CN100446740C - Cotton bar, cotton bar type suppository and preparing technique - Google Patents
Cotton bar, cotton bar type suppository and preparing technique Download PDFInfo
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- CN100446740C CN100446740C CNB2004101044821A CN200410104482A CN100446740C CN 100446740 C CN100446740 C CN 100446740C CN B2004101044821 A CNB2004101044821 A CN B2004101044821A CN 200410104482 A CN200410104482 A CN 200410104482A CN 100446740 C CN100446740 C CN 100446740C
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Abstract
The present invention discloses a cotton bar and a cotton bar type suppository and a preparation technology thereof. The surface, or the surface and the inner part of the cotton bar are saturated with substrate; the cotton bar has the preparation method that absorbent cotton, non-woven fabric or other plant fibre sheet are rolled into a cylinder in a certain shape, and then the cylinder is impregnated into melted hot substrate till at least the surface of the cotton bar is saturated with the substrate; the suppository comprises a pin prepared by mixing the substrate and medicines, and infusing the substrate and the medicines into a pin belt made of PVC and PE in a certain shape, and the cotton bar with the surface, or the surface and the inner part saturated with the substrate for insertion. The cotton bar and the suppository prepared from the cotton bar of the present invention have the characteristics that the surface, or the surface and the inner part of the cotton bar are absorbed in the substrate and saturated with the substrate to form one layer of protective layers on at least the surface of the cotton bar, thereby improving the utilization rate of the medicines, controlling all of the dosages of the medicines, and simultaneously preventing the phenomena of formless suppositories during preparation.
Description
Technical field
The present invention relates to a kind of cotton sliver, cotton sliver type suppository and preparation technology thereof, belong to pharmaceutical sanitary field.
Background technology
Suppository has long history as a dosage form independently, and it is to be mixed and made into for a kind of solid preparation that inserts the different tracts of human body by principal agent and certain substrate.The fusing point of suppository is near body temperature, insert can melt rapidly behind the tract, softening, and mixed and have an effect with juice.The advantage of suppository has been avoided stimulation and the issuable gastrointestinal side effect of oral drugs to stomach, avoids medicine to be destroyed by gastric acid and Digestive system; Can prevent or reduce the toxic and side effects of medicine to liver; Absorb soon than oral administration, action time is long again; Accept by children's with to taking the inconvenient patient of oral medicine easily; Be used for gynecological and anorectal disease, act on direct and evident in efficacy.
Suppository is distributed in mucous membrane surface by topical, both can treat local illness, but also the per rectum mucosa is gone into blood with drug absorption, the treatment systemic disease.
The preparation method of suppository is: base is melted built in heating in water bath, then medicine is added in the substrate by different way, mix homogeneously is to as in the mould, and cooling, the demoulding promptly obtain suppository.
General suppository commonly used is DNAcarrier free, because the suppository that dissolves can not in time be absorbed in the body fully, owing to the outflow of medicine and substrate, the meeting pollution clothes is made troubles to user in use.And this outflow concentration that also can cause medicine can not remain valid for a long time in vivo.Therefore, existing many technical staff improve the structure of suppository, make tampon and suppository integrated, can avoid medicinal liquid to flow out, and do not pollute clothing, and can promote drug absorption, long action time, use advantages such as easy to carry.
Such as, application number is 89210570.4 the cotton base of a kind of protection for the health of woman articles for use hollow cylindrical, makes by medical absorbent cotton, and be axle with the cellulosic inner core, the cotton layer of cylinder of the typing shape that the absorbent cotton sheet is rolled into; Be coated with to carry out on the cotton pilum body and the skim dextrin arranged as sealing coat; Be coated with on the sealing coat that shoe is made up of the glycerin gelatine layer four-layer structure of glycerol that contains certain moisture content and gelatin mixture.With this cotton base is that substrate can be made various vaginal suppositories.This suppository can fully keep medicine concentration in vivo, to reach curative effect, can prevent the outflow of medicine and liquid again, and is very easy to use.But this technology is more loaded down with trivial details, can improve the processing cost of product, is not easy to large-scale industrial production.
The patent No. is 96216798.3 the compound bolt of a kind of medicinal vagina, belongs to medical suppository.It is by the medicine key that is streamline bomb shape, and half is embedding and be fixed with the health tampon in it, and the afterbody of health tampon is provided with the bolt lead-in wire and constitutes.The medicine key also can be molded as warhead form, duckbill shape.Its processing technique is simple, self have lubrication, can avoid medicinal liquid to flow out, and do not pollute clothing, and can promote drug absorption, long action time, uses easy to carry.Though this patent technology is simple and easy to do, the suppository material is softer, also causes key to be difficult for being shaped easily in system bolt process, can't use.
