CN106727685A - Ear is earwaxed cleaning fluid and preparation method thereof - Google Patents
Ear is earwaxed cleaning fluid and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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Abstract
Ear is earwaxed cleaning fluid, and it belongs to ear's nursing external used medicine field.Cartilaginous auditory canal skin has ceruminous gland, secretes light yellow viscous liquid, claims to earwax.The shape such as mucus of earwaxing having, clinical at present and ceruminal impaction taking-up is mainly takes out agglomerate of earwaxing with aural forceps or cerumen hook.Ear of the present invention cleaning fluid of earwaxing is mainly and is prepared from by purified water, boric acid, glycerine, ethanol, phenol, chlorhexidine acetate, menthol, borneol, sodium acid carbonate, and its parts by weight is respectively 90~110 parts of purified water, 0.1~0.3 part of boric acid, 40~60 parts of glycerine, 4~6 parts of ethanol, 0.3~0.4 part of chlorhexidine acetate, 0.005~0.015 part of menthol, 0.005~0.015 part of borneol, 1~3 part of phenol, 0.5~1.5 part of sodium acid carbonate.It is good that the present invention softens disintegration ear effect of earwaxing, and with antibacterial, it is antipruritic, alleviate the effect such as tinnitus, otalgia, dysacousis.
Description
Technical field
The invention belongs to ear's nursing external used medicine field, and in particular to a kind of ear is earwaxed cleaning fluid and preparation method thereof.
Background technology
Cartilaginous auditory canal skin has ceruminous gland, secretes light yellow viscous liquid, claims to earwax.The shape of earwaxing having is as glued
Liquid, is commonly called as " oily ear ".Earwax to borrow under normal circumstances and the mandibular movement such as chew, dehisce with sheet form Self-discharged, if earwaxing
Gradually conglomerate, blocks external auditory meatus, claims ceruminal impaction (impacted cerumen).Ear ceruminal impaction may occur in which that hearing subtracts
Move back, tinnitus, otalgia, in addition dizziness, expansion of being earwaxed after chance water, external auditory meatus is blocked completely, make dysacousis, can also stimulate external auditory meatus
Cause otitis externa, if compressing stimulates eardrum, tinnitus can be caused, occasionally have because compressing middle ear cause dizziness person.
Clinical at present and ceruminal impaction taking-up is mainly takes out agglomerate of earwaxing with aural forceps or cerumen hook.If being difficult to take greatly and firmly
The person of going out, first instills 5% sodium bicarbonate injection, drips 4~6 times daily, and with the taking-up of above-mentioned apparatus or douche can be used after softening
Remove.For existing otitis externa person, should first control inflammation, then take and earwax.But this kind of method is with pain, for children's ear Ding
Occurring insufferable pain cerumen Patients with Embolization more.Sodium bicarbonate injection system medicine, softening, lofting effect are unsatisfactory, and
It is antipruritic with antibacterial, alleviate the effect such as tinnitus, otalgia, dysacousis.
The content of the invention
Soften ear effect of earwaxing it is an object of the present invention to provide one kind good, and with antibacterial, it is antipruritic, alleviate tinnitus, otalgia, listen
The power ear of effect such as go down is earwaxed cleaning fluid and preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of ear is earwaxed cleaning fluid, and described ear cleaning fluid of earwaxing is mainly by purified water, boric acid, glycerine, ethanol, benzene
Phenol, chlorhexidine acetate, menthol, borneol sodium acid carbonate are prepared from, its parts by weight be respectively 90~110 parts purified water,
0.1~0.3 part of boric acid, 40~60 parts of glycerine, 4~6 parts of ethanol, 0.3~0.4 part of chlorhexidine acetate, 0.005~
0.015 part of menthol, 0.005~0.015 part of borneol, 1~3 part of phenol, 0.5~1.5 part of sodium acid carbonate.
Ear of the present invention is earwaxed cleaning fluid, and the parts by weight of the purified water that ear is earwaxed described in cleaning fluid are 90 parts,
The parts by weight of described boric acid are 0.1 part, and the parts by weight of described glycerine are 40 parts, the weight portion of described ethanol
Number is 4 parts, and the parts by weight of described chlorhexidine acetate are 0.3 part, and the parts by weight of described menthol are 0.005
Part, the parts by weight of described borneol are 0.005 part, and the parts by weight of described phenol are 1 part, described sodium acid carbonate
Parts by weight be 0.5 part.
