CN1795852A - Suppository of Metronidazole and preparation technique - Google Patents
Suppository of Metronidazole and preparation technique Download PDFInfo
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- CN1795852A CN1795852A CN 200410104481 CN200410104481A CN1795852A CN 1795852 A CN1795852 A CN 1795852A CN 200410104481 CN200410104481 CN 200410104481 CN 200410104481 A CN200410104481 A CN 200410104481A CN 1795852 A CN1795852 A CN 1795852A
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- suppository
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- metronidazole
- clotrimazole
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Abstract
A Shuangzuotai suppository is prepared proportionally from metronidazole, mycosporin, chlorhexidine acetate, matrix, cotton suppository saturated by said matrix, and a tubular band made of PVC or PE.
Description
Technical field
The present invention relates to a kind of suppository and preparation technology thereof, particularly metronidazole,clotrimazole and chlorhexidine acetate suppositories and preparation method thereof, belong to pharmaceutical sanitary field.
Background technology
Metronidazole,clotrimazole and chlorhexidine acetate suppositories is a kind of gynecological nonprescription drugs medicine commonly used, and general every piece contains metronidazole 0.2g, clotrimazole 0.16g, chlorhexidine acetate 8mg.The safe inspection of two azoles is applicable to bacterial vaginitis, colpitis mycotica, trichomonal vaginitis and mixed infective vaginitis for antimicrobial drug.Adjuvant in its preparation process is mainly the semi-synthetic fatty acid ester of excipient, paraffin, softening agent lanoline.
The metronidazole,clotrimazole and chlorhexidine acetate suppositories suppository of Xiao Shouing is DNAcarrier free in the market, and is the same with general suppository, because the suppository that dissolves can not in time be absorbed in the body fully, owing to the outflow of medicine and substrate, the meeting pollution clothes is made troubles to user in use.And this outflow concentration that also can cause medicine can not remain valid for a long time in vivo.
In order to overcome above-mentioned defective, the improvement to various suppositorys is disclosed in the prior art.Disclosing the cotton base of a kind of protection for the health of woman articles for use hollow cylindrical as Chinese patent application 89210570.4, made by medical absorbent cotton, is axle with the cellulosic inner core, the cotton layer of cylinder of the typing shape that the absorbent cotton sheet is rolled into; Be coated with to carry out on the cotton pilum body and the skim dextrin arranged as sealing coat; Be coated with on the sealing coat that shoe is made up of the glycerin gelatine layer four-layer structure of glycerol that contains certain moisture content and gelatin mixture.With this cotton base is that substrate can be made various vaginal suppositories.This suppository can fully keep medicine concentration in vivo, to reach curative effect, can prevent the outflow of medicine and liquid again, and is very easy to use.But this technology is more loaded down with trivial details, can improve the processing cost of product, is not easy to large-scale industrial production.
The patent No. is 96216798.3 the compound bolt of a kind of medicinal vagina, and by the medicine key that is streamline bomb shape, half is embedding and be fixed with the health tampon in it, and the afterbody of health tampon is provided with the bolt lead-in wire and constitutes.The medicine key also can be molded as warhead form, duckbill shape.Its processing technique is simple, self have lubrication, can avoid medicinal liquid to flow out, and do not pollute clothing, and can promote drug absorption, long action time, uses easy to carry.
Therefore, under the enlightenment with above-mentioned prior art, commercially available metronidazole,clotrimazole and chlorhexidine acetate suppositories is made half embedding and be fixed with the medicine key of health tampon, can be avoided medicinal liquid to flow out, do not pollute clothing, and can promote drug absorption, long action time, use easy to carry.It is softer that but the medicine key that contains the health tampon really exists the suppository material, also causes key to be difficult for being shaped easily in system bolt process, can't use.
Summary of the invention
The object of the present invention is to provide a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent, metronidazole,clotrimazole and chlorhexidine acetate suppositories agent half is embedding and be fixed with treated health tampon, keep concentration medicine and dosage, and can promote drug absorption, long action time, use easy to carryly, occur deformed phenomenon in the time of simultaneously can preventing to make bolt.
