CN1033998C - Medicine "Yufukang" for treating arthritis and its preparation - Google Patents
Medicine "Yufukang" for treating arthritis and its preparation Download PDFInfo
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- CN1033998C CN1033998C CN93100059A CN93100059A CN1033998C CN 1033998 C CN1033998 C CN 1033998C CN 93100059 A CN93100059 A CN 93100059A CN 93100059 A CN93100059 A CN 93100059A CN 1033998 C CN1033998 C CN 1033998C
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Abstract
The present invention discloses a medicine which is prepared from 100 to 160g of prepared nux vomica powder, 20 to 30g of scorpion, 15 to 25g of angelica, 15 to 25g of common floweringquince fruit, 15 to 25g of medicinal cyathula root, 15 to 25g of ledebouriella root, 15 to 25g of fineleaf schizonepeta herb and 15 to 25g of safflower. The raw materials can be made into tablets, or capsules, or watered pills. The present invention is mainly used for treating rheumatoid arthritis, rheumatic arthritis, and rheumatic cold arthralgia.
Description
The present invention relates to a kind of medicine and compound method thereof of treatment of arthritis, the particularly medicine of Chinese medicine rheumatoid arthritis and compound method thereof.
Arthritis is common clinical, frequently-occurring disease.American Rheumatism Association is divided into 13 classes with arthritis, and is wherein comparatively common with rheumatoid arthritis especially, and etiology unknown.Show as repeated relapsing, symmetry, multiple arthritis in early days, late period, the joint deformity of distinct program can appear in arthritis, be a kind of disability rate than higher, and do not have the disease of specific treatment again.At present, both at home and abroad western medicines that adopt more, one line medicines such as aspirin commonly used, indometacin, piroxicam, chlofenamic acid, ibuprofen, naproxen, Phenylbutazone powder, two wires medicine and glucocorticoid medicines such as golden preparation, penicillamine, levamisole, chloroquine; But these curative effect of medication instabilities, side effect is big, and patient is difficult for accepting.Domestic Chinese medicine preparation commonly used has Radix Tripterygii Wilfordii, Tripterygium hypoglaucum etc., and the curative effect of this class medicine is also unstable, stomach, intestinal is stimulated bigger, and patient also is difficult for accepting; Therefore, the medicine of studying a kind of treatment of arthritis is very important.
The objective of the invention is to overcome the shortcoming of prior art, a kind of treatment of arthritis is provided, especially rheumatoid arthritis curative effect the best, minimum medicine and the compound method thereof of untoward reaction.
Medicine of the present invention is according to the theory of Chinese medical science basis, and according to the design of " searches ends ", selecting Semen Strychni, Scorpio for use is that principal agent is formed.Medicine of the present invention has promoting the flow of QI in the collateral by warming the meridian, the effect of wind-expelling pain-stopping.Semen Strychni activating collaterals and eliminating stagnation, subduing swelling and relieving pain in the side; It is deep that Scorpio is worn muscle, by the wet wind that removes, and relieving convulsion relieving dizziness, high fever, infantile convulsions, epilepsy, etc., and the merit that suppresses the caused muscle twitches of Semen Strychni is arranged, and two medicines share, and " one searches one ends " is strengthened dispeling being detained in the wet heresy of the wind and cold of meridians.Help with Flos Carthami, the hot temperature of loosing is logical again, blood circulation promoting and blood stasis dispelling, logical regulating menstruation arteries and veins; The Radix Cyathulae invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation and sharp joint; The Radix Angelicae Sinensis nourishing blood and promoting blood circulation again can pain relieving; Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral, and energy removing dampness; Herba Schizonepetae, Radix Saposhnikoviae pain relieving.Exopathogen goes, QI and blood row, then sick spontaneous recovery.
