CN113577253A - Formula for non-surgical treatment of suppurative otitis media and use method - Google Patents
Formula for non-surgical treatment of suppurative otitis media and use method Download PDFInfo
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- CN113577253A CN113577253A CN202110942002.2A CN202110942002A CN113577253A CN 113577253 A CN113577253 A CN 113577253A CN 202110942002 A CN202110942002 A CN 202110942002A CN 113577253 A CN113577253 A CN 113577253A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21001—Chymotrypsin (3.4.21.1)
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Abstract
The invention discloses a formula for non-surgical treatment of suppurative otitis media and a using method thereof, comprising the following steps: the preparation method comprises the following steps: preparing 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease, 10-25 g of prednisolone and 500-800 g of ionized water, and grinding: 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone are poured into a crushing device, the crushing time is 1-2 minutes, and after the crushing, 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone are poured into the grinding device. The invention treats the ear canal mucous membrane or the tympanic membrane by placing the wet absorbent cotton in the external ear canal, utilizing the body temperature in the ear canal to volatilize the active ingredients in the wet absorbent cotton and adsorbing the active ingredients on the inflammatory ear canal mucous membrane for a long time, and solves the problem of poor treatment effect of the existing non-operative treatment medicament for treating suppurative otitis media.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a formula for non-surgical treatment of suppurative otitis media and a use method thereof.
Background
The existing non-operative treatment medicine for treating suppurative otitis media directly drips liquid medicine into auditory canals and external auditory canals, so that the liquid medicine flows out in a short time, the treatment effect is general, the effect is worse when serious illness occurs, and the phenomena of slow effect, poor medicinal effect, slow dry ears and the like can occur after the medicine is used.
Disclosure of Invention
In order to solve the problems in the background art, the invention aims to provide a formula for non-operative treatment of suppurative otitis media and a use method thereof, which have the advantage of good treatment effect and solve the problem of poor treatment effect of the existing non-operative treatment medicines for suppurative otitis media.
In order to achieve the purpose, the invention provides the following technical scheme: a formula for non-surgical treatment of suppurative otitis media and a using method thereof comprise the following steps:
the preparation method comprises the following steps: preparing 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease, 10-25 g of prednisolone and 500-800 g of ionized water;
a crushing and grinding step: pouring 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into a crushing device, crushing for 1-2 minutes, pouring 5-15 g of crushed resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into a grinding device, and grinding for 2-3 minutes to enable powder particles of the resorcinol, the lincomycin, the halter for ox protease and the prednisolone to be finer;
stirring: pouring 5-15 g of ground resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into the stirring device, and then pouring 500-800 g of ionized water into the stirring device, wherein the stirring time is 3-5 minutes, so that powder particles of resorcinol, lincomycin, halter for ox protease and prednisolone are completely dissolved into the ionized water to obtain a liquid medicine;
a storage step: pouring the liquid medicine into a storage bottle, and then placing the storage bottle in the storage box for storage;
the method comprises the following steps: the user prepares a cotton piece earlier, cuts into the cotton sliver with the cotton piece again, then takes out the storage bottle from the storage box, inserts the cotton sliver in the inside liquid medicine of storage bottle, makes the liquid medicine invade wet cotton sliver, obtains wet absorbent cotton, places wet absorbent cotton in outer auditory canal, and the free time is 24 hours.
Preferably, in the grinding and grinding step, an observation hole is formed in the front face of the grinding device, a piece of transparent glass with the same shape and size as the observation hole is prepared, and the transparent glass is fixed inside the observation hole through glue, so that a user can observe the processing condition inside the grinding device, and the situation that the grinding device cannot be timely processed when an unexpected condition occurs is avoided.
Preferably, in the stirring step, the stirring tank of the stirring device is made of transparent glass, so that a user can conveniently observe the mixing progress of the resorcinol, the lincomycin, the halter for ox protease and the prednisolone with the ionized water.
Preferably, in the storing step, the storage bottle is a transparent tank with scales, so that a user can conveniently observe the amount of the liquid medicine.
Preferably, in the storing step, a bottle cap is arranged at the top of the storage bottle, the bottle cap is made of sealing rubber, and the storage bottle is sealed by the bottle cap, so that external dust is prevented from entering the storage bottle.
