CN101485702A - Compound tea polyphenol vaginal suppository - Google Patents
Compound tea polyphenol vaginal suppository Download PDFInfo
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- CN101485702A CN101485702A CNA2009101191927A CN200910119192A CN101485702A CN 101485702 A CN101485702 A CN 101485702A CN A2009101191927 A CNA2009101191927 A CN A2009101191927A CN 200910119192 A CN200910119192 A CN 200910119192A CN 101485702 A CN101485702 A CN 101485702A
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- suppository
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- tea polyphenol
- tampon
- compound tea
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Abstract
The invention discloses a compound tea polyphenol pessary. Drug compositions of the pessary comprise tea polyphenol, seabuckthorn oil, and a common suppository base;; the suppository in vivo is also embedded with tampon; the surface and the inside of the tampon are saturated by the common suppository base so as to keep effective concentration and dosage of drugs; and the compound tea polyphenol pessary is used for treating colpitis, cervicitis, cervical erosion, and other gynecological diseases.
Description
Technical field
The present invention relates to a kind of compound tea polyphenol vaginal suppository for the treatment of gynaecopathias such as vaginitis, cervicitis, cervical erosion and preparation method thereof, be used for vagina local application, the treatment gynaecopathia belongs to field of medicaments.
Technical background
Vaginitis, cervicitis, cervical erosion are the women of child-bearing age's commonly encountered diseases, frequently-occurring disease, and sickness rate accounts for the women of child-bearing age's 60%, influences women's physical and mental health and quality of life, and active prevention and treatment gynecological inflammation are the important channels that ensures female body health.
The medicine and the method for the above-mentioned disease of treatment are a lot of at present, but these methods and medicine all have many deficiencies and limitation, as: the pharmacotherapy side effect with antibiotic and hormone is bigger, physiotherapys such as laser, carbon freezing, and general patient is difficult for accepting.Secondly, all there are different problems in the dosage form water preparation of external used medicine, ordinary suppository, unguentum, powder etc.At first, the degree of depth that enters vagina is not enough, and medicine can not directly act on focus; It two is that medicine enters part medicine outflow is arranged after vagina dissolves, and directly influences effective administration concentration; It three is very easily pollution clothes of the rheuminess thing that outflows with medicine, causes new infection chance.
Main ingredient of the present invention is tea polyphenols and Oleum Hippophae.Recent study personnel have carried out research extensively and profoundly to tea polyphenols, and tea polyphenols is the general name of catechin in the Folium Camelliae sinensis, acetone class, phenolic acids and anthocyan chemical compound.Because the medicine of tea polyphenols and health care are worth, tea polyphenols has become medicine, food circle hot of research and development, studies show that tea polyphenols has antibiotic, sterilization, antivirus action, and its sterilizing power is higher 100 times than ethanol.The effect that catechin compounds all has killing and suppresses many noxious bacteria, fungus and virus, as: gold-coloured staphylococci, vibrio cholera, vibrio flavus, vibrio parahaemolytious, bacillus cereus, have a liking for aqueous vapor unicellular, have a liking for water subspecies escherichia coli, Salmonella enteritidis, Salmonella typhimurium, bacillus botulinus, beard and hair fungus, influenza virus A and B, human body rotavirus and HIV (human immunodeficiency virus) etc.When suppressing harmful bacterium propagation, promoted the growth of profitable strain, improve the vagina microorganism environment, play chemical probiotics.Through relevant expert's repetition test, successfully develop and the supercritical CO 2 abstraction technique extracted, concentrate with tradition and abstraction technique combines, preparation high-purity tea polypenols new technology.This technology had both improved the purity and the yield of tea