CN1709481A - Chinese medicine formulation for treating disney disease and toxuria, and its preparing method - Google Patents
Chinese medicine formulation for treating disney disease and toxuria, and its preparing method Download PDFInfo
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- CN1709481A CN1709481A CN 200510031642 CN200510031642A CN1709481A CN 1709481 A CN1709481 A CN 1709481A CN 200510031642 CN200510031642 CN 200510031642 CN 200510031642 A CN200510031642 A CN 200510031642A CN 1709481 A CN1709481 A CN 1709481A
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Abstract
The present invention relates to a Chinese medicine preparation for curing nephrosis and uremia with obvious therapeutic effect. Said Chinese medicine preparation is made up by using 16 Chinese medicinal materials of rhubarb, licorice, astragalus root, mulberry root bark, flavescent sophora root, pilose asiabell root, bighead atractylodes rhizome, poria and others. Said Chinese medicine preparation can be made into capsule or dripping pills. Besides, said invention also provides its preparation process and concrete steps.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to a kind of nephropathy, uremic Chinese medicine preparation and preparation method thereof of being used for the treatment of.
Background technology:
Soft capsule in the Chinese medicine preparation or drop pill, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a granule, has listed the national drug standards in.
The technology features that has treatment nephropathy, uremic Chinese medicine preparation NIAODUQING KELI now is that filtrate concentrates, is dried to dried cream with after the prescription medicinal material extract, and the broken back of dried cream powder adds adjuvants such as suitable sugar, dextrin, starch and mixes, granulation, drying, promptly.The NIAODUQING KELI agent exists and need take after mixing it with hot water, and dose is big, and mouthfeel is poor, uses, carries equal inconvenience, and diabetes and obesity patient such as can not take at shortcoming.
Summary of the invention:
The purpose of this invention is to provide a kind of treatment nephropathy, uremia's Chinese medicine preparation and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved by the following scheme.
Treatment nephropathy, uremic Chinese medicine preparation, it is that main component is the NIAODUQING soft capsule or the drop pill of Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Radix Astragali, SANGQUPI, Radix Sophorae Flavescentis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Flos Chrysanthemi, Radix Polygoni Multiflori Preparata, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Plantaginis, Radix Bupleuri.
Its preparation method is:
(1) drug main wants constituent and weight percent consumption thereof as follows:
Radix Et Rhizoma Rhei, Radix Glycyrrhizae, each 1-3% of Radix Bupleuri, the Radix Astragali, SANGQUPI, Radix Codonopsis, the Radix Paeoniae Alba, each 4-8% of Rhizoma Chuanxiong, Radix Sophorae Flavescentis, Flos Chrysanthemi, each 2-5% of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, each 8-11% of Herba Plantaginis.
(2) above medical material is decocted with water 3 times, 3 hours for the first time, each 2 hours of second and third time, collecting decoction, being condensed into relative density is the clear paste of 1.25 (80 ℃ of surveys), is dried to dried cream, is ground into fine powder, crosses 120 mesh sieves, gets mixing fine powders, standby.
(3) get the mixing fine powders of (2) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations of following material or other proper auxiliary materials: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
(4) with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other proper auxiliary materials, use with by arbitrary proportion, add (2) prepared mixing fine powders after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of treatment nephropathy, uremic Chinese medicine preparation, it is that main component is the NIAODUQING soft capsule or the drop pill of Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Radix Astragali, SANGQUPI, Radix Sophorae Flavescentis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Flos Chrysanthemi, Radix Polygoni Multiflori Preparata, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Plantaginis, Radix Bupleuri.
Chinese medicine preparation of the present invention is mainly used in chronic renal failure, and azotemia phase and uremia are early stage, Chinese medical discrimination belongs to insufficiency of the spleen turbid damp disease and spleen deficiency and blood stasis disease person.Can reduce creatinine, blood urea nitrogen, stablize renal function, delay dialysis time; To improving renal anemia, increasing blood calcium, reduction serium inorganic phosphorus also have certain effect.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption thereof are as follows:
Radix Et Rhizoma Rhei 40g, Radix Glycyrrhizae 36g, Radix Bupleuri 60g, Radix Astragali 160g, SANGQUPI, Radix Codonopsis, the Radix Paeoniae Alba, each 120g of Rhizoma Chuanxiong, Radix Sophorae Flavescentis, each 80g of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Flos Chrysanthemi 100g, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, each 200g of Herba Plantaginis.
(2) above medical material is decocted with water 3 times, 3 hours for the first time, each 2 hours of second and third time, collecting decoction, being condensed into relative density is the clear paste of 1.25 (80 ℃ of surveys), is dried to dried cream, is ground into fine powder, crosses 120 mesh sieves, gets mixing fine powders, standby.
(3) a kind of treatment nephropathy, uremic Chinese medicine preparation soft capsule are the NIAODUQING soft capsules, its preparation method is to get (2) prepared mixing fine powders, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule;
(4) a kind of treatment nephropathy, uremic Chinese medicine preparation drop pill are the NIAODUQING drop pill, its preparation method is a mixing fine powders of getting (2) gained, Polyethylene Glycol PEG6000500g, stearic acid 100g, Poloxamer18850g, treat to add in the mixing fine powders of (2) gained after Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
Advantage of the present invention is:
Carry, taking convenience, the crowd that can take be wide, do not have bad smell, the bioavilability height is conducive to improve and treats Effect.
