CN100408070C

CN100408070C - Medicine for treating gynecopathy inflammation and its production method

Info

Publication number: CN100408070C
Application number: CNB2005100566867A
Authority: CN
Inventors: 李景华; 卢劲伟; 邓向东
Original assignee: LINGFENG PHARMACEUTICAL CO Ltd GUANGXI
Current assignee: Guangxi Gehongtang Pharmaceutical Co ltd; Jinji Pharmaceutical Co ltd
Priority date: 2005-04-14
Filing date: 2005-04-14
Publication date: 2008-08-06
Anticipated expiration: 2025-04-14
Also published as: CN1686351A

Abstract

The present invention relates to a medicine for treating gynecopathy inflammation and a production method of the medicine. The medicine for treating gynecopathy inflammation is prepared from 7.2 to 17.2 shares of scabrousstem greenbrier rhizome, 7.2 to 17.2 shares of european verbena, 7.2 to 17.2 shares of spica prunellae, 7.2 to 17.2 shares of cherokee rose root, 2.3 to 12.3 shares of common andrographis herb, 2.3 to 12.3 shares of corydalis tuber, 2.3 to 12.3 shares of leatherleaf mahonia, 2.3 to 12.3 shares of nutgrass galingale rhizome, 0.5 to 10.4 shares of angelica and 9.5 to 19.4 shares of suberect spatholobus. The present invention has the following production method: thick paste is prepared by pulverization, oil extraction and covering, alcohol extraction and water extraction (partial common andrographis herb is extracted by alcohol or water; after the residual common andrographis herb is pulverized, the residual common andrographis herb is added and is uniformly mixed), and the medicine for treating gynecopathy inflammation is prepared according to pharmacy requirements. The medicine of the present invention has efficiency of clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis and promoting qi circulation to relieve pain, and the medicine for treating gynecopathy inflammation has favorable therapeutic action on patients with gynecological inflammation, such as a stasis toxin internal intradermal syndrome which comprises endometritis, annexitis and pelvic inflammatory diseases, a syndrome of qi stagnation and blood stasis and a damp-heat stasis type. After the clinical trial, the medicine for treating gynecopathy inflammation has the advantages of safe and reliable performance, no obvious adverse reaction and no toxic or side effect.

Description

A kind of medicine and production method thereof for the treatment of gynecological inflammation

Technical field

The present invention relates to a kind of medicine for the treatment of gynecological inflammation, particularly relate to and treat medicine and the production method thereof that endometritis, adnexitis, pelvic inflammatory disease belong to symptom of stagnation of blood stasis and toxin, syndrome of qi stagnation and blood stasis, humid-heat stagnation type gynecological inflammation.

Background technology

Gynecological inflammation refers to the inflammation that female internal genital organs and connective tissue on every side thereof, pelvic peritoneum take place, can be divided into acute and chronic two classes, clinical its pathological change of acute and chronic gynecological inflammation comprises endometritis, myometritis, adnexitis, inflammation of pelvic connective tissue and pelvioperitonitis, wherein adnexitis is the most common, when body's immunity descends, endocrine changes or exogenous pathogenic bacterium are invaded, all can cause the generation of inflammation.To be pathogen invade through the placental separation face endometritis, is diffused into the uterine decidua layer and the inflammation that causes, and pilosity is born in intrauterine surgical, miscarriage and puerperal; Adnexitis claims adnexitis again, for perioophoritis takes place for the fimbriated extremity of fallopian adhesion of ovary and inflammation.Above inflammation is everlasting after fatigue, the sexual intercourse, increase the weight of during defecation and menstruation before and after increase the weight of.

China tradition traditional Chinese medical science has a lot of treatises to the treatment of gynecological inflammation, has also put down in writing the Chinese medicinal formulae of many treatment gynecological inflammations, and these prescriptions are one of China's pools of traditional Chinese medicine important compositions according to the different syndromes of gynecological inflammation and different.The ancient Chinese medicine theory is fully being summed up, excavating and utilized to the modern Chinese medicine theory also, and many science treatises have also proposed the method and the medicine of a large amount of Chinese traditional treatment gynecological inflammations, and the Chinese traditional treatment gynecological inflammation has been played directive function preferably.Some pharmaceutical factories and Chinese medicine institute have also been released the Chinese patent medicine of some treatment gynecological inflammations over the years, but the price that these Chinese patent medicines have is higher, and patient is difficult to accept, and the specific aim that has is not strong, and curative effect only plays the auxiliary treatment effect not as people's will.

Summary of the invention

The purpose of this invention is to provide a kind of to gynecological inflammation is with strong points, evident in efficacy, prescription is uncomplicated, moderate Chinese patent medicine and production method thereof.