polyphenols.Meet the requirement of suitability for industrialized production again, help tea polyphenols more effectively in medicine and Applications in Food Industry to raw material, solvent use, making route, production process safety and product colour, productive rate, purity aspects.Oleum Hippophae is the pure natural plant oil that extracts from Fructus Hippophae, finds through the modern scientific research of nearly half a century, and the active component in the sea buckthorn fruit is kind surplus in the of 200 nearly.Wherein 36 kinds of flavone and phenolic compounds, 6 kinds of vitamin, 22 kinds of fatty acids, 42 kinds of lipids.The former Soviet Union is used for treating radiation damage, burn, encolpitis, endocervicitis, cervical erosion stomach function regulating, duodenal ulcer to Oleum Hippophae and obtains good effect, and have no side effect.In recent years, scientific research both at home and abroad and clinical verification: Oleum Hippophae has tangible analgesia, antiinflammatory, minimizing inflammation to ooze out, promote the effect that mucosa is repaired, to acute radiodermatitis, mucosal inflammation, inactive scytitis, ulcer, poor wound healing etc., better curative effect is arranged all.Oleum Hippophae has characteristics such as pure natural, highly enriched, high-tech, no solvent residue, retentive activity composition.The Oleum Hippophae that extracts from seed of Fructus Hippophae is 100% all-natural product, and wherein contained VE activity exceeds the Radix Achyranthis Bidentatae that synthesizes VE especially, and (natural VE contains α, β, γ, δ four type tocopherols; Only contain α type tocopherol in the synthetic VE, and only the antioxidation of δ type tocopherol is exactly 100 times of α type tocopherol).20 tons of sea buckthorn fruits extract 1 ton of hippophae rhamnoides seed, 1 ton of Oleum Hippophae of 20 tons of seed extractions, and the 250ml Oleum Hippophae needs 100 kilograms of Fructus Hippophae to concentrate.Oleum Hippophae manufacture the supercritical CO 2 abstraction technique that has adopted international advanced person.It is a kind of environmental protection separating substances of pure physical process.The method of supercritical CO 2 supercritical gas extracting Oleum Hippophae, it is characterized in that with seed of Fructus Hippophae or sea-buckthorn pomace be raw material, with CO2 is to extract solvent out, at pressure 10～30Mpa, extracting under the supercriticality that temperature is 32～45 ℃, blood pressure lowering step by step under 3245 ℃, Oleum Hippophae separates voluntarily with CO2, and the CO2 recirculation uses.This method flow process is short, and equipment is simple, easily amplifies, and oily yield reaches 90%, and product does not have residual hazard.
Summary of the invention:
The invention provides a kind of compound tea polyphenol vaginal suppository for the treatment of gynaecopathias such as vaginitis, cervicitis, cervical erosion, its ingredient is made up of with the 1:1 ratio tea polyphenols and Oleum Hippophae, and used substrate is suppository base commonly used.The invention provides and a kind ofly medicine directly can be sent into the vagina depths, make effective ingredient directly act on focus, and can make medicine not outflow, avoid superinfection, safe and reliable suppository.Compound tea polyphenol vaginal suppository of the present invention and preparation method thereof; on the surface of tampon or surface and inside thereof be adsorbed with substrate and saturated by substrate; at least form layer protective layer on the tampon surface; except that advantage with the suppository that generally has tampon; also can improve the utilization rate of medicine; make all dosages controlled, occur deformed phenomenon simultaneously in the time of can preventing to make bolt.Be used for by pathogenic microbial various vaginitiss such as antibacterial, fungus, mycete, infusorian, cervicitis, cervical erosion, leucorrhea abnormal etc.Have following effect: clean the moon protects the moon, can make pudendum moist smooth; Destroy pathogenic bacterium in intravaginal living environment, thoroughly killing pathogenic bacteria, eliminate various colpitis, do not destroy the intravaginal acid-base balance, can form a kind of protecting film in intravaginal, vagina is carried out is repaired and protection.
