CN104306328A - Polyhexamethylene guanidine auristilla - Google Patents
Polyhexamethylene guanidine auristilla Download PDFInfo
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- CN104306328A CN104306328A CN201410609087.2A CN201410609087A CN104306328A CN 104306328 A CN104306328 A CN 104306328A CN 201410609087 A CN201410609087 A CN 201410609087A CN 104306328 A CN104306328 A CN 104306328A
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- polyhexamethylene guanidine
- auristilla
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- minutes
- purified water
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses polyhexamethylene guanidine auristilla, and relates to the technical field of medicines. The polyhexamethylene guanidine auristilla comprises the following components: 0.1-1% of polyhexamethylene guanidine hydrochloride, 1% of a synergist and 98-98.9% of purified water. A productive technology of the polyhexamethylene guanidine auristilla comprises the following steps: 1, according to the proportion, adding the polyhexamethylene guanidine hydrochloride into a small amount of purified water, and stirring for 5 minutes to obtain a solution A; 2, according to the proportion, adding the synergist into a small amount of purified water, and stirring for 5 minutes to obtain a solution B; 3, according to the proportion, adding the solution A and the solution B into purified water, and stirring for 30 minutes to obtain the polyhexamethylene guanidine auristilla. The polyhexamethylene guanidine auristilla is wide in disease adaptability, non-toxic, non-irritating and free of side effects, and can play a very good role in protecting eardrum.
Description
Technical field:
The present invention relates to medical art, be specifically related to a kind of [Dan.
Background technology:
[Dan treatment is a kind of simple and easy to do local therapeutic approaches, is usually used in the treatment of the otopathy such as suppurative otitis media, otitis externa, auditory meatus mycosis.Grasp correct administrated method, not only can obtain satisfied therapeutic effect, and can also effectively prevent or alleviate untoward reaction.
Medicine temperature should be close with body temperature.Medicine bottle should be placed on the palm of the hand before using [Dan to seal a little while, or be placed on hot water cup side about 10 minutes, make fluid temperature and body temperature as far as possible close, in order to avoid temperature too low stimulation vestibulum auris internae organ, cause the untoward reaction such as dizzy, nauseating.
Medication is appropriate to the occasion gets seat or lateral position.Generally get seat lateral deviation head or lie on one's side on bed when dripping medicine, suffering from ear external auditory canal opening upwards, with hands (children's is to the back lower place) tractive auricle rearwardly and upwardly, after external auditory meatus is stretching, drip medicine again.Medicinal liquid can be made so slowly to flow in ear along external auditory meatus, otherwise medicinal liquid not easily arrive diseased region.Before dripping medicine, the dry cotton swab of purulent secretion sterilization wiped clean or rinse with sterile solution, making medicine play maximum therapy effect.
Tragus is pressed gently after dripping medicine.[Dan generally each 3 ~ 5, every day 3 times.Dropping liquid too much not only wastes medicinal liquid, and likely causes the uncomfortable reactions such as dizzy.Keep original body position after dropping liquid 3 ~ 5 minutes, and press tragus 3 ~ 5 times gently with finger, make medicinal liquid flow into middle ear through perforation of ear drum place by External Force Acting.
Existing [Dan more or less all also exists certain drawback.
Summary of the invention:
The object of this invention is to provide polyhexamethylene guanidine [Dan, its indication is extensive, nontoxic, non-stimulated, have no side effect, and can play a very good protection to tympanum.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions: its component prescription is than as follows: Polyhaxemethylenguanidine Hydrochloride 0.1%-1%, synergist 1%, pure water 98%-98.9%.
Production technology of the present invention is as follows:
One, according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride is added in a small amount of pure water, then stir 5 minutes, obtain solution A;
Two, according to aforementioned proportion, synergist is added in a small amount of pure water, then stir 5 minutes, obtain solution B;
Three, according to aforementioned proportion, solution A and solution B are joined in pure water, stir and namely obtain polyhexamethylene guanidine [Dan in 30 minutes.
