CN100502839C - 用于天然结合型雌激素混合物压片的预制剂 - Google Patents
用于天然结合型雌激素混合物压片的预制剂 Download PDFInfo
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- CN100502839C CN100502839C CNB2006101684418A CN200610168441A CN100502839C CN 100502839 C CN100502839 C CN 100502839C CN B2006101684418 A CNB2006101684418 A CN B2006101684418A CN 200610168441 A CN200610168441 A CN 200610168441A CN 100502839 C CN100502839 C CN 100502839C
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- 239000000203 mixture Substances 0.000 title claims abstract description 198
- 238000009472 formulation Methods 0.000 title claims abstract description 105
- 229940035811 conjugated estrogen Drugs 0.000 title claims abstract description 72
- 239000000126 substance Substances 0.000 claims abstract description 97
- 239000000284 extract Substances 0.000 claims abstract description 96
- 229940088597 hormone Drugs 0.000 claims abstract description 78
- 239000005556 hormone Substances 0.000 claims abstract description 78
- 238000000034 method Methods 0.000 claims abstract description 74
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- 229940011871 estrogen Drugs 0.000 claims abstract description 59
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- 241000283073 Equus caballus Species 0.000 claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
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- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 56
- 239000003937 drug carrier Substances 0.000 claims description 54
- 239000007864 aqueous solution Substances 0.000 claims description 36
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 34
- 239000008101 lactose Substances 0.000 claims description 34
- 210000002700 urine Anatomy 0.000 claims description 26
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- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 19
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 19
- 238000009826 distribution Methods 0.000 claims description 19
- 229960003399 estrone Drugs 0.000 claims description 19
- RYWZPRVUQHMJFF-KSZLIROESA-N 17alpha-Dihydroequilenin Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CC[C@H]3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-KSZLIROESA-N 0.000 claims description 18
- RYWZPRVUQHMJFF-UHFFFAOYSA-N 17alpha-Dihydroequilenin Natural products OC1=CC=C2C(CCC3(C4CCC3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-UHFFFAOYSA-N 0.000 claims description 18
- 239000012141 concentrate Substances 0.000 claims description 18
- 229930182834 17alpha-Estradiol Natural products 0.000 claims description 17
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 claims description 17
- PDRGHUMCVRDZLQ-UHFFFAOYSA-N d-equilenin Natural products OC1=CC=C2C(CCC3(C4CCC3=O)C)=C4C=CC2=C1 PDRGHUMCVRDZLQ-UHFFFAOYSA-N 0.000 claims description 17
- PDRGHUMCVRDZLQ-WMZOPIPTSA-N equilenin Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CCC3=O)C)=C4C=CC2=C1 PDRGHUMCVRDZLQ-WMZOPIPTSA-N 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- RYWZPRVUQHMJFF-BZSNNMDCSA-N (13s,14s,17s)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CC[C@@H]3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-BZSNNMDCSA-N 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
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- 239000003960 organic solvent Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
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- QMLVWIVCALQEEX-AKXYIILFSA-M sodium;[(13s,14s)-13-methyl-17-oxo-12,14,15,16-tetrahydro-11h-cyclopenta[a]phenanthren-3-yl] sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2C(CC[C@]3([C@H]4CCC3=O)C)=C4C=CC2=C1 QMLVWIVCALQEEX-AKXYIILFSA-M 0.000 claims description 4
- 239000011343 solid material Substances 0.000 claims description 3