The patent No. is 96216798.3 the compound bolt of a kind of medicinal vagina, by the medicine key that is streamline bomb shape, half is embedding and be fixed with treated health tampon in it, the afterbody of health tampon is provided with the bolt lead-in wire and constitutes, can keep concentration medicine and dosage, and can promote drug absorption, medicine key also can be made into warhead form, duckbill shape, its processing technique simple, self have lubrication, can avoid medicinal liquid to flow out, do not pollute clothing, long action time, use easy to carryly, occur deformed phenomenon in the time of simultaneously can preventing to make bolt.
In order to realize the present invention, the invention provides a kind of compound tea polyphenol suppository, the key of described suppository comprises following composition and content: tea polyphenols 100-400g, Oleum Hippophae 100-400g, and suppository substrate commonly used, it is characterized in that also being embedded with in the described suppository tampon, the surface of described tampon or surface and inner saturated by suppository substrate commonly used.
Preferred key comprises following pharmaceutical compositions and content: tea polyphenols 200g, and Oleum Hippophae 200g, described substrate for preparation suppository substrate commonly used, can be a kind of of water solublity, hydrophilic or fat-soluble substrate.Include but not limited to one or more combination of plate synthetic fatty acid glyceride type, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, Myrj 45; The combination of one or more that wherein preferred substrate is semi-synthetic fatty acid glyceride class, lanoline, Polyethylene Glycol, poloxamer or paraffin.
The consumption of substrate commonly used adopts disclosed ratio in the prior art with the heavy content of medicines of key, preferably adopts following substrate and content: lanoline accounts for key gross weight 3g-45g paraffin and accounts for the semi-synthetic fatty glyceride of key gross weight 3g-45g to account for the described tampon of key gross weight 120g-2300g be column or suitable other shapes that prepare suppository that medical absorbent cotton, non-woven fabrics or other plant fiber are made.
The preparation method of tampon of the present invention is: the cylinder of the definite shape that absorbent cotton, non-woven fabrics or other plant fibre plate are rolled into; putting into the hot radical matter of dissolving, to flood the surface of tampon at least saturated by substrate; described hot radical matter is to make substrate maintain the substrate of molten condition; the fusion temperature of substrate depends on the substrate that is adopted; common fusion temperature is 20-80 ℃, preferred 30-50 ℃. the saturated substrate of substrate forms layer protecting film or fully soaks into the surface and gets final product.Through experimental results show that for the absorbent cotton tampon, generally flood 1-360 second, preferred 10-30 can reach capacity second.The mixed proportion of medicine and substrate generally can be controlled in 1:1-1:80, is preferably 1:5-1:50.Described suppository can be made into circle, ellipse, triangle, star, prismatic, rectangle, taper or duckbill etc., but is not limited thereto, and conveniently is as the criterion so that the patient is comfortable when using, and how shelves the organization of human body at position with suppository and decides.For the ease of taking out, also can be provided with the bolt lead-in wire at the suppository afterbody.
Suppository of the present invention also comprises a bolt band that is used to pack, and material is PVC, PE, described bolt band for corresponding with the shape of suppository own, several suppositorys are coated on wherein a sealed packet load respectively.The suppository that comprises 1-20 piece of independent packaging in preferred each the bolt band of the present invention in each package panel, comprises one to two row's suppository.
Described suppository can adopt disclosed method preparation in the prior art.For example, the preparation of described suppository comprises the steps: 1) with PVC, PE, the sheet material lettering, be blow molded into and contain several and the corresponding sheet material that has the groove of evagination of suppository shape, three peripheries of outer emboss pit are welded into contain several and bolt band, cooling, the molding corresponding hollow of suppository shape, that be used for splendid attire and shaping suppository are standby again; 2) pretreatment tampon obtains surface or surface and inner by the saturated tampon of substrate; 3) with after the fusing of tampon substrate, proportionally add medicine, be stirred into medicinal liquid, standby; 4) medicinal liquid for preparing is poured in the bolt band, insert treated tampon then, cooling forming.5) post processing.Described post processing comprises seals, shears the bolt band.