Another object of the present invention is to provide the preparation method of above-mentioned metronidazole,clotrimazole and chlorhexidine acetate suppositories agent, method is simple for this, is easy to suitability for industrialized production.
In order to realize the object of the invention, the invention provides a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent, the key of described suppository comprises following composition and content:
Metronidazole 100～300g
Clotrimazole 100～300g
And suppository substrate commonly used, it is characterized in that also being embedded with in the described suppository tampon, the surface of described tampon or surface and inner saturated by suppository substrate commonly used.
Preferred key comprises following pharmaceutical compositions and content:
Metronidazole 200g
Clotrimazole 160g
Chlorhexidine acetate 8mg
Described substrate for preparation suppository substrate commonly used, can be a kind of of water solublity, hydrophilic or fat-soluble substrate.Include but not limited to one or more combination of semi-synthetic fatty acid glyceride class, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, the hard ester acid esters of polyoxyethylene; Wherein preferred substrate is one or more the combination wherein of semi-synthetic fatty acid glyceride class, lanoline, paraffin, Polyethylene Glycol or poloxamer.The heavy content of medicines of the consumption of substrate commonly used and key adopts disclosed ratio in the prior art, preferably adopts following substrate and content:
Lanoline accounts for suppository gross weight 3g～45g
Paraffin accounts for suppository gross weight 3g～45g
Semi-synthetic fatty acid glyceride accounts for suppository gross weight 120g～2300g
Described tampon is column or suitable other shapes that prepare suppository that medical absorbent cotton, non-woven fabrics or other plant fiber are made.
The preparation method of tampon of the present invention is: it is saturated by substrate that the cylinder of the typing shape that absorbent cotton, non-woven fabrics or other plant fibre plate are rolled into, the hot radical matter of putting into fusing flood the surface of tampon at least.
Described hot radical matter is to make substrate maintain the substrate of molten condition, and the fusion temperature of substrate depends on the substrate that is adopted, and common fusion temperature is 20～80 ℃, preferred 30-50 ℃.
The saturated of the saturated substrate of substrate gets final product with surface formation layer protecting film or abundant the infiltration.Through experimental results show that for the absorbent cotton tampon, generally flooded 1～360 second, can reach capacity in preferred 10～30 seconds.
The mixed proportion of substrate and medicine generally can be controlled in 1: 1～1: 80, was preferably 1: 5～1: 50.
Described suppository can be made into circle, ellipse, triangle, star, prismatic, rectangle, taper or duckbill etc., but is not limited thereto, and conveniently is as the criterion so that the patient is comfortable when using, and how shelves the organization of human body at position with suppository and decides.
For the ease of taking out, also can be provided with the bolt lead-in wire at the suppository afterbody.
Suppository of the present invention also comprises a bolt band that is used to pack, and material is PVC, PE, described bolt band for corresponding with the shape of suppository own, several suppositorys are coated on wherein a sealed packet load respectively.
The suppository that comprises 1-20 piece of independent packaging in preferred each the bolt band of the present invention in each package panel, comprises one to two row's suppository.
Described suppository can adopt disclosed method preparation in the prior art.For example, the preparation of described suppository comprises the steps:
1) with PVC, PE sheet material lettering, be blow molded into and contain several and the corresponding sheet material that has the groove of evagination of suppository shape, three peripheries of outer emboss pit are welded into contain several and bolt band, cooling, the molding corresponding hollow of suppository shape, that be used for splendid attire and shaping suppository are standby again;
2) pretreatment tampon obtains surface or surface and inner by the saturated tampon of substrate;
3) with after the suppository base fusing, proportionally add medicine, be stirred into medicinal liquid, standby;
4) medicinal liquid for preparing is poured in the bolt band, insert treated tampon then, cooling forming.
5) post processing.
Described post processing comprises seals, shears the bolt band.
More particularly, the preparation method of bolt base of the present invention comprises the steps:
The preparation method of bolt band is: with PVC, PE sheet material earlier 50～150 ℃ of preheatings, 70～150 ℃ of blow moldings, again 90～180 ℃ of welding, then at 0～30 ℃ of cooling forming, last edging is standby.