Summary of the invention
The object of the present invention is to provide a kind of cotton sliver, cotton sliver surface forms protective layer, keeps concentration medicine and dosage, and occurs deformed phenomenon when preventing to make bolt.
Another object of the present invention is to provide a kind of preparation technology of surface-treated cotton sliver, this processing technique is simple and easy to do, is easy to suitability for industrialized production.
A further object of the present invention is to provide a kind of suppository, and this suppository is composited by cotton sliver and key, and is not yielding, can pollution clothes when the patient uses, and the concentration that medicine can be remained valid in vivo for a long time is convenient to the patient and is used.
An also purpose of the present invention is to provide a kind of preparation technology of suppository, and this processing technique is simple and easy to do, is easy to suitability for industrialized production.
In order to realize the object of the invention, the invention provides a kind of cotton sliver, the surface of described cotton sliver or surface and inner saturated by substrate.
Described cotton sliver is column or suitable other shapes that prepare suppository that medical absorbent cotton, non-woven fabrics or other plant fiber are made.
Described substrate for preparation suppository substrate commonly used, can be a kind of of water solublity, hydrophilic or fat-soluble substrate.Include but not limited to one or more combination of semi-synthetic fatty acid glyceride class, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, the hard ester acid esters of polyoxyethylene; Wherein preferred substrate is wherein a kind of of semi-synthetic fatty acid glyceride class, lanoline, paraffin, Polyethylene Glycol, gelatin or poloxamer.
The preparation method of a kind of surface-treated cotton sliver of the present invention is: the cylinder of the typing shape that absorbent cotton, non-woven fabrics or other plant fibre plate are rolled into, the hot radical matter dipping of putting into fusing is saturated by substrate to the surface of cotton sliver at least.
Described hot radical matter is to make substrate maintain the substrate of molten condition, and the fusion temperature of substrate depends on the substrate that is adopted, and common fusion temperature is 20～80 ℃, preferred 30-50 ℃.
The saturated of substrate gets final product with surface formation layer protecting film or abundant the infiltration.
For the absorbent cotton cotton sliver, generally flooded 1～360 second, can reach capacity in preferred 10～30 seconds.
In order to realize another purpose of the present invention, the invention provides a kind of suppository, described suppository comprises the key that substrate and medicament mixed constitute, and it is characterized in that, also comprises surface or surface and inner by the saturated cotton sliver of substrate.
The key that described substrate and medicament mixed constitute can be disclosed various compositions and content thereof in the prior art.Medicine can need be different compositions according to what treat, as Chinese medicine powder, water medicine powder or the combination of these two, includes but not limited to metronidazole, clotrimazole, chlorhexidine acetate or other Chinese medicine compositions.Described substrate is one or more mixing such as semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, the ratio that the mixing of its mesostroma can adopt those skilled in the art to use always, preferred mixed proportion is 1: 1～1: 10.
Suppository of the present invention also comprises a bolt band that is used to pack, and material is PVC, PE, described bolt band for corresponding with the shape of suppository own, several suppositorys are coated on wherein a sealed packet load respectively.
The suppository that comprises 3-20 piece of independent packaging in preferred each the bolt band of the present invention.
Usually the used substrate of key and the matrix phase of handling cotton sliver with, but also can be different, when two kinds of substrate not simultaneously, general two kinds of substrate are similar base system, as are all a kind of of water solublity, hydrophilic or fat-soluble substrate.
The mixed proportion of substrate and medicine generally can be controlled in 1: 1～1: 80, was preferably 1: 5～1: 50.
Described suppository can be made into circle, ellipse, triangle, star, prismatic, rectangle, taper or duckbill etc., but is not limited thereto, and conveniently is as the criterion so that the patient is comfortable when using, and how shelves the organization of human body at position with suppository and decides.
For the ease of taking out, also can be provided with the bolt lead-in wire at the suppository afterbody.The material of bolt lead-in wire is a cotton thread.
Described suppository can adopt disclosed method preparation in the prior art.For example, the preparation of described suppository comprises the steps:
1) with PVE, PE sheet material lettering, be blow molded into and contain several and the corresponding sheet material that has the groove of evagination of suppository shape, be welded into again contain several and the bolt band corresponding hollow of suppository shape, that be used for splendid attire and shaping suppository, cooling, molding, last edging is standby;
2) pretreatment tampon obtains surface or surface and inner by the saturated tampon of substrate;
3) with after the suppository base fusing, proportionally add medicine, be stirred into medicinal liquid, standby;
4) medicinal liquid for preparing is poured in the bolt band, insert treated tampon then, cooling forming;
5) post processing.