Claims (3)
1, a kind of treatment nephropathy, uremic Chinese medicine preparation is characterized in that it is that main component is the NIAODUQING soft capsule or the drop pill of Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Radix Astragali, SANGQUPI, Radix Sophorae Flavescentis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Flos Chrysanthemi, Radix Polygoni Multiflori Preparata, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Plantaginis, Radix Bupleuri.
2, a kind of preparation method for the treatment of nephropathy, uremic Chinese medicine preparation is characterized in that:
(1) medicine constituent and percentage by weight consumption thereof are as follows:
Radix Et Rhizoma Rhei, Radix Glycyrrhizae, each 1-3% of Radix Bupleuri, the Radix Astragali, SANGQUPI, Radix Codonopsis, the Radix Paeoniae Alba, each 4-8% of Rhizoma Chuanxiong, Radix Sophorae Flavescentis, Flos Chrysanthemi, each 2-5% of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, each 8-11% of Herba Plantaginis;
(2) above medical material is decocted with water 3 times, 3 hours for the first time, each 2 hours of second and third time, collecting decoction, being condensed into relative density is the clear paste of 1.25 (80 ℃ of surveys), is dried to dried cream, is ground into fine powder, crosses 120 mesh sieves, gets mixing fine powders, standby;
(3) get (2) prepared mixing fine powders, add suitable adjuvant after, make soft capsule or drop pill;
The preparation of soft capsule method: get the mixing fine powders of (2) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations of following material or other proper auxiliary materials: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other proper auxiliary materials, use with by arbitrary proportion, add (2) prepared mixing fine powders after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly.
3, a kind of preparation method for the treatment of nephropathy, uremic Chinese medicine preparation according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Radix Bupleuri each 2%, the Radix Astragali 8%, SANGQUPI, Radix Codonopsis, the Radix Paeoniae Alba, Rhizoma Chuanxiong each 6%, Radix Sophorae Flavescentis, Flos Chrysanthemi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) each 4%, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Herba Plantaginis each 10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100316429A CN100341548C (en) | 2005-06-01 | 2005-06-01 | Chinese medicine formulation for treating disney disease and toxuria, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100316429A CN100341548C (en) | 2005-06-01 | 2005-06-01 | Chinese medicine formulation for treating disney disease and toxuria, and its preparing method |
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| Publication Number | Publication Date |
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| CN1709481A true CN1709481A (en) | 2005-12-21 |
| CN100341548C CN100341548C (en) | 2007-10-10 |
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| CNB2005100316429A Expired - Fee Related CN100341548C (en) | 2005-06-01 | 2005-06-01 | Chinese medicine formulation for treating disney disease and toxuria, and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446558A (en) * | 2013-07-26 | 2013-12-18 | 杨德俊 | Traditional Chinese medicine for treating chronic nephritis |
| CN104524111A (en) * | 2014-12-31 | 2015-04-22 | 曲向阳 | Medicine for treating nephropathy |
| CN115184500A (en) * | 2022-07-19 | 2022-10-14 | 康臣药业(霍尔果斯)有限公司 | Quality detection method of traditional Chinese medicine composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408425A (en) * | 2002-09-05 | 2003-04-09 | 申志荣 | New Chinese medicine for curing uraemia |
| CN1294971C (en) * | 2004-04-15 | 2007-01-17 | 朱来明 | 'Niaoduqing' granule taken after being mixed with boiling water for cutting uraemia |
-
2005
- 2005-06-01 CN CNB2005100316429A patent/CN100341548C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446558A (en) * | 2013-07-26 | 2013-12-18 | 杨德俊 | Traditional Chinese medicine for treating chronic nephritis |
| CN103446558B (en) * | 2013-07-26 | 2015-09-23 | 杨德俊 | A kind of Chinese medicine for the treatment of chronic nephritis |
| CN104524111A (en) * | 2014-12-31 | 2015-04-22 | 曲向阳 | Medicine for treating nephropathy |
| CN115184500A (en) * | 2022-07-19 | 2022-10-14 | 康臣药业(霍尔果斯)有限公司 | Quality detection method of traditional Chinese medicine composition |
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| Publication number | Publication date |
|---|---|
| CN100341548C (en) | 2007-10-10 |
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Effective date of registration: 20150930 Address after: 410331 Hunan province Changsha city Changsha national biological industry base Kang Road No. 109 Patentee after: HUNAN TIANDI HENGYI PHARMACEUTICAL CO.,LTD. Address before: Shaoshan City, Hunan province 410007 Changsha Road No. 39 Victoria Star City Taurus room 1202 Patentee before: Wang Hengxin |
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Address after: 410331 No. 109 Kangtian Road, Changsha National Biological Industrial Base, Hunan Province Patentee after: TIANDI HENGYI PHARMACEUTICAL Co.,Ltd. Address before: 410331 No. 109 Kangtian Road, Changsha National Biological Industrial Base, Changsha City, Hunan Province Patentee before: HUNAN TIANDI HENGYI PHARMACEUTICAL CO.,LTD. |
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