Get the suppository base of having got ready and put into 30～150 ℃ of heat fused of container, preferred temperature is 80 ℃; Proportionally get medicated powder after sieving and under 20～100 ℃, increase progressively to put in the substrate of having dissolved and be made into medicinal liquid, or add a small amount of substrate in advance and stir into pasty state, add a large amount of substrate again and be made into medicinal liquid by equivalent, stir 5～60 minutes standby.
Elder generation's pre-heating device is irritated the interlayer temperature with material loading and is controlled in 20～80 ℃, and the baiting valve temperature is controlled at 20～80 ℃, and the pouring head temperature is controlled at 20～80 ℃.
The medicinal liquid for preparing is installed in the batch can, open stirring arm and stirred 5～60 minutes.Put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band, groundwater increment is 0.1～5g, inserts saturated tampon then ,-15～35 ℃ of cooled and solidified, molding are through heat-sealing mouthful, cut edge, shear and obtain finished product.
The fineness of medicated powder wherein is about 100 orders.
Described bolt band is that PVC or PE material are made, and has the sheet material of groove of the corresponding evagination of shape of a plurality of and suppository, and this sheet material prepares in advance according to the shape of suppository, and preparation process is bought PVC, PE sheet material lettering, blow molding.Concrete technology is as follows: first preheating, and welding again, cooling forming then, last edging is standby.Medicinal liquid seals, shears behind bolt band groove internal cooling, obtains having the suppository of this packing, and dress is sold behind the box, during use suppository is taken out to get final product from the bolt band.
Metronidazole,clotrimazole and chlorhexidine acetate suppositories of the present invention and preparation method thereof; on the surface of tampon or surface and inside thereof be adsorbed with substrate and saturated by substrate; at least form layer protective layer on the tampon surface; except that advantage with the suppository that generally has tampon; also can improve the utilization rate of medicine; make all dosages controlled, occur deformed phenomenon simultaneously in the time of can preventing to make bolt.Metronidazole,clotrimazole and chlorhexidine acetate suppositories of the present invention can effectively be treated bacterial vaginitis, colpitis mycotica, trichomonal vaginitis and mixed infective vaginitis, and is more effective than prior dosage form, and easy to use.
The specific embodiment
Describe the present invention in detail below in conjunction with the drawings and specific embodiments, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Description of drawings
The sketch map that Fig. 1 is used to prepare the bolt strap material of suppository and fastens band for the present invention;
Fig. 2 is that Figure 1A-A is to cutaway view;
Fig. 3 is for having the sketch map of the suppository of bolt band, cotton sliver for the present invention;
Fig. 4 is that Fig. 3 B-B is to cutaway view;
Fig. 5 has the sketch map of the suppository of bolt band, cotton sliver for Fig. 3 the present invention.
Below be specific embodiments of the invention.
Embodiment 1
Present embodiment is a kind of surface-treated tampon, and the tampon surface adsorption has semi-synthetic fatty acid glyceride substrate.Its preparation method is: after 80 ℃ of fusings of semi-synthetic fatty acid heating, under 45 ℃, put into tampon 30 seconds, adsorb saturated, tampon formation layer protective layer.
With embodiment 1, different is, used substrate is Polyethylene Glycol, and heating-up temperature is 90 ℃, puts into cotton sliver 50 seconds under 50 ℃.
With embodiment 1, different is, used substrate is paraffin, and heating-up temperature is 120 ℃, puts into cotton sliver 10 seconds under 80 ℃.
Embodiment 4
With embodiment 1, different is, used substrate is poloxamer, and heating-up temperature is 60 ℃, puts into cotton sliver 60 seconds under 30 ℃.
With embodiment 1, different is, used substrate is gelatin, and heating-up temperature is 150 ℃, puts into cotton sliver 5 seconds under 75 ℃.
With embodiment 1, different is, used substrate is 1 kilogram of lanoline, 3 kilograms in paraffin, and 50 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 90 ℃, puts into the absorbent cotton tampon 50 seconds under 50 ℃.
With embodiment 1, different is, used substrate is 5 kilograms of lanolines, 5 kilograms in paraffin, and 100 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 120 ℃, puts into tampon 10 seconds under 80 ℃.