The inventor is in secular medical practice, from motherland's traditional medical theory, through research for many years, tens kinds of Chinese medicinal formulaes have been screened, compare repeatedly, therefrom choose some medicines and prescription, carried out pharmacodynamics, pharmacology and research experiment such as clinical, finally invented a kind of good effect, extensive, moderate, the advanced feasible Chinese patent medicine of production technology in medicine source, the main active and the weight content of its raw material are as follows:

Rhizoma Smilacis Scobinicaulis 4.2～17.2 Herba Verbenae 4.2～17.2 Herba Andrographis 2.3～12.3 Radix Angelicae Sinensis 0.5～10.4 Caulis Spatholobi 6.5～19.4

Rhizoma Corydalis 2.3～12.3 Spica Prunellaes 4.2～17.2 Caulis Mahoniaes 2.3～12.3 Radix Rosae Laevigataes 4.2～17.2 Rhizoma Cyperis 2.3～12.3

Above-mentioned Chinese medicine can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia and other Chinese medicine handbook, in order to understand the mechanism that the present invention treats disease, now respectively distinguish the flavor of in the prescription effect of Chinese medicine and the effect in prescription thereof are described below: Herba Verbenae, Herba Andrographis heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, inducing diuresis to remove edema are monarch drug altogether; Rhizoma Smilacis Scobinicaulis, Spica Prunellae, Caulis Mahoniae three medicines match and are ministerial drug, altogether the effect of principal drug assistance heat clearing and inflammation relieving, dampness removing leukorrhagia stopping, Hua Yu Xiao Disorder; Radix Angelicae Sinensis, Caulis Spatholobi, Radix Rosae Laevigatae tool liver and kidney tonifying, controlling nocturnal emission with astringent drugs nourishing blood for regulating menstruation, blood stasis dispelling antiinflammatory altogether are assistant, to take into account it, transfer immunity of organisms, and collaborative monarch-minister drug amounts to heat clearing away, dries, the effect of blood stasis dispelling.Rhizoma Corydalis, the soothing the liver promoting the circulation of QI to relieve pain of Rhizoma Cyperi are for making.All medicines share, and play clearing away heat-damp and promoting diuresis altogether, nourishing blood for regulating menstruation, blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain.

Chinese medicine composition best in quality umber content of the present invention is:

Rhizoma Smilacis Scobinicaulis 6～12 Herba Verbenae 6～12 Herba Andrographis 4～8 Radix Angelicae Sinensis 3～6 Caulis Spatholobis 8～16

Rhizoma Corydalis 4～8 Spica Prunellaes 6～12 Caulis Mahoniaes 4～8 Radix Rosae Laevigataes 8～16 Rhizoma Cyperis 4～8

The composition of Chinese medicine composition of the present invention and content the best in quality also can adopt following proportioning (weight portion):

Rhizoma Smilacis Scobinicaulis 3.35 Herba Verbenae 3.35 Herba Andrographis 2 Radix Angelicae Sinensis 1.5 Caulis Spatholobis 4

Rhizoma Corydalis 2 Spica Prunellaes 3.35 Caulis Mahoniaes 2 Radix Rosae Laevigataes 4 Rhizoma Cyperis 2

Above-mentioned composition can be used as the prescription of institute of traditional Chinese medicine's treatment gynecological inflammation, and patients is fried in shallow oil soup and taken; Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make any dosage form on the pharmaceuticss such as capsule, tablet, granule, slow releasing capsule, soft capsule, drop pill, oral liquid, concrete production method is as follows:

1, the production method of capsule:

(1) get 7/25 of Herba Andrographis total amount, it be ground into fine powder with superfine communication technique, with 100 ℃～120 ℃ high pressure steam sterilizations 30～60 minutes, intermediate products A;

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation.

(3) medicinal residues D adds 3～8 times of amount 45%～75% alcohol reflux 2～4 hours, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E.

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 3～8 times of amounts, heating extraction twice, each 1～3 hour, water be carried part F.

(5) C, E and F are mixed, add intermediate products A, drying is ground into fine powder, gets intermediate products dried cream powder G.

(6) get intermediate products dried cream powder G and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, In Aluminium Foil Packing, and packing gets the finished capsule product agent.

Perhaps produce by the following method:

(3) medicinal residues D adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E, and medicinal residues F transfers water and puies forward operation.

(4) together, add the water of 3～8 times of amounts, add the medicinal residues F after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1～3 hour, water be carried part G.

(5) C, E and G are mixed, add intermediate products A, drying is ground into fine powder, gets intermediate products dried cream powder H.

(6) get intermediate products dried cream powder H and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, In Aluminium Foil Packing, and packing gets the finished capsule product agent.

Above-described adjuvant is a magnesium stearate, or meets other adjuvant of international and national Specification, and addition is for doing particulate 0.3-1%.

2, the production method of soft capsule:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 3～8 times of amounts, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1～3 hour, water be carried part F.

(4) B, D and F mixing are concentrated, drying is ground into fine powder, gets intermediate products dried cream powder G.

(5) get intermediate products dry extract G and A, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then suspended matter H fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.

3, the production method of slow releasing capsule:

(5) press the total amount of intermediate products dry extract G and A, spermaceti or other blocker coating of adding 0.5～5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain the finished product slow releasing capsule.

4, the production method of drop pill:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 24 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(5) with the polyethylene glycol 6000 heating and melting, get intermediate products A and G again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃～15 ℃ liquid paraffin or other liquid, and with the 50/component velocity system of dripping, drop pill gets product.

5, the production method of tablet:

(1) get 7/25 of Herba Andrographis total amount and be ground into fine powder, with 100 ℃～120 ℃ high pressure steam sterilizations 30～60 minutes, intermediate products A;

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B ₁Aqueous solution C after the distillation ₁Standby; Medicinal residues D ₁Transfer the alcohol extraction operation.

(3) medicinal residues D ₁Add 3～8 times of amount 45～75% alcohol reflux 2～4 hours, extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E ₁

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 3～8 times of amounts, heating extraction twice, each 1～3 hour, water be carried part F ₁

(5) with C ₁, E ₁And F ₁Mix, add intermediate products A, drying is ground into fine powder, gets intermediate products dried cream powder G ₁

(6) get intermediate products dried cream powder G ₁Granulate, drying adds B ₁With appropriate amount of auxiliary materials mixing, tabletting, sugar coating or film-coat, packing gets finished tablet.

