CN106692490A - Sucrose-free compound isatis root granules and preparation method thereof - Google Patents
Sucrose-free compound isatis root granules and preparation method thereof Download PDFInfo
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- 239000008187 granular material Substances 0.000 title claims abstract description 45
- 241000334160 Isatis Species 0.000 title claims abstract description 42
- 150000001875 compounds Chemical class 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 46
- 229930006000 Sucrose Natural products 0.000 claims abstract description 44
- 239000000463 material Substances 0.000 claims abstract description 24
- 108010011485 Aspartame Proteins 0.000 claims abstract description 15
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 15
- 229960003438 aspartame Drugs 0.000 claims abstract description 15
- 235000010357 aspartame Nutrition 0.000 claims abstract description 15
- 239000000605 aspartame Substances 0.000 claims abstract description 15
- 239000004375 Dextrin Substances 0.000 claims abstract description 14
- 229920001353 Dextrin Polymers 0.000 claims abstract description 14
- 235000019425 dextrin Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 229960004793 sucrose Drugs 0.000 claims description 43
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- 239000010231 banlangen Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 13
- 239000002131 composite material Substances 0.000 claims description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 6
- 239000004411 aluminium Substances 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 235000020985 whole grains Nutrition 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 18
- 239000005720 sucrose Substances 0.000 abstract description 12
- 229940079593 drug Drugs 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
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- 230000006872 improvement Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 206010034038 Parotitis Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
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- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
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- 206010039101 Rhinorrhoea Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses sucrose-free compound isatis root granules and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The sucrose-free compound isatis root granules are prepared from the following raw materials in parts by weight: 1000-1400 parts of isatis root, 1600-2000 parts of isatis leaf, 4-8 parts of aspartame and 6-12 parts of dextrin. The invention also discloses a preparation method of the sucrose-free compound isatis root granules. The sucrose-free compound isatis root granules has the advantages of higher drug stability, lower auxiliary material dose and wider application range. The preparation method is simple, has the advantages of lower production cost than the sucrose type, high yield, cheap and accessible auxiliary materials, stable properties and wide market prospects, and is suitable for large-scale mass production.
Description
Technical field
The present invention relates to a kind of compound isatis root granules of no cane sugar type and preparation method thereof, belong to technical field of traditional Chinese medicines.
Background technology
According to Chinese Pharmacopoeia standard, prescription is Radix Isatidis 1200g, folium isatidis 1800g, aspartame to compound isatis root granules
6g, dextrin 8g, the taste Chinese medicine of the above two add water to cook secondary, each plus 5 times of medicinal material amount water, and 1 hour every time, filtration merged filter
Liquid, is concentrated under reduced pressure into proportion 1.25-1.26 (60 DEG C), adds triplication ethanol, stirs evenly, and stands 24 hours, and filtration, filtrate is reclaimed
Ethanol, is concentrated into proportion 1.25-1.28 (60 DEG C of surveys), and taking-up lets cool, and thick paste adds ethanol in proper amount to mix and must mix thick paste, by dextrin
It is well mixed with aspartame, then mixing thick paste is slowly added in auxiliary material, add water prepared softwood in right amount, the granulation of 12 mesh sieves is done
It is dry, 1000g sugar-free particles are made, 12-40 mesh whole grains, composite aluminium film packing is obtained final product.Composite isatis root for treatment anemopyretic cold it
Medicine, primary efficacy is clearing heat and detoxicating, cool blood.For warm disease heating, go out spot, anemopyretic cold, throat swells rotten, popular B-mode brain
Inflammation, hepatitis, parotitis person.
Compound isatis root granules of the prior art, are the particle containing sucrose, are had the following disadvantages：(1) granules of sugar agent
Easy deliquescence, softening are rotten, should not deposit long；(2) due to a large amount of amount of excipient using sucrose, specification is generally 15g/ bags, auxiliary
Material dose is big；(3) because sucrose has stronger bioactivity, gastritis can be triggered, causes fat, induced Diabetic and children
Carious tooth so that granule should not be used in diabetes etc. and prohibit sugared patient.
In consideration of it, be necessary to provide a kind of compound isatis root granules of no cane sugar type, to make up the deficiencies in the prior art.
