 parts of radix polygonati officinalis, 4-8 parts of hawthorn, rose 3-
5 parts, 3-5 parts of jujube, 4-6 parts of wheat, 3-5 parts of Radix Glycyrrhizae, 1-3 parts of fingered citron, 0.5-3 parts of fructus amomi.
Preferably, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include: 5-10 parts of oyster, notoginseng haulm 3-
5 parts, 3-5 parts of arillus longan, 3-5 parts of Rhizoma Gastrodiae, 4-6 parts of ganoderma lucidum.
Preferably, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include: 5-10 parts of keel, oyster 5-10
Part, 5-10 parts of tortoiseshell, 5-10 parts of turtle shell, 3-6 parts of tuber fleeceflower stem.
Preferably, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include: 5-10 parts of Radix Codonopsis, 3-5 parts of Rhizoma Atractylodis Macrocephalae,
5-10 parts of Radix Astragali, 1-3 parts of Radix Polygalae, 1-3 parts of Radix Angelicae Sinensis, 1-3 parts of Rhizoma Chuanxiong, 1-3 parts of dried orange peel.
Preferably, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include: 3-5 parts of Radix Rehmanniae, Radix Ophiopogonis 3-5 part,
3-5 parts of rhizoma anemarrhenae, 2-5 parts of Schisandra chinensis, 3-7 parts of Radix Salviae Miltiorrhizae, 3-6 parts of cortex albiziae, 3-6 parts of rhizoma cyperi, 1-3 parts of cape jasmine.
In the present invention, semen ziziphi spinosae mental-tranquilization, tonifying liver calming heart are monarch drug in a prescription；Ministerial drug lily Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, Poria cocos
Invigorating the spleen calming heart, clearing damp and promoting diuresis, fingered citron are relaxed liver stomach function regulating, promoting qi circulation to remove dampness, rose promoting qi circulation and removing obstruction in the collateral, regulating menstruation by adjusting the flow of blood, and four ministers are harmonious, clear away heart-fire
Relieving restlessness, resolving stagnation for tranquilization；Adjutant wheat, jujube, Radix Glycyrrhizae (wheat Radix Glycyrrhizae Ziziphi Jujubae Decoction) and middle emergency, relieving restlessness are calmed the nerves, and gather fingered citron, rose altogether
The function of rare colored relieve stagnation relieving restlessness.Mulberry fruit nourishing yin and nourishing blood, fructus lycii enriching yin and nourishing kidney, radix polygonati officinalis nourishing yin to moisten dryness, with the benefits of helping lily clearing away the heart fire and tranquillizing.
Fructus amomi qi-regulating dampness elimination, warm spleen nourishing the stomach, to mitigate mulberry fruit, fructus lycii grows greasy property；Make medicine hawthorn digesting stomach invigorating, promoting blood circulation to remove blood stasis, hawthorn
Fructus amomi is obtained, the stagnation of the circulation of vital energy must be capable, and dyspepsia can disappear, invigorating the spleen for eliminating dampness, and ascending the clear and descending the turbid helps ataraxia.Monarch compatibility, yin-nourishing profit
Lung, liver soothing and speen fortifying, nourishing liver and kidney, antitoxic heart-soothing and sedative, the heart, liver, spleen, lung, kidney the five internal organs are supported altogether, and abnormal heat obtains clearly, and spleen is wet to be seeped, and are tired of strongly fragrant obtain
Solution, the mind naturally peacefulness, actually rare enriching the blood to restore normal menstruation, resolving stagnation for tranquilization side.