Embodiment 8
With embodiment 1, different is, used substrate is 15 kilograms of lanolines, 5 kilograms in paraffin, and 300 kilograms of semi-synthetic fatty acid glyceride, heating-up temperature is 60 ℃, puts into tampon 360 seconds under 30 ℃.
Embodiment 9
With embodiment 1, different is, used substrate is gelatin, and heating-up temperature is 150 ℃, puts into tampon 5 seconds under 75 ℃.
Embodiment 10
Referring to accompanying drawing 1-3, get PVC or PE sheet material lettering, be blow molded into corresponding with the suppository shape, as to have the groove 2 of several outwards outstanding suppository shapes sheet material 1.Concrete technology is as follows: earlier 90 ℃ of preheatings, 100 ℃ of blow moldings, under 120 ℃, two sheet materials staggered relatively 1 are welded again, so that three limit portions, 3 welding of suppository groove form semi-closed structure, only stay an opening 4 to be used for dosing in outside limit portion, in room temperature cooling, molding, fastening of obtaining is with 10 (omitting among the figure) edging standby then.
The suppository base 400g (with embodiment 1) that gets among the embodiment 8 that has got ready puts into container, 20～100 ℃ of following heating in water bath fusings; Under 45 ℃, get medicated powder after sieve (100 order) in 1: 25 ratio and increase progressively to put in the substrate of having dissolved by equivalent and be made into medicinal liquid, stirred 30 minutes, standby.Medicated powder wherein is metronidazole 200g, clotrimazole 160g, chlorhexidine acetate 8mg.
Before the perfusion, the preheating of equipment elder generation, making material loading irritate the interlayer temperature is 55 ℃, and the baiting valve temperature is 45 ℃, and the pouring head temperature is 40 ℃.The medicinal liquid for preparing is installed in the batch can, opened the stirring arm stir about 30 minutes.Put bolt band 10 well, open the medicinal liquid stop valve, the 2.2g medicinal liquid is circulated in the groove of bolt band, insert saturated 7,0～25 ℃ of cooled and solidified of tampon then and make molding, obtain having the package panel 6 of suppository 5; Seal mouthful, cut edge, be cut into 1～20 piece or directly adorn box then.
Embodiment 11
The substrate of the suppository of embodiment 6 is heated to 30～150 ℃, treats substrate fusing back cooling, the hot radical matter dipping of in 30～80 ℃ tampon being put into fusing is saturated by substrate to the surface of tampon at least, makes tampon form layer protective layer.Can prevent to combine absorption medicinal liquid when making bolt, make all dosages controlled, occur deformed phenomenon when preventing to make bolt with medicine.
Getting substrate semi-synthetic fatty acid glyceride, lanoline, paraffin among the embodiment 6 puts in the container and dissolves 20～150 ℃ of heating, metronidazole 100～the 300g that under constantly stirring, added 100 mesh sieves, clotrimazole 100～300g, chlorhexidine acetate 6～10mg medicated powder, stirring, it is standby to be made into medicinal liquid.
Put the bolt band well, medicinal liquid is circulated in the opening 4 of PVC, PE bolt band, insert the good tampon 7 of pre-selection process, seal after the cooled and solidified, shear.Before the perfusion, the preheating of equipment elder generation, making material loading irritate the interlayer temperature is 20～80 ℃, and the baiting valve temperature is 20～80 ℃, and the pouring head temperature is 20～80 ℃.The medicinal liquid for preparing is installed in the batch can, opened the stirring arm stir about 5～60 minutes.Put bolt band 10 well, open the medicinal liquid stop valve, the 0.5-3g medicinal liquid is circulated in the groove of bolt band, insert saturated tampon then, 0～25 ℃ of cooled and solidified makes molding; Seal mouth then, cut edge, be cut into 1～20 piece.
