CN100496439C - Surface processed cotton sliver, suppository and its preparing process - Google Patents
Surface processed cotton sliver, suppository and its preparing process Download PDFInfo
- Publication number
- CN100496439C CN100496439C CNB2004100912600A CN200410091260A CN100496439C CN 100496439 C CN100496439 C CN 100496439C CN B2004100912600 A CNB2004100912600 A CN B2004100912600A CN 200410091260 A CN200410091260 A CN 200410091260A CN 100496439 C CN100496439 C CN 100496439C
- Authority
- CN
- China
- Prior art keywords
- parts
- suppository
- cotton sliver
- substrate
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The present invention discloses a kind of surface treated cotton sliver with adsorbed matrix in the surface or in the surface and inside, the preparation process of the surface treated cotton sliver, the suppository comprising the surface treated cotton sliver and suppository body and its preparation process. The surface treated cotton sliver has protecting layer formed on the surface to avoid medicine absorption causing waste during preparing suppository and control the medicine amount to shape the suppository.
Description
Technical field
The present invention relates to suppository and preparation technology thereof that a kind of health is composited with cotton sliver, by cotton sliver and key.Belong to pharmaceutical sanitary field.
Background technology
General commonly used suppository is DNAcarrier free, and the substrate of medicine and its filling effect is mixed and made into effigurate cylinder suppository, relies on suppository base constantly to dissolve in vivo and slowly releases medicine, reaches medical effect.But the suppository that dissolves can not in time be absorbed in the body fully, and owing to the outflow of medicine and substrate, the meeting pollution clothes is made troubles to user in use.And this outflow concentration that also can cause medicine can not remain valid for a long time in vivo.
Therefore, existing many technical staff improve the structure of suppository, make tampon and suppository integrated, can avoid medicinal liquid to flow out, and do not pollute clothing, and can promote drug absorption, long action time, use advantages such as easy to carry.
Such as, application number is 89210570.4 the cotton base of a kind of protection for the health of woman articles for use hollow cylindrical, makes by medical absorbent cotton, and be axle with the cellulosic inner core, the cotton layer of cylinder of the typing shape that the absorbent cotton sheet is rolled into; Be coated with to carry out on the cotton pilum body and the skim dextrin arranged as sealing coat; Be coated with on the sealing coat that shoe is made up of the glycerin gelatine layer four-layer structure of glycerol that contains certain moisture content and gelatin mixture.With this cotton base is that substrate can be made various vaginal suppositories.This suppository can fully keep medicine concentration in vivo, to reach curative effect, can prevent the outflow of medicine and liquid again, and is very easy to use.But this technology is more loaded down with trivial details, can improve the processing cost of product, is not easy to large-scale industrial production.
The patent No. is 96216798.3 the compound bolt of a kind of medicinal vagina, belongs to medical suppository.It is by the medicine key that is streamline bomb shape, and half is embedding and be fixed with the health tampon in it, and the afterbody of health tampon is provided with the bolt lead-in wire and constitutes.The medicine key also can be molded as warhead form, duckbill shape.Its processing technique is simple, self have lubrication, can avoid medicinal liquid to flow out, and do not pollute clothing, and can promote drug absorption, long action time, uses easy to carry.Though this patent technology is simple and easy to do, the suppository material is softer, also causes key to be difficult for being shaped easily in system bolt process, can't use.
Summary of the invention
The object of the present invention is to provide a kind of surface-treated cotton sliver, the cotton sliver surface forms protective layer, can prevent to combine absorption medicinal liquid when making bolt with medicine, makes all dosages controlled, occurs deformed phenomenon when preventing to make bolt.
Another object of the present invention is to provide a kind of preparation technology of surface-treated cotton sliver, this processing technique is simple and easy to do, is easy to suitability for industrialized production.
A further object of the present invention is to provide a kind of suppository, and this suppository is composited by cotton sliver and key, and is not yielding, is convenient to the patient and uses.