The present invention also provides the preparation methods with the composition of resolving stagnation for tranquilization, comprising steps of S1: hawthorn is adopted
Refluxing extraction is carried out with ethanol water, is filtered after extraction, collects filtrate and filter residue respectively；Filtrate is carried out ethyl alcohol to return
It receives, is then condensed into the first medicinal extract；Filter residue is subjected to decoction extraction with water, is filtered after extraction and collects filtrate；By filtrate
Supernatant is taken after standing；The pH value of supernatant is adjusted to 5.5-6.0, obtains hawthorn acidic aqueous solution；S2: by fingered citron and amomum powder
It is broken into coarse powder, is then placed in water and impregnates, carries out decoction extraction later, collects volatile oil and the dregs of a decoction respectively；S3: by the dregs of a decoction and its
He mixes surplus stock component, is then placed in hawthorn acidic aqueous solution and impregnates, carries out refluxing extraction, mistake after extraction later
It filters and collects filtrate；Supernatant is taken after filtrate is stood, and is then condensed into the second medicinal extract；S4: by the first medicinal extract and the second medicinal extract
Mixing, then low temperature drying crush later, are sieved, collect fine powder；Fine powder and volatile oil are uniformly mixed, obtained with relieve stagnation
The composition of tranquilizing the mind effect.
Preferably, in S1, the quality of ethanol water is 9-11 times of hawthorn quality, and the mass fraction of ethanol water is
70%, the time of refluxing extraction is 1.8-2.2 hours；The specific gravity of first medicinal extract is 1.24-1.26；It is more for decocting the number extracted
Secondary, preferably 2 times, decocting the time extracted every time is 2 hours；The quality of water is 9-11 times of filter residue quality；The time of standing
It is 6-8 hours.
Preferably, in S2, the quality of water is 9-11 times of the gross mass of fingered citron and fructus amomi, and the time of immersion is 55-65 points
Clock；Decocting the time extracted is 55-65 minutes.
Preferably, in S3, time of immersion is 5.6-6.4 hours, the number of refluxing extraction be it is multiple, preferably 2 times, often
The time of secondary refluxing extraction is 3 hours；The time of standing is 5-7 hours；The specific gravity of second medicinal extract is 1.24-1.26.
Preferably, in S4, the temperature of low temperature drying is no more than 60 DEG C, and sieving is to sieve with 100 mesh sieve.
The present invention also protects combinations of the above object in the drug and/or medicated premix that preparation has effects that resolving stagnation for tranquilization
Application.
It should be noted that the present invention be prepared have effects that the application method of the composition of resolving stagnation for tranquilization is preferred
Are as follows: each taking 10-15g, take every night 1 time, warm water is taken after mixing it with water or directly taken；Time of Administration can be according to disease
Feelings are adjusted.
The composition of above method preparation can be further prepared into pharmaceutically acceptable dosage form as needed.In addition, with
Above-mentioned composition is that drug made of active constituent also belongs to protection scope of the present invention.By directly making above-mentioned composition
It is prepared after the standby or pharmaceutically acceptable auxiliary material of addition, can be made into any pharmaceutically acceptable dosage form.The medicine of various dosage forms
Object can be prepared according to the conventional method of pharmaceutical field.
Technical solution provided by the invention has following the utility model has the advantages that (1) present invention with dual-purpose of drug and food material is main
Raw material, the composition being prepared have " nourishing yin and supplementing blood, relieving restlessness and restlessness, liver soothing and depression relief, mental-tranquilization " four large effects, and sample is simultaneous
It controls, makes overall plans, good effect takes safety；(2) present invention extracts hawthorn with 70% ethanol water, can be sufficiently
Extract flavone of hawthorn fruit class compound；And the acid feature for making full use of raw material hawthorn adds proper amount of acetic acid to adjust acidic aqueous solution