90 ℃ of preheatings, 100 ℃ of blow moldings are welded two sheet materials staggered relatively 1 under 120 ℃ more earlier,
Embodiment 12-14
With reference to the foregoing description, concrete technology and substrate, drug dose are as follows:
| Embodiment 12 | Embodiment 13 | Embodiment 14 | |
| The preparation of bolt band | PE sheet material, 50 ℃ of preheatings, 70 ℃ of blow moldings are at 180 ℃ of welding, room temperature cooling forming. | PVC sheet material is 150 ℃ of preheatings, 150 ℃ of blow moldings, 90 ℃ of welding, 0 ℃ of cooling forming. | Sheet material is 120 ℃ of preheatings, and 110 ℃ of blow moldings are cooled off again 100 ℃ of welding. |
| Substrate | Embodiment 1,30 ℃ of | 7 100 ℃ of | 3 150 ℃ of embodiment |
| Medicine | Metronidazole 100g clotrimazole 300g chlorhexidine acetate 10mg | Metronidazole 300g clotrimazole 100g chlorhexidine acetate 6mg | Metronidazole 250g clotrimazole 250g chlorhexidine acetate 9mg |
Claims (10)
1. metronidazole,clotrimazole and chlorhexidine acetate suppositories agent, the key of described suppository comprises following composition and content:
Metronidazole 100～300g
Clotrimazole 100～300g
Chlorhexidine acetate 6～10mg
And suppository substrate commonly used, it is characterized in that also being embedded with in the described suppository tampon, the surface of described tampon or surface and inner saturated by suppository substrate commonly used.
2. a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 1 is characterized in that, preferred key comprises following composition and content:
Metronidazole 200g
Clotrimazole 160g
Chlorhexidine acetate 8mg
3. a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 1 is characterized in that described tampon is column or suitable other shapes that prepare suppository that medical absorbent cotton, non-woven fabrics or other plant fiber are made.
4. a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 3, it is characterized in that described substrate at least a of preparation suppository commonly used water solublity, hydrophilic or fat-soluble substrate or with more than one combination of apoplexy due to endogenous wind, preferred substrate is one or more combination of semi-synthetic fatty acid glyceride class, hydrogenated vegetable oil, cocoa butter, lanoline, Polyethylene Glycol, poloxamer, paraffin, glycerol, gelatin, the hard ester acid esters of polyoxyethylene; Preferred substrate is one or more the combination wherein of semi-synthetic fatty acid glyceride class, lanoline, Polyethylene Glycol or poloxamer; Most preferably adopt following substrate and content:
Lanoline accounts for suppository gross weight 3g～45g
Paraffin accounts for suppository gross weight 3g～45g
Semi-synthetic fatty acid glyceride accounts for suppository gross weight 120g～2300g.
5. a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 1 is characterized in that described suppository also comprises a bolt band that is used to pack, described bolt band for corresponding with the shape of suppository own, several suppositorys are coated on wherein a sealed packet load respectively.
6. a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 1 is characterized in that also being provided with the bolt lead-in wire at the suppository afterbody.
7. the preparation method of the described a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent of claim 1 comprises the steps:
1) with PVC, PE sheet material lettering, be blow molded into and contain several and the corresponding sheet material that has the groove of evagination of suppository shape, three peripheries of outer emboss pit are welded into contain several and bolt band, cooling, the molding corresponding hollow of suppository shape, that be used for splendid attire and shaping suppository are standby again;
2) pretreatment tampon obtains surface or surface and inner by the saturated tampon of substrate;
3) with after the suppository base fusing, proportionally add medicine, be stirred into medicinal liquid, standby;
4) medicinal liquid for preparing is poured in the bolt band, insert treated tampon then, cooling forming.
5) post processing.
8. the preparation method of a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 7, described post processing comprise to be sealed, shears the bolt band.
9. the preparation method of a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 7 comprises the steps:
Get the suppository base of having got ready and put into 30～150 ℃ of heat fused of container, preferred temperature is 80 ℃; Get medicated powder after sieving and under 20～100 ℃, increase progressively to put in the substrate of having dissolved and be made into medicinal liquid, or add a small amount of substrate in advance and stir into pasty state, add a large amount of substrate again and be made into medicinal liquid by equivalent, stir 5～60 minutes standby.
Elder generation's pre-heating device is irritated the interlayer temperature with material loading and is controlled in 20～80 ℃, and the baiting valve temperature is controlled at 20～80 ℃, and the pouring head temperature is controlled at 20～80 ℃.
The medicinal liquid for preparing is installed in the batch can, open stirring arm and stirred 5～60 minutes.In mould, put the bolt band well, treat the bolt band transmit put in place after, open the medicinal liquid stop valve, medicinal liquid is circulated in the bolt band (PVC, PE), and groundwater increment is 0.1～5g, inserts saturated tampon then,-15～35 ℃ of cooled and solidified, molding are through heat-sealing mouthful, cut edge, shear and obtain finished product.For: it is saturated by substrate that the cylinder of the typing shape that absorbent cotton, non-woven fabrics or other plant fibre plate are rolled into, the hot radical matter of putting into fusing flood the surface of tampon at least.
10. the preparation method of a kind of metronidazole,clotrimazole and chlorhexidine acetate suppositories agent according to claim 7, wherein the pretreatment tampon is the cylinder of a typing shape that absorbent cotton, non-woven fabrics or other fibre plates are rolled into, and the hot radical matter dipping of putting into fusing is saturated by substrate to the surface of tampon at least.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101044817A CN100358521C (en) | 2004-12-28 | 2004-12-28 | Suppository of Metronidazole and preparation technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101044817A CN100358521C (en) | 2004-12-28 | 2004-12-28 | Suppository of Metronidazole and preparation technique |
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| CN1795852A true CN1795852A (en) | 2006-07-05 |
| CN100358521C CN100358521C (en) | 2008-01-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004101044817A Active CN100358521C (en) | 2004-12-28 | 2004-12-28 | Suppository of Metronidazole and preparation technique |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048729A (en) * | 2011-01-08 | 2011-05-11 | 广州固志医药科技有限公司 | Preparation for treating vaginitis |
| CN103284996A (en) * | 2013-06-03 | 2013-09-11 | 哈尔滨欧替药业有限公司 | Vagina swelling metronidazole clotrimazole suppository and preparation method and detection method thereof |
| CN103301098A (en) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | Compound chlorhexidine vaginal expansion suppository as well as preparation method and detection method thereof |
| CN103520085A (en) * | 2013-05-17 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof |
| CN104490871A (en) * | 2014-11-24 | 2015-04-08 | 江苏远恒药业有限公司 | Compound chlorhexidine acetate suppository, and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87206030U (en) * | 1987-04-02 | 1987-12-30 | 哈尔滨纺织科研所 | Women's medicated cotton suppository |
| CN2266416Y (en) * | 1996-12-18 | 1997-11-05 | 阎庚飞 | Medical suppository |
| AU2001286889A1 (en) * | 2000-08-31 | 2002-03-13 | Abbott Laboratories | Process and intermediates for preparing retroviral protease inhibitors |
-
2004
- 2004-12-28 CN CNB2004101044817A patent/CN100358521C/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048729A (en) * | 2011-01-08 | 2011-05-11 | 广州固志医药科技有限公司 | Preparation for treating vaginitis |
| CN102048729B (en) * | 2011-01-08 | 2012-08-08 | 广州固志医药科技有限公司 | Preparation for treating vaginitis |
| CN103520085A (en) * | 2013-05-17 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof |
| CN103520085B (en) * | 2013-05-17 | 2015-08-19 | 哈尔滨欧替药业有限公司 | Clotrimazole or its salt expansible plug and preparation method |
| CN103284996A (en) * | 2013-06-03 | 2013-09-11 | 哈尔滨欧替药业有限公司 | Vagina swelling metronidazole clotrimazole suppository and preparation method and detection method thereof |
| CN103284996B (en) * | 2013-06-03 | 2014-10-15 | 哈尔滨欧替药业有限公司 | Vagina swelling metronidazole clotrimazole suppository and preparation method and detection method thereof |
| CN103301098A (en) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | Compound chlorhexidine vaginal expansion suppository as well as preparation method and detection method thereof |
| CN103301098B (en) * | 2013-06-21 | 2014-12-31 | 哈尔滨欧替药业有限公司 | Compound chlorhexidine vaginal expansion suppository as well as preparation method and detection method thereof |
| CN104490871A (en) * | 2014-11-24 | 2015-04-08 | 江苏远恒药业有限公司 | Compound chlorhexidine acetate suppository, and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100358521C (en) | 2008-01-02 |
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| C06 | Publication | ||
| PB01 | Publication | ||
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