An also purpose of the present invention is to provide a kind of preparation technology of suppository, and this processing technique is simple and easy to do, is easy to suitability for industrialized production.
In order to realize the object of the invention, the invention provides a kind of surface-treated cotton sliver, it is characterized in that cotton sliver surface or surface and inside thereof are adsorbed with substrate.
Described substrate is preparation suppository substrate commonly used, can be water solublity or fat-soluble etc.Such as: wherein a kind of such as semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin; Wherein a kind of of semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol or poloxamer preferably wherein.
The preparation method of a kind of surface-treated cotton sliver of the present invention comprises the steps:
After described substrate heat fused, under 20～80 ℃, put into cotton sliver 1～60 second.
General fusion temperature is controlled in 30～150 ℃, and the cotton sliver adsorbing base is to reach capacity to good at 10～30 seconds.
The cotton sliver that process method of the present invention makes; its surface or surface and inside thereof are adsorbed with substrate; described surface treated cotton sliver; can make cotton sliver form layer protective layer; absorb medicinal liquid in the time of can preventing to combine the system bolt with medicine; avoid waste, and make all dosages controlled, occur deformed phenomenon when preventing to make bolt.
In order to realize another purpose of the present invention, the invention provides a kind of suppository, described suppository comprises the key that substrate and medicament mixed constitute, and it is characterized in that, also comprises surface or surface and the inner cotton sliver that is adsorbed with substrate thereof.
Described suppository can be made into circle, ellipse, triangle, star, prismatic, rectangle, taper or duckbill etc., but is not limited thereto, and conveniently is as the criterion so that the patient is comfortable when using, and how shelves the organization of human body at position with suppository and decides.
For the ease of taking out, also can be provided with the bolt lead-in wire at the suppository afterbody.
Key of the present invention is a substrate and the mixing of medicine, and what medicine can be according to treatment need be different compositions.Described substrate is one or more mixing such as semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, the ratio that the mixing of its mesostroma can adopt those skilled in the art to use always, preferred mixed proportion is 1:1～1:10.
The mixed proportion of substrate and medicine generally can be controlled in 1:1～1:80, is preferably 1:5～1:50.
The preparation method of a kind of suppository of the present invention comprises the steps:
1) pretreatment of cotton sliver
After the substrate heat fused, under 20～80 ℃, put into cotton sliver 1～60 second, get the surface-treated cotton sliver;
2) medicinal liquid preparation
After suppository base fusing earlier, be that 1:1～1:80 adds medicine with medicine and substrate weight ratio again, be stirred into medicinal liquid, standby;
3) preparation of suppository
The medicinal liquid for preparing is inserted mould, insert the surface-treated cotton sliver then ,-15～35 ℃ of following cooling formings get final product.
Specifically, fusing substrate can adopt the mode of heating in water bath, and bath temperature is controlled between 20～150 ℃, and the blended temperature of medicine and substrate is 20～100 ℃, and mixing time is 5～60 minutes, and medicine and substrate weight ratio are preferably 1:5～1:50.
Equipment and technology that the preparation of suppository adopts the present invention to use always, perfusion, plug, gland are specially:
(1) before the perfusion, the preheating of equipment elder generation, material loading filling interlayer, baiting valve, pouring head temperature are 20～80 ℃;
When (2) medicinal liquid for preparing being installed to batch can, stirred 5～60 minutes, open the medicinal liquid stop valve, medicinal liquid is circulated in the mould of different shape, insert surface treated cotton sliver then ,-15～35 ℃ of following cooling formings.
(3) at last the suppository gland of molding is got final product.
Suppository of the present invention can be according to the difference of treatment disease, and therapentic part difference (as positions such as vagina, anuses) is added different ingredients, plays lubricated, antibiotic, antiinflammatory, parasite killing, convergence, pain relieving, effect such as antipruritic.