6, the production method of granule:

(2) medicinal residues C adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, medicinal residues E.

(5) get intermediate products dried cream powder G and appropriate amount of auxiliary materials mixing, granulate, drying and A mixing, packing gets the finished particle agent.

7, the production method of oral liquid:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil B ₃Aqueous solution C after the distillation ₃Standby; Medicinal residues D ₃Transfer the alcohol extraction operation.

(2) medicinal residues D ₃Add 3～8 times of amount 45～75% alcohol reflux 2～4 hours, extracting solution filters, and filtrate recycling ethanol gets alcohol extraction part E ₃

(3) with the medicinal residues after the above-mentioned alcohol extraction with Herba Andrographis, Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 3～8 times of amounts, heating extraction twice, each 1～3 hour, water carry part F ₃

(4) with C ₃, E ₃And F ₃Mix concentrating, get the intermediate products fluid extract G of 1.05～1.20/55～60 ℃ of relative densities ₃

(5) get intermediate products B ₃And G ₃With an amount of syrup or Mel mixing, sterilization, fill gets the finished product oral solutions.

Other dosage form such as pill, unguentum, buccal tablet etc. can carry out with reference to pharmacopeia or Chinese medicinal preparation method.

The extracting method of above-mentioned Chinese medicine composition has provided to be carried oily enclose+alcohol extraction+water and carries, except with carrying oily enclose+alcohol extraction+water carries, can also adopt the extracting method of microwave, ultrasonic extraction, carbon dioxide supercritical fluid extraction or other Chinese medicine preparation, these extracting method have had report in scientific and technical literature, pharmacy corporation can adopt extracting method according to concrete practical situation, its objective is the extracts active ingredients in this medicine composition medical material, make any dosage form pharmaceutically, just can provide to dose a patient with.

Instructions of taking:

Capsule, 3 times on the one, one time 4, every 0.37 the gram;

Soft capsule, oral, one time 2,3 times on the one;

Slow releasing capsule, oral, one time 2,1-2 time on the one, every 0.7 the gram;

Drop pill, oral, one time 10,3 times on the one;

Granule, 2 times on the one, each 1 bag, every bag 8 gram;

Tablet, 3 times on the one, one time 6, every 0.45 the gram;

Oral liquid, every day 3 times, each 10ml.

The present invention compared with the prior art, its outstanding substantive distinguishing features and obvious improvement is:

The present invention is preferred above-mentioned Chinese medicine under Chinese medical theory instructs, science compatibility, making in addition, make each medicine cooperatively interact, can guarantee to greatest extent the group effect and the pharmaceutically-active performance of this product reasonable formula, all medicines share, play clearing away heat-damp and promoting diuresis altogether, nourishing blood for regulating menstruation, blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain.

1, through clinical verification, that the present invention has is antibiotic, antiinflammatory, analgesic activity: this product dilution factor is staphylococcus aureus to be had killing action at 1: 160 o'clock; Dilution factor is beta hemolytic streptococcus, streptococcus anaerobius, escherichia coli to be had killing action at 1: 5 o'clock; Dilution factor is that effect in 1: 10 o'clock had killing action to gonococcus in 20 minutes; Due to the on Carrageenan due to rat foot swelling, the Oleum Tiglii due to auricle edema, the cotton balls due to granulation tissue hyperplasia and the acetic acid peritonitis obvious suppression effect is all arranged, also can improve the white mice hot plate reaction threshold of pain, reduce white mice writhing response number of times.

2, raw material is easy to get, the prescription science, and production technology advanced person, workable, moderate product price is fit to suitability for industrialized production.

3, production technology adopt to be pulverized, is carried oily enclose, alcohol extraction, water and mentions corresponding sterilizing methods, carries oily enclose and has guaranteed that the extraction of Radix Angelicae Sinensis, Rhizoma Cyperi active ingredient volatile oil and preservation, alcohol extraction step (extract the active ingredient esters of Herba Andrographis etc.; The glycoside of Herba Verbenae etc.; The alkaloid of Caulis Mahoniae, tannin etc.; Radix Angelicae Sinensis, Rhizoma Cyperi active ingredient volatilization wet goods), thus product active constituent content height, the bioavailability height, and not perishable, long shelf-life.

4, production technology advanced person, workable, according to each flavor Effective Components of Chinese Herb character and preparation requirement, successively adopt international advanced pharmaceutical technology and equipment such as superfine communication technique, multiple-effect decompression technology, spray drying technology, three-dimensional hybrid technology in the production.

5, the result of product studies on acute toxicity of the present invention and long term toxicity research shows, is safe by intending with using the daily dose and the course of treatment product of the present invention.

The specific embodiment

Below be embodiments of the invention:

Embodiment 1

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount, it be ground into fine powder with superfine communication technique, with 110 ℃ of high pressure steam sterilizations 45 minutes, intermediate products A;

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 8 times of water gagings, soak 1 hour, extract volatile oil 4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation.

(3) medicinal residues D adds 3 times of amount 50% alcohol reflux 4 hours, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E.

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 5 times of amounts, soaked 1 hour, heating extraction twice, each 2 hours, water be carried part F.