(pH5.5-6.0) medicinal materials such as semen ziziphi spinosae, Poria cocos, fructus lycii, mulberry fruit, rose are extracted, can sufficiently be extracted effective in Chinese medicine
Ingredient, furthermore, fingered citron, fructus amomi pass through coarse powder, refluxing extraction volatile oil, then mix to boil with remaining dregs of a decoction and mention, and effective component is extracted
More sufficiently；(3) oyster, notoginseng haulm, arillus longan, Rhizoma Gastrodiae, ganoderma lucidum, Ke Yizeng is added on the basis of basic components in the present invention
The crowd of strong benefiting qi for tranquillization, transquilization with heavy material effect, suitable chronic insomnia takes；It is (4) of the invention on the basis of basic components,
Keel, oyster, tortoiseshell, turtle shell, tuber fleeceflower stem are added, relieve stagnation relieving restlessness can be enhanced, transquilization with heavy material effect is suitable for osteopyrexia and fever
Insomnia crowd takes；(5) Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Polygalae (system), Radix Angelicae Sinensis, river is added on the basis of basic components in the present invention
Rhizome of chuanxiong, dried orange peel, can be enhanced replenish qi to invigorate the spleen, invigorating QI and blood the effect of, be suitable for the insufficiency of heart and spleen insomnia crowd take；(6) of the invention
On the basis of basic components, Radix Rehmanniae, Radix Ophiopogonis, rhizoma anemarrhenae, Schisandra chinensis, Radix Salviae Miltiorrhizae, cortex albiziae, rhizoma cyperi, cape jasmine is added, can be enhanced feeding
Negative heat-clearing, relieving restlessness and restlessness effect are suitable for that fire excess from yin deficiency insomnia crowd takes.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described.Implement below
Example is only used for clearly illustrating technical solution of the present invention, therefore is intended only as example, and cannot be used as a limitation and limit this hair
Bright protection scope.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
The preparation present invention has effects that each raw material component of the composition of resolving stagnation for tranquilization is to be used as to match according to parts by weight,
When production can according to corresponding ratio increase or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production
Can also in grams, weight can increase or reduce, but the quality proportioning constant rate between each composition.
The present invention provide it is a kind of have effects that the composition of resolving stagnation for tranquilization, raw material components are by weight, comprising: semen ziziphi spinosae
5-10 parts, 3-5 parts of lily, 3-5 parts of Poria cocos, 3-5 parts of fructus lycii, 3-5 parts of mulberry fruit, 3-5 parts of radix polygonati officinalis, 4-8 parts of hawthorn, rose 3-5
Part, 3-5 parts of jujube, 4-6 parts of wheat, 3-5 parts of Radix Glycyrrhizae, 1-3 parts of fingered citron, 0.5-3 parts of fructus amomi.
In further embodiment of the invention, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include:
5-10 parts of oyster, 3-5 parts of notoginseng haulm, 3-5 parts of arillus longan, 3-5 parts of Rhizoma Gastrodiae, 4-6 parts of ganoderma lucidum.
In further embodiment of the invention, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include:
5-10 parts of keel, 5-10 parts of oyster, 5-10 parts of tortoiseshell, 5-10 parts of turtle shell, 3-6 parts of tuber fleeceflower stem.
In further embodiment of the invention, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include:
5-10 parts of Radix Codonopsis, 3-5 parts of Rhizoma Atractylodis Macrocephalae, 5-10 parts of Radix Astragali, 1-3 parts of Radix Polygalae, 1-3 parts of Radix Angelicae Sinensis, 1-3 parts of Rhizoma Chuanxiong, 1-3 parts of dried orange peel.
In further embodiment of the invention, have effects that the raw material components of the composition of resolving stagnation for tranquilization further include:
3-5 parts of Radix Rehmanniae, Radix Ophiopogonis 3-5 part, 3-5 parts of rhizoma anemarrhenae, 2-5 parts of Schisandra chinensis, 3-7 parts of Radix Salviae Miltiorrhizae, 3-6 parts of cortex albiziae, 3-6 parts of rhizoma cyperi, Cape jasmine
It is 1-3 parts sub-.