- NLLMJANWPUQQTA-UBDQQSCGSA-N 7,8-didehydro-17beta-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4C3=CCC2=C1 NLLMJANWPUQQTA-UBDQQSCGSA-N 0.000 claims description 2
- WKRLQDKEXYKHJB-UHFFFAOYSA-N Equilin Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3=CCC2=C1 WKRLQDKEXYKHJB-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- WKRLQDKEXYKHJB-HFTRVMKXSA-N equilin Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 WKRLQDKEXYKHJB-HFTRVMKXSA-N 0.000 claims description 2
- NLLMJANWPUQQTA-SPUZQDLCSA-N estra-1,3,5(10),7-tetraene-3,17alpha-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4C3=CCC2=C1 NLLMJANWPUQQTA-SPUZQDLCSA-N 0.000 claims description 2
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- 159000000000 sodium salts Chemical class 0.000 claims description 2
- HBVSSZJQFZAJLK-RXQQAGQTSA-M sodium;[(13s,14s,17r)-17-hydroxy-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthren-3-yl] sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2C(CC[C@]3([C@H]4CC[C@H]3O)C)=C4C=CC2=C1 HBVSSZJQFZAJLK-RXQQAGQTSA-M 0.000 claims description 2
- HBVSSZJQFZAJLK-UVJOBNTFSA-M sodium;[(13s,14s,17s)-17-hydroxy-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthren-3-yl] sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2C(CC[C@]3([C@H]4CC[C@@H]3O)C)=C4C=CC2=C1 HBVSSZJQFZAJLK-UVJOBNTFSA-M 0.000 claims description 2
- LMJQCTISQYSLPF-JOWXCZTESA-M sodium;[(8r,9s,13s,14s,17r)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 LMJQCTISQYSLPF-JOWXCZTESA-M 0.000 claims description 2
- VUCAHVBMSFIGAI-ZFINNJDLSA-M estrone sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 VUCAHVBMSFIGAI-ZFINNJDLSA-M 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 238000012106 screening analysis Methods 0.000 claims 1
- 229960000747 sodium estrone sulfate Drugs 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- 238000012545 processing Methods 0.000 abstract description 11
- 238000012360 testing method Methods 0.000 description 51
- 239000003826 tablet Substances 0.000 description 22
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- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 239000007891 compressed tablet Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- -1 sulfate ester Chemical class 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- HVDGDHBAMCBBLR-UHFFFAOYSA-N enterolactone Chemical compound OC1=CC=CC(CC2C(C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-UHFFFAOYSA-N 0.000 description 3
- 230000009969 flowable effect Effects 0.000 description 3
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- 229910052708 sodium Inorganic materials 0.000 description 3
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- 229910021653 sulphate ion Inorganic materials 0.000 description 3
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- 239000007909 solid dosage form Substances 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- HUUTWYHKKBIOMQ-UHFFFAOYSA-N 3-[(3-hydroxyphenyl)methyl]-3h-furan-2-one Chemical compound OC1=CC=CC(CC2C(OC=C2)=O)=C1 HUUTWYHKKBIOMQ-UHFFFAOYSA-N 0.000 description 1
- 206010003439 Artificial menopause Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
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- 239000002706 dry binder Substances 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
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- 238000004817 gas chromatography Methods 0.000 description 1
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- 238000010943 off-gassing Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01129840.3 | 2001-12-14 | ||
| EP01129840 | 2001-12-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028262077A Division CN1298313C (zh) | 2001-12-14 | 2002-12-12 | 用于天然结合型雌激素混合物压片的预制剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1977862A CN1977862A (zh) | 2007-06-13 |
| CN100502839C true CN100502839C (zh) | 2009-06-24 |
Family
ID=8179550
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101684418A Expired - Fee Related CN100502839C (zh) | 2001-12-14 | 2002-12-12 | 用于天然结合型雌激素混合物压片的预制剂 |
| CNB028262077A Expired - Fee Related CN1298313C (zh) | 2001-12-14 | 2002-12-12 | 用于天然结合型雌激素混合物压片的预制剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028262077A Expired - Fee Related CN1298313C (zh) | 2001-12-14 | 2002-12-12 | 用于天然结合型雌激素混合物压片的预制剂 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8273728B2 (enExample) |
| EP (1) | EP1458363B1 (enExample) |
| JP (1) | JP4695838B2 (enExample) |
| CN (2) | CN100502839C (enExample) |
| AR (1) | AR037642A1 (enExample) |
| AU (1) | AU2002358682B2 (enExample) |
| BR (1) | BR0214954A (enExample) |
| CA (1) | CA2470209A1 (enExample) |
| ES (1) | ES2403218T3 (enExample) |
| MX (1) | MXPA04005767A (enExample) |
| PL (1) | PL205544B1 (enExample) |
| TW (1) | TWI332400B (enExample) |
| WO (1) | WO2003051337A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9586335B2 (en) * | 2010-01-27 | 2017-03-07 | Sd3, Llc | Blade guard with dust collection |
| TWI332400B (en) * | 2001-12-14 | 2010-11-01 | Solvay Pharm Gmbh | Preformulation for the tableting of natural mixtures of conjugated estrogens |
| US8349819B2 (en) | 2002-10-09 | 2013-01-08 | Dr. Reddy's Laboratories New York, Inc. | Steroid extraction process from urine sources |
| US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US20090232897A1 (en) * | 2008-03-14 | 2009-09-17 | Bijayananda Sahoo | Pharmaceutical compositions comprising conjugated estrogens |
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- 2002-11-29 TW TW091134752A patent/TWI332400B/zh not_active IP Right Cessation
- 2002-12-04 AR ARP020104698A patent/AR037642A1/es unknown
- 2002-12-12 CA CA002470209A patent/CA2470209A1/en not_active Abandoned
- 2002-12-12 CN CNB2006101684418A patent/CN100502839C/zh not_active Expired - Fee Related
- 2002-12-12 PL PL368730A patent/PL205544B1/pl unknown
- 2002-12-12 MX MXPA04005767A patent/MXPA04005767A/es active IP Right Grant
- 2002-12-12 CN CNB028262077A patent/CN1298313C/zh not_active Expired - Fee Related
- 2002-12-12 WO PCT/EP2002/014104 patent/WO2003051337A1/de not_active Ceased
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- 2002-12-12 AU AU2002358682A patent/AU2002358682B2/en not_active Ceased
- 2002-12-12 BR BR0214954-0A patent/BR0214954A/pt not_active IP Right Cessation
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| CN1036328A (zh) * | 1987-12-22 | 1989-10-18 | 阿克佐公司 | 治疗更年期疾病和骨质疏松症的药物剂量单位 |
| CN1197387A (zh) * | 1995-07-26 | 1998-10-28 | 杜拉梅德药品有限公司 | 共轭雌激素药物组合物及其应用方法 |
| CN1298313C (zh) * | 2001-12-14 | 2007-02-07 | 索尔瓦药物有限公司 | 用于天然结合型雌激素混合物压片的预制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL368730A1 (en) | 2005-04-04 |
| CN1298313C (zh) | 2007-02-07 |
| TW200408400A (en) | 2004-06-01 |
| CN1607944A (zh) | 2005-04-20 |
| HK1075007A1 (en) | 2005-12-02 |
| CA2470209A1 (en) | 2003-06-26 |
| CN1977862A (zh) | 2007-06-13 |
| ES2403218T3 (es) | 2013-05-16 |
| AU2002358682A1 (en) | 2003-06-30 |
| JP4695838B2 (ja) | 2011-06-08 |
| AU2002358682B2 (en) | 2009-03-26 |
| BR0214954A (pt) | 2004-12-14 |
| JP2005516923A (ja) | 2005-06-09 |
| US20120237666A1 (en) | 2012-09-20 |
| US8329679B2 (en) | 2012-12-11 |
| EP1458363B1 (de) | 2013-01-16 |
| HK1104220A1 (zh) | 2008-01-11 |
| WO2003051337A1 (de) | 2003-06-26 |
| PL205544B1 (pl) | 2010-04-30 |
| MXPA04005767A (es) | 2004-09-10 |
| AR037642A1 (es) | 2004-11-17 |
| US8273728B2 (en) | 2012-09-25 |
| TWI332400B (en) | 2010-11-01 |
| EP1458363A1 (de) | 2004-09-22 |
| US20050009800A1 (en) | 2005-01-13 |
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