Ear of the present invention is earwaxed cleaning fluid, and the parts by weight of the purified water that ear is earwaxed described in cleaning fluid are 110 parts,
The parts by weight of described boric acid are 0.3 part, and the parts by weight of described glycerine are 60 parts, the weight portion of described ethanol
Number is 6 parts, and the parts by weight of described chlorhexidine acetate are 0.4 part, and the parts by weight of described menthol are 0.015
Part, the parts by weight of described borneol are 0.015 part, and the parts by weight of described phenol are 3 parts, described sodium acid carbonate
Parts by weight be 1.5 parts.
Ear of the present invention is earwaxed cleaning fluid, and the parts by weight of the purified water that ear is earwaxed described in cleaning fluid are 100 parts,
The parts by weight of described boric acid are 0.2 part, and the parts by weight of described glycerine are 50 parts, the weight portion of described ethanol
Number is 5 parts, and the parts by weight of described chlorhexidine acetate are 0.35 part, and the parts by weight of described menthol are 0.01
Part, the parts by weight of described borneol are 0.01 part, and the parts by weight of described phenol are 2 parts, described sodium acid carbonate
Parts by weight be 1 part.
Ear of the present invention is earwaxed the preparation method of cleaning fluid, is comprised the following steps：
Step 1, the purified water, glycerine, the boric acid that weigh constant weight respectively according to parts by weight, first by constant weight
Purified water heats up, and after being heated to 62~68 DEG C, during load weighted glycerine, boric acid are added into purified water under conditions of stirring, stirs
100~500rad/min of mix rotating speed, 1~5KW of agitator power, 5~15min of mixing time, after being completely dissolved, obtain solvent
A is stand-by；
Step 2, the ethanol, chlorhexidine acetate, menthol, borneol, the phenol that weigh constant weight respectively according to parts by weight,
Chlorhexidine acetate, menthol, borneol, phenol, speed of agitator 100 will be separately added into load weighted ethanol under conditions of stirring
~500rad/min, 1~5KW of agitator power, 5~15min of mixing time, obtain solvent B stand-by after being completely dissolved；
Step 3, the sodium acid carbonate that constant weight is weighed according to parts by weight, solvent orange 2 A obtained in step 1 and step 2 are made
After the solvent B mixing for obtaining, load weighted sodium acid carbonate is added to be stirred, 100~500rad/min of speed of agitator, agitator work(
1~5KW of rate, 5~15min of mixing time, obtain described ear and earwax cleaning fluid.
Ear of the present invention is earwaxed cleaning fluid, by purified water, ethanol, boric acid, sodium acid carbonate, glycerine, phenol, acetic acid chlorine
Oneself is fixed, menthol, borneol composition, and the effect of wherein glycerine is skin water lock, wetting, and the effect of boric acid is hydrotropy, anti-corrosion, acetic acid
The effect of Chlorhexidine is the anti-antibacterial, anti-inflammatory in duct, and the effect of menthol is antipruritic in duct, and the effect of borneol is duct
Interior refrigerant, cooling, second alcohol and water is solvent, and the effect of sodium acid carbonate is ear is earwaxed disintegration, loosely.
Ear of the present invention earwaxes cleaning fluid proterties for colourless or light color liquid, and pH value is 5.5~7, the pH with body fluid
Value is close；Application method of the present invention：Unilateral ear drips 3-4 drops, is detained -15 minutes 10 minutes, and then same method drop is another picks up the ears,
3 times/day.Soften the purpose that ear is earwaxed therefore, it is possible to reach, so as to improve related symptoms.
Ear of the present invention is earwaxed cleaning fluid, and cytotoxicity is not more than 2 grades, without sensitization, without MMi reaction, without cause
Jump reaction, total number of bacterial colonies≤100cfu/ml, fungus colony sum≤100cfu/ml, pathogenic entero becteria, suppurative ball
Bacterium, saccharomytes, Pseudomonas aeruginosa, hemolytic streptococcus do not detect.
The present invention has antibacterial, antipruritic, the effect such as alleviation tinnitus, otalgia, dysacousis.
Specific embodiment
Specific embodiment one：
The parts by weight of the purified water that present embodiment middle ear are earwaxed described in cleaning fluid are 100 parts, described boric acid
Parts by weight are 0.2 part, and the parts by weight of described glycerine are 50 parts, and the parts by weight of described ethanol are 5 parts, institute
The parts by weight of the chlorhexidine acetate stated are 0.35 part, and the parts by weight of described menthol are 0.01 part, described ice
The parts by weight of piece are 0.01 part, and the parts by weight of described phenol are 2 parts, and the parts by weight of described sodium acid carbonate are
It is 1 part.
