CN103070969A - Chinese medicinal composition for reducing blood fat and preparation method thereof - Google Patents
Chinese medicinal composition for reducing blood fat and preparation method thereof Download PDFInfo
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- CN103070969A CN103070969A CN2012103557412A CN201210355741A CN103070969A CN 103070969 A CN103070969 A CN 103070969A CN 2012103557412 A CN2012103557412 A CN 2012103557412A CN 201210355741 A CN201210355741 A CN 201210355741A CN 103070969 A CN103070969 A CN 103070969A
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Abstract
The invention provides a Chinese medicinal composition for reducing blood fat and a preparation method thereof. The composition comprises Salvia miltiorrhiza, hawthorn and prepared rehmannia root in a certain weight ratio. The Chinese medicinal composition for reducing blood fat provided by the invention has reasonable composition, significant effect on reducing blood fat, and can be widely used in prevention and treatment of hyperlipidemia and related diseases.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicinal composition for reducing blood fat and preparation method thereof.
Background technology
Hyperlipidemia belongs to commonly encountered diseases in clinical, with advancing age, its sickness rate also obviously increases.A large amount of epidemiological studies show that it is the independent hazard factor that cardiovascular disease occurs that dyslipidemia raises, and statistical data in recent years shows that more cardiovascular disease has become first cause of disease of Chinese population death, accounts for 40% of general population mortality rate.Therefore to the cause of disease, the pathological study of hyperlipidemia with seek to prevent and treat the new active drug of this disease, become problem very outstanding and urgent in the current medical research.
The research of Chinese medicine prevention hyperlipidemia has also obtained larger progress.The colleague of the traditional prescription of checking, this also develops and has developed a collection of new blood fat reducing Chinese Traditional Medicines combination many researchs.For example, CN 95113605 discloses blood fat reducing and the arteriosclerosis pharmaceutical composition take Fructus Crataegi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Chrysanthemi and Rhizoma Chuanxiong as basic recipe; CN 99122693 discloses the blood fat lowering capsule that is comprised of Chinese medicines such as Fructus Crataegi, the Radix Polygoni Multiflori, Rhizoma Alismatis, Radix Bupleuri, Radix Salviae Miltiorrhizaes; CN00107136 discloses the Antilipidemic pharmaceutical compositions that the water extract of a kind of alcohol extract by the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori and Fructus Crataegi, Rhizoma Chuanxiong, Semen Coicis, Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli etc. forms; CN 1263772A discloses and a kind ofly has been comprised of Fructus Crataegi, the Radix Polygoni Multiflori, Rhizoma Alismatis, Radix Bupleuri, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Semen Raphani, Radix Curcumae, has that strengthening spleen, tonifying kidney is soothing the liver, promoting blood circulation to remove stagnancy blood stasis dispelling effect, and treatment fatty liver, hyperlipemia effect are better; CN1283288C discloses and a kind ofly has been prepared from by Radix Puerariae, Fructus Crataegi, Rhizoma Alismatis, Radix Polygoni Multiflori and Radix Angelicae Sinensis, has promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling, strengthening spleen, tonifying kidney, clearing away heat-damp and promoting diuresis effect, is used for the treatment of hyperlipidemia, can reach the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.Yet these compositionss all are to be made by multiple natural Chinese medicine basically, composition relative complex not only, and quality control is inconvenient, and is difficult to carry out more deep structure effect research, and what be unfavorable for medicine clinically uses and studies.
Summary of the invention
Purpose of the present invention namely is to provide a kind of compositions less, and composition is relatively simple, use is comparatively convenient, the antilipemic Chinese herbal medicine group and the medicine that are easy to further investigate.
Another object of the present invention is to provide the preparation method of said composition.
Technical scheme of the present invention is as follows:
A kind of Chinese medicinal composition for reducing blood fat is comprised of Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Rehmanniae Preparata, and the parts by weight of each several part are: Radix Salviae Miltiorrhizae 30-40 part, Fructus Crataegi 30-40 part, Radix Rehmanniae Preparata 20-30 part.
Especially, described a kind of Chinese medicinal composition for reducing blood fat, the parts by weight of each several part are: 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Fructus Crataegis, 25 parts of Radix Rehmanniae Preparata.
A kind of method for preparing described Chinese medicinal composition for reducing blood fat, concrete steps are:
(1) takes by weighing weight portion Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Rehmanniae Preparata, adding the decocting that 8-12 doubly measures boils 2-3 time, each 2-3h, merging filtrate, being evaporated to relative density is 1.10-1.20(60 ℃), concentrated solution adds ethanol, precipitate in 75～85% pure liquid, getting the precipitate with ethanol supernatant, to be evaporated to relative density be 1.10-1.20(60 ℃), get extractum.