Such as, about joining the preparation technology of stilbene warming YANG bolt:
1. leaching process: 8 parts～21 parts of Radix Ginsengs, Fructus Cnidii add 60～80% alcohol reflux secondaries for 22 parts～36 parts, for the first time amount of alcohol added is 4～6 times of Fructus Cnidii amount, refluxed 2～3 hours, for the second time amount of alcohol added is 2～4 times of Fructus Cnidii amount, refluxes filtration 1～2 hour, merging filtrate, reclaim ethanol, be concentrated into the clear paste of relative density 1.20～1.30 (60～70 ℃), standby; 13 parts～27 parts of all the other Radixs Astragali, 13 parts～27 parts of Herba Epimedii, 8 parts～21 parts of Herba Leonuris, 3 parts～7 parts of Radix Dipsacis, 3 parts～7 parts of Spina Gleditsiaes, 3 parts～7 parts of Ramulus Cinnamomi, 3 parts～7 parts of Fructus Aurantiis, 8 parts～21 parts in Radix Glycyrrhizae, decoct with water secondary, for the first time amount of water is 8～10 times of Chinese crude drug amount, decocted 2～3 hours, amount of water is 5～8 times of amounts of Chinese crude drug amount for the second time, decocted 1～2 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.30～1.32 (60～70 ℃), and is to be cooled to room temperature, adding ethanol makes and contains alcohol amount and reach 65～75%, stir evenly, left standstill 24～36 hours, filter, filtrate for later use, precipitation merges cleaning mixture and filtrate with an amount of 50%～70% washing with alcohol, reclaims ethanol and is concentrated into the thick paste that relative density is 1.24～1.28 (60～70 ℃), add above-mentioned Radix Ginseng clear paste mixing, being diluted to relative density is the clear paste of 1.22～1.26 (60～70 ℃), and spray drying gets medicated powder.
2. tampon pretreatment: get substrate, be placed on water-bath internal heating to 30～150 ℃, make its fusing, wait to melt the back temperature when dropping to 20～80 ℃, immersed cotton sliver 1～60 second, make form behind the layer protective layer standby.
3. prepare burden
(1) heats substrate down at 20～150 ℃, then temperature is reduced to 20～80 ℃;
(2) get the medicated powder that has extracted, join in the substrate by the equivalent incremental method, stirred 5～60 minutes, it is standby fully to be mixed into viscous liquid.
The perfusion, plug
(1) before the perfusion, the preheating of equipment elder generation, material loading filling interlayer, baiting valve, pouring head temperature are 20～80 ℃;
When (2) medicinal liquid for preparing being installed to batch can, stirred 5～60 minutes, open the medicinal liquid stop valve, medicinal liquid is circulated in the mould of different shape, insert surface treated cotton sliver then ,-15～35 ℃ of following cooling formings.
Equipment and technology that filtration, spray drying, the simmer down to those skilled in the art that adopted among the preparation technology of ginseng stilbene warming YANG bolt of the present invention use always.
Suppository of the present invention has adopted the surface-treated cotton sliver, and the cotton sliver surface forms protective layer, can prevent to combine absorption medicinal liquid when making bolt with medicine, avoids waste, and makes all dosages controlled, occurs deformed phenomenon when preventing to make bolt.
Preparation technology of the present invention is simple and easy to do, is easy to suitability for industrialized production.
The specific embodiment
Following embodiment is for further describing the present invention, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Embodiment 1
Present embodiment is a kind of surface-treated cotton sliver, and the cotton sliver surface adsorption has semi-synthetic fatty acid glyceride substrate.
Its preparation method is: after 80 ℃ of fusings of semi-synthetic fatty acid glyceride heating, under 45 ℃, put into cotton sliver 30 seconds, adsorb saturated, cotton sliver formation layer protective layer.
Embodiment 2
With embodiment 1, different is, used substrate is Polyethylene Glycol, and heating-up temperature is 90 ℃, puts into cotton sliver 50 seconds under 50 ℃.