Preferably, in the preparation step, the ionized water is normal saline water, so that the ionized water has a certain disinfection function, and is convenient for a user to use.
Preferably, in the storing step, the storage tank is a constant temperature safe so as to avoid the temperature of the external environment from influencing the effect of the liquid medicine in the storage bottle.
Preferably, in the using step, the cotton sheet is a medical dust-free cotton sheet, so that toxic and harmful bacteria in the cotton sheet are prevented, and secondary infection of suppurative otitis media is avoided.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention treats the ear canal mucous membrane or tympanic membrane by placing the wet absorbent cotton in the external ear canal, volatilizing the active ingredients in the wet absorbent cotton by utilizing the body temperature in the ear canal and adsorbing the active ingredients on the inflammatory ear canal mucous membrane or tympanic membrane for a long time, thereby solving the problem of poor treatment effect of the traditional treatment medicine for non-operative treatment of suppurative otitis media.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
a formula for non-surgical treatment of suppurative otitis media and a using method thereof comprise the following steps:
the preparation method comprises the following steps: preparing 5g of resorcinol, 30g of lincomycin, 50g of halter for ox protease, 10g of prednisolone and 500g of ionized water;
a crushing and grinding step: pouring 5g of resorcinol, 30g of lincomycin, 50g of halter for ox protease and 10g of prednisolone into a crushing device, crushing for 1 minute, pouring 5g of crushed resorcinol, 30g of lincomycin, 50g of halter for ox protease and 10g of prednisolone into a grinding device, and grinding for 2 minutes to make the powder particles of the resorcinol, the lincomycin, halter for ox protease and the prednisolone smaller;
stirring: pouring 5g of ground resorcinol, 30g of lincomycin, 50g of halter for ox protease and 10g of prednisolone fine particles into a stirring device, and then pouring 500g of ionized water into the stirring device, wherein the stirring time is 3 minutes, so that the resorcinol, the lincomycin, halter for ox protease and the prednisolone powder particles are completely melted into the ionized water to obtain a liquid medicine;
a storage step: pouring the liquid medicine into a storage bottle, and then placing the storage bottle in the storage box for storage;
the method comprises the following steps: the user prepares a cotton piece earlier, cuts into the cotton sliver with the cotton piece again, then takes out the storage bottle from the storage box, inserts the cotton sliver in the inside liquid medicine of storage bottle, makes the liquid medicine invade wet cotton sliver, obtains wet absorbent cotton, places wet absorbent cotton in outer auditory canal, and the free time is 24 hours.
Example two:
a formula for non-surgical treatment of suppurative otitis media and a using method thereof comprise the following steps:
the preparation method comprises the following steps: preparing 10g of resorcinol, 35g of lincomycin, halter for ox g of protease, 17.5g of prednisolone and 650g of ionized water;
a crushing and grinding step: pouring 10g of prepared resorcinol, 35g of lincomycin, 65g of halter for ox protease and 17.5g of prednisolone into a crushing device, crushing for 1 minute and 30 seconds, pouring 10g of crushed resorcinol, 35g of lincomycin, halter for ox protease and 17.5g of the prednisolone into a grinding device, grinding for 2 minutes and 30 seconds, and enabling powder particles of the resorcinol, the lincomycin, halter for ox protease and the prednisolone to be finer;
stirring: pouring 10g of ground resorcinol, 35g of lincomycin, 65g of halter for ox protease and 17.5g of prednisolone fine particles into a stirring device, pouring 650g of ionized water into the stirring device, and stirring for 4 minutes to completely melt the resorcinol, lincomycin, halter for ox protease and prednisolone powder particles into the ionized water to obtain a liquid medicine;
a storage step: pouring the liquid medicine into a storage bottle, and then placing the storage bottle in the storage box for storage;
the method comprises the following steps: the user prepares a cotton piece earlier, cuts into the cotton sliver with the cotton piece again, then takes out the storage bottle from the storage box, inserts the cotton sliver in the inside liquid medicine of storage bottle, makes the liquid medicine invade wet cotton sliver, obtains wet absorbent cotton, places wet absorbent cotton in outer auditory canal, and the free time is 24 hours.