(6) get intermediate products dried cream powder G and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, In Aluminium Foil Packing, and packing gets finished product, and name of product is " a golden balosam capsule ".

Embodiment 2

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 7 Herba Verbenae 7 Herba Andrographis 4 Radix Angelicae Sinensis 3 Caulis Spatholobis 8

Rhizoma Corydalis 4 Spica Prunellaes 7 Caulis Mahoniaes 4 Radix Rosae Laevigataes 8 Rhizoma Cyperis 4

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount, it be ground into fine powder with superfine communication technique, with 120 ℃ of high pressure steam sterilizations 30 minutes, intermediate products A;

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 3 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation.

(3) medicinal residues D adds 3 times of amount 75% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E, and medicinal residues F transfers water and puies forward operation.

(4) together, add the water of 4 times of amounts, soaked 1 hour, add the medicinal residues F after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 2.5 hours, water be carried part G.

(6) get intermediate products dried cream powder H and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, In Aluminium Foil Packing, and packing gets finished product, and name of product is " a golden balosam capsule ".

Embodiment 3

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 9 Herba Verbenae 9 Herba Andrographis 6 Radix Angelicae Sinensis 4 Caulis Spatholobis 12

Rhizoma Corydalis 6 Spica Prunellaes 9 Caulis Mahoniaes 6 Radix Rosae Laevigataes 12 Rhizoma Cyperis 6

Its technological process of production is:

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 6 times of water gagings, soak 1 hour, extract volatile oil 2 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation.

(3) medicinal residues D adds 6 times of amount 60% alcohol reflux 3 hours, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E.

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 6 times of amounts, soaked 1 hour, heating extraction twice, each 3 hours, water be carried part F.

Embodiment 4

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 12 Herba Verbenae 12 Herba Andrographis 8 Radix Angelicae Sinensis 6 Caulis Spatholobis 16

Rhizoma Corydalis 8 Spica Prunellaes 12 Caulis Mahoniaes 8 Radix Rosae Laevigataes 16 Rhizoma Cyperis 8

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount, it be ground into fine powder with superfine communication technique, with 115 ℃ of high pressure steam sterilizations 60 minutes, intermediate products A;

(3) medicinal residues D adds 6 times of amount 60% alcohol reflux 3 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E, and medicinal residues F transfers water and puies forward operation.

(4) together, add the water of 6 times of amounts, soaked 1 hour, add the medicinal residues F after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 3 hours, water be carried part G.

Embodiment 5

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 4 times of water gagings, soak 1 hour, extract volatile oil 3.5 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 4 times of amount 65% alcohol reflux 4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 4 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 2.5 hours, water be carried part F.

(5) get intermediate products dry extract G and A, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then suspended matter H fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out finished product, name of product is " a golden fragrant soft capsule ".

Embodiment 6

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 7 Herba Verbenae 7 Herba Andrographis 3.8 Radix Angelicae Sinensis 3.1 Caulis Spatholobis 8.3

Rhizoma Corydalis 4.1 Spica Prunellaes 7.1 Caulis Mahoniaes 4.2 Radix Rosae Laevigataes 8.1 Rhizoma Cyperis 4.2

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 8 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 4 times of amount 55% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 7 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1.5 hours, water be carried part F.

Embodiment 7

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 6.8 Herba Verbenae 6.7 Herba Andrographis 3.9 Radix Angelicae Sinensis 2.9 Caulis Spatholobis 8.1

Rhizoma Corydalis 3.8 Spica Prunellaes 6.7 Caulis Mahoniaes 4 Radix Rosae Laevigataes 8 Rhizoma Cyperis 4

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 8 times of amount 65% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

Embodiment 8

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 33 Herba Verbenae 33 Herba Andrographis 20 Radix Angelicae Sinensis 16 Caulis Spatholobis 41

Rhizoma Corydalis 21 Spica Prunellaes 33 Caulis Mahoniaes 20 Radix Rosae Laevigataes 40 Rhizoma Cyperis 19

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3 times of water gagings, soak 1 hour, extract volatile oil 2 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 3 times of amount 65% alcohol reflux 3 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 8 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 3 hours, water be carried part F.

(5) press the total amount of intermediate products dry extract G and A, spermaceti or other blocker coating of adding 0.5～5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, get finished product, name of product is " a golden fragrant slow releasing capsule " or " slow release gold balosam capsule ".

Embodiment 9

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 7 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 7 times of amount 70% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 5 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1.5 hours, water be carried part F.

Embodiment 10

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 33.5 Herba Verbenae 33.5 Herba Andrographis 20 Radix Angelicae Sinensis 15 Caulis Spatholobis 41

Rhizoma Corydalis 21 Spica Prunellaes 33.5 Caulis Mahoniaes 21 Radix Rosae Laevigataes 41 Rhizoma Cyperis 21

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 8 times of water gagings, soak 1 hour, extract volatile oil 4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 8 times of amount 55% alcohol reflux 3.5 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(3) together, add the water of 5 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 2.5 hours, water be carried part F.

Embodiment 11

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 35 Herba Verbenae 35 Herba Andrographis 21 Radix Angelicae Sinensis 16 Caulis Spatholobis 42

Rhizoma Corydalis 22 Spica Prunellaes 35 Caulis Mahoniaes 22 Radix Rosae Laevigataes 43 Rhizoma Cyperis 22

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 4 times of water gagings, soak 1 hour, extract volatile oil 2.5 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 3 times of amount 70% alcohol reflux 2.5 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

(5) with the polyethylene glycol 6000 heating and melting, get intermediate products A and G again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃～15 ℃ liquid paraffin or other liquid, with the 50/component velocity system of dripping, get finished product, name of product is " a golden fragrant drop pill ".