Embodiment 3
With embodiment 1, different is, used substrate is paraffin, and heating-up temperature is 120 ℃, puts into cotton sliver 10 seconds under 80 ℃.
Embodiment 4
With embodiment 1, different is, used substrate is poloxamer, and heating-up temperature is 60 ℃, puts into cotton sliver 60 seconds under 30 ℃.
Embodiment 5
With embodiment 1, different is, used substrate is gelatin, and heating-up temperature is 150 ℃, puts into cotton sliver 5 seconds under 75 ℃.
Embodiment 6
Present embodiment is a ginseng stilbene warming YANG suppository, and for cotton sliver and key are composited, described suppository be circle, and afterbody is provided with a bolt and goes between.
Cotton sliver is pressed the method preparation of embodiment 1, and used substrate is glycerol, and heating-up temperature is 50 ℃, puts into cotton sliver 40 seconds under 25 ℃, and there is one deck glycerol protective layer on the cotton sliver surface.
The preparation method of ginseng stilbene warming YANG bolt is:
(1) preparation of medicated powder:
Get Radix Ginseng 300g, Fructus Cnidii 600g, add 70% alcohol reflux secondary, add ethanol 4500 grams for the first time, refluxed 2 hours, add for the second time ethanol 2700 grams, refluxed 1.5 hours, filter merging filtrate, reclaim ethanol, be concentrated into the extractum of relative density 1.25 (70 ℃ of surveys), standby;
Radix Astragali 400g, Herba Epimedii 400g, Herba Leonuri 300g, Radix Dipsaci 100g, Spina Gleditsiae 100g, Ramulus Cinnamomi 100g, Fructus Aurantii 100g, Radix Glycyrrhizae 300g are decocted with water secondary, amount of water is 15kg for the first time, decocted 2 hours, amount of water is 10kg for the second time, decocted 1.5 hours, collecting decoction filters, and filtrate is concentrated into the extractum that relative density is 1.30 (70 ℃ of surveys);
To be cooled to room temperature, add ethanol and make and contain alcohol amount and reach 65%, stir evenly, left standstill 24 hours, filter, filtrate for later use, precipitation 65% washing with alcohol merges cleaning mixture and filtrate, recovery ethanol, being concentrated into relative density is the thick paste of 1.24 (70 ℃ of surveys); Add above-mentioned Radix Ginseng, Fructus Cnidii extractum mixing, being diluted to relative density is the extractum of 1.22 (70 ℃ of surveys), with extractum with the pressure of 3kg/cm2 through mister head, become the droplet shape to spray in the hothouse, mix with the thermal current that is heated to 250 ℃ simultaneously, after heat exchange, be dried, promptly get dry medicated powder;
(2) batching
In water-bath, add purified water and reach 4/5 of watermark, the thermometer of temperature controller is transferred to 55 ℃, the semi-synthetic fatty acid glyceride 1680g that gets ready that gets then, lanoline 240g put into water-bath heating (80 ℃ of temperature) fusing, then temperature are reduced to 45 ℃; Get the Chinese medicine powder 280g that has extracted and cross 100 mesh sieves, joining said temperature by the equivalent incremental method is in 45 ℃ the substrate, stirs 30 minutes, and the viscous liquid that fully is mixed into certain flowability is standby.
(3) perfusion, plug, gland
Before the perfusion, the preheating of equipment elder generation, material loading is irritated 55 ℃ of interlayer temperature, 45 ℃ of baiting valve temperature, 40 ℃ of pouring head temperature;
Install in the batch can preparing standby medicinal liquid, opening stirring arm stirred 30 minutes, put the mould medicine bottle well, after the conveyer belt of waiting to be loaded with the mould of plastics medicine bottle puts in place, open the medicinal liquid stop valve, make medicinal liquid be circulated into that groundwater increment is 2.2g/ piece in the medicine bottle, insert saturated tampon then, cooling (temperature is 0-25 ℃) makes molding, makes the 1000 pieces of suppositorys that meet the requirements.