Ear described in present embodiment is earwaxed the preparation method of cleaning fluid, is comprised the following steps：
Step 1, the purified water for weighing 100 parts respectively according to parts by weight, 50 parts of glycerine, 0.2 part of boric acid, first will
Purified water heats up, and after being heated to 65 DEG C, during load weighted glycerine, boric acid are added into purified water under conditions of stirring, stirring turns
Fast 200rad/min, agitator power 1KW, mixing time 10min, after being completely dissolved, obtain solvent orange 2 A stand-by；
Step 2, the ethanol for weighing 5 parts respectively according to parts by weight, 0.35 part of chlorhexidine acetate, 0.01 part of peppermint
Brain, 0.01 part of borneol, 2 parts of phenol, will be separately added into chlorhexidine acetate, thin under conditions of stirring in load weighted ethanol
Lotus brain, borneol, phenol, speed of agitator 100rad/min, agitator power 1KW, mixing time 5min, obtain molten after being completely dissolved
Agent B is stand-by；
Step 3, the sodium acid carbonate that 1 part is weighed according to parts by weight, will be molten obtained in solvent orange 2 A obtained in step 1 and step 2
After agent B mixing, load weighted sodium acid carbonate is added to be stirred, speed of agitator 200rad/min, agitator power 2KW, stirring
Time 10min, obtains described ear and earwaxes cleaning fluid.
Ear cleaning fluid of earwaxing prepared by present embodiment is used to patient, patient 20, male patient 10, female patient
10, total illness ear is 24 ears, at 6~60 years old age, using preceding symptom, there is ear itching, and there is sallow Hearing, duct depths
Color is earwaxed, and in embolism shape, 20 patients have all made external auditory meatus secretion smear, and test under microscope finds spore shape or silk
Shape mould.
Present embodiment external application dips appropriate ear and earwaxes cleaning fluid using swab stick every time, or ear cleaning fluid of earwaxing is direct
Swab stick is sprayed onto, swab stick gently revolves taking-up of turning around in duct, or directly instills duct, is within 4 days 1 course for the treatment of four times a day.
Effect after present embodiment use, total to cure number 132, total ear of curing is 204 ears, wherein by one
What course of therapy was cured is 60,71 ears, and what is cured by two courses for the treatment of is 59,114 ears, is cured by three courses for the treatment of
Be 13,19 ears, total cure rate reaches 100%.
Specific embodiment two：
The parts by weight of the purified water that present embodiment middle ear are earwaxed described in cleaning fluid are 110 parts, described boric acid
Parts by weight are 0.3 part, and the parts by weight of described glycerine are 60 parts, and the parts by weight of described ethanol are 6 parts, institute
The parts by weight of the chlorhexidine acetate stated are 0.4 part, and the parts by weight of described menthol are 0.015 part, described ice
The parts by weight of piece are 0.015 part, and the parts by weight of described phenol are 3 parts, the parts by weight of described sodium acid carbonate
It is 1.5 parts.
Ear described in present embodiment is earwaxed the preparation method of cleaning fluid, is comprised the following steps：
Step 1, the purified water for weighing 110 parts respectively according to parts by weight, 60 parts of glycerine, 0.3 part of boric acid, first will
Load weighted purified water heats up, and after being heated to 68 DEG C, load weighted glycerine, boric acid is added into purified water under conditions of stirring
In, speed of agitator 500rad/min, agitator power 5KW, mixing time 5min after being completely dissolved, obtain solvent orange 2 A stand-by；
Step 2, the ethanol for weighing 6 parts respectively according to parts by weight, 0.4 part of chlorhexidine acetate, 0.015 part of peppermint
Brain, 0.015 part of borneol, 3 parts of phenol, will be separately added into load weighted ethanol under conditions of stirring chlorhexidine acetate,
Menthol, borneol, phenol, speed of agitator 500rad/min, agitator power 5KW, mixing time 5min, obtain after being completely dissolved
Solvent B is stand-by；
Step 3, the sodium acid carbonate that constant weight is weighed according to parts by weight, solvent orange 2 A obtained in step 1 and step 2 are made
After the solvent B mixing for obtaining, load weighted sodium acid carbonate is added to be stirred, speed of agitator 500rad/min, agitator power
5KW, mixing time 5min, obtain described ear and earwax cleaning fluid.