Described post processing comprises seals, shears the bolt band.
Wherein the preparation process of bolt band is: at 50～150 ℃ of preheatings, 70～150 ℃ of blow moldings, 90～180 ℃ of welding, 0～30 ℃ of cooling forming, last edging is standby with sheet material.
The process of pretreatment tampon is referring to the preparation process of aforementioned cotton sliver.
Get the suppository base of having got ready and put into 20～100 ℃ of heat fused of water-bath, preferred temperature is 80 ℃; Under 20～100 ℃, get medicated powder after sieving and increase progressively to put in the substrate of having dissolved by equivalent and be made into medicinal liquid, or add a small amount of substrate in advance and stir into pasty state, add a large amount of substrate again and be made into medicinal liquid, stir 5～60 minutes standby.
Elder generation's pre-heating device is irritated the interlayer temperature with material loading and is controlled in 20～80 ℃, and the baiting valve temperature is controlled at 20～80 ℃, and the pouring head temperature is controlled at 20～80 ℃.
The medicinal liquid for preparing is installed in the batch can, open stirring arm and stirred 5～60 minutes.Put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, groundwater increment is 0.1～5g, inserts saturated tampon then ,-15～35 ℃ of cooled and solidified make molding, seal then, cut edge, shear and obtain finished product.
The fineness of medicated powder wherein is about 100 orders.
Cotton sliver of the present invention and the suppository of making thereof; on the surface of cotton sliver or surface and inside thereof be adsorbed with substrate and saturated by substrate, form layer protective layer on the cotton sliver surface at least, improve the utilization rate of medicine; make all dosages controlled, occur deformed phenomenon simultaneously in the time of can preventing to make bolt.
The specific embodiment
Describe the present invention in detail below in conjunction with the drawings and specific embodiments, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Description of drawings
The sketch map that Fig. 1 is used to prepare the bolt strap material of suppository and fastens band for the present invention;
Fig. 2 is that Figure 1A-A is to cutaway view;
Fig. 3 is for having the sketch map of the suppository of bolt band, cotton sliver for the present invention;
Fig. 4 is that Fig. 3 B-B is to cutaway view;
Fig. 5 has the sketch map of the suppository of bolt band, cotton sliver for Fig. 3 the present invention.
Below be specific embodiments of the invention.
Present embodiment is a kind of surface-treated cotton sliver, and the cotton sliver surface adsorption has semi-synthetic fatty acid glyceride substrate.Its preparation method is: after 80 ℃ of fusings of semi-synthetic fatty acid heating, under 45 ℃, put into cotton sliver 30 seconds, adsorb saturated, cotton sliver formation layer protective layer.
With embodiment 1, different is, used substrate is Polyethylene Glycol, and heating-up temperature is 90 ℃, puts into cotton sliver 50 seconds under 50 ℃.
With embodiment 1, different is, used substrate is paraffin, and heating-up temperature is 120 ℃, puts into cotton sliver 10 seconds under 80 ℃.
Embodiment 4
With embodiment 1, different is, used substrate is poloxamer, and heating-up temperature is 60 ℃, puts into cotton sliver 60 seconds under 30 ℃.
With embodiment 1, different is, used substrate is gelatin, and heating-up temperature is 150 ℃, puts into cotton sliver 5 seconds under 75 ℃.
Embodiment 6
With embodiment 1, different is, used substrate is 1 kilogram of lanoline, 3 kilograms in paraffin, and 50 kilograms of semi-synthetic fatty acid glyceride (concrete consumption will be arranged), heating-up temperature is 90 ℃, puts into the absorbent cotton tampon 50 seconds under 50 ℃.
With embodiment 1, different is, used substrate is 5 kilograms of lanolines, 5 kilograms in paraffin, and 100 kilograms of semi-synthetic fatty acid glyceride (concrete consumption will be arranged), heating-up temperature is 120 ℃, puts into tampon 10 seconds under 80 ℃.
Embodiment 8
With embodiment 1, different is, used substrate is 15 kilograms of lanolines, 5 kilograms in paraffin, and 300 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 60 ℃, puts into tampon 360 seconds under 30 ℃.