(3) then the tampon gland of molding is got final product.
Embodiment 7
Present embodiment is a ginseng stilbene warming YANG suppository, and for cotton sliver and key are composited, described suppository is taper.
Cotton sliver is pressed the method preparation of embodiment 1, and there is one deck semi-synthetic fatty acid glyceride protective layer on the cotton sliver surface.
Preparation method is with embodiment 6, and the component of different pharmaceutical compositions is Radix Ginseng 160 grams, Fructus Cnidii 300 grams, the Radix Astragali 270 grams, Herba Epimedii 180 grams, Herba Leonuri 100 grams, Radix Dipsaci 30 grams, Spina Gleditsiae 30 grams, Ramulus Cinnamomi 30 grams, Fructus Aurantii 30 grams, Radix Glycyrrhizae 80 grams; When extracting Radix Ginseng, Fructus Cnidii, concentration of ethanol is 80%, and amount of alcohol added is 6 times of medical material amount for the first time, and extraction time is 3 hours, and amount of alcohol added is 4 times of medical material amount for the second time, and extraction time is 2 hours, and the relative density of extractum is 1.22 (65 ℃ of surveys);
The Radix Astragali, Herba Epimedii, Herba Leonuri, Radix Dipsaci, Spina Gleditsiae, Ramulus Cinnamomi, Fructus Aurantii, when Radix Glycyrrhizae carries out water extraction, for the first time amount of water is 9 times of Chinese crude drug amount, decocts 2 hours, and the second time, amount of water was 7 times of amounts of Chinese crude drug amount, decocted 1.5 hours, the relative density of extractum is 1.30 (65 ℃ of surveys);
During ethanol extraction, concentration of ethanol is 70%, and time of repose is 20 hours, and the relative density of gained thick paste is 1.26 (65 ℃ of surveys), merges after the relative density of dilution extractum is 1.23 (65 ℃ of surveys).
Described substrate is lanoline, and the mixed proportion of lanoline and medicine is 50:1, and suppository is duckbill.
Embodiment 8
With embodiment 6, different is that the component of pharmaceutical composition is Radix Ginseng 210 grams, Fructus Cnidii 200 grams, the Radix Astragali 180 grams, Herba Epimedii 220 grams, Herba Leonuri 80 grams, Radix Dipsaci 40 grams, Spina Gleditsiae 60 grams, Ramulus Cinnamomi 40 grams, Fructus Aurantii 40 grams, Radix Glycyrrhizae 180 grams.
Described substrate is the mixing of 5 parts of lanolines and 1 part of Polyethylene Glycol, and the mixed proportion of substrate and medicine is 80:1, and suppository is oval.
Embodiment 9
With embodiment 6, different is that the component of pharmaceutical composition is Radix Ginseng 80 grams, Fructus Cnidii 350 grams, the Radix Astragali 130 grams, Herba Epimedii 130 grams, Herba Leonuri 180 grams, Radix Dipsaci 60 grams, Spina Gleditsiae 40 grams, Ramulus Cinnamomi 70 grams, Fructus Aurantii 60 grams, Radix Glycyrrhizae 120 grams.
Described substrate is the mixing of 5 parts of semi-synthetic fatty acid glyceride and 5 parts of poloxamers, and the mixed proportion of substrate and medicine is 5:1, and suppository is prismatic.
Although the present invention has been done detailed explanation and has quoted some instantiations as proof, for a person skilled in the art, only otherwise leave that the spirit and scope of the present invention can be done various variations or correction is obvious.
Claims (8)
1. a surface-treated cotton sliver is characterized in that, cotton sliver surface and inside thereof are adsorbed with substrate; Described substrate is wherein a kind of of semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol or poloxamer.
2. prepare the method for the described a kind of surface-treated cotton sliver of claim 1, it is characterized in that, comprise the steps:
After described substrate heat fused, under 20～80 ℃, put into cotton sliver 1～60 second, form.