Ear cleaning fluid of earwaxing prepared by present embodiment is used to patient, patient 20, patient's effects on hearing before and after
Contrast is as shown in table 1：From table 1 it follows that being earwaxed after cleaning fluid using the ear described in present embodiment, patient's hearing can
Enough return to normal good hearing level.
Table 1 earwaxed using ear before and after cleaning fluid patient's hearing contrast table (dB)
Ear described in present embodiment is earwaxed cleaning fluid, and cytotoxicity is not more than 2 grades, total number of bacterial colonies≤100cfu/
Ml, fungus colony sum≤100cfu/ml, pathogenic entero becteria, pyococcus, saccharomytes, Pseudomonas aeruginosa, hemolytic
Streptococcus does not detect.
Specific embodiment three：
The parts by weight of the purified water that present embodiment middle ear are earwaxed described in cleaning fluid are 90 parts, the weight of described boric acid
Amount number is 0.1 part, and the parts by weight of described glycerine are 40 parts, and the parts by weight of described ethanol are 4 parts, described
The parts by weight of chlorhexidine acetate be 0.3 part, the parts by weight of described menthol are 0.005 part, described borneol
Parts by weight be 0.005 part, the parts by weight of described phenol are 1 part, and the parts by weight of described sodium acid carbonate are
It is 0.5 part.
Ear described in present embodiment is earwaxed the preparation method of cleaning fluid, is comprised the following steps：
Step 1, the purified water for weighing 90 parts respectively according to parts by weight, 40 parts of glycerine, 0.1 part of boric acid, first will
Load weighted purified water heats up, and after being heated to 62 DEG C, load weighted glycerine, boric acid is added into purified water under conditions of stirring
In, speed of agitator 100rad/min, agitator power 1KW, mixing time 15min after being completely dissolved, obtain solvent orange 2 A stand-by；
Step 2, the ethanol for weighing 4 parts respectively according to parts by weight, 0.3 part of chlorhexidine acetate, 0.005 part of peppermint
Brain, 0.005 part of borneol, 1 part of phenol, will be separately added into load weighted ethanol under conditions of stirring chlorhexidine acetate,
Menthol, borneol, phenol, speed of agitator 500rad/min, agitator power 1KW, mixing time 15min, after being completely dissolved
It is stand-by to solvent B；
Step 3, the sodium acid carbonate that constant weight is weighed according to parts by weight, solvent orange 2 A obtained in step 1 and step 2 are made
After the solvent B mixing for obtaining, load weighted sodium acid carbonate is added to be stirred, speed of agitator 100rad/min, agitator power
1KW, mixing time 15min, obtain described ear and earwax cleaning fluid.
Ear described in present embodiment is earwaxed cleaning fluid, and cytotoxicity is not more than 2 grades, total number of bacterial colonies≤100cfu/
Ml, fungus colony sum≤100cfu/ml, pathogenic entero becteria, pyococcus, saccharomytes, Pseudomonas aeruginosa, hemolytic
Streptococcus does not detect.Present embodiment has antibacterial, antipruritic, the effect such as alleviation tinnitus, otalgia, dysacousis.
Claims (9)
1. a kind of ear is earwaxed cleaning fluid, it is characterised in that：Described ear earwax cleaning fluid be mainly by purified water, boric acid, glycerine,
Ethanol, phenol, chlorhexidine acetate, menthol, borneol sodium acid carbonate are prepared from, and its parts by weight is respectively 90~110 parts
Purified water, 0.1~0.3 part of boric acid, 40~60 parts of glycerine, 4~6 parts of ethanol, 0.3~0.4 part of chlorhexidine acetate,
0.005~0.015 part of menthol, 0.005~0.015 part of borneol, 1~3 part of phenol, 0.5~1.5 part of bicarbonate
Sodium.
2. ear according to claim 1 is earwaxed cleaning fluid, it is characterised in that：The purified water that ear is earwaxed described in cleaning fluid
Parts by weight are 90 parts, and the parts by weight of described boric acid are 0.1 part, and the parts by weight of described glycerine are 40 parts, institute
The parts by weight of the ethanol stated are 4 parts, and the parts by weight of described chlorhexidine acetate are 0.3 part, described menthol
Parts by weight are 0.005 part, and the parts by weight of described borneol are 0.005 part, and the parts by weight of described phenol are 1
Part, the parts by weight of described sodium acid carbonate are 0.5 part.