The content of the invention
An object of the present invention, is to provide a kind of compound isatis root granules of no cane sugar type.It is of the invention without sucrose
The compound isatis root granules of type, have the following advantages that：(1) stability of medicine is improved.(2) auxiliary material dose is reduced.(3) expand
Range of application.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of compound isatis root granules of no cane sugar type, by
The raw material of following parts by weight is made：Radix Isatidis 1000-1400 parts, folium isatidis 1600-2000 parts, aspartame 4-8 parts and paste
It is smart 6-12 parts.
Compound isatis root granules of the invention, are no cane sugar type, are had the following advantages that：(1) stability of medicine is improved.Cause
The moisture absorption is difficult without sucrose granules to go bad, improve medicine stability, the guaranteed clinical efficacy of medicine.(2) auxiliary material clothes are reduced
Consumption.Due to reducing a large amount of amount of excipient using sucrose, specification is changed into 5g/ bags, ensure that treatment from original 15g/ bags
On the basis of effect, greatly reduce auxiliary material dose.(3) range of application is expanded.Make many children, old age without sucrose granules and prohibit
The medication limitation of sugared patient is released.
Proterties：, to brown granular, gas is micro-, and taste is sweet for brown color.
Function with cure mainly：It is clearing heat and detoxicating, cool blood.For warm disease heating, go out spot, anemopyretic cold, throat and swell rotten, popular second
The illnesss such as type encephalitis, hepatitis, parotitis.
Usage and consumption：Orally, a 5g, 3 times a day, severe is doubled, and children are cut down according to the circumstance.Flu-prevention, encephalitis, one day
5g, takes medicine continuously 5.
Specification：Per packed 5g.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
Further, it is made up of the raw material of following parts by weight：1200 parts of Radix Isatidis, 1800 parts of folium isatidis, 6 parts of aspartame
With 8 parts of dextrin.
It is using above-mentioned further beneficial effect：Above-mentioned is optimal parameter.It is obtained without sucrose using this optimal parameter
The drug effect of the compound isatis root granules of type is optimal.
The second object of the present invention, is the preparation method of the compound isatis root granules for providing above-mentioned no cane sugar type.This hair
Bright preparation method is simple, easy to operate, wide market, is adapted to large-scale batch production.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of system of the compound isatis root granules of no cane sugar type
Preparation Method, comprises the following steps：
(1) extracted before：Radix Isatidis 1000-1400 weight portions, folium isatidis 1600-2000 weight portions are weighed, two are added water to cook
It is secondary, the water of 4-6 times of weight of Radix Isatidis and folium isatidis is added every time, each 0.5-1.5 hours, filtration, merging filtrate is concentrated under reduced pressure
It is 1.25-1.26 to proportion at 60 DEG C, it is 40-6%'s to add the mass concentration of 2.5-3.5 times of weight of Radix Isatidis and folium isatidis
Ethanol, stirs evenly, and stands 22-26 hours, and filtering, filtrate recycling ethanol is concentrated under reduced pressure into thick paste；
(2) preparation is made：In the thick paste that step (1) is obtained, the mass concentration for adding 0.5-1.5 times of thick paste weight is
The ethanol of 40-60%, mixes, and obtains mixing thick paste；Dextrin 6-12 weight portions are well mixed with aspartame 4-8 weight portions,
Obtain auxiliary material；Mixing thick paste is slowly added in above-mentioned auxiliary material again, adds the water of above-mentioned 1.5-2.5 times of weight of mixing thick paste, system
Grain, dries, whole grain, and packing obtains final product the compound isatis root granules of the no cane sugar type.
Preparation method of the invention is simple, easy to operate, wide market, is adapted to large-scale batch production.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
Further, relative density of step (1) thick paste at 60 DEG C is 1.25-1.28.
Further, the particle diameter of step (2) described granulation is 12 mesh, and the dry temperature is 90-110 DEG C, the whole grain
Particle diameter be 12-40 mesh, the packing uses composite aluminium film.
The invention has the advantages that：
1st, compound isatis root granules of the invention, are no cane sugar type, are had the following advantages that：(1) stability of medicine is improved.