3. suppository, described suppository comprise the key that substrate and medicament mixed constitute, and it is characterized in that, also comprise surface and the inner cotton sliver that is adsorbed with substrate thereof.
4. suppository according to claim 3 is characterized in that, described substrate is one or more mixing in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol or the gelatin.
5. according to claim 3 or 4 described suppositorys, it is characterized in that, be provided with the bolt lead-in wire at the suppository afterbody.
6. prepare the method for the described a kind of suppository of claim 5, it is characterized in that, comprise the steps:
1) pretreatment of cotton sliver
After the substrate heat fused, under 20～80 ℃, put into cotton sliver 1～60 second, get the surface-treated cotton sliver;
2) key preparation
After suppository base fusing earlier, be that 1:1～1:80 adds medicine with medicine and substrate weight ratio again, be stirred into medicinal liquid, standby;
3) preparation of suppository
The medicinal liquid for preparing is inserted mould, insert the surface-treated cotton sliver then ,-15～35 ℃ of following cooling formings get final product.
7. the preparation method of a kind of suppository according to claim 6, it is characterized in that, fusing substrate can adopt the mode of heating in water bath, bath temperature is controlled between 20～150 ℃, the blended temperature of medicine and substrate is 20～100 ℃, mixing time is 5～60 minutes, and medicine and substrate weight ratio are 1:5～1:50.
8. the preparation method of a kind of suppository according to claim 6, described suppository is characterized in that for ginseng stilbene warming YANG suppository, comprises the steps:
The medicated powder leaching process: 8 parts～21 parts of Radix Ginsengs, Fructus Cnidii add 60～80% alcohol reflux secondaries for 22 parts～36 parts, for the first time amount of alcohol added is 4～6 times of Fructus Cnidii amount, refluxed 2～3 hours, for the second time amount of alcohol added is 2～4 times of Fructus Cnidii amount, refluxes filtration 1～2 hour, merging filtrate, reclaim ethanol, be concentrated into the clear paste of relative density 1.20～1.30 in the time of 60～70 ℃, standby; 13 parts～27 parts of all the other Radixs Astragali, 13 parts～27 parts of Herba Epimedii, 8 parts～21 parts of Herba Leonuris, 3 parts～7 parts of Radix Dipsacis, 3 parts～7 parts of Spina Gleditsiaes, 3 parts～7 parts of Ramulus Cinnamomi, 3 parts～7 parts of Fructus Aurantiis, 8 parts～21 parts in Radix Glycyrrhizae, decoct with water secondary, for the first time amount of water is 8～10 times of Chinese crude drug amount, decocted 2～3 hours, amount of water is 5～8 times of amounts of Chinese crude drug amount for the second time, decocted 1～2 hour, collecting decoction, filter, it is 1.30～1.32 clear paste that filtrate is concentrated in the time of 60～70 ℃ relative density, to be cooled to room temperature, adding ethanol makes and contains alcohol amount and reach 65～75%, stir evenly, left standstill 24～36 hours, filter, filtrate for later use, precipitation merges cleaning mixture and filtrate with an amount of 50%～70% washing with alcohol, and recovery ethanol is concentrated into that relative density is the thick paste of 1.24-1.28 in the time of 60-70 ℃, add above-mentioned Radix Ginseng clear paste mixing, be diluted in the time of 60～70 ℃ relative density and be 1.22～1.26 clear paste, spray drying, medicated powder;
The tampon pretreatment: get substrate, be placed on water-bath internal heating to 30～150 ℃, make its fusing, wait to melt the back temperature when dropping to 20～80 ℃, immerse cotton sliver to saturated, make form behind the layer protective layer standby;
Batching:
(1) heats substrate down at 20～150 ℃, then temperature is reduced to 20～80 ℃;
(2) get the medicated powder that has extracted, join in the substrate by the equivalent incremental method, stirred 5～60 minutes, it is standby fully to be mixed into viscous liquid;
Perfusion, plug:
(1) before the perfusion, the preheating of equipment elder generation, material loading filling interlayer, baiting valve, pouring head temperature are 20～80 ℃;