(2) with extractum in 60～70 ℃ of dryings, obtain the dried cream of active component;
(3) dried cream powder is broken, sieve, the adding forming agent is an amount of, makes soft material with 70～90% ethanol, granulates drying, granulate.
(4) agent of granule granulation, capsule, the tablet that drying is good.
Radix Salviae Miltiorrhizae has promoting blood flow to regulate menstruation among the present invention, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, relieving restlessness clears away heart-fire, the effect of nourishing blood to tranquillize the mind, except the heart, cerebrovascular system are had the myocardium shrinkage function of improvement, blood vessel dilating and reduce blood pressure, improve arteria coronaria and the function such as cerebral artery blood flow amount, play in addition blood fat reducing, so it is monarch drug; Fructus Crataegi has the effect of promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach, blood circulation promoting and blood stasis dispelling, is ministerial drug in the side, assists monarch drug, makes its dissipating depression of QI gas and does not hinder healthy energy, makes pathogen that outlet be arranged, jointly for primary symptom; Assistant is filled out the marrow promoting tissue regeneration by removing blood stasis with enrich blood YIN nourishing, beneficial essence of Radix Rehmanniae Preparata, makes blood fortune unimpeded.Three kinds of drug combinations just can reach reinforcing and reducing and execute treating both the principal and the secondary aspects of a disease at the same time.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but the scope that this should be interpreted as this bright above-mentioned theme only limits to following example, and all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Prescription:
35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Fructus Crataegis, 25 parts of Radix Rehmanniae Preparata
Preparation method:
(1) takes by weighing 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Fructus Crataegis, 25 parts of Radix Rehmanniae Preparata, the decocting that adds 10 times of amounts boils 3 times, each 2h, merging filtrate, being evaporated to relative density is 1.10(60 ℃), concentrated solution adds ethanol, precipitates in 80% pure liquid, and getting the precipitate with ethanol supernatant, to be evaporated to relative density be 1.12(60 ℃) extractum.
(2) with extractum in 65 ℃ of dryings, obtain the dried cream of active component;
(3) dried cream powder is broken, sieve, the adding dextrin is an amount of, makes soft material with 80% ethanol, granulates drying, granulate.
(4) the granule granulation agent that drying is good, packing.
Embodiment 2
Prescription:
40 parts of Radix Salviae Miltiorrhizaes, 40 parts of Fructus Crataegis, 30 parts of Radix Rehmanniae Preparata
Preparation method:
(1) takes by weighing 40 parts of Radix Salviae Miltiorrhizaes, 40 parts of Fructus Crataegis, 30 parts of Radix Rehmanniae Preparata, the decocting that adds 12 times of amounts boils 3 times, each 3h, merging filtrate, being evaporated to relative density is 1.15(60 ℃), concentrated solution adds ethanol, precipitates in 85% pure liquid, and getting the precipitate with ethanol supernatant, to be evaporated to relative density be 1.10(60 ℃) extractum.
(2) with extractum in 65 ℃ of dryings, obtain the dried cream of active component;
(3) dried cream powder is broken, sieve, add starch, microcrystalline Cellulose is an amount of, makes soft material with 80% ethanol, granulation, drying, granulate.
(4) tabletting makes tablet, packing.
Embodiment 3
Prescription:
30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Fructus Crataegis, 20 parts of Radix Rehmanniae Preparata
Preparation method:
(1) takes by weighing 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Fructus Crataegis, 20 parts of Radix Rehmanniae Preparata, the decocting that adds 8 times of amounts boils 2 times, each 2h, merging filtrate, being evaporated to relative density is 1.16(60 ℃), concentrated solution adds ethanol, precipitates in 75% pure liquid, and getting the precipitate with ethanol supernatant, to be evaporated to relative density be 1.20(60 ℃) extractum.
(2) with extractum in 60 ℃ of dryings, obtain the dried cream of active component;
(3) dried cream powder is broken, sieve, add starch, microcrystalline Cellulose is an amount of, makes soft material with 80% ethanol, granulation, drying, granulate.
(4) fill makes capsule, packing.
Claims (4)
1. a Chinese medicinal composition for reducing blood fat is characterized in that being comprised of Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Rehmanniae Preparata, and the parts by weight of each several part are: Radix Salviae Miltiorrhizae 30-40 part, Fructus Crataegi 30-40 part, Radix Rehmanniae Preparata 20-30 part.