Operation principle of the present invention: its main component is polyhexamethylene guanidine, to Grain-positive, gram-negative bacteria, there is broad-spectrum bactericidal action, to the pathogenic strain from otitis media, otitis externa, myringitis focus comprising staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, hemophilus influenza, there is bactericidal action.Its mechanism of action is that active ingredient becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly; Transdermal stimulation test, Eye irritation, repeatedly intact skin stimulate and a damaged skin experiment, belong to nonirritant; All belong to nontoxic through acute oral toxicity, acute inhalation toxicity, subacute toxicity test, micronucleus test; Be applicable in staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, hemophilus influenza, the following infection disease to caused by this agent sensitive strain: otitis media, otitis externa, myringitis.
The present invention has following beneficial effect: its indication is extensive, nontoxic, non-stimulated, have no side effect, and can play a very good protection to tympanum.
Detailed description of the invention:
This detailed description of the invention is by the following technical solutions: its component prescription is than as follows: Polyhaxemethylenguanidine Hydrochloride 0.5%, synergist 1%, pure water 98.5%.
The production technology of this detailed description of the invention is as follows:
One, according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride is added in a small amount of pure water, then stir 5 minutes, obtain solution A;
Two, according to aforementioned proportion, synergist is added in a small amount of pure water, then stir 5 minutes, obtain solution B;
Three, according to aforementioned proportion, solution A and solution B are joined in pure water, stir and namely obtain polyhexamethylene guanidine [Dan in 30 minutes.
This detailed description of the invention operation principle: its main component is polyhexamethylene guanidine, to Grain-positive, gram-negative bacteria, there is broad-spectrum bactericidal action, to the pathogenic strain from otitis media, otitis externa, myringitis focus comprising staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, hemophilus influenza, there is bactericidal action.Its mechanism of action is that active ingredient becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly; Transdermal stimulation test, Eye irritation, repeatedly intact skin stimulate and a damaged skin experiment, belong to nonirritant; All belong to nontoxic through acute oral toxicity, acute inhalation toxicity, subacute toxicity test, micronucleus test; Be applicable in staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, hemophilus influenza, the following infection disease to caused by this agent sensitive strain: otitis media, otitis externa, myringitis.
This detailed description of the invention has following beneficial effect: its indication is extensive, nontoxic, non-stimulated, have no side effect, and can play a very good protection to tympanum.
The above is only in order to illustrate technical scheme of the present invention and unrestricted, other amendment that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (2)
1. polyhexamethylene guanidine [Dan, is characterized in that its component prescription is than as follows: Polyhaxemethylenguanidine Hydrochloride 0.1%-1%, synergist 1%, pure water 98%-98.9%.
2. polyhexamethylene guanidine [Dan, is characterized in that its production technology is as follows:
(1), according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride is added in a small amount of pure water, then stir 5 minutes, obtain solution A;
(2), according to aforementioned proportion, synergist is added in a small amount of pure water, then stir 5 minutes, obtain solution B;
(3), according to aforementioned proportion, solution A and solution B are joined in pure water, stir and namely obtain polyhexamethylene guanidine [Dan in 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410609087.2A CN104306328A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine auristilla |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410609087.2A CN104306328A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine auristilla |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104306328A true CN104306328A (en) | 2015-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410609087.2A Pending CN104306328A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine auristilla |
Country Status (1)
| Country | Link |
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| CN (1) | CN104306328A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232455A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate auristilla |
| CN111617100A (en) * | 2020-06-15 | 2020-09-04 | 青岛美今生物科技有限公司 | Preparation method of ear canal cleaning bactericide containing double-attribute substances |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
-
2014
- 2014-11-04 CN CN201410609087.2A patent/CN104306328A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
Non-Patent Citations (2)
| Title |
|---|
| 王冰姝等: "聚六亚甲基胍类消毒剂的杀菌效果观察", 《中国热带医学》 * |
| 黄新宇: "盐酸聚六亚甲基胍消毒剂研究进展", 《中国卫生工程学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232455A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate auristilla |
| CN111617100A (en) * | 2020-06-15 | 2020-09-04 | 青岛美今生物科技有限公司 | Preparation method of ear canal cleaning bactericide containing double-attribute substances |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: WEI WANGKUI Effective date: 20150127 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150127 Address after: 044500 Shanxi city of Yongji Province East Ring Road No. 38 Applicant after: Wei Guogang Address before: 044500 Shanxi city of Yongji Province East Ring Road No. 38 Applicant before: Wei Guogang Applicant before: Wei Wangkui |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150128 |
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| RJ01 | Rejection of invention patent application after publication |