Example three:
a formula for non-surgical treatment of suppurative otitis media and a using method thereof comprise the following steps:
the preparation method comprises the following steps: preparing 15g of resorcinol, 40g of lincomycin, 80g of halter for ox protease, 25g of prednisone nylon and 800g of ionized water;
a crushing and grinding step: pouring 15g of resorcinol, 40g of lincomycin, 80g of halter for ox protease and 25g of prednisolone into a crushing device, crushing for 2 minutes, pouring 15g of crushed resorcinol, 40g of lincomycin, halter for ox protease and 25g of prednisolone into a grinding device, and grinding for 3 minutes to make the powder particles of resorcinol, lincomycin, halter for ox protease and prednisolone finer;
stirring: pouring 15g of ground resorcinol, 40g of lincomycin, 80g of halter for ox protease and 25g of prednisolone fine particles into a stirring device, and pouring 800g of ionized water into the stirring device, wherein the stirring time is 5 minutes, so that the resorcinol, the lincomycin, halter for ox protease and the prednisolone powder particles are completely melted into the ionized water to obtain a liquid medicine;
a storage step: pouring the liquid medicine into a storage bottle, and then placing the storage bottle in the storage box for storage;
the method comprises the following steps: the user prepares a cotton piece earlier, cuts into the cotton sliver with the cotton piece again, then takes out the storage bottle from the storage box, inserts the cotton sliver in the inside liquid medicine of storage bottle, makes the liquid medicine invade wet cotton sliver, obtains wet absorbent cotton, places wet absorbent cotton in outer auditory canal, and the free time is 24 hours.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A formula for non-surgical treatment of suppurative otitis media and a using method thereof are characterized in that: the method comprises the following steps:
the preparation method comprises the following steps: preparing 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease, 10-25 g of prednisolone and 500-800 g of ionized water;
a crushing and grinding step: pouring 5-15 g of resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into a crushing device, crushing for 1-2 minutes, pouring 5-15 g of crushed resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into a grinding device, and grinding for 2-3 minutes to enable powder particles of the resorcinol, the lincomycin, the halter for ox protease and the prednisolone to be finer;
stirring: pouring 5-15 g of ground resorcinol, 30-40 g of lincomycin, 50-80 g of halter for ox protease and 10-25 g of prednisolone into the stirring device, and then pouring 500-800 g of ionized water into the stirring device, wherein the stirring time is 3-5 minutes, so that powder particles of resorcinol, lincomycin, halter for ox protease and prednisolone are completely dissolved into the ionized water to obtain a liquid medicine;
a storage step: pouring the liquid medicine into a storage bottle, and then placing the storage bottle in the storage box for storage;
the method comprises the following steps: the user prepares a cotton piece earlier, cuts into the cotton sliver with the cotton piece again, then takes out the storage bottle from the storage box, inserts the cotton sliver in the inside liquid medicine of storage bottle, makes the liquid medicine invade wet cotton sliver, obtains wet absorbent cotton, places wet absorbent cotton in outer auditory canal, and the free time is 24 hours.
2. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: and in the step of crushing and grinding, an observation hole is formed in the front surface of the grinding device, transparent glass with the same shape and size as the observation hole is prepared, and the transparent glass is fixed in the observation hole through glue, so that a user can observe the processing condition inside the grinding device, and the condition that accidents happen cannot be timely processed.
3. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the stirring step, a stirring tank in the stirring device is made of transparent glass, so that a user can conveniently observe the mixing progress of the resorcinol, the lincomycin, the halter for ox protease and the prednisolone and the ionized water.
4. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the storage step, the storage bottle is a transparent tank with scales, so that a user can conveniently observe the amount of the liquid medicine.
5. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the storage step, a bottle cap is arranged at the top of the storage bottle and is made of sealing rubber, the storage bottle is sealed through the bottle cap, and external dust is prevented from entering the storage bottle.
6. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the preparation step, the ionized water is normal saline water, so that the ionized water has a certain disinfection function, and is convenient for a user to use.
7. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the storage step, the storage box is a constant-temperature safe box, so that the effect that the temperature of the external environment influences the liquid medicine in the storage bottle is avoided.