Embodiment 12

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 6.7 Herba Verbenae 6.7 Herba Andrographis 4 Radix Angelicae Sinensis 3 Caulis Spatholobis 8

Rhizoma Corydalis 4 Spica Prunellaes 6.7 Caulis Mahoniaes 4 Radix Rosae Laevigataes 8 Rhizoma Cyperis 4

Its technological process of production is:

(2) medicinal residues C adds 4 times of amount 60% alcohol reflux 3.5 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

Embodiment 13

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(2) medicinal residues C adds 5 times of amount 65% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation.

Embodiment 14

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 11 Herba Verbenae 11 Herba Andrographis 7 Radix Angelicae Sinensis 5 Caulis Spatholobis 14

Rhizoma Corydalis 7 Spica Prunellaes 11 Caulis Mahoniaes 7 Radix Rosae Laevigataes 14 Rhizoma Cyperi .7

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount and be ground into fine powder, with 115 ℃ of high pressure steam sterilizations 40 minutes, intermediate products A ₁

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B ₁Aqueous solution C after the distillation ₁Standby; Medicinal residues D ₁Transfer the alcohol extraction operation.

(3) medicinal residues D ₁Add 5 times of amount 60% alcohol reflux 4 hours with remaining Herba Andrographis, Herba Verbenae, Caulis Mahoniae, extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E ₁

(4) with the medicinal residues after the above-mentioned alcohol extraction with Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, add the water of 8 times of amounts, soaked 1 hour, heating extraction twice, each 3 hours, water carry part F ₁

(6) get intermediate products dried cream powder G ₁Granulate, drying adds B ₁With appropriate amount of auxiliary materials mixing, tabletting, sugar coating or film-coat, packing gets finished product, and name of product is " a golden scented tea ".

Embodiment 15

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount and be ground into fine powder, with 120 ℃ of high pressure steam sterilizations 30 minutes, intermediate products A ₁

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 2.5 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B ₁Aqueous solution C after the distillation ₁Standby; Medicinal residues D ₁Transfer the alcohol extraction operation.

(3) medicinal residues D ₁Add 4 times of amount 50% alcohol reflux 3.5 hours, extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E ₁

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 7 times of amounts, soaked 1 hour, heating extraction twice, each 2.5 hours, water be carried part F ₁

Embodiment 16

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 35 Herba Verbenae 34 Herba Andrographis 21 Radix Angelicae Sinensis 14 Caulis Spatholobis 41

Rhizoma Corydalis 20 Spica Prunellaes 33 Caulis Mahoniaes 23 Radix Rosae Laevigataes 42 Rhizoma Cyperis 19

Its technological process of production is:

(1) get 7/25 of Herba Andrographis total amount and be ground into fine powder, with 115 ℃ of high pressure steam sterilizations 50 minutes, intermediate products A ₁

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 4 times of water gagings, soak 1 hour, extract volatile oil 4 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B ₁Aqueous solution C after the distillation ₁Standby; Medicinal residues D ₁Transfer the alcohol extraction operation.

(3) medicinal residues D ₁Add 4 times of amount 70% alcohol reflux 4 hours, extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E ₁

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 5 times of amounts, soaked 1 hour, heating extraction twice, each 2 hours, water be carried part F ₁

Embodiment 17

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 2 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 7 times of amount 60% alcohol reflux 2.5 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, medicinal residues E.

(3) together, add the water of 7 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1 hour, water be carried part F.

(5) get intermediate products dried cream powder G and appropriate amount of auxiliary materials mixing, granulate, drying and A mixing, packing gets finished product, and name of product is " a golden fragrant granule ".

Embodiment 18

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 30 Herba Verbenae 31 Herba Andrographis 19 Radix Angelicae Sinensis 14 Caulis Spatholobis 39

Rhizoma Corydalis 18 Spica Prunellaes 31 Caulis Mahoniaes 18 Radix Rosae Laevigataes 38 Rhizoma Cyperis 18

Its technological process of production is:

(2) medicinal residues C adds 3 times of amount 70% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, medicinal residues E.

(3) together, add the water of 4 times of amounts, soaked 1 hour, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 3 hours, water be carried part F.

Embodiment 19

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 6.7 Herba Verbenae 6.8 Herba Andrographis 3.9 Radix Angelicae Sinensis 2.9 Caulis Spatholobis 7.9

Rhizoma Corydalis 3.8 Spica Prunellaes 6.6 Caulis Mahoniaes 3.9 Radix Rosae Laevigataes 8.1 Rhizoma Cyperis 3.8

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 4 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect oil-containing distillate (medicinal residues are handed over the alcohol extraction operation), separate, and get the volatile oil beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation.

(2) medicinal residues C adds 4 times of amount 55% alcohol reflux 2 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, medicinal residues E.

Embodiment 20

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 168 Herba Verbenae 168 Herba Andrographis 100 Radix Angelicae Sinensis 75 Caulis Spatholobis 200

Rhizoma Corydalis 100 Spica Prunellaes 168 Caulis Mahoniaes 100 Radix Rosae Laevigataes 200 Rhizoma Cyperis 100

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 4 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil B ₃Aqueous solution C after the distillation ₃Standby; Medicinal residues D ₃Transfer the alcohol extraction operation.

(2) medicinal residues D ₃Add 4 times of amount 60% alcohol reflux 2 hours, extracting solution filters, and filtrate recycling ethanol gets alcohol extraction part E ₃

(3) with the medicinal residues after the above-mentioned alcohol extraction with Herba Andrographis, Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 4 times of amounts, soaked 1 hour, heating extraction twice, each 1 hour, water carry part F ₃

(5) get intermediate products B ₃And G ₃With an amount of syrup or Mel mixing, sterilization, fill gets finished product, and name of product is " a golden fragrant oral liquid ".

Embodiment 21

Take by weighing following Chinese medicine ingredients (unit: g)

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 4 times of water gagings, soak 1 hour, extract volatile oil 2 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil B ₃Aqueous solution C after the distillation ₃Standby; Medicinal residues D ₃Transfer the alcohol extraction operation.

(2) medicinal residues D ₃Add 7 times of amount 60% alcohol reflux 2 hours, extracting solution filters, and filtrate recycling ethanol gets alcohol extraction part E ₃

(3) with the medicinal residues after the above-mentioned alcohol extraction with Herba Andrographis, Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 5 times of amounts, soaked 1 hour, heating extraction twice, each 2 hours, water carry part F ₃

Embodiment 22

Take by weighing following Chinese medicine ingredients (unit: g)

Rhizoma Smilacis Scobinicaulis 40 Herba Verbenae 40 Herba Andrographis 22 Radix Angelicae Sinensis 16 Caulis Spatholobis 43

Rhizoma Corydalis 22 Spica Prunellaes 40 Caulis Mahoniaes 21 Radix Rosae Laevigataes 44 Rhizoma Cyperis 23

Its technological process of production is:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 5 times of water gagings, soak 1 hour, extract volatile oil 3 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil B ₃Aqueous solution C after the distillation ₃Standby; Medicinal residues D ₃Transfer the alcohol extraction operation.

(2) medicinal residues D ₃Add 5 times of amount 60% alcohol reflux 4 hours with remaining Herba Andrographis, Herba Verbenae, Caulis Mahoniae, extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E ₃

(3) with the medicinal residues after the above-mentioned alcohol extraction with Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, add the water of 6 times of amounts, soaked 1 hour, heating extraction twice, each 1.5 hours, water carry part F ₃

Below be clinical research report of the present invention:

Medicine of the present invention entrusts provincial, and municipal level three tame hospitals to carry out clinical verification, and job step and experimental result are as follows:

Clinical data:

One, physical data:

Gold fragrant Capsules group (calling the treatment group in the following text) 115 examples, JINJI JIAONANG group (calling matched group in the following text) 69 examples, wherein the unmarried respectively is 2 examples, and pregnant artificial abortion's history is all arranged, all the other cases are the married woman.Each is organized data such as age, routine number and sees attached list.

Two, diagnosis, typing and case are selected

(1) symptom: based on few abdomen or flank pain, and have lower abdomen to weigh down to expand, lumbosacral aching pain, often before and after menstruation, increase the weight of after tired, the sexual life and during defecation, can accompany and see low grade fever, unusual, the menoxenia, mass in the abdomen of leukorrhagia, even cause sterile.

(2) gynecologial examination: the uterus often is the position, back, and limitation of activity or adhesion are fixed, and can touch streak thing in one or both sides during salpingitis, and mild tenderness is arranged; During the inflammation of pelvic cavity connective tissue, the one or both sides, uterus have that lamellar thickens, tenderness; Or touch enclosed mass in the pelvic cavity one or both sides.

(3) differentiation of symptoms and signs for classification of syndrome: select symptom of stagnation of blood stasis and toxin and syndrome of qi stagnation and blood stasis as the object of observation.

Symptom of stagnation of blood stasis and toxin card is seen low thermal fluctuation, lower abdomen dull pain or expand, and lumbosacral aching pain, uncomfortable through row, amount is many through preceding or menstrual period and tired postemphasis, the yellow thick flavor of leukorrhagia is smelly, yellowish urine dry stool, red tongue, yellow and greasy fur, slippery and rapid pulse.

Syndrome of qi stagnation and blood stasis card is seen lower abdominal pain such as acupuncture or long-term dull pain, pain in fixed position, or companion's lumbago, and menoxenia, purple coloured menses is black piece, leucorrhoea grow in quantity, dizzy asthenia, body of the tongue is dark violet ecchymosis, and tongue is white, hesitant pulse or heavy.

Three, observational technique

Adopt district's group at random, experiment contrast, double-blind method observe, the treatment group is each 4 with golden balosam capsule, matched group JINJI JIAONANG, instructions about how to take medicine, every day 3 times, warm water delivery service serve on for 4 weeks, two groups of medicament appearance character, dosage and pack just the same, only in the medicine bottle label with digital coding, to show difference, coding is maintained secrecy by producer, and make known off-test time side.Do chemical examination such as routine physical examination and routine blood test, leucorrhea smear (leucorrhea check for mycete, infusorian or gonococcus infection person not as the object of observation) to patient before taking medicine, after taking medicine weekly with examining once.Viewing duration is without other drug for diminishing inflammation and antibiosis (comprising the local topical medicine).

Four, efficacy assessment standard

(1) recovery from illness in the recent period: symptom and sign and gynecologial examination all recover normally, and the witness integration reduces more than 91%;

(2) produce effects: symptom and sign and gynecologial examination obviously improve, and the witness integration reduces more than the 61%-90%;

(3) take a turn for the better: symptom and sign and gynecologial examination all have and alleviate, and the witness integration reduces 31%-60%;

(4) invalid: the treatment back does not have improvement, and the witness integration reduces below 30%.

Five, result

(1) equal highly significant of witness integration difference (P＜0.01) before and after each pattern of syndrome pelvic inflammatory disease patient treatment of treatment group, matched group shows that two kinds of medicines are to the effect that all has clear improvement of above-mentioned pattern of syndrome pelvic inflammatory disease patient's symptom and sign; Each pattern of syndrome curative effect of treatment group and matched group is there was no significant difference (P＞0.05) relatively.Symptoms such as 115 examples are organized in treatment, and lower abdomen tenderness, leukorrhagia increase or Huang is smelly, adnexa thickens adhesion obviously alleviate or disappearance person's 69 examples recovery from illness obvious effective rate 60.0%, total effective rate 92.17%; Matched group 69 examples, recovery from illness obvious effective rate 60.87%, 91.30%, two group of curative effect there was no significant difference of total effective rate (P＞0.05).

(2) two kinds of pattern of syndrome curative effects of treatment group compare: symptom of stagnation of blood stasis and toxin slightly is better than syndrome of qi stagnation and blood stasis, but does not have significance meaning (R _{Stasis of blood poison}＜R _{Blood stasis}, U=0.75, P＞0.05).

(3) vaginal secretions check result: the 51 routine WBC positives (1～3+) are organized in treatment before the treatment, matched group 19 examples positive (1～3+), and turning out cloudy after the treatment is respectively 10 examples, 6 examples, and the person of not turning out cloudy also obviously improves (P＜0.01), two groups of there was no significant difference (X ²=0.55, P＞0.05).The 16 routine pyocyte positives (1～2+) are organized in treatment before the treatment, matched group 7 examples positive (1～2+), and turning out cloudy after the treatment is respectively 14 examples, 7 examples, two groups of there was no significant difference (X ²=0.03, P＞0.05).

(4) hemogram situation of change: blood WBC rising treatment group, matched group are respectively 14 examples, 3 examples before the treatment, and 13 examples, 2 examples are recovered normally to be respectively in the treatment back, two groups of there were significant differences (X ²=4.96, P＜0.01), the treatment group is better than matched group.

Six, toxic and side effects

Treatment is organized has take medicine aftersensation chest or epigastrium of 5 examples slightly uncomfortable in 115 examples, due to capsule is stranded in the esophagus in the time of may taking capsule formulation because of individual patients; Matched group also has 1 example disease to occur going up; It is slightly dry that the treatment group has 2 examples oropharynx to occur in addition.Do not find obvious toxic-side effects.

Seven, conclusion

Adopt golden balosam capsule to observe treatment symptom of stagnation of blood stasis and toxin, syndrome of qi stagnation and blood stasis pelvic inflammatory disease patient totally 115 examples, the result shows that this medicine can obviously improve patient's pelvic inflammatory disease symptom, have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain effect, and the blood WBC rising person due to the above-mentioned pattern of syndrome pelvic inflammatory disease is recovered normally, simultaneously to the effect of having clear improvement of unusual vaginal secretions.The result also shows its safety, and no obvious toxic-side effects has clinic popularization and application values preferably.

Eight, model case

Example 1 Tang, 31 years old, married, live in the Hua Qianglu of Nanning City No. 227.Because of distention and pain in the lower abdomen, lumbosacral aching pain January is surplus came institute to go to a doctor on the 14th in December in 1993, looked into palace body and adnexa tenderness, and leucorrhea yellow skin amount is medium, leucorrhea smear WBC+++, blood WBC9.6 * 10 ⁹/ L, N76%, light red tongue, yellow and thin fur, thready and rapid pulse, witness total mark 6 minutes is examined and is the chronic pelvic inflammatory disease symptom of stagnation of blood stasis and toxin, takes each 4 of golden balosam capsule, every day 3 times, connect abdomen 3 all backs above-mentioned symptoms and obviously alleviate, 4 all witness disappearances of week back, leucorrhea WBC ±, blood WBC6.0 * 10 ⁹/ L, N65%, palace body and adnexa do not have tenderness, and efficacy determination is recovery from illness in the recent period.

The Guangxi hydraulic power chamber 37 years old, is lived in example 2 fields, pregnant 4 produce on October 12nd, 1,1993 goes to a doctor, and tells few abdomen pain unbearably, companion's lumbosacral aching pain, aversion to cold and cold limbs, leukorrhagia increase nearly half a year, dialectical is the syndrome of qi stagnation and blood stasis pelvic inflammatory disease, and it is normal big movable not good enough to look into retroposition of uterus, tenderness +++, other the organizing slightly in the right side, uterus thickens tenderness +++, take golden balosam capsule after 4 weeks, each disease disappears, and it is normal that the woman examines the basin device, obtains recent recovery from illness.

Subordinate list: golden balosam capsule clinical verification efficacy analysis

Annotate: *-P＜0.01, A---treatment group, B---matched group.

Brief summary

Above clinical data discloses:

1, medicine of the present invention has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, and symptom of stagnation of blood stasis and toxin, syndrome of qi stagnation and blood stasis pelvic inflammatory disease patient are had therapeutical effect.

2, Drug therapy gynecological inflammation patient 115 examples of the present invention, total effective rate is 92.17%, it is capsular 91.30% that curative effect slightly is better than JINJI JIAONANG, thereby reach final purpose of the present invention.