In addition, the present invention also provides the above-mentioned preparation methods with the composition of resolving stagnation for tranquilization, including walk as follows
It is rapid:
S1: it uses the mass fraction of 9-11 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, extracts
It is filtered after 1.8-2.2 hours, collects filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, being then condensed into specific gravity is 1.24-
1.26 the first medicinal extract；Filter residue is multiple with the water boiling and extraction with 9-11 times of quality, preferably 2 times, extraction is decocted every time
Time is 2 hours, is filtered after extraction, and simultaneously merging filtrate is collected；Supernatant is taken after filtrate is stood 6-8 hours；In adjusting
The pH value of clear liquid obtains hawthorn acidic aqueous solution to 5.5-6.0；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 9-11 times of quality and impregnates 55-65 minutes, later
It decocts and extracts 55-65 minutes, collect volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components are mixed, and it is small to be then placed in immersion 5.6-6.4 in hawthorn acidic aqueous solution
When, refluxing extraction is repeatedly preferably 2 times later, and the time of each refluxing extraction is 3 hours, is filtered after extraction, is collected simultaneously
Merging filtrate；Supernatant is taken after filtrate is stood 5-7 hours, is then condensed into the second medicinal extract that specific gravity is 1.24-1.26；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Combined with specific embodiments below to the composition and preparation method thereof with resolving stagnation for tranquilization provided by the invention
It is described further.
Embodiment 1
Has effects that the composition of resolving stagnation for tranquilization the present embodiment provides a kind of, raw material components are by weight, comprising: wild jujube
8 parts of benevolence, 4 parts of lily, 4 parts of Poria cocos, 4 parts of fructus lycii, 3 parts of mulberry fruit, 5 parts of radix polygonati officinalis, 6 parts of hawthorn, 4 parts of rose, 4 parts of jujube, wheat 5
Part, 4 parts of Radix Glycyrrhizae, 2 parts of fingered citron, 1.5 parts of fructus amomi.
By above-mentioned raw material, using preparation method provided by the invention, preparation has effects that the composition of resolving stagnation for tranquilization:
S1: it uses the mass fraction of 10 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, it is small to extract 2
When after filter, collect filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, is then condensed into the first leaching that specific gravity is 1.25
Cream；By water boiling and extraction 2 times of filter residue with 10 times of quality, decocting the time extracted every time is 2 hours, mistake after extraction
Simultaneously merging filtrate is collected in filter；Supernatant is taken after filtrate is stood 7 hours；The pH value of supernatant is adjusted to 5.8, obtains hawthorn acid
Property aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 10 times of quality and impregnates 60 minutes, decocts mention later
It takes 60 minutes, collects volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components being mixed, is then placed in hawthorn acidic aqueous solution and impregnates 6 hours, it
Refluxing extraction 2 times afterwards, the time of each refluxing extraction are 3 hours, are filtered after extraction, and simultaneously merging filtrate is collected；By filtrate
Supernatant is taken after standing 6 hours, is then condensed into the second medicinal extract that specific gravity is 1.25；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Embodiment 2
Has effects that the composition of resolving stagnation for tranquilization the present embodiment provides a kind of, raw material components are by weight, comprising: wild jujube
8 parts of benevolence, 4 parts of lily, 4 parts of Poria cocos, 4 parts of fructus lycii, 3 parts of mulberry fruit, 5 parts of radix polygonati officinalis, 6 parts of hawthorn, 4 parts of rose, 4 parts of jujube, wheat 5
Part, 4 parts of Radix Glycyrrhizae, 2 parts of fingered citron, 1.5 parts of fructus amomi, 8 parts of oyster, 4 parts of notoginseng haulm, 4 parts of arillus longan, 4 parts of Rhizoma Gastrodiae, 5 parts of ganoderma lucidum.