2. a kind of Chinese medicinal composition for reducing blood fat according to claim 1 is characterized in that the parts by weight of each several part are: 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Fructus Crataegis, 25 parts of Radix Rehmanniae Preparata.
3. method for preparing claim 1 or 2 described Chinese medicinal composition for reducing blood fats is characterized in that concrete steps are:
(1) takes by weighing Radix Salviae Miltiorrhizae, Fructus Crataegi, the Radix Rehmanniae Preparata of weight portion, adding the decocting that 8-12 doubly measures boils 2-3 time, each 2-3h, merging filtrate, being evaporated to relative density is 1.10-1.20(60 ℃), concentrated solution adds ethanol, precipitates in 75～85% pure liquid, getting the precipitate with ethanol supernatant, to be evaporated to relative density be 1.10-1.20(60 ℃), get extractum;
(2) with extractum in 60～70 ℃ of dryings, obtain the dried cream of active component;
(3) dried cream powder is broken, sieve, the adding forming agent is an amount of, makes soft material with 70～90% ethanol, granulate, drying, granulate gets granule.
4. a kind of preparation method of Chinese medicinal composition for reducing blood fat as claimed in claim 3 is characterized in that granulation agent, capsule, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012103557412A CN103070969A (en) | 2012-09-24 | 2012-09-24 | Chinese medicinal composition for reducing blood fat and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084304A (en) * | 2019-12-17 | 2020-05-01 | 众心同创(厦门)电子商务有限公司 | Beverage capable of reducing blood cholesterol and preparation process thereof |
| CN115429836A (en) * | 2022-08-31 | 2022-12-06 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating arrhythmia |
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| US6413554B1 (en) * | 2000-11-14 | 2002-07-02 | Yong Il No | Compositions for treatment of hyperlipidemia and angina pectoris |
| EP1371368A1 (en) * | 2002-06-11 | 2003-12-17 | N.V. Nutricia | Salvianolic acid components as lipase inhibitors |
| KR20080004158A (en) * | 2006-07-05 | 2008-01-09 | 박영준 | Composition comprising an extract of nelumbo folium or herb complex for preventing or treating hyperlipidemia and arteriosclerosis |
| CN101107950A (en) * | 2007-08-10 | 2008-01-23 | 游文龙 | Whitethorn health-care tea and preparing method thereof |
| CN101342254A (en) * | 2007-07-11 | 2009-01-14 | 中国中医科学院中药研究所 | Combination of traditional Chinese medicine extract for preventing and treating atherosis, hyperlipemia, and preparation thereof |
| CN102326813A (en) * | 2010-07-13 | 2012-01-25 | 孟国良 | Salvia miltiorrhiza bge.f.alba functional beverage and preparation method thereof |
| CN102657719A (en) * | 2012-04-27 | 2012-09-12 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating hyperlipidemia |
-
2012
- 2012-09-24 CN CN2012103557412A patent/CN103070969A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6413554B1 (en) * | 2000-11-14 | 2002-07-02 | Yong Il No | Compositions for treatment of hyperlipidemia and angina pectoris |
| EP1371368A1 (en) * | 2002-06-11 | 2003-12-17 | N.V. Nutricia | Salvianolic acid components as lipase inhibitors |
| KR20080004158A (en) * | 2006-07-05 | 2008-01-09 | 박영준 | Composition comprising an extract of nelumbo folium or herb complex for preventing or treating hyperlipidemia and arteriosclerosis |
| CN101342254A (en) * | 2007-07-11 | 2009-01-14 | 中国中医科学院中药研究所 | Combination of traditional Chinese medicine extract for preventing and treating atherosis, hyperlipemia, and preparation thereof |
| CN101107950A (en) * | 2007-08-10 | 2008-01-23 | 游文龙 | Whitethorn health-care tea and preparing method thereof |
| CN102326813A (en) * | 2010-07-13 | 2012-01-25 | 孟国良 | Salvia miltiorrhiza bge.f.alba functional beverage and preparation method thereof |
| CN102657719A (en) * | 2012-04-27 | 2012-09-12 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating hyperlipidemia |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084304A (en) * | 2019-12-17 | 2020-05-01 | 众心同创(厦门)电子商务有限公司 | Beverage capable of reducing blood cholesterol and preparation process thereof |
| CN115429836A (en) * | 2022-08-31 | 2022-12-06 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating arrhythmia |
| CN115429836B (en) * | 2022-08-31 | 2023-09-12 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating arrhythmia |
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Application publication date: 20130501 |