3, this product is safe and reliable, and 115 examples are not all found obvious adverse reaction and toxic and side effects at viewing duration.

Claims

1. medicine for the treatment of gynecological inflammation is characterized in that making the raw materials of effective components component and is by weight:

Rhizoma Smilacis Scobinicaulis 4.2～17.2; Herba Verbenae 4.2～17.2; Herba Andrographis 2.3～12.3; Radix Angelicae Sinensis 0.5～10.4;

Caulis Spatholobi 6.5～19.4; Rhizoma Corydalis 2.3～12.3; Spica Prunellae 4.2～17.2; Caulis Mahoniae 2.3～12.3;

Radix Rosae Laevigatae 4.2～17.2; Rhizoma Cyperi 2.3～12.3.

2. the medicine of a treatment gynecological inflammation as claimed in claim 1 is characterized in that making the raw materials of effective components component and is by weight:

Rhizoma Smilacis Scobinicaulis 3.35; Herba Verbenae 3.35; Herba Andrographis 2; Radix Angelicae Sinensis 1.5; Caulis Spatholobi 4;

Rhizoma Corydalis 2; Spica Prunellae 3.35; Caulis Mahoniae 2; Radix Rosae Laevigatae 4; Rhizoma Cyperi 2.

3. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method capsule:

(2) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation;

(3) medicinal residues D adds 3～8 times of amount 45%～75% alcohol reflux 2～4 hours, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E;

(4) with the medicinal residues after the above-mentioned alcohol extraction with remaining Herba Andrographis and Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 3～8 times of amounts, heating extraction twice, each 1～3 hour, water be carried part F;

(5) C, E and F are mixed, add intermediate products A, drying is ground into fine powder, gets intermediate products dried cream powder G;

(6) get intermediate products dried cream powder G and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, aluminum-plastic packaged, and packing gets the finished capsule product agent;

Perhaps produce by the following method:

(3) medicinal residues D adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E, and medicinal residues F transfers water and puies forward operation;

(4) together, add the water of 3～8 times of amounts, add the medicinal residues F after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1～3 hour, water be carried part G;

(5) C, E and G are mixed, add intermediate products A, drying is ground into fine powder, gets intermediate products dried cream powder H;

(6) get intermediate products dried cream powder H and granulate, drying adds intermediate products B and appropriate amount of auxiliary materials mixing, and is encapsulated, aluminum-plastic packaged, and packing gets the finished capsule product agent.

4. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method soft capsule:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation;

(2) medicinal residues C adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, and medicinal residues E transfers water and puies forward operation;

(3) together, add the water of 3～8 times of amounts, add the medicinal residues E after the above-mentioned alcohol extraction then Rhizoma Smilacis Scobinicaulis, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Radix Rosae Laevigatae, heating extraction twice, each 1～3 hour, water be carried part F;

(4) B, D and F mixing are concentrated, drying is ground into fine powder, gets intermediate products dried cream powder G;

(5) get intermediate products dry extract G and A, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then suspended matter H fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the finished product soft capsule.

5. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method slow releasing capsule:

6. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method drop pill:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 24 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil, use beta-cyclodextrin inclusion compound, after the drying, weigh, and get intermediate products A; Aqueous solution B after the distillation is standby; Medicinal residues C transfers the alcohol extraction operation;

7. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method tablet:

(3) medicinal residues D adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste E;

(5) C, E and F are mixed, add intermediate products A, drying is ground into fine powder; Get intermediate products dried cream powder G;

(6) get intermediate products dried cream powder G and granulate, drying adds B and appropriate amount of auxiliary materials mixing, tabletting, and sugar coating or film-coat, packing gets finished tablet.

8. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method granule:

(2) medicinal residues C adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours with Herba Andrographis, Caulis Mahoniae, Herba Verbenae, and extracting solution filters, and filtrate recycling ethanol also concentrates, and gets thick paste D, medicinal residues E;

9. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that producing by the following method oral liquid:

(1) Radix Angelicae Sinensis, Rhizoma Cyperi add 3～8 times of water gagings, extract volatile oil 2～4 hours with steam distillation, collect the oil-containing distillate, separate, and get volatile oil B; Aqueous solution C after the distillation is standby; Medicinal residues D transfers the alcohol extraction operation;

(2) medicinal residues D adds 3～8 times of amount 45～75% alcohol reflux 2～4 hours, and extracting solution filters, and filtrate recycling ethanol gets alcohol extraction part E;

(3) with the medicinal residues after the above-mentioned alcohol extraction with Herba Andrographis, Rhizoma Smilacis Scobinicaulis, Herba Verbenae, Caulis Spatholobi, Rhizoma Corydalis, Spica Prunellae, Caulis Mahoniae, Radix Rosae Laevigatae, add the water of 3～8 times of amounts, heating extraction twice, each 1～3 hour, water carry part F;

(4) C, E and F mixing are concentrated, get the intermediate products fluid extract G of 1.05～1.20/55～60 ℃ of relative densities;

(5) get intermediate products B and G and an amount of syrup or Mel mixing, sterilization, fill gets the finished product oral liquid.

10. the medicine production method of a treatment gynecological inflammation as claimed in claim 1 or 2 is characterized in that and can comprise said other dosage form on pill, unguentum and the pharmaceutics according to the method preparation of pharmacopeia or pharmacy of Chinese materia medica.