Go bad because being difficult the moisture absorption without sucrose granules, improve medicine stability, the guaranteed clinical efficacy of medicine.(2) auxiliary material is reduced
Dose.Due to reducing a large amount of amount of excipient using sucrose, specification is changed into 5g/ bags, ensure that from original 15g/ bags
On the basis of curative effect, greatly reduce auxiliary material dose.(3) range of application is expanded.Without sucrose granules make many children, old age and
The medication limitation for prohibiting sugared patient is released.
2nd, preparation method of the invention is simple, and production cost is low compared with cane sugar type, and high income, auxiliary material is cheap and easy to get, property
Stabilization, wide market is adapted to large-scale batch production.
Specific embodiment
Principle of the invention and feature are described below in conjunction with specific embodiment, example is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.
Embodiment 1
The compound isatis root granules of the no cane sugar type of the present embodiment, are made up of the raw material of following weight：Radix Isatidis 1000kg,
Folium isatidis 2000kg, aspartame 4kg and dextrin 12kg.
The preparation method of the compound isatis root granules of above-mentioned no cane sugar type, comprises the following steps：
(1) extracted before：Weigh Radix Isatidis 1000kg, folium isatidis 2000kg, add water to cook it is secondary, every time add Radix Isatidis and
4 times of water of weight of folium isatidis, 0.5 hour every time, filtration, merging filtrate, proportion when being concentrated under reduced pressure into 60 DEG C is 1.25-
1.26, the mass concentration for adding 2.5 times of weight of Radix Isatidis and folium isatidis is 40% ethanol, is stirred evenly, and stands 22 hours, filtering,
Filtrate recycling ethanol, relative density is the thick paste of 1.25-1.28 when being concentrated under reduced pressure into 60 DEG C；
(2) preparation is made：In the thick paste that step (1) is obtained, the mass concentration for adding 0.5 times of thick paste weight is 40%
Ethanol, mixes, and obtains mixing thick paste；Dextrin 12kg is well mixed with aspartame 4kg, auxiliary material is obtained；Thick paste will be mixed again
It is slowly added in above-mentioned auxiliary material, adds above-mentioned 1.5 times of water of weight of mixing thick paste, is made the particle of 12 mesh, 90-110 DEG C of drying,
The particle of 12-40 mesh is made into, is dispensed using composite aluminium film, obtain final product the compound isatis root granules of the no cane sugar type.
Embodiment 2
The compound isatis root granules of the no cane sugar type of the present embodiment, are made up of the raw material of following weight：Radix Isatidis 1200kg,
Folium isatidis 1800kg, aspartame 6kg and dextrin 8kg.
The preparation method of the compound isatis root granules of above-mentioned no cane sugar type, comprises the following steps：
(1) extracted before：Weigh Radix Isatidis 1200kg, folium isatidis 1800kg, add water to cook it is secondary, every time add Radix Isatidis and
5 times of water of weight of folium isatidis, 1 hour every time, filtration, merging filtrate, proportion when being concentrated under reduced pressure into 60 DEG C is 1.25-1.26,
The mass concentration for adding 3 times of weight of Radix Isatidis and folium isatidis is 50% ethanol, is stirred evenly, and stands 24 hours, and filtering, filtrate is reclaimed
Ethanol, relative density is the thick paste of 1.25-1.28 when being concentrated under reduced pressure into 60 DEG C；
(2) preparation is made：In the thick paste that step (1) is obtained, the mass concentration for adding 1 times of thick paste weight is 50% second
Alcohol, mixes, and obtains mixing thick paste；Dextrin 8kg is well mixed with aspartame 6kg, auxiliary material is obtained；Thick paste will be mixed again slow
Add in above-mentioned auxiliary material, add above-mentioned 2 times of water of weight of mixing thick paste, be made the particle of 12 mesh, 90-110 DEG C of drying is made into
The particle of 12-40 mesh, is dispensed using composite aluminium film, obtains final product the compound isatis root granules of the no cane sugar type.
Embodiment 3
The compound isatis root granules of the no cane sugar type of the present embodiment, are made up of the raw material of following weight：Radix Isatidis 1400kg,
Folium isatidis 1600kg, aspartame 8kg and dextrin 6kg.