Pharmaceutical formulation of the present invention is made up of following medicine; Semen Strychni (processed) powder 100-160 gram, Scorpio 20-30 gram, Radix Angelicae Sinensis 15-25 gram, Fructus Chaenomelis 15-25 gram, Radix Cyathulae 15-25 gram, Radix Saposhnikoviae 15-25 gram, Herba Schizonepetae 15-25 gram, Flos Carthami 15-25 gram.
One of manufacturing process of the present invention is: after Semen Strychni is concocted, be ground into fine powder, add an amount of dextrin, making strychnine content is 1%; Scorpio was soaked into 2-4 hour with 75% ethanol, and oven dry (below 60 ℃) is ground into fine powder; Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Cyathulae, Fructus Chaenomelis, Flos Carthami mixing and water adding, per 1 gram crude drug adds 10 milliliters in water, decocts secondary, decocts 1.5 hours at every turn, merges decocting liquid twice, filters decompression, is concentrated into the extractum that proportion is 1.20-1.25 (room temperature).With above Semen Strychni Pulveratum, Scorpio powder mix homogeneously, add above-mentioned extractum and gelatinized corn starch, make granule, oven dry below 60 ℃, granulate, the magnesium stearate of adding 0.3% is pressed into 1000.Every heavy 0.3 gram, containing the strychnine amount is the 1.2-1.5 milligram.Two of manufacturing process of the present invention is: Semen Strychni, Scorpio powder are become fine powder, and two kinds of medicine mixings, standby.Get Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Cyathulae, Fructus Chaenomelis, Flos Carthami mixing and water adding, per 1 gram crude drug adds 10 milliliters in water, decocts secondary, does not fry in shallow oil the person at every turn 1.5 hours.Merge decoct twice, add yellow wine 200ml, be heated to 90-100 ℃, add Semen Strychni (processed) powder, Scorpio powder, mix thoroughly, from pot, took out in lasting 15 minutes, oven dry below 60 ℃, powder becomes fine powder, granulates, be pressed into 1000 or 1000 seed lacs of packing into and assist, every (grain) contains the strychnine amount is the 1.2-1.5 milligram; Or make water pill, it is the 0.4-0.5 milligram that every ball contains the strychnine amount.
Medicine of the present invention has antiinflammatory, analgesia, suppresses effects such as cellular immunization.Cure mainly rheumatoid arthritis, rheumatic arthritis, cold rheumatoid joint pain.Oral meal once begins to obey 3 every night, and having no adverse reaction adds a slice again, and maximum dose should not be above 5.Need polydipsia eliminating cold for resuscitation water when taking medicine.Generally need to obey 1-3 the course of treatment a 1-3 month course of treatment.It is preceding as taking a large amount of Western medicine to take this product, must slowly stop using.Take medicine the back if any dizziness, xerostomia, just suitable decrement or drink a large amount of eliminating cold for resuscitation water during untoward reaction such as dry, whole body stiff feeling, take medicine the back as use when occurring with obvious muscle twitches Radix Glycyrrhizae 100 restrain soaked drink it.Avoid with mung bean products, contain the same usefulness of medicine of Radix Glycyrrhizae, in order to avoid lessen the curative effect.Anemia of pregnant woman's forbidding.
Through sanitation Ministry tissue of rear-service department of Beijing Military Area Command hospitalize rheumatoid arthritis 350 examples, total effective rate is 96.28%, does not have rebound phenomenon after the drug withdrawal in the period of 1985-1986 in the present invention.Through the double-blind method observation of curative effect, its curative effect obviously is better than the import ibuprofen.It has effects such as tangible antiinflammatory, analgesia, inhibition cellular immunization (animal Mus and Canis familiaris L.) evidence; To no any untoward reaction such as its heart, liver,spleen,kidney, stomach, intestinals.Compare it with domestic and international similar drug and have determined curative effect, stable, do not have phenomenon repeatedly after the drug withdrawal, internal organs are had no adverse reaction, patient is easy to advantages such as acceptance.