By above-mentioned raw material, using preparation method provided by the invention, preparation has effects that the composition of resolving stagnation for tranquilization:
S1: it uses the mass fraction of 10 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, it is small to extract 2
When after filter, collect filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, is then condensed into the first leaching that specific gravity is 1.25
Cream；By water boiling and extraction 2 times of filter residue with 10 times of quality, decocting the time extracted every time is 2 hours, mistake after extraction
Simultaneously merging filtrate is collected in filter；Supernatant is taken after filtrate is stood 7 hours；The pH value of supernatant is adjusted to 5.8, obtains hawthorn acid
Property aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 10 times of quality and impregnates 60 minutes, decocts mention later
It takes 60 minutes, collects volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components being mixed, is then placed in hawthorn acidic aqueous solution and impregnates 6 hours, it
Refluxing extraction 2 times afterwards, the time of each refluxing extraction are 3 hours, are filtered after extraction, and simultaneously merging filtrate is collected；By filtrate
Supernatant is taken after standing 6 hours, is then condensed into the second medicinal extract that specific gravity is 1.25；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Embodiment 3
Has effects that the composition of resolving stagnation for tranquilization the present embodiment provides a kind of, raw material components are by weight, comprising: wild jujube
8 parts of benevolence, 4 parts of lily, 4 parts of Poria cocos, 4 parts of fructus lycii, 3 parts of mulberry fruit, 5 parts of radix polygonati officinalis, 6 parts of hawthorn, 4 parts of rose, 4 parts of jujube, wheat 5
Part, 4 parts of Radix Glycyrrhizae, 2 parts of fingered citron, 1.5 parts of fructus amomi, 7 parts of keel, 6 parts of oyster, 8 parts of tortoiseshell, 7 parts of turtle shell, 4.5 parts of tuber fleeceflower stem.
By above-mentioned raw material, using preparation method provided by the invention, preparation has effects that the composition of resolving stagnation for tranquilization:
S1: it uses the mass fraction of 10 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, it is small to extract 2
When after filter, collect filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, is then condensed into the first leaching that specific gravity is 1.25
Cream；By water boiling and extraction 2 times of filter residue with 10 times of quality, decocting the time extracted every time is 2 hours, mistake after extraction
Simultaneously merging filtrate is collected in filter；Supernatant is taken after filtrate is stood 7 hours；The pH value of supernatant is adjusted to 5.8, obtains hawthorn acid
Property aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 10 times of quality and impregnates 60 minutes, decocts mention later
It takes 60 minutes, collects volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components being mixed, is then placed in hawthorn acidic aqueous solution and impregnates 6 hours, it
Refluxing extraction 2 times afterwards, the time of each refluxing extraction are 3 hours, are filtered after extraction, and simultaneously merging filtrate is collected；By filtrate
Supernatant is taken after standing 6 hours, is then condensed into the second medicinal extract that specific gravity is 1.25；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Embodiment 4
Has effects that the composition of resolving stagnation for tranquilization the present embodiment provides a kind of, raw material components are by weight, comprising: wild jujube
8 parts of benevolence, 4 parts of lily, 4 parts of Poria cocos, 4 parts of fructus lycii, 3 parts of mulberry fruit, 5 parts of radix polygonati officinalis, 6 parts of hawthorn, 4 parts of rose, 4 parts of jujube, wheat 5
Part, 4 parts of Radix Glycyrrhizae, 2 parts of fingered citron, 1.5 parts of fructus amomi, 7 parts of Radix Codonopsis, 4 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Astragali, 2 parts of Radix Polygalae, 2 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiong,
2 parts of dried orange peel.
By above-mentioned raw material, using preparation method provided by the invention, preparation has effects that the composition of resolving stagnation for tranquilization:
S1: it uses the mass fraction of 10 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, it is small to extract 2
When after filter, collect filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, is then condensed into the first leaching that specific gravity is 1.25
Cream；By water boiling and extraction 2 times of filter residue with 10 times of quality, decocting the time extracted every time is 2 hours, mistake after extraction
Simultaneously merging filtrate is collected in filter；Supernatant is taken after filtrate is stood 7 hours；The pH value of supernatant is adjusted to 5.8, obtains hawthorn acid
Property aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 10 times of quality and impregnates 60 minutes, decocts mention later
It takes 60 minutes, collects volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components being mixed, is then placed in hawthorn acidic aqueous solution and impregnates 6 hours, it
Refluxing extraction 2 times afterwards, the time of each refluxing extraction are 3 hours, are filtered after extraction, and simultaneously merging filtrate is collected；By filtrate
Supernatant is taken after standing 6 hours, is then condensed into the second medicinal extract that specific gravity is 1.25；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Embodiment 5
Has effects that the composition of resolving stagnation for tranquilization the present embodiment provides a kind of, raw material components are by weight, comprising: wild jujube
8 parts of benevolence, 4 parts of lily, 4 parts of Poria cocos, 4 parts of fructus lycii, 3 parts of mulberry fruit, 5 parts of radix polygonati officinalis, 6 parts of hawthorn, 4 parts of rose, 4 parts of jujube, wheat 5
Part, 4 parts of Radix Glycyrrhizae, 2 parts of fingered citron, 1.5 parts of fructus amomi, 4 parts of Radix Rehmanniae, 4 parts of Radix Ophiopogonis, 4 parts of rhizoma anemarrhenae, 3 parts of Schisandra chinensis, 5 parts of Radix Salviae Miltiorrhizae, cortex albiziae
4.5 parts, 4.5 parts of rhizoma cyperi, 2 parts of cape jasmine.