Embodiment 9
Referring to accompanying drawing 1-3, get PVC or PE sheet material lettering, be blow molded into corresponding with the suppository shape, as to have the groove 2 of several outwards outstanding suppository shapes sheet material 1.Concrete technology is as follows: earlier 50～150 ℃ of preheatings, 100 ℃ of blow moldings, under 120 ℃, two sheet materials staggered relatively 1 are welded again, so that three limit portions, 3 welding of suppository groove form semi-closed structure, only stay an opening 4 to be used for dosing in outside limit portion, in room temperature cooling, molding, fastening of obtaining is with 10 (omitting among the figure) edging standby then.
In water-bath, add purified water and reach watermark, get any suppository base of the embodiment 1 to 8 that has got ready and put into receptacle 20～100 ℃ of heat fused.
Under 45 ℃, get medicated powder after sieve (100 order) in 1: 5～1: 50 ratio and increase progressively to put in the substrate of having dissolved by equivalent and be made into medicinal liquid, or add a small amount of substrate in advance and stir into pasty state and add a large amount of substrate and be made into medicinal liquid, stirred 30 minutes, standby.
Before the perfusion, the preheating of equipment elder generation, making material loading irritate the interlayer temperature is 55 ℃, and the baiting valve temperature is 45 ℃, and the pouring head temperature is 40 ℃.The medicinal liquid for preparing is installed in the batch can, opened the stirring arm stir about 30 minutes.Put bolt band 10 (material PVC, PE) well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, the 2.2g medicinal liquid is circulated in the bolt band by an opening 4, insert 7,0～25 ℃ of cooled and solidified of tampon saturated among the embodiment 1 then and make molding, obtain having the package panel 6 of suppository 5; Seal then, cut edge, shear, through being packaged to be finished product.
Referring to accompanying drawing 1-3, get PVC or PE sheet material lettering, be blow molded into corresponding with the suppository shape, as to have the groove 2 of several outwards outstanding suppository shapes sheet material 1.Concrete technology is as follows: earlier 50～150 ℃ of preheatings, 70～150 ℃ of blow moldings, again in 90～180 ℃ of welding of temperature, three limit portions, 3 welding of suppository groove are formed semi-closed structure, only stay an opening 4 to be used for dosing in outside limit portion, then in 0～30 ℃ of cooling, molding, it is standby that fastening of obtaining at last brought all the limit.
With reference to embodiment 9, to get the suppository base of having got ready and put into 20～100 ℃ of heat fused of water-bath, preferred temperature is 80 ℃; Under 20～100 ℃, get medicated powder after sieving and increase progressively to put in the substrate of having dissolved by equivalent and be made into medicinal liquid, or add a small amount of substrate in advance and stir into pasty state, add a large amount of substrate again and be made into medicinal liquid, stir 5～60 minutes standby.
Elder generation's pre-heating device is irritated the interlayer temperature with material loading and is controlled in 20～80 ℃, and the baiting valve temperature is controlled at 20～80 ℃, and the pouring head temperature is controlled at 20～80 ℃.
The medicinal liquid for preparing is installed in the batch can, open stirring arm and stirred 5～60 minutes.Put the bolt band well, after treating that the transmission of bolt band puts in place, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, groundwater increment is 0.1～5g, inserts 7 ,-15～35 ℃ of cooled and solidified of any saturated tampon of embodiment 2-6 kind then and makes molding, seal, cut edge, be cut into 1～20 piece/sheet then, obtain finished product 6.
Claims (12)
1. cotton sliver is characterized in that the surface of described cotton sliver or surface and inner to be produced suppository substrate commonly used saturated, and described substrate is a kind of of water solublity, hydrophilic or fat-soluble substrate; Comprise one or more combination of semi-synthetic fatty acid glyceride, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, Myrj 45.
2. cotton sliver according to claim 1 is characterized in that described substrate is wherein a kind of of semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol or poloxamer.
3. a kind of cotton sliver according to claim 1 is characterized in that, described cotton sliver is the columnar shape that medical absorbent cotton, non-woven fabrics or other fibers are made.
4. the method for preparing each described cotton sliver of claim 1-3 is characterized in that the cylinder of definite shape that absorbent cotton, non-woven fabrics or other fibers are rolled into, and the hot radical matter dipping of putting into fusing is saturated by substrate to the surface of cotton sliver at least.
5. method according to claim 4 is characterized in that described hot radical matter is to make substrate maintain the substrate of molten condition, and the fusion temperature of substrate is 20～80 ℃, and dip time is 1～360 second.
6. method according to claim 5, the fusion temperature that it is characterized in that substrate is 30-50 ℃, dip time is 10～60 seconds.
