CN101254289A - Skin disease traditional Chinese medicine preparation and novel preparation thereof - Google Patents
Skin disease traditional Chinese medicine preparation and novel preparation thereof Download PDFInfo
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- CN101254289A CN101254289A CNA2007100174605A CN200710017460A CN101254289A CN 101254289 A CN101254289 A CN 101254289A CN A2007100174605 A CNA2007100174605 A CN A2007100174605A CN 200710017460 A CN200710017460 A CN 200710017460A CN 101254289 A CN101254289 A CN 101254289A
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Abstract
The invention relates to a traditional Chinese medicine preparation for the treatment of skin diseases and a new preparation method. The method is to take lightyellow sophora root, sessile stemona root, pricklyash peel and densefruit pittany root-bark for decocting by adding water, the filtrate is merged and condensed to the appropriate amount, borax is added for stirring till the dissolution; realgar is smashed into fine powder for preparing granules, the granules are added in the solution to prepare lotions, suppositories, effervescent suppositories, effervescent tablets, ointments, gels and so on; compared with the more original preparation method, the preparation method is simple, the cost is saved, the usage by a patient is move convenient, so the preparation method is more applicable to the industrialized mass production.
Description
One, technical field
The present invention relates to field of traditional Chinese, be specifically related to a kind of skin disease Chinese medicine preparation and new preparation method thereof.
Two, background technology
A kind of skin disease Chinese medicine preparation involved in the present invention records in the 15th the 111st page of Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ", and standard code WS3-B-2918-98 is the medicine of existing national standard.Its standard is as follows:
[prescription] Radix Sophorae Flavescentis 250g Radix Stemonae 250g Pericarpium Zanthoxyli 250g
Cortex Dictamni 250g Borax 167g Realgar 83g
[method for making] above Six-element, Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni decoct with water secondary, and each 2 hours, filter, merging filtrate is concentrated in right amount, adds Borax, stirs and makes dissolving, makes 1000ml, and medicinal liquid is packing while stirring; Realgar powder is broken into fine powder, makes granule, and other is distributed into pouch, promptly.
[character] this product is brown liquid, and the pouch content is orange-red granule.
[discriminating] (summary).
[function with cure mainly] detoxifcation parasite killing, antipruritic convergence, blood circulation promoting and blood stasis dispelling.Be used for scabies, eczema, seborrheic dermatitis, itching skin disease, tinea versicolor.
[usage and consumption] external is cleaned affected part with warm water, will shake up in the appended pouch Realgar granule adding medicinal liquid before using, take out the part medicinal liquid, dilute with warm water, put on the skin outward or the washout affected part in 1: 150 ratio, sooner or later respectively once, consumption can be decided by affected part area size, or follows the doctor's advice.
[specification] every bottled 100ml, attached in addition pouch dress Realgar 8.3g
[attention] this product only is for external application, and must guard against inlet.
[storage] sealing, lucifuge is put shady and cool place.
The whole nation has the imitated production in six tame pharmaceutical factories at present, is respectively QingHua DeRen Xi'an XingFu Pharmaceutical Co., Ltd, Jingxiutang (Pharmaceutical) Co., Ltd., Guangzhou, Shaanxi Guan'ai Pharmaceutical Co., Ltd., Shanxi SiZhuang Pharmacy Co., Ltd, Shaanxi Mo Meide pharmaceutical Co. Ltd and Xinglin Baima Medicine Co., Ltd., Jiangxi Prov..
In recent years, extensive patients reflects again and again, said preparation uses very inconvenient, especially " with shaking up in the appended pouch Realgar granule adding medicinal liquid ", according to investigations, six tame pharmacy corporations all adopt plastics small package bag (about 7 * 4.7cm) (valve bags) dress Realgar granule, reinstall slightly larger with quality packaging bag (about 9 * 5.8cm) (valve bags), the patient pours the Realgar granule into bore from pouch in use only 1.7 centimetres bottleneck, very big difficulty is arranged, concrete as: 1. in packing plastic bottle, extract this process of bottle stopper that has aperture and require great effort very much, if too for a short time not opening firmly firmly too greatly then might make medicinal liquid spill; 2. from packaging bag the Realgar granule is poured into the bottle, it is outer or Realgar sticked on hand Realgar can be sprinkled upon bottle usually, and because sack is very soft, when toppling over, is difficult to whole Realgars are poured out, and understands some and sticks on the sack and cause waste.
Up to the present, also find not solve the report of this defective, so the method that searching can solve this defective will certainly be subjected to the welcome of extensive patients, wins vast market, will promote the well-being of mankind.
Three, summary of the invention
A kind of skin disease Chinese medicine preparation that the present invention relates to is characterized in that, is made by the following weight proportion raw material:
Radix Sophorae Flavescentis 10.00～30.00% Radixs Stemonae 10.00～30.00% Pericarpium Zanthoxylies 10.00～30.00%
Cortex Dictamni 10.00～30.00% Boraxs 6.68～20.04% Realgars 3.32～9.96%.
A kind of skin disease Chinese medicine preparation that the present invention relates to is characterized in that, is made by following optimum weight proportion raw material:
Radix Sophorae Flavescentis 20.00% Radix Stemonae 20.00% Pericarpium Zanthoxyli 20.00%
Cortex Dictamni 20.00% Borax 13.36% Realgar 6.64%
The new preparation method of a kind of skin disease Chinese medicine preparation of the present invention may further comprise the steps:
1. measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification;
2. get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, each 2 hours, filter, merging filtrate is concentrated in right amount, adds Borax, stirs and makes dissolving, and is standby;
3. Realgar powder is broken into fine powder, makes granule, and is standby;
4. with the above-mentioned 1000ml that 2. makes, add above-mentioned Realgar granule, stir evenly, add suspending agent, packing while stirring, promptly.
The 2. middle Radix Sophorae Flavescentis of above-mentioned steps, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni decoct with water secondary, add 10 times of water gagings for the first time, decoct 2 hours, add 8 times of water gagings for the second time, decoct 2 hours, filter, and merging filtrate is concentrated into relative density 1.10 (50 ℃).
The 4. middle suspending agent of above-mentioned steps, it can be xanthan gum or sodium carboxymethyl cellulose (CMC-Na) or sodium citrate etc.
A kind of skin disease Chinese medicine preparation of the present invention can be made into various dosage forms, and a kind of as in lotion, suppository, effervescent suppository, effervescent tablet, ointment, the gel is preferably lotion.
Chinese medicine preparation of the present invention was through 25 months normal temperature and pressure stability tests, and the result shows, has good stability.Be the safety of Chinese medicine preparation of the present invention certainly, after the Chinese medicine preparation listing of the present invention, find this medication effect better by the follow up survey in market, no obvious toxic-side effects.
The new preparation method of a kind of skin disease Chinese medicine preparation of the present invention has its outstanding advantage, as follows: 1. technology is through research repeatedly, stable, quality controllable, be easy to carry, the patient takes like a shot, and has more science: Realgar is a sulfide-based mineral Realgar family Realgar, is arsenical crystallization Ore Realgar Realgar (realgar As
2S
2), and contain a small amount of other heavy metallic salt, and suffering, temperature, toxicity is stronger, and is for oral administration suitable careful, can not excessive clothes of a specified duration.Contraindication in pregnancy can be from skin absorbs, and the outer time spent should not large tracts of land be coated with the lasting for a long time use of scrape along, must guard against fire and forges, and promptly is decomposed into arsenic trioxide (As after burning is forged
2O
3), promptly arsenicum has severe toxicity.Realgar is joined in the medicinal liquid, and so both physicochemical properties of the side of considering Realgar is considered the reasonability of preparation process again, more important consideration to patient's ease of use.2. preparation technology is easy, steady quality, taking convenience, cost is low, helps industrialized great production: former each bottle of process stipulation lotion is with one bag of Realgar, then need small one and large one totally two packaging bags altogether, so not only wasted resource but also not environmental protection, consuming time in the preparation process, effort, bring very big inconvenience to industrialized great production, and the present invention these defectives have thoroughly been solved.
The new preparation method of a kind of skin disease Chinese medicine preparation of the present invention has its significant beneficial effect, and is as follows:
| Original preparation method | The invention provides new preparation method | |
| Process | Complicated | Simply |
| Using method | Loaded down with trivial details and dangerous | Simple and safety |
| Produce danger coefficient | Greatly | Little |
| Produce the same period | Long | Short |
| Cost | High | Low |
| Environmental pollution | Greatly | Little |
The present invention brings very big improvement to production process, reduces cost, and reduces the production degree of danger, shortens greatly and produces the same period, reduces environmental pollution, and most important is not influence control of product quality and can not produce under the toxic and side effects prerequisite, simplifying production technology.
Four, the specific embodiment
Below in conjunction with instantiation the present invention is described in further detail, but is not to be used for limiting protection scope of the present invention.
Embodiment 1
Pharmaceutical formulation:
Radix Sophorae Flavescentis 250.0g Radix Stemonae 250.0g Pericarpium Zanthoxyli 250.0g
Cortex Dictamni 250.0g Borax 167.0g Realgar 83.0g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, and is standby; Concentrated solution is made 1000ml, add above-mentioned Realgar granule, stir evenly, add hydroxymethyl cellulose sodium, packing while stirring, promptly.
Embodiment 2
Pharmaceutical formulation:
Radix Sophorae Flavescentis 125.0g Radix Stemonae 375.0g Pericarpium Zanthoxyli 125.0g
Cortex Dictamni 375.0g Borax 125.5g Realgar 124.5g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, adds in the above-mentioned concentrated solution; Taking polyethylene glycol 250g, heating makes fusing, adds concentrated solution, with adding with stirring, stirs evenly, and impouring scribbles in the suppository mold of lubricant, makes suppository, promptly.
Embodiment 3
Pharmaceutical formulation:
Radix Sophorae Flavescentis 375.0g Radix Stemonae 125.0g Pericarpium Zanthoxyli 375.0g
Cortex Dictamni 125.0g Borax 208.5g Realgar 41.5g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, adds in the above-mentioned concentrated solution, and dry (50 ℃) are pulverized, and sieve, and adds 2 times of amount effervescent powder, is added in the Myrj 45 that has melted, pours into into suppository, promptly.
Embodiment 4
Pharmaceutical formulation:
Radix Sophorae Flavescentis 271.0g Radix Stemonae 250.0g Pericarpium Zanthoxyli 271.0g
Cortex Dictamni 250.0g Borax 83.5g Realgar 124.5g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, adds in the above-mentioned concentrated solution, and dry (50 ℃) are pulverized, and gradation adds sodium bicarbonate, citric acid and starch, and gradation is granulated, and fully mixing is pressed into effervescent tablet, promptly.
Embodiment 5
Pharmaceutical formulation:
Radix Sophorae Flavescentis 250.0g Radix Stemonae 229.0g Pericarpium Zanthoxyli 250.0g
Cortex Dictamni 229.0g Borax 250.5g Realgar 41.5g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, adds in the above-mentioned concentrated solution, and it is an amount of to add ethyl hydroxybenzoate 0.3g, lanoline 60g and vaseline, and mixing is made ointment, promptly.
Embodiment 6
Pharmaceutical formulation:
Radix Sophorae Flavescentis 187.5g Radix Stemonae 312.5g Pericarpium Zanthoxyli 187.5g
Cortex Dictamni 312.5g Borax 187.5g Realgar 62.5g
Preparation method:
Measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification; Get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, add 10 times of water gagings for the first time, decocted 2 hours, add 8 times of water gagings for the second time, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃), the adding Borax, and stirring makes dissolving; Realgar powder is broken into fine powder, makes granule, adds in the above-mentioned concentrated solution, gets Tragacanth, agar and adds water-soluble expanding, and in 80 ℃ of heating in water bath 30min, keeps temperature to add concentrated solution, crosses 60 mesh sieves while hot, and cooling is made gel, promptly.
Claims (7)
1. a skin disease Chinese medicine preparation is characterized in that, is made by the following weight proportion raw material:
Radix Sophorae Flavescentis 10.00～30.00% Radixs Stemonae 10.00～30.00% Pericarpium Zanthoxylies 10.00～30.00%
Cortex Dictamni 10.00～30.00% Boraxs 6.68～20.04% Realgars 3.32～9.96%.
2. skin disease Chinese medicine preparation according to claim 1 is characterized in that, is made by the following weight proportion raw material:
Radix Sophorae Flavescentis 20.00% Radix Stemonae 20.00% Pericarpium Zanthoxyli 20.00%
Cortex Dictamni 20.00% Borax 13.36% Realgar 6.64%.
3. the preparation method of a kind of skin disease Chinese medicine preparation according to claim 1 and 2 is characterized in that, the process following steps:
1. measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification;
2. get Radix Sophorae Flavescentis, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni and decoct with water secondary, each 2 hours, filter, merging filtrate is concentrated in right amount, adds Borax, stirs and makes dissolving, and is standby;
3. Realgar powder is broken into fine powder, makes granule, and is standby;
4. with the above-mentioned 1000ml that 2. makes, add above-mentioned Realgar granule, stir evenly, add suspending agent, packing while stirring, promptly.
4. the preparation method of a kind of Chinese medicine composition according to claim 3, it is characterized in that the 2. middle Radix Sophorae Flavescentis of step, the Radix Stemonae, Pericarpium Zanthoxyli, Cortex Dictamni decoct with water secondary, add for the first time 10 times of water gagings, decocted 2 hours, for the second time add 8 times of water gagings, decocted 2 hours, filter, merging filtrate is concentrated into relative density 1.10 (50 ℃).
5. suspending agent according to claim 3 is characterized in that it can be xanthan gum or sodium carboxymethyl cellulose (CMC-Na) or sodium citrate etc.
6. a kind of Chinese medicine composition according to claim 1 and 2 is characterized in that it is lotion, suppository, effervescent suppository, effervescent tablet, ointment or gel.
7. a kind of Chinese medicine composition according to claim 6 is characterized in that it is a lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100174605A CN101254289A (en) | 2007-03-02 | 2007-03-02 | Skin disease traditional Chinese medicine preparation and novel preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100174605A CN101254289A (en) | 2007-03-02 | 2007-03-02 | Skin disease traditional Chinese medicine preparation and novel preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101254289A true CN101254289A (en) | 2008-09-03 |
Family
ID=39889612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100174605A Pending CN101254289A (en) | 2007-03-02 | 2007-03-02 | Skin disease traditional Chinese medicine preparation and novel preparation thereof |
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| Country | Link |
|---|---|
| CN (1) | CN101254289A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772722A (en) * | 2012-07-31 | 2012-11-14 | 陆利勇 | Traditional Chinese medicine decoction for treating scabies |
| CN103083599A (en) * | 2013-01-05 | 2013-05-08 | 张德修 | Traditional Chinese medicine lotion for treating cutaneous pruritus |
| CN107115510A (en) * | 2017-06-28 | 2017-09-01 | 长春德泰恒医疗技术有限公司 | Lotion preparation for Mucocutaneous diseases and preparation method thereof |
-
2007
- 2007-03-02 CN CNA2007100174605A patent/CN101254289A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772722A (en) * | 2012-07-31 | 2012-11-14 | 陆利勇 | Traditional Chinese medicine decoction for treating scabies |
| CN103083599A (en) * | 2013-01-05 | 2013-05-08 | 张德修 | Traditional Chinese medicine lotion for treating cutaneous pruritus |
| CN103083599B (en) * | 2013-01-05 | 2014-06-25 | 张德修 | Traditional Chinese medicine lotion for treating cutaneous pruritus |
| CN107115510A (en) * | 2017-06-28 | 2017-09-01 | 长春德泰恒医疗技术有限公司 | Lotion preparation for Mucocutaneous diseases and preparation method thereof |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Open date: 20080903 |