The preparation method of the compound isatis root granules of above-mentioned no cane sugar type, comprises the following steps：
(1) extracted before：Weigh Radix Isatidis 1400kg, folium isatidis 1600kg, add water to cook it is secondary, every time add Radix Isatidis and
6 times of water of weight of folium isatidis, 1.5 hours every time, filtration, merging filtrate, proportion when being concentrated under reduced pressure into 60 DEG C is 1.25-
1.26, the mass concentration for adding 3.5 times of weight of Radix Isatidis and folium isatidis is 60% ethanol, is stirred evenly, and stands 26 hours, filtering,
Filtrate recycling ethanol, relative density is the thick paste of 1.25-1.28 when being concentrated under reduced pressure into 60 DEG C；
(2) preparation is made：In the thick paste that step (1) is obtained, the mass concentration for adding 1.5 times of thick paste weight is 60%
Ethanol, mixes, and obtains mixing thick paste；Dextrin 6kg is well mixed with aspartame 8kg, auxiliary material is obtained；Mixing thick paste is delayed again
Slowly add in above-mentioned auxiliary material, add above-mentioned 2.5 times of water of weight of mixing thick paste, be made the particle of 12 mesh, 90-110 DEG C of drying is whole
Into the particle of 12-40 mesh, dispensed using composite aluminium film, obtain final product the compound isatis root granules of the no cane sugar type.
Contrast test
Compared with cane sugar type particle, the experiment of this research only auxiliary material specification change, therefore extraction process route and sheet
The extraction process code of the cane sugar type particle of applicant is consistent.The concrete technology of the cane sugar type compound isatis root granules of the applicant
It is as follows：
Weigh Radix Isatidis, the folium isatidis of recipe quantity, add water to cook it is secondary, each amount of water be 5 times of medicinal material amounts, 1 is small every time
When, filtration, merging filtrate is concentrated under reduced pressure into proportion 1.25-1.26 (60 DEG C of surveys), adds triplication ethanol, stirs evenly, and stands 24 small
When, filtration, filtrate recycling ethanol is concentrated under reduced pressure into proportion 1.25-1.28 (60 DEG C of surveys), and taking-up lets cool, and weighs, sign.
Sugar type granules of the invention, although specification is different from original cane sugar type particle, but the only change of auxiliary material specification,
Its preceding extraction process, every bag be consistent (be shown in Table 1) with raw sugar type particle containing crude drug amount and usage and dosage, that is, ensure
The security of medicine is with validity consistent with original product.
Rear crude drug amount compares table 1 with dose before changing
Case 1
Patient Huang, female, 20 years old, student.【Main suit】Anemopyretic cold, abscess of throat.In on 2 4th, 2016 to Laibin City
One pharmacy buys the compound isatis root granules of no cane sugar type of the invention, and main component is Radix Isatidis and smalt in the medicine
Leaf, Radix Isatidis cures mainly anemopyretic cold, and folium isatidis is mainly used in the diseases such as abscess of throat.Course for the treatment of of the medicine two day, Huang takes one
After the individual course for the treatment of, above symptom eliminates reach the effect of healing.
Case 2
Patient it is deep certain, man, 35 years old, work.【Main suit】Pharyngeal discomfort, there is foreign body sensation, dense phlegm, low fever.On November 3rd, 2016
To Laibin City health clinic, doctor has opened a composite isatis root for the no cane sugar type of the invention of the course for the treatment of to him
Grain, and exhort and drink water patient more.The compound isatis root granules of no cane sugar type of the invention belong to pure Chinese medicinal preparation, for heat-clearing solution
Poison, cool blood relieving sore-throat, and with antivirus action, for treating pharyngitis, there is good effect.Patient takes disease after a course for the treatment of
Shape is eased.
Case 3
Patient Lee, man, 23 years old.【Main suit】Cough, rhinorrhea, from head to foot headache, courbature 3 days, ill health.
On May 6th, 2016 arrives Laibin City health clinic, and diagnosis are the infection of the upper respiratory tract or flu, allows patient to take this
The no cane sugar type compound isatis root granules of invention, and advise patient's usually appropriate activity, build up health, strengthen the immunity of body
And resistance against diseases.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all it is of the invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (5)
1. a kind of compound isatis root granules of no cane sugar type, it is characterised in that be made up of the raw material of following parts by weight：Radix Isatidis
1000-1400 parts, folium isatidis 1600-2000 parts, aspartame 4-8 parts and dextrin 6-12 parts.
2. compound isatis root granules of a kind of no cane sugar type according to claim 1, it is characterised in that by following weight portion
Several raw materials are made：8 parts of 1200 parts of Radix Isatidis, 1800 parts of folium isatidis, 6 parts of aspartame and dextrin.
3. a kind of preparation method of the compound isatis root granules of no cane sugar type, it is characterised in that comprise the following steps：
(1) extracted before：Weigh Radix Isatidis 1000-1400 weight portions, folium isatidis 1600-2000 weight portions, add water to cook it is secondary, often
The water of secondary addition 4-6 times of weight of Radix Isatidis and folium isatidis, each 0.5-1.5 hours, filtration, merging filtrate is concentrated under reduced pressure into 60
DEG C when proportion be 1.25-1.26, add 2.5-3.5 times of weight of Radix Isatidis and folium isatidis mass concentration for 40-60% second
Alcohol, stirs evenly, and stands 22-26 hours, and filtering, filtrate recycling ethanol is concentrated under reduced pressure into thick paste；
(2) preparation is made：In the thick paste that step (1) is obtained, it is 40- to add the 0.5-1.5 times of mass concentration of thick paste weight
60% ethanol, mixes, and obtains mixing thick paste；Dextrin 6-12 weight portions are well mixed with aspartame 4-8 weight portions, are obtained
Auxiliary material；Mixing thick paste is slowly added in above-mentioned auxiliary material again, adds the water of above-mentioned 1.5-2.5 times of weight of mixing thick paste, granulation is done
Dry, whole grain, packing obtains final product the compound isatis root granules of the no cane sugar type.
4. a kind of preparation method of the compound isatis root granules of no cane sugar type according to claim 3, it is characterised in that step
Suddenly relative density of (1) the described thick paste at 60 DEG C is 1.25-1.28.
5. a kind of preparation method of the compound isatis root granules of no cane sugar type according to claim 3, it is characterised in that step
Suddenly the particle diameter of (2) described granulation is 12 mesh, and the dry temperature is 90-110 DEG C, and the particle diameter of the whole grain is 12-40 mesh, institute
State packing and use composite aluminium film.
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| CN201611145917.6A CN106692490A (en) | 2016-12-13 | 2016-12-13 | Sucrose-free compound isatis root granules and preparation method thereof |
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| CN201611145917.6A CN106692490A (en) | 2016-12-13 | 2016-12-13 | Sucrose-free compound isatis root granules and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787198A (en) * | 2019-12-19 | 2020-02-14 | 河南庚贤堂制药有限公司 | Production process of sugar-free isatis root granules |
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|---|---|---|---|---|
| CN102727667A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Compound isatis root puffed granules and preparation method of same |
| CN104288194A (en) * | 2014-10-30 | 2015-01-21 | 黄琴 | Preparation method for compound radix isatidis granules |
| CN104983691A (en) * | 2015-06-28 | 2015-10-21 | 赵明亮 | Preparation method and application of compound indigowoad root granules |
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2016
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|---|---|---|---|---|
| CN102727667A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Compound isatis root puffed granules and preparation method of same |
| CN104288194A (en) * | 2014-10-30 | 2015-01-21 | 黄琴 | Preparation method for compound radix isatidis granules |
| CN104983691A (en) * | 2015-06-28 | 2015-10-21 | 赵明亮 | Preparation method and application of compound indigowoad root granules |
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| 国家药品监督管理局 编: "《国家中成药标准汇编 眼科 耳鼻喉科 皮肤科 分册》", 31 December 2002 * |
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|---|---|---|---|---|
| CN110787198A (en) * | 2019-12-19 | 2020-02-14 | 河南庚贤堂制药有限公司 | Production process of sugar-free isatis root granules |
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