In particular, the preparation method of bolt base of the present invention comprises the steps: that the preparation method of bolt band is: earlier 50-150 ℃ of preheating, 70-150 ℃ of blow molding is again 90-180 ℃ of welding with PVC, PE sheet material, at 0-30 ℃ of cooling forming, last edging is standby then.Get the suppository base of having got ready and put into container 30-150 ℃ heat fused, preferred temperature is 80 ℃; The thing of proportionally getting it filled increases progressively to put in the substrate of having dissolved by equivalent under 20-100 ℃ and is made into medicinal liquid, or adds a small amount of substrate in advance and stir into pasty state, adds a large amount of substrate again and is made into medicinal liquid, stir 5-60 minute standby.Elder generation's pre-heating device is irritated the interlayer temperature with material loading and is controlled in 20-80 ℃, and the baiting valve temperature is controlled at 20-80 ℃, and the pouring head temperature is controlled at 20-80 ℃.The medicinal liquid for preparing is installed in the material loading filling, open stirring arm and stirred 5-60 minute.Put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, groundwater increment is 0.1-5g, inserts saturated tampon then ,-15-35 ℃ of cooled and solidified, molding are through sealing, cut edge, shear by the time finished product.Described bolt band is that PVC or PE material are made, and has the sheet material of groove of the corresponding evagination of shape of a plurality of and suppository, and this sheet material is according to the shape of suppository equipment in advance, and preparation process constitutes PVC, PE sheet material lettering, blow molding.Concrete technology is as follows: first preheating, and welding again, cooling forming then, last edging is standby.Medicinal liquid seals, shears behind bolt band groove internal cooling, obtains having the suppository of this packing, and dress is sold behind the box, during use suppository is taken out to get final product from the bolt band.
The specific embodiment
Embodiment 1 present embodiment is a kind of surface-treated tampon, and the tampon surface adsorption has semi-synthetic fatty acid glyceride substrate.Its preparation method is: after 80 ℃ of fusings of semi-synthetic fatty acid heating, under 45 ℃, put into tampon 30 seconds, adsorb saturated, tampon formation layer protecting film.
Embodiment 2 is with embodiment 1, and different is, used substrate is 1 kilogram of lanoline, 3 kilograms in paraffin, and 50 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 90 ℃, puts into cotton sliver 50 seconds under 50 ℃.
Embodiment 3 is with embodiment 1, and different is, used substrate is 15 kilograms of lanolines, 5 kilograms in paraffin, and 300 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 60 ℃, puts into cotton sliver 360 seconds under 30 ℃.
Embodiment 4 gets PVC or PE sheet material lettering, being blow molded into corresponding with the suppository shape, as to have the groove 2 of several outwards outstanding suppository shapes sheet material. concrete technology is as follows: earlier 90 ℃ of preheatings, 100 ℃ of blow moldings, under 120 ℃, two sheet materials staggered relatively are welded again, so that three limit portion welding of suppository groove form semi-closed structure, only stay an opening to be used for dosing in outside limit portion, in room temperature cooling, molding, it is standby that the bolt that obtains is brought all the limit then.The suppository base 400g (with embodiment 1) that gets among the embodiment 3 that has got ready puts into container, 20-100 ℃ of following heating in water bath fusing; Under 45 ℃, by 1; 25 the ratio thing of getting it filled increases progressively to put in the substrate of having dissolved by equivalent and is made into medicinal liquid, stirs 30 minutes, and is standby.Medicine wherein is tea polyphenols and Oleum Hippophae 1:1 mixture.Before the perfusion, first pre-heating device, it is 55 ℃ that material loading is irritated the interlayer temperature, and the baiting valve temperature is 45 ℃, and the pouring head temperature is 40 ℃.The medicinal liquid for preparing is installed in the material loading filling, open stirring arm and stirred 30 minutes.Put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, and groundwater increment is 2.2g, inserts saturated tampon then, 0-25 ℃ of cooled and solidified, molding, the package panel that obtains having suppository is through sealing, cut edge, be cut into 1-20 piece or directly adorn box.