3. ear according to claim 1 is earwaxed cleaning fluid, it is characterised in that：The purified water that ear is earwaxed described in cleaning fluid
Parts by weight are 110 parts, and the parts by weight of described boric acid are 0.3 part, and the parts by weight of described glycerine are 60 parts, institute
The parts by weight of the ethanol stated are 6 parts, and the parts by weight of described chlorhexidine acetate are 0.4 part, described menthol
Parts by weight are 0.015 part, and the parts by weight of described borneol are 0.015 part, and the parts by weight of described phenol are 3
Part, the parts by weight of described sodium acid carbonate are 1.5 parts.
4. ear according to claim 1 is earwaxed cleaning fluid, it is characterised in that：The purified water that ear is earwaxed described in cleaning fluid
Parts by weight are 100 parts, and the parts by weight of described boric acid are 0.2 part, and the parts by weight of described glycerine are 50 parts, institute
The parts by weight of the ethanol stated are 5 parts, and the parts by weight of described chlorhexidine acetate are 0.35 part, described menthol
Parts by weight are 0.01 part, and the parts by weight of described borneol are 0.01 part, and the parts by weight of described phenol are 2
Part, the parts by weight of described sodium acid carbonate are 1 part.
5. a kind of described ears of one of claim 1-4 are earwaxed the preparation method of cleaning fluid, it is characterised in that：Including following step
Suddenly：
Step 1, the purified water, glycerine, the boric acid that weigh constant weight respectively according to parts by weight, first by the purifying of constant weight
Water heats up, and after being heated to 62~68 DEG C, during load weighted glycerine, boric acid are added into purified water under conditions of stirring, stirring turns
Speed 100~500rad/min, 1~5KW of agitator power, 5~15min of mixing time, after being completely dissolved, obtain solvent orange 2 A and treat
With；
Step 2, the ethanol, chlorhexidine acetate, menthol, borneol, the phenol that weigh constant weight respectively according to parts by weight, are stirring
To be separately added into chlorhexidine acetate, menthol, borneol, phenol under conditions of mixing in load weighted ethanol, speed of agitator 100~
500rad/min, 1~5KW of agitator power, 5~15min of mixing time, obtain solvent B stand-by after being completely dissolved；
Step 3, the sodium acid carbonate that constant weight is weighed according to parts by weight, by obtained in solvent orange 2 A obtained in step 1 and step 2
After solvent B mixing, load weighted sodium acid carbonate is added to be stirred, 100~500rad/min of speed of agitator, agitator power 1
~5KW, 5~15min of mixing time, obtain described ear and earwax cleaning fluid.
6. ear according to claim 5 is earwaxed the preparation method of cleaning fluid, it is characterised in that：Purified water heats up in step 1,
Heating-up temperature is to 65 DEG C.
7. ear according to claim 5 is earwaxed the preparation method of cleaning fluid, it is characterised in that：Speed of agitator is in step 1
200rad/min, agitator power 1KW, mixing time 10min.
8. ear according to claim 5 is earwaxed the preparation method of cleaning fluid, it is characterised in that：Speed of agitator is in step 2
100rad/min, agitator power 1KW, mixing time 5min.
9. ear according to claim 5 is earwaxed the preparation method of cleaning fluid, it is characterised in that：Speed of agitator is in step 3
200rad/min, agitator power 2KW, mixing time 10min.
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Cited By (5)
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| CN111617104A (en) * | 2020-06-02 | 2020-09-04 | 福州安得尔卫生技术开发有限公司 | Ear canal cleaning and antibacterial spray |
| CN115804809A (en) * | 2021-09-11 | 2023-03-17 | 武汉左点科技有限公司 | External auditory canal cleaning fluid and preparation method thereof |
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| RU2813879C1 (en) * | 2023-06-07 | 2024-02-19 | Александр Витальевич Ляхович | Anti-inflammatory composition (versions) for local application in oral cavity and upper respiratory tract |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108158855A (en) * | 2017-12-27 | 2018-06-15 | 江苏博瑞思康生物科技有限公司 | A kind of external auditory canal cleaning solution and its preparation method |
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| CN115804809A (en) * | 2021-09-11 | 2023-03-17 | 武汉左点科技有限公司 | External auditory canal cleaning fluid and preparation method thereof |
| CN116370531A (en) * | 2023-02-22 | 2023-07-04 | 海孵(海南自贸区)医疗科技有限责任公司 | Preparation method of auditory canal cleaning liquid |
| RU2813879C1 (en) * | 2023-06-07 | 2024-02-19 | Александр Витальевич Ляхович | Anti-inflammatory composition (versions) for local application in oral cavity and upper respiratory tract |
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