8. The formula for the non-surgical treatment of suppurative otitis media and the use method according to claim 1, wherein the formula comprises the following components: in the using step, the cotton sheet is a medical dust-free cotton sheet, so that toxic and harmful bacteria in the cotton sheet are prevented, and secondary infection of suppurative otitis media is avoided.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110942002.2A CN113577253A (en) | 2021-08-17 | 2021-08-17 | Formula for non-surgical treatment of suppurative otitis media and use method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110942002.2A CN113577253A (en) | 2021-08-17 | 2021-08-17 | Formula for non-surgical treatment of suppurative otitis media and use method |
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1715308A1 (en) * | 1988-08-10 | 1992-02-28 | Ленинградский Государственный Институт Усовершенствования Врачей Им.С.М.Кирова | Method for treatment of purulent perforative otitis |
| CN1077116A (en) * | 1993-04-01 | 1993-10-13 | 李恕辉 | The externally-applied powder and the manufacture method of treatment otitis media |
| US20040175383A1 (en) * | 2002-12-06 | 2004-09-09 | Barr Philip J. | Methods and compositions for treatment of otitis media |
| CN1795838A (en) * | 2004-12-28 | 2006-07-05 | 哈尔滨欧替药业股份有限公司 | Cotton bar, cotton bar type suppository and preparing technique |
| US20120252720A1 (en) * | 2003-12-12 | 2012-10-04 | Otic Pharma Ltd. | Compositions for treatment of ear disorders and methods of use thereof |
| CN103585263A (en) * | 2013-11-22 | 2014-02-19 | 新乡医学院 | Traditional Chinese medicine composition for treating chronic suppurative otitis media and preparation method thereof |
| CN104644682A (en) * | 2013-11-22 | 2015-05-27 | 陈华 | Traditional Chinese medicine formula for treating suppurative otitis media |
| CN110772570A (en) * | 2019-11-01 | 2020-02-11 | 河南一付良方健康科技有限公司 | Traditional Chinese medicine formula for treating otitis media and preparation method thereof |
| RU2749857C1 (en) * | 2019-12-23 | 2021-06-17 | Псарева Нелли Александровна | Method for combatting otitis media and otitis externa |
| CN213852700U (en) * | 2020-07-27 | 2021-08-03 | 连云港市第二人民医院(连云港市临床肿瘤研究所) | Earplug suitable for treatment of mycotic otitis externa |
-
2021
- 2021-08-17 CN CN202110942002.2A patent/CN113577253A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1715308A1 (en) * | 1988-08-10 | 1992-02-28 | Ленинградский Государственный Институт Усовершенствования Врачей Им.С.М.Кирова | Method for treatment of purulent perforative otitis |
| CN1077116A (en) * | 1993-04-01 | 1993-10-13 | 李恕辉 | The externally-applied powder and the manufacture method of treatment otitis media |
| US20040175383A1 (en) * | 2002-12-06 | 2004-09-09 | Barr Philip J. | Methods and compositions for treatment of otitis media |
| US20120252720A1 (en) * | 2003-12-12 | 2012-10-04 | Otic Pharma Ltd. | Compositions for treatment of ear disorders and methods of use thereof |
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| CN103585263A (en) * | 2013-11-22 | 2014-02-19 | 新乡医学院 | Traditional Chinese medicine composition for treating chronic suppurative otitis media and preparation method thereof |
| CN104644682A (en) * | 2013-11-22 | 2015-05-27 | 陈华 | Traditional Chinese medicine formula for treating suppurative otitis media |
| CN110772570A (en) * | 2019-11-01 | 2020-02-11 | 河南一付良方健康科技有限公司 | Traditional Chinese medicine formula for treating otitis media and preparation method thereof |
| RU2749857C1 (en) * | 2019-12-23 | 2021-06-17 | Псарева Нелли Александровна | Method for combatting otitis media and otitis externa |
| CN213852700U (en) * | 2020-07-27 | 2021-08-03 | 连云港市第二人民医院(连云港市临床肿瘤研究所) | Earplug suitable for treatment of mycotic otitis externa |
Non-Patent Citations (1)
| Title |
|---|
| 师海波: "《基层医疗机构合理用药指南》", 中华医学电子音像出版社, pages: 1420 * |
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