Embodiment: it is standby to get Semen Strychni (processed) powder 156 gram, Scorpio 25 grams, Radix Angelicae Sinensis 20 grams, Fructus Chaenomelis 20 grams, Radix Cyathulae 20 grams, Radix Saposhnikoviae 20 grams, Herba Schizonepetae 20 grams, Flos Carthami 20 grams.Get Semen Strychni (processed) powder, add the dextrin mixing, making strychnine content is 1%; After Scorpio was soaked into 2-4 hour with 75% ethanol, oven dry (below 60 ℃) was ground into fine powder.Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Cyathulae, Fructus Chaenomelis, Flos Carthami mixing and water adding, per 1 gram crude drug adds water 10ml, boils and fries in shallow oil secondary, decocts 1.5 hours, merges the secondary decocting liquid, filters, and is evaporated to the extractum that proportion is 1.2-1.25 (room temperature).With Semen Strychni (processed) powder, Scorpio powder mix homogeneously, add above-mentioned extractum and an amount of starch, make granule.Oven dry below 60 ℃, granulate, the magnesium stearate of adding 0.3% is pressed into 1000.Every heavy 0.3 gram contains 1.5 milligrams of strychnine amounts.This product is by " Chinese pharmacopoeia regulation and Ministry of Public Health carry out every inspection about the regulation of medicine sanitary standard, all up to specification, check result is as follows: 1. tablet weight variation (plain sheet): by " Chinese pharmacopoeia version appendix in 1985 7 pages " inspection techniques of weight differential " carries out, 20 middle smallest pieces weigh 0.295 gram, the most large stretch of heavy 0.315 gram, average sheet heavily is 0.3075 gram, through calculating, does not have the slice, thin piece that exceeds weight differential.2. disintegration: by " appendix of Chinese pharmacopoeia version in 1985 method 7 pages of disintegrations is checked, is limited to 25-30 minute when dissolving, and all meets the regulation of disintegration.3. health examination: press the inspection of Ministry of Public Health " medicine sanitary standard " regulation, all up to specification.4. other: meet " 6 pages of tablets of appendix of Chinese pharmacopoeia version in 1985 regulation.5. assay: contain hypertoxic medicine Semen Strychni in this product.Must measure the content and the regulation safety dosage of main hypertoxic composition strychnine alkali in the Semen Strychni in the standard.Therefore, by " content assaying method has carried out the assay of strychnine alkali under 35 pages of Semen Strychni subitems of Chinese pharmacopoeia appendix of version in 1985, and the disturbed condition and the response rate situation of content measurement are groped with regard to other composition of this product, the result shows, other composition in this product does not almost disturb the strychnine assay, and the response rate is also satisfied.Proof uses official method to measure the content of strychnine, is feasible to reach control this product quality.
Claims (6)
1. the medicine of a treatment of arthritis is characterized in that it is that raw material is made with following composition; Semen Strychni (processed) powder 100-160 gram, Scorpio 20-30 gram, Radix Angelicae Sinensis 15-25 gram, Herba Schizonepetae 15-25 gram, Fructus Chaenomelis 15-25 gram, Radix Cyathulae 15-25 gram, Radix Saposhnikoviae 15-25 gram, Flos Carthami 15-25 gram.
2. the medicine of treatment of arthritis according to claim 1 is characterized in that it is that described raw material is made tablet by following technology, after Semen Strychni is concocted, is ground into fine powder, adds an amount of dextrin, and making the strychnine amount is 1%; Scorpio was soaked into 2-4 hour with 75% ethanol, and oven dry (below 60 ℃) is ground into fine powder; Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Cyathulae, Fructus Chaenomelis, Flos Carthami mixing and water adding, per 1 gram crude drug adds water 10ml, decocts secondary, the each decoction 1.5 hours merges decocting liquid twice, filters, reduces pressure, be concentrated into the extractum that proportion is 1.20-1.25 (room temperature), with Semen Strychni Pulveratum, Scorpio powder mix homogeneously, add above-mentioned extractum and appropriate amount of starch and stick with paste, make granule, oven dry below 60 ℃, granulate adds 0.3% magnesium stearate, be pressed into 1000, every heavy 0.3 gram contains strychnine 1.2-1.5mg.