7. suppository, described suppository comprise the key that substrate and medicinal mixture constitute, and it is characterized in that the inside of described suppository also is embedded with each described cotton sliver of a claim 1-3.
8. suppository according to claim 7, it is characterized in that described suppository also comprises a bolt band that is used to pack, described bolt band for corresponding with the shape of suppository own, several suppositorys are coated on wherein a package panel respectively, the used substrate of described key is identical or different with the substrate of handling cotton sliver; The used substrate of described key is one or more the mixing of semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin.
9. suppository according to claim 8 is characterized in that described medicine is Chinese medicine powder or water medicine powder, and wherein the used substrate of key and the mixed proportion of medicine are 1: 1～1: 80.
10. suppository according to claim 8 is characterized in that the substrate that described key is used and the mixed proportion of medicine are 1: 5～1: 50.
11. suppository according to claim 8 is characterized in that the substrate that described key is used and the mixed proportion of medicine are 1: 1～1: 10.
12. the preparation method of the described suppository of claim 8 comprises the steps:
1) with the sheet material lettering, be blow molded into and contain several and the corresponding sheet material that has the groove of evagination of suppository shape, be welded into again contain several and the bolt band corresponding hollow of suppository shape, that be used for splendid attire and shaping suppository, cooling, molding, last edging is standby;
2) pretreatment cotton sliver obtains surface or surface and inner by the saturated cotton sliver of substrate;
3) with after the suppository base fusing, proportionally add medicine, be stirred into medicinal liquid, standby;
4) medicinal liquid for preparing is poured in the bolt band, insert treated cotton sliver then, cooling forming,
5) post processing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101044821A CN100446740C (en) | 2004-12-28 | 2004-12-28 | Cotton bar, cotton bar type suppository and preparing technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101044821A CN100446740C (en) | 2004-12-28 | 2004-12-28 | Cotton bar, cotton bar type suppository and preparing technique |
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| Publication Number | Publication Date |
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| CN1795838A CN1795838A (en) | 2006-07-05 |
| CN100446740C true CN100446740C (en) | 2008-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004101044821A Active CN100446740C (en) | 2004-12-28 | 2004-12-28 | Cotton bar, cotton bar type suppository and preparing technique |
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| CN (1) | CN100446740C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288089A (en) * | 2014-08-25 | 2015-01-21 | 哈尔滨欧替药业有限公司 | Separated-type suppository combination treatment unit |
| CN109157418A (en) * | 2018-10-26 | 2019-01-08 | 江西九华药业有限公司 | A kind of Chinese medicine suppository forming method |
| CN113577253A (en) * | 2021-08-17 | 2021-11-02 | 胡高连 | Formula for non-surgical treatment of suppurative otitis media and use method |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2050752U (en) * | 1989-05-30 | 1990-01-10 | 李红玉 | Hollow column tapy cotton-plug |
| CN2145030Y (en) * | 1992-12-04 | 1993-11-03 | 李红玉 | Carrier embolus |
| CN2257486Y (en) * | 1996-07-10 | 1997-07-09 | 吕荣钊 | Medical compound pessary |
| CN2266416Y (en) * | 1996-12-18 | 1997-11-05 | 阎庚飞 | Medical suppository |
| CN2266414Y (en) * | 1996-07-10 | 1997-11-05 | 吕荣钊 | Forming & packing two-purpose die set box for vagina & anus suppository |
| CN1413696A (en) * | 2002-11-15 | 2003-04-30 | 贵州长生制药有限责任公司 | Suppository for treating gynecopathy and its preparation technology |
-
2004
- 2004-12-28 CN CNB2004101044821A patent/CN100446740C/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2050752U (en) * | 1989-05-30 | 1990-01-10 | 李红玉 | Hollow column tapy cotton-plug |
| CN2145030Y (en) * | 1992-12-04 | 1993-11-03 | 李红玉 | Carrier embolus |
| CN2257486Y (en) * | 1996-07-10 | 1997-07-09 | 吕荣钊 | Medical compound pessary |
| CN2266414Y (en) * | 1996-07-10 | 1997-11-05 | 吕荣钊 | Forming & packing two-purpose die set box for vagina & anus suppository |
| CN2266416Y (en) * | 1996-12-18 | 1997-11-05 | 阎庚飞 | Medical suppository |
| CN1413696A (en) * | 2002-11-15 | 2003-04-30 | 贵州长生制药有限责任公司 | Suppository for treating gynecopathy and its preparation technology |
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| CN1795838A (en) | 2006-07-05 |
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