Embodiment 5 is heated to 30-150 ℃ with the substrate of the suppository of embodiment 2, treats substrate fusing back cooling, and the hot radical matter dipping of in 30-80 ℃ tampon being put into fusing is saturated by substrate to the surface of tampon at least, makes tampon form layer protective layer.Can prevent to combine absorption medicinal liquid when making bolt, make all dosages controlled, occur deformed phenomenon when preventing to make bolt with medicine.Get substrate semi-synthetic fatty acid glyceride, wool grease, paraffin among the embodiment 2 and put in the container 20-150 ℃ of heat fused, adding medicine in constantly stirring, stirring, it is standby to be made into medicinal liquid.Put the bolt band well, medicinal liquid is circulated in the opening of PVC, PE bolt band, insert the good tampon of pre-selection process, seal after the cooled and solidified, shear.Before the perfusion, first pre-heating device, it is 20-80 ℃ that material loading is irritated the interlayer temperature, and the baiting valve temperature is 20-80 ℃, and the pouring head temperature is 20-80 ℃.The medicinal liquid for preparing is installed in the material loading filling, open stirring arm and stirred 5-60 minute.Put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, and groundwater increment is 0.5.-3g, inserts saturated tampon then, 0-25 ℃ of cooled and solidified, molding, the package panel that obtains having suppository is through sealing, cut edge, be cut into 1-20 piece or directly adorn box.
Claims (4)
1. compound tea polyphenol vaginal suppository is characterized in that this suppository ingredient is grouped into by following one-tenth:
Tea polyphenols 50%
Oleum Hippophae 50%.
2. according to claims 1 described compound tea polyphenol vaginal suppository, it is characterized in that its substrate for preparation suppository substrate commonly used, can be a kind of of water solublity, hydrophilic or fat-soluble substrate.Include but not limited to one or more combination of semi-synthetic fatty acid glyceride class, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, Myrj 45.
3. according to the preparation method of claims 1 described compound tea polyphenol vaginal suppository, it is characterized in that, the cylinder of the definite shape that absorbent cotton, non-woven fabrics or other plant fibre plate are rolled into, putting into the hot radical matter of dissolving, to flood the surface of tampon at least saturated by substrate, make the medicine key that is streamline bomb shape, also can be provided with the bolt lead-in wire at the suppository afterbody.
4. according to claims 1 described compound tea polyphenol vaginal suppository, it is characterized in that using in the vagina local application preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101191927A CN101485702A (en) | 2009-03-09 | 2009-03-09 | Compound tea polyphenol vaginal suppository |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101191927A CN101485702A (en) | 2009-03-09 | 2009-03-09 | Compound tea polyphenol vaginal suppository |
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| Publication Number | Publication Date |
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| CN101485702A true CN101485702A (en) | 2009-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2009101191927A Pending CN101485702A (en) | 2009-03-09 | 2009-03-09 | Compound tea polyphenol vaginal suppository |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9320640B2 (en) | 2012-06-29 | 2016-04-26 | The Procter & Gamble Company | Method of attaching a withdrawal member to a pessary device |
| IT202000004582A1 (en) | 2020-03-06 | 2021-09-06 | Alfasigma Spa | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT AND PREVENTION OF ATROPHY AND VAGINAL DRYNESS. |
-
2009
- 2009-03-09 CN CNA2009101191927A patent/CN101485702A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9320640B2 (en) | 2012-06-29 | 2016-04-26 | The Procter & Gamble Company | Method of attaching a withdrawal member to a pessary device |
| IT202000004582A1 (en) | 2020-03-06 | 2021-09-06 | Alfasigma Spa | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT AND PREVENTION OF ATROPHY AND VAGINAL DRYNESS. |
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Open date: 20090722 |