By above-mentioned raw material, using preparation method provided by the invention, preparation has effects that the composition of resolving stagnation for tranquilization:
S1: it uses the mass fraction of 10 times of quality to carry out refluxing extraction for 70% ethanol water hawthorn, it is small to extract 2
When after filter, collect filtrate and filter residue respectively；Filtrate is subjected to ethyl alcohol recycling, is then condensed into the first leaching that specific gravity is 1.25
Cream；By water boiling and extraction 2 times of filter residue with 10 times of quality, decocting the time extracted every time is 2 hours, mistake after extraction
Simultaneously merging filtrate is collected in filter；Supernatant is taken after filtrate is stood 7 hours；The pH value of supernatant is adjusted to 5.8, obtains hawthorn acid
Property aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, is then placed in the water of 10 times of quality and impregnates 60 minutes, decocts mention later
It takes 60 minutes, collects volatile oil and the dregs of a decoction respectively；
S3: the dregs of a decoction and other surplus stock components being mixed, is then placed in hawthorn acidic aqueous solution and impregnates 6 hours, it
Refluxing extraction 2 times afterwards, the time of each refluxing extraction are 3 hours, are filtered after extraction, and simultaneously merging filtrate is collected；By filtrate
Supernatant is taken after standing 6 hours, is then condensed into the second medicinal extract that specific gravity is 1.25；
S4: the first medicinal extract and the second medicinal extract are mixed, then dry under conditions of being no more than 60 DEG C, are crushed later, mistake
100 meshes collect fine powder；Fine powder and volatile oil are uniformly mixed, the composition with resolving stagnation for tranquilization is obtained.
Have effects that the composition of resolving stagnation for tranquilization for what the embodiment of the present invention 1 to embodiment 5 was prepared, by test come
Evaluate its effect.
1, anti-insomnia, antidepressant effect
Laboratory sample: what embodiment 1-5 was prepared has effects that the composition of resolving stagnation for tranquilization.
Experimental subjects: insomnia, depression are examined using " Chinese Spirit Obstacles classification and diagnostic criteria " (CCMD-3)
Disconnected standard, collects 200 cases, wherein insomniacs 100 altogether, and depression person 100.
Treatment method: insomniacs, depression person are respectively divided into 5 groups, every group 20 (corresponding index is without statistics between each group
Learn difference).What every group of patient took corresponding group respectively has effects that the composition of resolving stagnation for tranquilization, 10g/ times, 1 time a day, before sleeping
Warm water is taken after mixing it with water, 10 days as one therapeutic course, even served 2 courses for the treatment of.
Observation method: (1) curative effect to insomnia with Pittsburg Sleep Quality Index scale (PSQI) is evaluated.PSQI is by 23
A entry is constituted, and the entry for participating in score is combined into 7 ingredients, and by 0-3 points of score, add up each component score is each ingredient
PSQI total score (0-21), higher expression sleep quality is poorer, and PSQI total score is more than 7 points of the case for being included in insomnia.
(2) curative effect to depression is evaluated with Hamilton scale (HAMD).HAMD total score can preferably reflect depression
The severity of shape, higher expression depressive symptom is more serious, and it is depression case that HAMD (17 versions) total score, which is more than 17 points,.