When (2) medicinal liquid for preparing being installed to batch can, stirred 5～60 minutes, open the medicinal liquid stop valve, medicinal liquid is circulated in the mould of different shape, insert surface treated cotton sliver then ,-15～35 ℃ of following cooling formings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100912600A CN100496439C (en) | 2004-12-01 | 2004-12-01 | Surface processed cotton sliver, suppository and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100912600A CN100496439C (en) | 2004-12-01 | 2004-12-01 | Surface processed cotton sliver, suppository and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1781467A CN1781467A (en) | 2006-06-07 |
| CN100496439C true CN100496439C (en) | 2009-06-10 |
Family
ID=36772349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100912600A Active CN100496439C (en) | 2004-12-01 | 2004-12-01 | Surface processed cotton sliver, suppository and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100496439C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494918B (en) * | 2013-10-11 | 2015-04-29 | 哈尔滨欧替药业有限公司 | Ginseng and astragalus yang-warming vaginal dilation suppository as well as preparation method and detection method thereof |
| CN103735688B (en) * | 2013-12-31 | 2016-03-30 | 哈尔滨欧替药业有限公司 | For joining the refining Chinese medicine composition of stilbene warming YANG vaginal expansion plug agent and expansible plug thereof and method for making |
-
2004
- 2004-12-01 CN CNB2004100912600A patent/CN100496439C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN1781467A (en) | 2006-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112138055A (en) | Traditional Chinese medicine composition, preparation method and application | |
| CN100496439C (en) | Surface processed cotton sliver, suppository and its preparing process | |
| CN101972466A (en) | Traditional Chinese medicine cataplasm capable of rapidly relieving pain of dysmenorrhea and regulating menstruation and preparation method thereof | |
| CN104547797A (en) | Dampness-affected analgesic cataplasm and preparation method thereof | |
| CN102343026A (en) | Traditional Chinese medicine composition for treating diabetes and preparation method thereof | |
| CN100450517C (en) | Dysmenorrhea treating Chinese traditional medicine preparation | |
| CN1262296C (en) | Medicine composition, preparing method and use for preparing gynacecopathia medicine | |
| CN100446740C (en) | Cotton bar, cotton bar type suppository and preparing technique | |
| CN1027347C (en) | Kidney protection and impotence recovery bag and its making process | |
| CN1055834C (en) | Quick results detumescence pain stop paste and preparing process | |
| CN112717084A (en) | Traditional Chinese medicine composition for treating hyperprolactinemia, preparation method and application | |
| CN101375955B (en) | Sperm-passing formulation for treating non-ejaculation symptom and preparation method thereof | |
| CN101254289A (en) | Skin disease traditional Chinese medicine preparation and novel preparation thereof | |
| CN101204431B (en) | Preparation method of Chinese traditional medicine capsule for acne and splash | |
| CN1965945A (en) | Tincture having ageratum and mint for treating heat rash | |
| CN205729805U (en) | A kind of genistein composite particles preparation system | |
| CN1709481A (en) | Chinese medicine formulation for treating disney disease and toxuria, and its preparing method | |
| CN1795852A (en) | Suppository of Metronidazole and preparation technique | |
| CN102716249A (en) | Medicinal composition for treating hyperplasia of prostate and preparation method thereof | |
| CN101485702A (en) | Compound tea polyphenol vaginal suppository | |
| CN101138593A (en) | Preparation method of Chinese medicine unction and emplastrum for treating external hemorrhoid (ancient ink ointment for curing piles ) | |
| CN110522816A (en) | A kind of cow-bezoar infantile umbilical paste and preparation method thereof | |
| CN104147604A (en) | Suppository substrate and preparation method thereof | |
| CN1413696A (en) | Suppository for treating gynecopathy and its preparation technology | |
| CN113730338A (en) | Formula for vaginal muscle repair |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |