CA2470209A1 - Pre-formulation for the tabletting of natural mixtures of conjugated estrogens - Google Patents

Pre-formulation for the tabletting of natural mixtures of conjugated estrogens Download PDF

Info

Publication number
CA2470209A1
CA2470209A1 CA002470209A CA2470209A CA2470209A1 CA 2470209 A1 CA2470209 A1 CA 2470209A1 CA 002470209 A CA002470209 A CA 002470209A CA 2470209 A CA2470209 A CA 2470209A CA 2470209 A1 CA2470209 A1 CA 2470209A1
Authority
CA
Canada
Prior art keywords
weight
preformulation
pharmaceutical
support material
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002470209A
Other languages
English (en)
French (fr)
Inventor
Bernd Thumbeck
Ingo Bonnacker
Martina Lerch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2470209A1 publication Critical patent/CA2470209A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002470209A 2001-12-14 2002-12-12 Pre-formulation for the tabletting of natural mixtures of conjugated estrogens Abandoned CA2470209A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01129840.3 2001-12-14
EP01129840 2001-12-14
PCT/EP2002/014104 WO2003051337A1 (de) 2001-12-14 2002-12-12 Präformulierung für die tablettierung von natürlichen gemischen konjugierter oestrogene

Publications (1)

Publication Number Publication Date
CA2470209A1 true CA2470209A1 (en) 2003-06-26

Family

ID=8179550

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002470209A Abandoned CA2470209A1 (en) 2001-12-14 2002-12-12 Pre-formulation for the tabletting of natural mixtures of conjugated estrogens

Country Status (13)

Country Link
US (2) US8273728B2 (enExample)
EP (1) EP1458363B1 (enExample)
JP (1) JP4695838B2 (enExample)
CN (2) CN100502839C (enExample)
AR (1) AR037642A1 (enExample)
AU (1) AU2002358682B2 (enExample)
BR (1) BR0214954A (enExample)
CA (1) CA2470209A1 (enExample)
ES (1) ES2403218T3 (enExample)
MX (1) MXPA04005767A (enExample)
PL (1) PL205544B1 (enExample)
TW (1) TWI332400B (enExample)
WO (1) WO2003051337A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9586335B2 (en) * 2010-01-27 2017-03-07 Sd3, Llc Blade guard with dust collection
TWI332400B (en) * 2001-12-14 2010-11-01 Solvay Pharm Gmbh Preformulation for the tableting of natural mixtures of conjugated estrogens
US8349819B2 (en) 2002-10-09 2013-01-08 Dr. Reddy's Laboratories New York, Inc. Steroid extraction process from urine sources
US6992075B2 (en) * 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US20090232897A1 (en) * 2008-03-14 2009-09-17 Bijayananda Sahoo Pharmaceutical compositions comprising conjugated estrogens
WO2010144865A2 (en) 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
CA2768452A1 (en) * 2009-07-16 2011-01-20 Avantor Performance Materials, Inc. Material and process for incorporation of low dosage active pharmaceutical ingredients and use thereof
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
EP2787987B1 (de) * 2011-12-08 2016-06-01 Hexal AG Neue pharmazeutische statin-zusammensetzung
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
US20210246928A1 (en) * 2020-02-11 2021-08-12 Carl Chasse Fastener having improved wobble control, fastening system including the same, and method of forming the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487152A (en) * 1967-02-07 1969-12-30 Hoffmann La Roche Tablets containing 7 - chloro - 2 - methylamino - 5 - phenyl - 3h - 1,4 - benzodiazepine-4-oxide and conjugated estrogenic substances
US4154820A (en) 1976-02-23 1979-05-15 Akzona Incorporated Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers
DE3535536A1 (de) * 1985-10-04 1987-04-09 Lentia Gmbh Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut
EP0322020A1 (en) * 1987-12-22 1989-06-28 Akzo N.V. Pharmaceutical dosage unit for treating climacteric complaints and osteoporosis
WO1997004752A1 (en) * 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
ATE264110T1 (de) 1996-08-30 2004-04-15 Solvay Pharm Gmbh Prozess zur gewinnung von oestrogenen aus stutenharn
DK0923381T3 (da) 1996-08-30 2004-05-10 Solvay Pharm Gmbh Fremgangsmåde til fremstilling af östrogener ud fra hoppeurin
US6200289B1 (en) 1998-04-10 2001-03-13 Milestone Scientific, Inc. Pressure/force computer controlled drug delivery system and the like
JP2000156938A (ja) 1998-11-19 2000-06-06 Hokuto Denko Kk 電池の充放電試験装置
TWI332400B (en) * 2001-12-14 2010-11-01 Solvay Pharm Gmbh Preformulation for the tableting of natural mixtures of conjugated estrogens

Also Published As

Publication number Publication date
PL368730A1 (en) 2005-04-04
CN100502839C (zh) 2009-06-24
CN1298313C (zh) 2007-02-07
TW200408400A (en) 2004-06-01
CN1607944A (zh) 2005-04-20
HK1075007A1 (en) 2005-12-02
CN1977862A (zh) 2007-06-13
ES2403218T3 (es) 2013-05-16
AU2002358682A1 (en) 2003-06-30
JP4695838B2 (ja) 2011-06-08
AU2002358682B2 (en) 2009-03-26
BR0214954A (pt) 2004-12-14
JP2005516923A (ja) 2005-06-09
US20120237666A1 (en) 2012-09-20
US8329679B2 (en) 2012-12-11
EP1458363B1 (de) 2013-01-16
HK1104220A1 (zh) 2008-01-11
WO2003051337A1 (de) 2003-06-26
PL205544B1 (pl) 2010-04-30
MXPA04005767A (es) 2004-09-10
AR037642A1 (es) 2004-11-17
US8273728B2 (en) 2012-09-25
TWI332400B (en) 2010-11-01
EP1458363A1 (de) 2004-09-22
US20050009800A1 (en) 2005-01-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20151009

FZDE Discontinued

Effective date: 20151009