3. the medicine of treatment of arthritis according to claim 1 is characterized in that it is the medicament that described raw material is made by following technology; After the Semen Strychni process of preparing Chinese medicine, be ground into fine powder, add an amount of dextrin, mixing, make that to contain the strychnine amount be 1%, the Scorpio powder is become fine powder, two kinds of medicine mixings, standby, get Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Cyathulae, Fructus Chaenomelis, Flos Carthami mixing and water adding, decoct secondary, per 1 gram crude drug adds water 10ml, decocted 1.5 hours, merge decoct twice, add yellow wine 200ml, heat 90-100 ℃, add Semen Strychni (processed) powder, Scorpio powder, mix thoroughly, from pot, took out in lasting 15 minutes, oven dry below 60 ℃, powder becomes fine powder, makes medicinal preparation for oral administration.
4. the medicine of treatment of arthritis according to claim 3 is characterized in that said medicament is that tablet or glue are assisted, and every (grain) contains the strychnine amount is the 1.2-1.5 milligram.
5. the medicine of treatment of arthritis according to claim 4 is characterized in that said medicament is a water pill, and it is the 0.4-0.5 milligram that every ball contains the strychnine amount.
6. according to arbitrary described medicine among the claim 1-5, wherein the optimum amount proportioning of crude drug is:
Semen Strychni (processed) powder 156 grams, Scorpio 25 grams, Radix Angelicae Sinensis 20 grams, Fructus Chaenomelis 20 grams, Radix Cyathulae 20 grams, Radix Saposhnikoviae 20 grams, Herba Schizonepetae 20 grams, Flos Carthami 20 grams.
Priority Applications (1)
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CN93100059A CN1033998C (en) | 1993-01-04 | 1993-01-04 | Medicine "Yufukang" for treating arthritis and its preparation |
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CN93100059A CN1033998C (en) | 1993-01-04 | 1993-01-04 | Medicine "Yufukang" for treating arthritis and its preparation |
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CN1074128A CN1074128A (en) | 1993-07-14 |
CN1033998C true CN1033998C (en) | 1997-02-12 |
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CN93100059A Expired - Lifetime CN1033998C (en) | 1993-01-04 | 1993-01-04 | Medicine "Yufukang" for treating arthritis and its preparation |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1325058C (en) * | 2002-12-30 | 2007-07-11 | 首都医科大学北京神经科学研究所 | Application of sodium selenite in preparation of medicine for treating wind, dampness and cold caused arthralgia |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1052639C (en) * | 1994-02-02 | 2000-05-24 | 李庆和 | Traditional Chinese medicine capsule for treating rheumatoid arthritis |
CN1059572C (en) * | 1996-05-15 | 2000-12-20 | 李义乐 | Medicament for curing Rheumatoid and hyperosteogeny and preparation thereof |
CN104758452A (en) * | 2014-01-07 | 2015-07-08 | 黑龙江省传奇生物医药科技开发有限公司 | Illness-preventing and immunity-strengthening traditional Chinese medicine pills or granules for human body health protection and preparation method thereof |
CN111569042A (en) * | 2020-06-28 | 2020-08-25 | 马淑珍 | Traditional Chinese medicine preparation for improving human immunity and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1049970A (en) * | 1989-09-07 | 1991-03-20 | 苏宝娟 | A kind of preparation method of Dressed plaster |
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1993
- 1993-01-04 CN CN93100059A patent/CN1033998C/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1049970A (en) * | 1989-09-07 | 1991-03-20 | 苏宝娟 | A kind of preparation method of Dressed plaster |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1325058C (en) * | 2002-12-30 | 2007-07-11 | 首都医科大学北京神经科学研究所 | Application of sodium selenite in preparation of medicine for treating wind, dampness and cold caused arthralgia |
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CN1074128A (en) | 1993-07-14 |
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Expiration termination date: 20130104 Granted publication date: 19970212 |