(3) curative effect judges benchmark: it is effective, effective, invalid that symptom improvement degree is divided into；It is effective: 100% or more original symptom
It disappears；Effective: 60% or more original symptom disappears or mitigates；Invalid: 60% or less original symptom mitigates or entirely without mitigation.
As a result: clinical effectiveness statistics is as shown in table 1 below.
The curative effect of 1 each group of table
PSQI total score evaluation situation (each cell mean) is shown in Table 2.
2 PSQI total score evaluation result of table
HAMD total score evaluation situation (each cell mean) is shown in Table 3.
3 HAMD total score evaluation result of table
| Group | Before medication | After medication (20 days) |
| Embodiment 1 | 23.15 | 14.85 |
| Embodiment 2 | 22.68 | 13.92 |
| Embodiment 3 | 22.97 | 13.58 |
| Embodiment 4 | 23.04 | 13.07 |
| Embodiment 5 | 23.17 | 12.93 |
2, several typical cases are enumerated.
(1) it is high certain, female, 29 years old, sale, work of often going on business, often insomnia in this year, sometimes all through the night, it is difficult to
It falls asleep, uneasy then dusk aggravation of sleeping, spiritlessness and weakness, body is tired out, hypomnesia；Start to take the offer of the embodiment of the present invention 2 afterwards
Has effects that the composition (warm water is taken after mixing it with water, 1 time a day, each 10g) of resolving stagnation for tranquilization, by the 10th day, night, which sleeps, had taken great strides in one's progress, every night
It can sleep 4-5 hours, appetite is promoted, and spirit improves；It continuously takes 20 days, sleep restores normal, and energetic, reminiscence is just
Often.
(2) fourth, male, entrepreneur, 35 years old, nearly three months operating pressures were big, depression, and crouch not peaceful, not firm, main table of sleeping
It is now difficult to fall asleep, sleep in easily wake up with a start, dreaminess is lain awake all night when serious, next day insobriety, vexed amnesia；After start to take this
The composition (warm water is taken after mixing it with water, 1 time a day, each 10g) that inventive embodiments 5 provided have effects that resolving stagnation for tranquilization, by the 10th day,
It can sleep every night 4-5 hours, sleep quality significantly improves, and the next day state of mind improves；Continuously to take 20 days, sleep restores normal,
Happy, energetic, reminiscence is normal.
It should be noted that unless otherwise indicated, technical term or scientific term used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustratively, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indication or suggestion relative importance or implicitly indicates the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include one or more of the features.In the description of the present invention,
The meaning of " plurality " is two or more, unless otherwise specifically defined.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (10)
1. a kind of have effects that the composition of resolving stagnation for tranquilization, which is characterized in that raw material components are by weight, comprising:
5-10 parts of semen ziziphi spinosae, 3-5 parts of lily, 3-5 parts of Poria cocos, 3-5 parts of fructus lycii, 3-5 parts of mulberry fruit, 3-5 parts of radix polygonati officinalis, 4-8 parts of hawthorn,
3-5 parts of rose, 3-5 parts of jujube, 4-6 parts of wheat, 3-5 parts of Radix Glycyrrhizae, 1-3 parts of fingered citron, 0.5-3 parts of fructus amomi.
2. according to claim 1 have effects that the composition of resolving stagnation for tranquilization, which is characterized in that raw material components further include:
5-10 parts of oyster, 3-5 parts of notoginseng haulm, 3-5 parts of arillus longan, 3-5 parts of Rhizoma Gastrodiae, 4-6 parts of ganoderma lucidum.
3. according to claim 1 have effects that the composition of resolving stagnation for tranquilization, which is characterized in that raw material components further include:
5-10 parts of keel, 5-10 parts of oyster, 5-10 parts of tortoiseshell, 5-10 parts of turtle shell, 3-6 parts of tuber fleeceflower stem.
4. according to claim 1 have effects that the composition of resolving stagnation for tranquilization, which is characterized in that raw material components further include:
5-10 parts of Radix Codonopsis, 3-5 parts of Rhizoma Atractylodis Macrocephalae, 5-10 parts of Radix Astragali, 1-3 parts of Radix Polygalae, 1-3 parts of Radix Angelicae Sinensis, 1-3 parts of Rhizoma Chuanxiong, 1-3 parts of dried orange peel.
5. according to claim 1 have effects that the composition of resolving stagnation for tranquilization, which is characterized in that raw material components further include:
3-5 parts of Radix Rehmanniae, Radix Ophiopogonis 3-5 part, 3-5 parts of rhizoma anemarrhenae, 2-5 parts of Schisandra chinensis, 3-7 parts of Radix Salviae Miltiorrhizae, 3-6 parts of cortex albiziae, rhizoma cyperi 3-6
Part, 1-3 parts of cape jasmine.
6. the described in any item preparation methods with the composition of resolving stagnation for tranquilization of claim 1-5, which is characterized in that packet
Include step:
S1: hawthorn is subjected to refluxing extraction using ethanol water, is filtered after extraction, collects filtrate and filter residue respectively；It will
The filtrate carries out ethyl alcohol recycling, is then condensed into the first medicinal extract；The filter residue is subjected to decoction extraction with water, after extraction
It filters and collects filtrate；Supernatant is taken after the filtrate is stood；The pH value of the supernatant is adjusted to 5.5-6.0, obtains mountain
Short, bristly hair or beard acidic aqueous solution；
S2: being ground into coarse powder for fingered citron and fructus amomi, be then placed in water and impregnate, and carries out decoction extraction later, collects volatilization respectively
Oil and the dregs of a decoction；
S3: the dregs of a decoction and other surplus stock components are mixed, is then placed in the hawthorn acidic aqueous solution and impregnates, later
Refluxing extraction is carried out, is filtered after extraction and collects filtrate；Supernatant is taken after the filtrate is stood, is then condensed into second
Medicinal extract；
S4: first medicinal extract and second medicinal extract being mixed, then low temperature drying, are crushed, are sieved later, collect fine powder；
The fine powder and the volatile oil are uniformly mixed, obtain described having effects that the composition of resolving stagnation for tranquilization.
7. the preparation method with the composition of resolving stagnation for tranquilization according to claim 6, it is characterised in that:
In S1, the quality of the ethanol water is 9-11 times of the hawthorn quality, the mass fraction of the ethanol water
It is 70%, the time of the refluxing extraction is 1.8-2.2 hours；The specific gravity of first medicinal extract is 1.24-1.26；
It is described decoct extract number be it is multiple, preferably 2 times, every time decoct extraction time be 2 hours；
The quality of water is 9-11 times of the filter residue quality；
The time of the standing is 6-8 hours.
8. the preparation method with the composition of resolving stagnation for tranquilization according to claim 6, it is characterised in that:
In S2, the quality of water is 9-11 times of the gross mass of the fingered citron and the fructus amomi, and the time of the immersion is 55-65 points
Clock；The time for decocting extraction is 55-65 minutes.
9. the preparation method with the composition of resolving stagnation for tranquilization according to claim 6, it is characterised in that:
In S3, time of the immersion is 5.6-6.4 hours, the number of the refluxing extraction be it is multiple, preferably 2 times, every time
The time of refluxing extraction is 3 hours；The time of the standing is 5-7 hours；The specific gravity of second medicinal extract is 1.24-1.26；
In S4, the temperature of the low temperature drying is no more than 60 DEG C, and the sieving is to sieve with 100 mesh sieve.
10. the described in any item compositions of claim 1-5 have effects that the drug of resolving stagnation for tranquilization and/or drug addition in preparation
Application in agent.
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| CN114452350A (en) * | 2022-02-22 | 2022-05-10 | 郑淑之 | Jujube kernel wine capable of relieving insomnia |
| CN114568707A (en) * | 2022-03-16 | 2022-06-03 | 齐鲁工业大学 | Protein energy bar suitable for depression susceptible population |
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| CN114452350A (en) * | 2022-02-22 | 2022-05-10 | 郑淑之 | Jujube kernel wine capable of relieving insomnia |
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